author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00308438	chr1:92329399	1	92329399	TGFBR3	Open sea	-0.0033	0.00033	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00342358	chr1:92350112	1	92350112	TGFBR3	North shore	-0.0027	0.00029	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0022	0.0002	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00857921	chr1:92257380	1	92257380	TGFBR3	Open sea	0.015	0.0017	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	-0.00094	0.00011	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.004	0.00019	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08648138	chr1:92247732	1	92247732	TGFBR3	Open sea	-0.00066	0.000077	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.0025	0.00011	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.0053	0.00015	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.011	0.0011	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17074704	chr1:92350430	1	92350430	TGFBR3	North shore	-0.0026	0.00019	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.002	0.00015	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	0.0027	0.00016	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.0033	0.0003	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25769732	chr1:92295946	1	92295946	TGFBR3	Open sea	0.0028	0.00026	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.24796	0.00287	2.9e-156	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11855117	chr1:92293627	1	92293627	TGFBR3	Open sea	0.64565	0.00751	8.8e-156	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17468459	chr1:92208474	1	92208474	TGFBR3	Open sea	0.66671	0.0087	1.7e-146	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.26003	0.00374	1.7e-138	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00342358	chr1:92350112	1	92350112	TGFBR3	North shore	0.45451	0.00683	4.6e-135	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25769732	chr1:92295946	1	92295946	TGFBR3	Open sea	0.41394	0.00623	5.799999999999999e-135	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17074704	chr1:92350430	1	92350430	TGFBR3	North shore	0.19626	0.00315	7.8e-130	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18539768	chr1:92149139	1	92149139	TGFBR3	Open sea	0.61997	0.01001	2.8e-129	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00308438	chr1:92329399	1	92329399	TGFBR3	Open sea	0.51838	0.00901	2.1000000000000003e-123	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg02061431	chr1:92150549	1	92150549	TGFBR3	Open sea	-0.20889	0.00372	1.5999999999999999e-121	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.20997	0.00383	1.3e-119	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	0.48726	0.00919	5.5e-117	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17080882	chr1:92191625	1	92191625	TGFBR3	Open sea	0.29631	0.00611	4.7e-110	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.15172	0.00361	5.5e-99	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	0.14598	0.00351	3.2e-98	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	0.0022	None	1.3999999999999999e-96	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg21116284	chr1:92216881	1	92216881	TGFBR3	Open sea	0.40024	0.01008	8.2e-95	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.0027	None	4.6e-93	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.0016	None	8.900000000000001e-89	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19846193	chr1:92352084	1	92352084	TGFBR3	Island	0.00042	None	1.1e-84	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00857921	chr1:92257380	1	92257380	TGFBR3	Open sea	0.16229	0.00478	2.3999999999999997e-83	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.153196	0.00815911	9.648322e-78	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg01081930	chr1:92284280	1	92284280	TGFBR3	Open sea	0.23466	0.00786	2.9000000000000004e-74	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.145811	0.00816833	1.586125e-70	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	-0.14144	0.00817357	1.9819120000000002e-66	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.140431	0.00817475	1.677061e-65	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.135761	0.00818013	2.679224e-61	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	0.132881	0.00818335	8.847231e-59	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.131221	0.00818518	2.3597229999999998e-57	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.11651	0.00517	6.6e-56	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.127137	0.00818957	6.383499e-54	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	-0.122994	0.00819388	1.4885819999999998e-50	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.119319	0.00819759	1.159762e-47	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.119117	0.00819779	1.663826e-47	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg03006077	chr1:92234946	1	92234946	TGFBR3	Open sea	-1.79167	0.06293	7.319999999999999e-46	-	25282492_fetal_vs_adult_liver
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	0.36793	0.01953	1.3e-45	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03003526	chr1:92223917	1	92223917	TGFBR3	Open sea	-0.05858	0.00312	1.9e-45	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0023	None	8.900000000000001e-44	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03006077	chr1:92234946	1	92234946	TGFBR3	Open sea	-0.06167	0.00344	6.199999999999999e-43	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.11147	0.00820512	8.750892999999999e-42	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	0.110812	0.00820572	2.606525e-41	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.108232	0.00820807	1.771878e-39	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.104938	0.00821098	3.339317e-37	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.104569	0.00821131	5.95113e-37	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg09790580	chr1:92171309	1	92171309	TGFBR3	Open sea	-	-	3.63e-36	-	23526956_clear_cell_renal_carcinoma
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-1.98373	0.09443	7.81e-36	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	-0.102077	0.00821344	2.77065e-35	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	-0.101859	0.00821363	3.8622619999999997e-35	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	-0.101643	0.00821381	5.360451e-35	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg02061431	chr1:92150549	1	92150549	TGFBR3	Open sea	-1.87714	0.09396	2.9499999999999997e-34	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	-0.0994503	0.00821564	1.4363420000000002e-33	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0982554	0.00821662	8.364067e-33	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	-0.0979275	0.00821689	1.351242e-32	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	0.0976762	0.00821709	1.949436e-32	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.09749	0.00821724	2.5561999999999997e-32	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0972309	0.00821745	3.723917e-32	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.0959664	0.00821846	2.302028e-31	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.09545	0.00821887	4.80994e-31	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	-0.0953144	0.00821898	5.833609e-31	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	-0.0938729	0.00822011	4.4562059999999995e-30	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg21116284	chr1:92216881	1	92216881	TGFBR3	Open sea	1.61233	0.0927	4.65e-30	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0915617	0.00822189	1.087966e-28	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0915609	0.00822189	1.0892460000000001e-28	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	-0.0915065	0.00822193	1.173076e-28	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg17074704	chr1:92350430	1	92350430	TGFBR3	North shore	1.7998	0.10917	1.68e-28	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	-0.0895537	0.0082234	1.6372360000000002e-27	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-	-	2.0500000000000002e-26	-	28056824_age_4_vs_age_0
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	0.0862639	0.00822579	1.221472e-25	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg00342358	chr1:92350112	1	92350112	TGFBR3	North shore	1.46281	0.10166	9.93e-25	-	25282492_fetal_vs_adult_liver
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.428059	0.0417416	1.322042e-24	None	39706196_Hannah-M.-Smith_bmi_discovery
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg23721586	chr1:92197531	1	92197531	TGFBR3	Open sea	2.88602	0.20252	1.7999999999999997e-24	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.0841292	0.0082273	1.839388e-24	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0839593	0.00822742	2.27593e-24	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0839361	0.00822744	2.342806e-24	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.0839355	0.00822744	2.344716e-24	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	0.00104874	0.00010083	3.38e-24	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	0.467089	0.0462499	6.485381e-24	None	39706196_Hannah-M.-Smith_bmi_discovery
Nones K	-	24500968	2014-05-09	Pancreatic ductal adenocarcinoma	EFO_0002517	-	Table S4	DNA methylation	Pancreatic ductal adenocarcinoma	-	Beta values	-	Illumina HumanMethylation450	Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata	-	196	1	-	Missing	None	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-	-	8.11e-24	-	24500968_pancreatic_ductal_adenocarcinoma
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg00857921	chr1:92257380	1	92257380	TGFBR3	Open sea	0.01021	0.00103	3.2000000000000003e-23	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0818007	0.0082289	3.279952e-23	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.080828	0.00822956	1.06708e-22	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0805241	0.00822976	1.538242e-22	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25204077	chr1:92350786	1	92350786	TGFBR3	North shore	0.02105	0.0019	2.4e-22	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0800886	0.00823005	2.59162e-22	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-2.7	0.281	3.6000000000000003e-22	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	-0.0798092	0.00823023	3.616363e-22	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	-0.0795792	0.00823039	4.753388e-22	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	-0.0795715	0.00823039	4.797179e-22	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0790347	0.00823074	9.052571e-22	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03003526	chr1:92223917	1	92223917	TGFBR3	Open sea	0.00094	None	1e-21	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	0.0789121	0.00823082	1.0459609999999999e-21	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.0777438	0.00823158	4.0966039999999996e-21	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0992036	0.010512	4.396507e-21	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.289212	0.0310431	1.3438419999999999e-20	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	0.0763393	0.00823248	2.058867e-20	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	0.0755312	0.00823299	5.144342e-20	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.0727511	0.00823469	1.115972e-18	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0722889	0.00823497	1.840874e-18	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg17468459	chr1:92208474	1	92208474	TGFBR3	Open sea	-0.22063	0.0252	1.95e-18	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01081930	chr1:92284280	1	92284280	TGFBR3	Open sea	0.0721048	0.00823508	2.244885e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.0715602	0.0082354	4.0265e-18	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg24879809	chr1:92351641	1	92351641	TGFBR3	Island	3.19406	0.3684	4.32e-18	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0713792	0.00823551	4.884576e-18	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.0713737	0.00823551	4.913458e-18	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	-0.0712942	0.00823556	5.347447e-18	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	0.071204	0.00823561	5.886332e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2422722 (gene symbol: TGFBR3)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2422722 (gene symbol: TGFBR3)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	None	None	7.2e-18	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2422722__gene_symbol__tgfbr3__meta-analysis
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	0.424979	0.0494254	8.765371e-18	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.211715	0.0246271	8.884418e-18	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	2.3	0.274	1.1e-17	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0702501	0.00823617	1.612537e-17	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	0.0702238	0.00823619	1.657791e-17	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25204077	chr1:92350786	1	92350786	TGFBR3	North shore	0.00074	None	1.7e-17	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	-0.0701972	0.0082362	1.704642e-17	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	-0.0699152	0.00823637	2.28996e-17	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.0696855	0.0082365	2.909838e-17	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.0693378	0.0082367	4.1750790000000006e-17	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg17080882	chr1:92191625	1	92191625	TGFBR3	Open sea	-0.17661	0.0211	5.57e-17	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0879827	0.0105029	5.916593e-17	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	0.387883	0.0463986	6.754135e-17	None	39706196_Hannah-M.-Smith_body_fat_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.205881	0.0246493	7.189152e-17	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	0.0685158	0.00823717	9.736713e-17	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.265376	0.0319178	9.903808999999999e-17	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0872881	0.0105263	1.205964e-16	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.0681958	0.00823735	1.350147e-16	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19846193	chr1:92352084	1	92352084	TGFBR3	Island	0.0013	None	1.6e-16	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-2.3	0.273	1.6e-16	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	0.0678502	0.00823754	1.918631e-16	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0678409	0.00823755	1.936849e-16	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	0.0053	None	2.1e-16	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	-0.0676975	0.00823763	2.239507e-16	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.067379	0.00823781	3.08924e-16	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	-0.0673742	0.00823781	3.10418e-16	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	0.03675	0.00412	3.6e-16	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0670024	0.00823802	4.509486e-16	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.066945	0.00823805	4.776405e-16	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0668835	0.00823808	5.079207e-16	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.066729	0.00823817	5.927219e-16	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg23721586	chr1:92197531	1	92197531	TGFBR3	Open sea	-0.18478	0.0229	6.67e-16	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.066278	0.00823842	9.281965e-16	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0662514	0.00823843	9.529872e-16	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	-0.0661765	0.00823847	0.000000000000001026352	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0659628	0.00823859	0.000000000000001267577	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.260959	0.0326086	0.000000000000001292978	None	39706196_Hannah-M.-Smith_bmi_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19756345	chr1:92351956	1	92351956	TGFBR3	Island	0.00043	0.000054	0.0000000000000015	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	0.0657088	0.00823873	0.000000000000001627787	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	-0.0683054	0.00857269	0.000000000000001733684	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.0655926	0.00823879	0.000000000000001824631	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.252891	0.0318987	0.000000000000002362902	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0652483	0.00823898	0.000000000000002555735	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	0.0049	0.00053	0.0000000000000027	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0650693	0.00823907	0.000000000000003042754	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	0.0650651	0.00823908	0.000000000000003055252	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0649452	0.00823914	0.000000000000003433231	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	0.0646618	0.00823929	0.00000000000000451881	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	-0.0645632	0.00823935	0.000000000000004970723	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.033	0.00423	0.0000000000000056	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.0644029	0.00823943	0.000000000000005802541	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	0.064145	0.00823957	0.000000000000007435641	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0641377	0.00823957	0.000000000000007488411	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	0.00072843	9.29e-05	0.000000000000011	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.242162	0.0313472	0.00000000000001174715	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.0885014	0.0114775	0.00000000000001329656	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	0.0662519	0.0086005	0.0000000000000141104	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	2.6	0.338	0.000000000000016	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0630724	0.00824013	0.00000000000002064665	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	-0.0628394	0.00824025	0.00000000000002571731	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	-0.0627636	0.00824029	0.00000000000002761802	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.042	0.00549	0.000000000000034	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	0.0624342	0.00824046	0.00000000000003760572	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg26659853	chr1:92282206	1	92282206	TGFBR3	Open sea	0.03168	0.00389	0.000000000000046	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0867501	0.0114928	0.00000000000004670977	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.0621224	0.00824062	0.00000000000005029825	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.06189	0.00824074	0.00000000000006241436	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0616106	0.00824089	0.00000000000008081806	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.073375	0.00984361	0.00000000000009555485	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17074704	chr1:92350430	1	92350430	TGFBR3	North shore	0.0093	0.0013	0.000000000000096	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.312136	0.041897	0.00000000000009767298	None	39706196_Hannah-M.-Smith_body_fat_discovery
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg16382382	chr1:92351047	1	92351047	TGFBR3	Island	0.00638	9e-04	0.000000000000106	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	-0.0612625	0.00824106	0.0000000000001113434	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0612168	0.00824109	0.0000000000001161071	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg00342358	chr1:92350112	1	92350112	TGFBR3	North shore	-0.042	0.00497	0.00000000000014	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0607997	0.0082413	0.0000000000001700077	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11855117	chr1:92293627	1	92293627	TGFBR3	Open sea	-0.0086	0.0012	0.00000000000018	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08648138	chr1:92247732	1	92247732	TGFBR3	Open sea	0.01495	0.0019	0.00000000000026	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	0.0602887	0.00824155	0.0000000000002702796	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0602508	0.00824157	0.0000000000002796884	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	-0.043	0.00591	0.00000000000028	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.0602094	0.00824159	0.0000000000002903562	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	0.0599847	0.0082417	0.0000000000003554912	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0758835	0.0105062	0.0000000000005347091	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	0.359327	0.0497771	0.0000000000005465981	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg04516138	chr1:92250760	1	92250760	TGFBR3	Open sea	-0.013	0.00156	0.00000000000057	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0593845	0.008242	0.0000000000006082624	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	-0.0593752	0.008242	0.0000000000006133139	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.223276	0.0310098	0.0000000000006260618	None	39706196_Hannah-M.-Smith_bmi_discovery
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.032	0.00387	0.00000000000066	None	32795589_Kyung-WK_atopy_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15326069	chr1:92179761	1	92179761	TGFBR3	Open sea	-0.0013	0.00018	0.00000000000067	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09790580	chr1:92171309	1	92171309	TGFBR3	Open sea	-0.00047	0.000066	0.00000000000083	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	-0.0590267	0.00824218	0.0000000000008356451	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg04516138	chr1:92250760	1	92250760	TGFBR3	Open sea	-0.014	0.00167	0.00000000000084	None	32795589_Kyung-WK_atopy_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.228219	0.0320078	0.000000000001042516	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.0587233	0.00824232	0.000000000001092426	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.044	0.00612	0.0000000000011	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0585954	0.00824239	0.000000000001222476	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.296712	0.0417749	0.000000000001271614	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	-0.0582722	0.00824254	0.000000000001622915	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0581871	0.00824258	0.000000000001748219	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	0.018	0.00222	0.0000000000021	None	32795589_Kyung-WK_eosinophilia_discovery
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg11855117	chr1:92293627	1	92293627	TGFBR3	Open sea	0.0052	0.00066	0.0000000000021	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	0.0579377	0.0082427	0.000000000002172418	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.029	0.00361	0.0000000000023	None	32795589_Kyung-WK_eosinophilia_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00857921	chr1:92257380	1	92257380	TGFBR3	Open sea	-0.0018	0.00026	0.0000000000024	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.0054	None	0.0000000000025	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	-0.0576456	0.00824284	0.000000000002798658	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0787925	0.0112966	0.000000000003191976	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	0.213183	0.0306363	0.000000000003562124	None	39706196_Hannah-M.-Smith_bmi_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11855117	chr1:92293627	1	92293627	TGFBR3	Open sea	0.0012	0.00017	0.0000000000036	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	0.0573109	0.008243	0.000000000003735658	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02391982	chr1:92256764	1	92256764	TGFBR3	Open sea	0.262864	0.0379517	0.000000000004472619	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.0570019	0.00824315	0.00000000000486993	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.0567863	0.00824325	0.000000000005854288	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0565341	0.00824337	0.000000000007255657	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0718288	0.0104776	0.000000000007392784	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	-0.0097	0.0014	0.0000000000077	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0564329	0.00824341	0.000000000007906126	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	0.0564255	0.00824342	0.000000000007955638	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	-0.0561289	0.00824356	0.00000000001022206	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.072502	0.0106568	0.00000000001061699	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.049	0.00722	0.000000000012	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	-0.0559011	0.00824366	0.00000000001238237	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	0.0582317	0.00859332	0.0000000000127915	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	0.0558606	0.00824368	0.00000000001281003	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.0557438	0.00824373	0.00000000001412843	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0557332	0.00824374	0.00000000001425421	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0556994	0.00824375	0.00000000001466311	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0555547	0.00824382	0.00000000001654833	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0555509	0.00824382	0.00000000001660122	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0555426	0.00824383	0.00000000001671574	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0554823	0.00824385	0.00000000001757838	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.0553799	0.0082439	0.00000000001914336	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0552673	0.00824395	0.00000000002102165	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0552237	0.00824397	0.00000000002179712	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0710199	0.0106123	0.00000000002277903	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg26542412	chr1:92350568	1	92350568	TGFBR3	North shore	0.01829	0.0027	0.0000000000237	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00976081	chr1:92292815	1	92292815	TGFBR3	Open sea	-0.0550674	0.00824404	0.0000000000248126	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.0035	None	0.000000000026	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.0549725	0.00824409	0.00000000002683791	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	-0.300904	0.0452115	0.00000000002904573	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	0.307487	0.0462909	0.00000000003175928	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg23721586	chr1:92197531	1	92197531	TGFBR3	Open sea	-0.04104	0.00582	0.000000000032	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	-0.0810201	0.0122013	0.00000000003240998	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0545813	0.00824426	0.00000000003703677	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg25285383	chr1:92347850	1	92347850	TGFBR3	North shelf	-2.397669	0.3626	0.0000000000378	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.0545517	0.00824428	0.00000000003794847	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0614955	0.00929571	0.00000000003832208	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.0545204	0.00824429	0.00000000003893451	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0544959	0.0082443	0.00000000003972332	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.505506	0.0766146	0.00000000004287461	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.480591	0.0731627	0.00000000005216892	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.203565	0.0310581	0.00000000005746493	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	0.053981	0.00824453	0.00000000006045593	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.0539784	0.00824453	0.00000000006058549	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	-0.0539103	0.00824456	0.00000000006402478	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0537723	0.00824463	0.00000000007159975	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	0.0537291	0.00824465	0.00000000007414487	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.055	0.00848	0.000000000076	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	-0.0536061	0.0082447	0.00000000008188411	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.0535806	0.00824471	0.00000000008358613	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0535125	0.00824474	0.00000000008829929	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0725826	0.0111963	0.00000000009296824	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24879809	chr1:92351641	1	92351641	TGFBR3	Island	0.00011	None	0.000000000098	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg19846193	chr1:92352084	1	92352084	TGFBR3	Island	0.00973	0.0015	0.000000000106	-	23334450_rheumatoid_arthritis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17080882	chr1:92191625	1	92191625	TGFBR3	Open sea	-0.00064	0.0001	0.00000000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0531686	0.00824489	0.0000000001163681	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	-0.0531538	0.0082449	0.0000000001177554	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0531235	0.00824491	0.0000000001206387	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0531206	0.00824491	0.0000000001209193	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.053108	0.00824492	0.0000000001221491	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.0629882	0.00980977	0.0000000001395811	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.1587	0.024726	0.0000000001413404	None	39706196_Hannah-M.-Smith_body_fat_discovery
Zeilinger S	-	23691101	2013-05-17	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking discovery	Table S1	DNA methylation	Smoking	Age, sex, body mass index, alcohol consumption and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	1011	1	60.8	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	-	-	0.000000000142	-	23691101_smoking_current_vs_never_smoking_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0528819	0.00824502	0.0000000001462856	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21116284	chr1:92216881	1	92216881	TGFBR3	Open sea	-0.0022	0.00034	0.00000000016	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01081930	chr1:92284280	1	92284280	TGFBR3	Open sea	0.0527617	0.00824507	0.0000000001609613	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0527529	0.00824508	0.0000000001620841	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.052728	0.00824509	0.0000000001653164	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.0526643	0.00824511	0.0000000001738922	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0526057	0.00824514	0.0000000001821594	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.198453	0.0311556	0.0000000001941451	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	0.0524278	0.00824522	0.0000000002096699	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	-0.0074	0.0012	0.00000000023	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0703948	0.0111067	0.0000000002395262	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_4
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09790580	chr1:92171309	1	92171309	TGFBR3	Open sea	-0.01077	0.00161	0.00000000025	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.206986	0.0327058	0.0000000002532932	None	39706196_Hannah-M.-Smith_body_fat_discovery
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg15326069	chr1:92179761	1	92179761	TGFBR3	Open sea	-2.206941	0.3491	0.000000000259	-	27105112_hiv_infection_discovery
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	1.6	0.252	0.00000000027	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	-0.052087	0.00824536	0.00000000027416	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0518321	0.00824547	0.0000000003346839	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	-0.051829	0.00824547	0.0000000003355006	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg17074704	chr1:92350430	1	92350430	TGFBR3	North shore	-0.00056652	8.94e-05	0.000000000351	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	-0.0548848	0.00874437	0.0000000003558157	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0665979	0.0106315	0.0000000003852579	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0515391	0.0082456	0.0000000004204543	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	2	0.325	0.00000000045	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0660637	0.0106347	0.0000000005369577	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	0.0511604	0.00824576	0.0000000005636426	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg26542412	chr1:92350568	1	92350568	TGFBR3	North shore	0.01204	0.00184	0.00000000057	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0511145	0.00824578	0.0000000005839101	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	0.0508285	0.0082459	0.000000000727426	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-2	0.33	0.00000000077	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0505299	0.00824602	0.0000000009139019	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15983901	chr1:92366037	1	92366037	TGFBR3	Open sea	0.0502805	0.00824613	0.000000001104676	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01081930	chr1:92284280	1	92284280	TGFBR3	Open sea	0.0502122	0.00824616	0.000000001163295	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0500889	0.00824621	0.000000001277076	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0500889	0.00824621	0.000000001277085	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0500825	0.00824621	0.000000001283293	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.112684	0.0185723	0.000000001332693	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0560779	0.00926016	0.000000001431149	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0498919	0.00824629	0.000000001481583	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0497973	0.00824633	0.000000001590864	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.0497667	0.00824634	0.000000001627884	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	0.057	0.00951	0.0000000017	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	-0.0496793	0.00824638	0.000000001738145	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	0.0495887	0.00824641	0.000000001860222	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0495672	0.00824642	0.000000001890467	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	0.0495542	0.00824643	0.000000001908879	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0495318	0.00824644	0.000000001941182	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	0.0495175	0.00824644	0.000000001962045	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.049495	0.00824645	0.000000001995308	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0493948	0.00824649	0.000000002150206	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	-0.0493497	0.00824651	0.000000002223662	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0493035	0.00824653	0.000000002301474	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.0685938	0.0114837	0.000000002380953	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0627174	0.010518	0.000000002535839	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	-0.0605922	0.0101777	0.000000002686057	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	0.203823	0.0343077	0.000000002884023	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0489849	0.00824666	0.000000002915205	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.0622488	0.0104894	0.000000003014639	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.00064	0.00011	0.0000000033	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.0488087	0.00824673	0.000000003320223	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.0487642	0.00824675	0.000000003430897	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.061887	0.0104967	0.000000003809605	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	0.0485829	0.00824682	0.000000003920186	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24879809	chr1:92351641	1	92351641	TGFBR3	Island	-0.000084	0.000014	0.000000004	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0485447	0.00824684	0.000000004031605	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02391982	chr1:92256764	1	92256764	TGFBR3	Open sea	-0.0494328	0.00840938	0.00000000423511	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0482701	0.00824695	0.000000004928157	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg23721586	chr1:92197531	1	92197531	TGFBR3	Open sea	-0.004	0.00064	0.0000000054	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0481418	0.008247	0.000000005411225	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0480899	0.00824702	0.000000005619395	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	-0.0480561	0.00824703	0.00000000575894	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.0667545	0.0114561	0.000000005761452	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	-0.0041	0.0007	0.000000006	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.054108	0.00931251	0.000000006367437	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0672766	0.0115905	0.000000006590772	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.0670277	0.0115542	0.000000006722242	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.0665944	0.0114811	0.000000006755076	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	0.0477969	0.00824713	0.000000006948299	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26648031	chr1:92258256	1	92258256	TGFBR3	Open sea	-0.0477789	0.00824714	0.000000007039673	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.0477694	0.00824715	0.000000007087825	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.18343	0.0316721	0.000000007095715	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0476966	0.00824717	0.000000007470473	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0662453	0.011477	0.000000007992632	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.0475904	0.00824722	0.000000008063958	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0475841	0.00824722	0.000000008100848	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.00567	0.00098	0.0000000084	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.0475264	0.00824724	0.00000000844395	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	0.285579	0.0496235	0.000000008815773	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.0472094	0.00824737	0.00000001059712	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0809697	0.0141459	0.00000001061386	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.441183	0.0771354	0.00000001085431	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0642249	0.0112393	0.00000001122838	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.0470614	0.00824742	0.00000001177651	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.0470467	0.00824743	0.00000001190013	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0470348	0.00824743	0.00000001200158	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	-0.0469549	0.00824746	0.00000001270265	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.0573945	0.0100987	0.00000001345697	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg17074704	chr1:92350430	1	92350430	TGFBR3	North shore	-0.00057581	0.00010066	0.0000000138	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15983901	chr1:92366037	1	92366037	TGFBR3	Open sea	0.0467789	0.00824753	0.00000001439151	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.0034	0.00056	0.000000015	None	33564054_Kashima-K_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	-0.170359	0.0301339	0.00000001596541	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16382382	chr1:92351047	1	92351047	TGFBR3	Island	-0.000045	0.000008	0.000000016	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25769732	chr1:92295946	1	92295946	TGFBR3	Open sea	0.0098	0.0017	0.000000016	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0465285	0.00824763	0.00000001717468	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.175318	0.0310987	0.00000001752717	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08135617	chr1:92317088	1	92317088	TGFBR3	Open sea	-0.0464305	0.00824767	0.00000001840119	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0463434	0.0082477	0.00000001956155	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.0518055	0.00922214	0.00000001972403	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	0.0015	None	0.00000002	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	-0.0462405	0.00824774	0.00000002102516	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	-0.0691599	0.0123364	0.00000002106129	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02391982	chr1:92256764	1	92256764	TGFBR3	Open sea	0.213295	0.0380568	0.00000002118694	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	-0.0462222	0.00824775	0.00000002129536	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	-0.0461967	0.00824776	0.00000002167951	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Zeilinger S	-	23691101	2013-05-17	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking discovery	Table S1	DNA methylation	Smoking	Age, sex, body mass index, alcohol consumption and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	1011	1	60.8	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	-	-	0.0000000221	-	23691101_smoking_current_vs_never_smoking_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0461554	0.00824777	0.00000002231409	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	-0.0461363	0.00824778	0.00000002261424	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	0.0461216	0.00824779	0.00000002284775	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.028	0.00499	0.000000023	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0459801	0.00824784	0.00000002521824	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0514697	0.00923446	0.00000002538485	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0458802	0.00824788	0.00000002703267	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Any maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	6685	13	0	Missing	European,East Asian,African,Admixed,Other	cg17074704	chr1:92350430	1	92350430	TGFBR3	North shore	-0.005	0.001	0.0000000274	-	27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.058292	0.0104883	0.00000002779577	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	1.9	0.343	0.000000028	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.0457971	0.00824791	0.00000002863762	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0457879	0.00824791	0.00000002882218	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	-0.045714	0.00824794	0.00000003033762	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	0.0012	0.00021	0.000000031	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	-0.034	0.00563	0.000000032	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04702101	chr1:92167308	1	92167308	TGFBR3	Open sea	0.0456246	0.00824797	0.00000003227324	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	-0.17551	0.0318135	0.00000003498294	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0717263	0.0130325	0.00000003782358	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	-0.026	0.00429	0.000000039	None	32795589_Kyung-WK_atopy_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.191808	0.0348893	0.00000003904086	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.0453103	0.00824809	0.00000004007598	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	-0.033	0.0056	0.000000041	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0452697	0.00824811	0.00000004121042	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0452666	0.00824811	0.00000004129645	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0616578	0.0112548	0.00000004363555	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0573138	0.0104717	0.00000004491907	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg17074704	chr1:92350430	1	92350430	TGFBR3	North shore	-0.006	0.001	0.000000045	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.077578	0.0141907	0.00000004656336	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.0450782	0.00824818	0.00000004698573	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.0450732	0.00824818	0.00000004714441	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	0.0450015	0.00824821	0.00000004951123	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	-0.0449549	0.00824822	0.0000000511112	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25285383	chr1:92347850	1	92347850	TGFBR3	North shelf	-0.00089	0.00016	0.000000054	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.053573	0.00985491	0.00000005530917	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0448238	0.00824827	0.00000005588149	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.0447449	0.0082483	0.00000005896073	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0616216	0.0113676	0.0000000602683	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P19652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0446647	0.00824833	0.00000006225472	P19652	41361833_Josephine_Robertson_P19652_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.397132	0.0733595	0.00000006262759	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.0445884	0.00824836	0.00000006555314	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26659853	chr1:92282206	1	92282206	TGFBR3	Open sea	-0.012	0.0022	0.000000066	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.0445769	0.00824836	0.00000006606557	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0567613	0.0105089	0.00000006719803	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.06089	0.0112762	0.00000006773169	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0445312	0.00824838	0.00000006814124	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16382382	chr1:92351047	1	92351047	TGFBR3	Island	0.0025	0.00045	0.000000069	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	-0.0445051	0.00824839	0.00000006935294	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg10012640	chr1:92351216	1	92351216	TGFBR3	Island	0.00625	0.0012	0.0000000716	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	-0.0444243	0.00824842	0.00000007323889	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.0501316	0.0093218	0.00000007652057	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00976081	chr1:92292815	1	92292815	TGFBR3	Open sea	-0.0443374	0.00824845	0.00000007765167	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	-0.0460192	0.00858065	0.00000008302597	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0442315	0.00824849	0.00000008338048	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	0.164522	0.0307239	0.00000008672343	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.0440872	0.00824854	0.00000009184994	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-1.3	0.237	0.000000095	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.044034	0.00824856	0.00000009517727	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17468459	chr1:92208474	1	92208474	TGFBR3	Open sea	-0.00032	0.00006	0.000000096	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.03	0.00558	0.000000097	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0439904	0.00824858	0.00000009799033	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0439727	0.00824859	0.00000009915601	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0438658	0.00824862	0.000000106479	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	-0.0437755	0.00824866	0.0000001130776	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	0.0437701	0.00824866	0.0000001134808	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01081930	chr1:92284280	1	92284280	TGFBR3	Open sea	0.0437351	0.00824867	0.0000001161509	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18539768	chr1:92149139	1	92149139	TGFBR3	Open sea	0.0019	None	0.00000012	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Aghagoli G	The Neonatal Neurobehavior and Outcomes in Very Preterm Infants	32967004	07-04-2021	cry acoustics factor 2	None	None	Supplementary Table 2	cry acoustics factor 2	DNA methylation	Sex, PMA, recruitment site, proportions of epithelial cells	None	Beta values	Illumina HumanMethylationEPIC	Buccal	None	335	1	Infants	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.045	0.009	0.00000012	None	32967004_Aghagoli-G_cry_acoustics_factor_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	-0.043685	0.00824869	0.0000001200788	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	-0.0455003	0.00859479	0.0000001214365	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0436112	0.00824872	0.0000001261021	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08135617	chr1:92317088	1	92317088	TGFBR3	Open sea	-0.0436072	0.00824872	0.0000001264387	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	-0.0435803	0.00824873	0.0000001287056	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	0.0435162	0.00824875	0.0000001342816	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	0.0435152	0.00824875	0.0000001343702	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.043507	0.00824875	0.0000001351071	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg17468459	chr1:92208474	1	92208474	TGFBR3	Open sea	-0.0091	0.0017	0.000000141	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	-0.0434225	0.00824878	0.0000001428561	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Any maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	6685	13	0	Missing	European,East Asian,African,Admixed,Other	cg00342358	chr1:92350112	1	92350112	TGFBR3	North shore	-0.008	0.002	0.000000144	-	27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0433811	0.0082488	0.000000146809	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.0432815	0.00824883	0.000000156759	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18539768	chr1:92149139	1	92149139	TGFBR3	Open sea	-0.0011	0.00021	0.00000016	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.0432372	0.00824885	0.0000001613978	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17080882	chr1:92191625	1	92191625	TGFBR3	Open sea	-0.0432267	0.00824885	0.0000001625163	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00308438	chr1:92329399	1	92329399	TGFBR3	Open sea	0.0432144	0.00824886	0.0000001638325	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26648031	chr1:92258256	1	92258256	TGFBR3	Open sea	-0.0431539	0.00824888	0.0000001704702	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.170616	0.0326177	0.0000001707488	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Yang BZ	-	23332324	2013-02-01	Child abuse	-	-	Appendix B	DNA methylation	Child abuse	Sex, age and ethnicity	Beta values	-	Illumina HumanMethylation450	Saliva	-	192	1	10	Both	European,African,Admixed,Other	cg26542412	chr1:92350568	1	92350568	TGFBR3	North shore	-	-	0.000000171	-	23332324_child_abuse
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	0.0431422	0.00824888	0.0000001717852	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.043099	0.0082489	0.0000001767145	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.04308	0.00824891	0.0000001789315	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.216235	0.0414551	0.0000001847124	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	-0.043027	0.00824893	0.0000001852416	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0429896	0.00824894	0.0000001898296	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25204077	chr1:92350786	1	92350786	TGFBR3	North shore	0.0022	None	0.00000019	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	0.0429727	0.00824894	0.0000001919311	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0429468	0.00824895	0.0000001952054	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0547551	0.0105239	0.0000001987943	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent COPD (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent COPD (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18078	1	Adults (18-65y)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.039	0.00742	0.0000002	None	Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0428754	0.00824898	0.0000002045214	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.042874	0.00824898	0.0000002047078	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	-0.0453774	0.00874013	0.0000002110063	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0427884	0.00824901	0.0000002164479	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.0463553	0.00893907	0.0000002180665	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	0.0427687	0.00824902	0.000000219241	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	-0.0427548	0.00824902	0.0000002212301	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	0.0427056	0.00824904	0.0000002284201	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03003526	chr1:92223917	1	92223917	TGFBR3	Open sea	0.0028	None	0.00000023	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03003526	chr1:92223917	1	92223917	TGFBR3	Open sea	-0.0426528	0.00824906	0.000000236372	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0738235	0.0142906	0.0000002424501	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	-0.0425834	0.00824908	0.0000002472614	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	GZMK protein levels (SeqId = 9545-156)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GZMK protein levels (SeqId = 9545-156)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granzyme K	774	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-1.29	0.25	0.00000025	None	Gadd-DA_gzmk_protein_levels__seqid___9545-156__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.0425328	0.0082491	0.0000002554857	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.0424972	0.00824911	0.0000002614413	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16946848	chr1:92167282	1	92167282	TGFBR3	Open sea	0.0424809	0.00824912	0.0000002642145	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00976081	chr1:92292815	1	92292815	TGFBR3	Open sea	-0.0424687	0.00824912	0.0000002663057	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.029	0.00566	0.00000028	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0957112	0.0186396	0.0000002860021	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.0423175	0.00824918	0.0000002935861	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0422941	0.00824918	0.0000002980464	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0422894	0.00824919	0.0000002989477	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.039	0.00755	0.0000003	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15983901	chr1:92366037	1	92366037	TGFBR3	Open sea	0.0422701	0.00824919	0.0000003026801	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.0422447	0.0082492	0.0000003076613	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0951544	0.018594	0.0000003135491	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04702101	chr1:92167308	1	92167308	TGFBR3	Open sea	0.0422091	0.00824921	0.0000003147763	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0421714	0.00824923	0.000000322492	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.1063027	0.0208183	0.0000003287	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg23636324	chr1:92351686	1	92351686	TGFBR3	Island	0.00576	0.00109	0.00000033	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.0421005	0.00824925	0.0000003374949	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	1.9	0.368	0.00000037	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.0418839	0.00824933	0.0000003876305	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.0418785	0.00824933	0.0000003889656	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.032	0.00633	0.0000004	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0950781	0.0187536	0.0000004029848	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	-0.0418046	0.00824935	0.0000004077045	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	-0.0417934	0.00824936	0.0000004106438	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.16027	0.0316547	0.0000004168061	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0417361	0.00824938	0.0000004258652	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg19846193	chr1:92352084	1	92352084	TGFBR3	Island	1.326304	0.2623	0.000000428	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01081930	chr1:92284280	1	92284280	TGFBR3	Open sea	0.0417087	0.00824939	0.0000004333494	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.21552	0.0426363	0.0000004351404	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0579538	0.0114947	0.0000004666711	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23721586	chr1:92197531	1	92197531	TGFBR3	Open sea	0.0049	0.00097	0.00000047	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.0716136	0.0142159	0.0000004770726	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09790580	chr1:92171309	1	92171309	TGFBR3	Open sea	0.0419849	0.00833999	0.0000004856102	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.17735	0.0352565	0.0000004946462	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01081930	chr1:92284280	1	92284280	TGFBR3	Open sea	-0.041488	0.00824946	0.0000004984143	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0414867	0.00824946	0.0000004988243	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	0.00385	0.00077	0.0000005	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	-0.0414391	0.00824948	0.0000005140405	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0575805	0.0114683	0.0000005204508	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0567992	0.0113227	0.0000005326927	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	-0.0413336	0.00824952	0.000000549423	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0934917	0.0186633	0.0000005523851	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0940748	0.018789	0.0000005595083	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0572618	0.0114381	0.0000005614699	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0523768	0.0104731	0.0000005767299	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0412392	0.00824955	0.0000005830293	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09790580	chr1:92171309	1	92171309	TGFBR3	Open sea	0.0412366	0.00824955	0.0000005839782	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26648031	chr1:92258256	1	92258256	TGFBR3	Open sea	0.0412094	0.00824956	0.0000005940559	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00342358	chr1:92350112	1	92350112	TGFBR3	North shore	0.0411968	0.00824956	0.0000005987953	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0715396	0.0143392	0.0000006136135	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0710492	0.0142416	0.0000006143774	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0411447	0.00824958	0.0000006186691	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.0411234	0.00824959	0.0000006270179	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0523481	0.0105075	0.0000006365764	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0714651	0.0143556	0.0000006490114	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	0.0410683	0.00824961	0.0000006490257	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09838042	chr1:92351547	1	92351547	TGFBR3	Island	0.00034	0.000068	0.00000065	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg00342358	chr1:92350112	1	92350112	TGFBR3	North shore	-0.01	0.002	0.000000657	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	-0.0481434	0.00967832	0.0000006620667	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	0.0410205	0.00824962	0.0000006687294	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.0409855	0.00824963	0.0000006835311	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Sikdar S	PACE	31536415	2019-09-19	Prenatal smoke exposure	EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318	Inverse varience-weighted fixed-effects meta-analysis	Table S1	DNA methylation	Prenatal smoke exposure	Maternal age, socioeconomic position, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Cord blood, whole blood	None	5648	9	Infants	Both	European, African, Unclear	cg17074704	chr1:92350430	1	92350430	TGFBR3	North shore	-0.0052	0.0011	0.00000069	None	31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity, white blood cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg17074704	chr1:92350430	1	92350430	TGFBR3	North shore	-0.005	0.001	0.000000694	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08624246	chr1:92202987	1	92202987	TGFBR3	Open sea	0.0409495	0.00824965	0.0000006990495	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.0409484	0.00824965	0.0000006995725	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.0570331	0.0115054	0.0000007235879	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.040873	0.00824967	0.0000007332568	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.0408202	0.00824969	0.0000007577443	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	-0.0407741	0.00824971	0.0000007798136	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	0.144732	0.0292859	0.0000007803453	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.0565783	0.0114569	0.0000007964734	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.0455738	0.00926884	0.0000008888403	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	-0.02	0.00415	0.00000089	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0405501	0.00824978	0.0000008960653	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0522025	0.01063	0.0000009165807	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	1.6	0.322	0.00000093	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0404652	0.00824981	0.000000944352	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.208892	0.0426049	0.0000009523469	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	0.0404323	0.00824982	0.0000009637079	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0689972	0.0140792	0.0000009654887	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0539962	0.0110251	0.000000980602	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00976081	chr1:92292815	1	92292815	TGFBR3	Open sea	-0.0404002	0.00824983	0.0000009830306	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Sikdar S	PACE	31536415	2019-09-19	Prenatal smoke exposure	EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318	Inverse varience-weighted fixed-effects meta-analysis	Table S1	DNA methylation	Prenatal smoke exposure	Maternal age, socioeconomic position, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Cord blood, whole blood	None	5648	9	Infants	Both	European, African, Unclear	cg11855117	chr1:92293627	1	92293627	TGFBR3	Open sea	-0.0048	0.001	0.000001	None	31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0454502	0.00929504	0.000001020484	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_2
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity, white blood cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg11855117	chr1:92293627	1	92293627	TGFBR3	Open sea	-0.005	0.001	0.00000103	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.0403103	0.00824986	0.000001038979	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0402493	0.00824988	0.000001078651	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00342358	chr1:92350112	1	92350112	TGFBR3	North shore	0.0402243	0.00824989	0.000001095353	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.0402203	0.00824989	0.000001098058	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01081930	chr1:92284280	1	92284280	TGFBR3	Open sea	0.040208	0.00824989	0.000001106414	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.04988	0.0102429	0.000001129399	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0558281	0.0114808	0.000001169759	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.0400611	0.00824994	0.000001210599	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.0478807	0.00986552	0.000001226529	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.040024	0.00824996	0.000001238361	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	0.0399913	0.00824997	0.000001263378	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0399632	0.00824998	0.000001285287	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.0399629	0.00824998	0.000001285471	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.0399582	0.00824998	0.000001289162	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02391982	chr1:92256764	1	92256764	TGFBR3	Open sea	0.040865	0.00843845	0.000001293826	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0399446	0.00824998	0.000001299906	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01081930	chr1:92284280	1	92284280	TGFBR3	Open sea	-0.008	0.0017	0.0000013	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Chu A.	Atherosclerosis Risk in Communities, FHS	29097680	2017-11-03	Chronic kidney disease	EFO_0003884	Meta-analysis of estimated glomerular filtration rate EWAS	Supplementary Data 13	DNA methylation	Chronic kidney disease	Age, sex, batch effects, ancestry (other), prevalent diabetes, hypertension	Beta Values	None	Illumina HumanMethylation450	Whole Blood	None	4859	2	Adults	Both	African, European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.024	0.0049	0.0000013	None	29097680_Chu-A._chronic_kidney_disease_meta-analysis_of_estimated_glomerular_filtration_rate_ewas
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26648031	chr1:92258256	1	92258256	TGFBR3	Open sea	-0.0398923	0.00825	0.000001342017	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03003526	chr1:92223917	1	92223917	TGFBR3	Open sea	0.0398741	0.00825001	0.000001356993	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	0.0398666	0.00825001	0.000001363197	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.0505449	0.0104652	0.000001380427	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0692504	0.0143446	0.000001395622	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg17080882	chr1:92191625	1	92191625	TGFBR3	Open sea	-0.1818	0.0377078	0.000001437808	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	0.0397544	0.00825004	0.000001459486	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0447542	0.0092966	0.000001493852	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26648031	chr1:92258256	1	92258256	TGFBR3	Open sea	-0.0396888	0.00825007	0.000001518789	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg23721586	chr1:92197531	1	92197531	TGFBR3	Open sea	-0.00057009	0.00011793	0.00000154	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0446882	0.00930153	0.000001567634	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0504044	0.0105018	0.000001605632	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	-0.0394914	0.00825013	0.000001711437	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0510322	0.0106676	0.000001736419	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	-0.0394408	0.00825015	0.00000176452	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.0393768	0.00825017	0.00000183394	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0393559	0.00825017	0.00000185712	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.026	0.00538	0.0000019	None	Robert-F-Hillary_Incident_COPD_Basic_model
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	18413	1	Adults (18-65y)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.21	0.0432	0.0000019	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model
Argos M	-	25325195	2014-10-17	Urinary arsenic concentrations	EFO_0004880, CHEBI_27563	Discovery	Table 2	DNA methylation	Urinary arsenic concentrations	Age, sex and technical covariates	Beta values	ug/g	Illumina HumanMethylation450	Urine	-	400	1	43	Both	South Asian	cg00857921	chr1:92257380	1	92257380	TGFBR3	Open sea	0.021	0.004	0.00000198	-	25325195_urinary_arsenic_concentration_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0392393	0.00825021	0.000001991873	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0391675	0.00825024	0.000002079508	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	-0.0063	0.0013	0.0000021	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00342358	chr1:92350112	1	92350112	TGFBR3	North shore	0.002	None	0.0000022	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0390726	0.00825027	0.00000220108	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03003526	chr1:92223917	1	92223917	TGFBR3	Open sea	0.0390576	0.00825027	0.000002220933	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	-0.0461573	0.00975071	0.000002224896	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0875289	0.0184911	0.000002226673	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_4
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.141871	0.03	0.00000224	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.039035	0.00825028	0.000002251021	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09790580	chr1:92171309	1	92171309	TGFBR3	Open sea	0.0392764	0.00830405	0.000002268412	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	0.0390168	0.00825028	0.000002275709	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.052	0.0111	0.0000023	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0389562	0.0082503	0.000002359407	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	-0.0406432	0.00861468	0.000002404916	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.0388943	0.00825032	0.000002448008	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	0.0388934	0.00825032	0.000002449409	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.038886	0.00825033	0.000002460178	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	0.0388713	0.00825033	0.000002481802	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.038833	0.00825034	0.000002538891	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	-0.0387753	0.00823861	0.000002542656	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03003526	chr1:92223917	1	92223917	TGFBR3	Open sea	0.0387874	0.00825036	0.000002608709	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	0.0387655	0.00825037	0.000002642713	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.0462219	0.00984137	0.000002668099	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0387477	0.00825037	0.000002670795	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	-0.0387439	0.00825037	0.000002676844	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	-0.0457153	0.00974857	0.000002764215	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_3
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg11855117	chr1:92293627	1	92293627	TGFBR3	Open sea	-0.005	0.001	0.00000279	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	0.0386711	0.0082504	0.000002794811	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	0.0386691	0.0082504	0.000002798185	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01081930	chr1:92284280	1	92284280	TGFBR3	Open sea	0.0386489	0.0082504	0.000002831766	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08624246	chr1:92202987	1	92202987	TGFBR3	Open sea	0.0389849	0.0083224	0.000002833948	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0386374	0.00825041	0.000002851115	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0528409	0.0112877	0.000002876128	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.0385884	0.00825042	0.000002934883	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Witt S	None	32080920	02-02-2020	alcohol withdrawal recovery	None	discovery	Table S1	DNA methylation	alcohol withdrawal recovery	Age, Smoking, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylationEPIC	whole blood	two weeks after vs active withdrawal	99	1	Adults	Males	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	1.7	0.343	0.000003	None	32080920_Witt-S_alcohol_withdrawal_recovery_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02391982	chr1:92256764	1	92256764	TGFBR3	Open sea	0.177295	0.0379508	0.000003009473	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	0.214034	0.0458665	0.000003086262	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.0535569	0.0114765	0.000003088494	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.0384895	0.00825045	0.000003111298	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02391982	chr1:92256764	1	92256764	TGFBR3	Open sea	0.0392764	0.00842827	0.00000318866	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0384188	0.00825048	0.000003243556	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17080882	chr1:92191625	1	92191625	TGFBR3	Open sea	-0.0383976	0.00825048	0.000003284325	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	-0.0383648	0.00825049	0.000003348208	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16946848	chr1:92167282	1	92167282	TGFBR3	Open sea	0.0383201	0.00825051	0.000003437301	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04516138	chr1:92250760	1	92250760	TGFBR3	Open sea	0.0383129	0.00825051	0.000003451921	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.0487814	0.0105057	0.000003458439	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0383073	0.00825051	0.000003463267	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.0382869	0.00825052	0.00000350499	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0654065	0.0140996	0.000003532921	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	0.040514	0.00873393	0.000003536462	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	0.0396889	0.00856267	0.000003598177	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Nene N	FORECEE [4C] Program	33228781	2020-11-23	cervicovaginal microbiome status	EFO_0011013	O-type vs L-type	Supplementary Table 7	cervicovaginal microbiome status	DNA methylation	Age, cell composition (reference free)	None	Beta Values	Illumina HumanMethylationEPIC	Cervical smear	None	448	1	Adults	Females	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.14	0.03	0.0000036	None	33228781_Nene-N_cervicovaginal_microbiome_status_o-type_vs_l-type
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	-0.0382411	0.00825053	0.000003600312	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0382378	0.00825053	0.000003607388	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0486712	0.0105103	0.000003673338	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.047847	0.010335	0.000003695243	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0493063	0.0106525	0.000003713088	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04702101	chr1:92167308	1	92167308	TGFBR3	Open sea	-0.0421653	0.00911151	0.000003729308	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0522488	0.0112996	0.000003797257	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	ADI1 protein levels (SeqId = 12457-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADI1 protein levels (SeqId = 12457-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.14	0.03	0.0000038	None	Gadd-DA_adi1_protein_levels__seqid___12457-10__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.0380918	0.00825058	0.000003928993	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0380752	0.00825058	0.000003967052	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	-0.98	0.213	0.000004	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.038047	0.00825059	0.00000403305	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08624246	chr1:92202987	1	92202987	TGFBR3	Open sea	0.0380447	0.00825059	0.000004038244	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0517573	0.0112327	0.000004104957	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.04279	0.00928714	0.000004110914	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	-0.0430933	0.0093556	0.000004136481	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg18969353	chr1:92371953	1	92371953	TGFBR3	Open sea	0.1164718	0.0252994	0.00000415	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13078798	chr1:92203667	1	92203667	TGFBR3	Open sea	0.0061	0.0013	0.0000042	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0379762	0.00825062	0.000004202788	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Any maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	6685	13	0	Missing	European,East Asian,African,Admixed,Other	cg11855117	chr1:92293627	1	92293627	TGFBR3	Open sea	-0.004	0.001	0.00000424	-	27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0657913	0.0143078	0.00000429579	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_2
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	2.08	0.448	0.0000043	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	0.151479	0.0329624	0.000004345888	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15983901	chr1:92366037	1	92366037	TGFBR3	Open sea	0.0397965	0.00866017	0.000004356385	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	DNASE2B protein levels (SeqId = 6533-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DNASE2B protein levels (SeqId = 6533-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Deoxyribonuclease-2-beta	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.138	0.03	0.0000044	None	Gadd-DA_dnase2b_protein_levels__seqid___6533-20__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.0378931	0.00825064	0.000004410942	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0482882	0.0105194	0.000004460766	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	0.0378729	0.00825065	0.000004462983	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0378426	0.00825066	0.000004542165	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.037827	0.00825066	0.000004583392	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	0.0378233	0.00825066	0.000004593156	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16946848	chr1:92167282	1	92167282	TGFBR3	Open sea	0.0378232	0.00825066	0.000004593535	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	0.024	0.00533	0.0000046	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17080882	chr1:92191625	1	92191625	TGFBR3	Open sea	0.0401145	0.00875694	0.000004668255	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	-0.0377363	0.00825069	0.000004830723	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.0467273	0.0102234	0.000004902345	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.0414012	0.00905901	0.000004913172	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.038907	0.00851758	0.000004967741	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15983901	chr1:92366037	1	92366037	TGFBR3	Open sea	0.03806	0.00833239	0.000004970861	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.0476503	0.0104332	0.000004983988	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26551819	chr1:92228825	1	92228825	TGFBR3	Open sea	0.0376212	0.00825073	0.000005162968	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0486285	0.0106668	0.000005184813	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0376118	0.00825073	0.00000519109	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	GZMA protein levels (SeqId = 3440-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GZMA protein levels (SeqId = 3440-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granzyme A	774	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-1.14	0.25	0.0000052	None	Gadd-DA_gzma_protein_levels__seqid___3440-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15326069	chr1:92179761	1	92179761	TGFBR3	Open sea	0.0376016	0.00825073	0.000005221706	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	0.0375968	0.00825073	0.000005236257	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0375841	0.00825074	0.000005274682	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00308438	chr1:92329399	1	92329399	TGFBR3	Open sea	0.014	0.0031	0.0000053	None	33450751_Mulder-RH_sex_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	0.134667	0.0295773	0.000005323256	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.0420179	0.00923223	0.000005376617	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0049	None	0.0000054	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0652829	0.0143703	0.000005592419	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01002341	chr1:92351682	1	92351682	TGFBR3	Island	-0.000051	0.000011	0.0000056	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	-0.0374767	0.00825077	0.000005611189	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.0374665	0.00825077	0.000005644109	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.0447933	0.0098676	0.000005685403	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	-0.0374428	0.00825078	0.000005721648	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17080882	chr1:92191625	1	92191625	TGFBR3	Open sea	0.0396863	0.00874576	0.000005730105	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16946848	chr1:92167282	1	92167282	TGFBR3	Open sea	-0.0373983	0.0082508	0.000005869839	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01081930	chr1:92284280	1	92284280	TGFBR3	Open sea	0.0373772	0.0082508	0.000005941242	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0373424	0.00825081	0.000006061109	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg17080882	chr1:92191625	1	92191625	TGFBR3	Open sea	0.175464	0.0387967	0.00000614729	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	-0.0460115	0.0101804	0.000006243106	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.037287	0.00825083	0.000006256574	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	0.0372806	0.00825083	0.000006279291	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	-0.0372626	0.00825084	0.000006344546	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0510442	0.0113042	0.000006365467	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.0372263	0.00825085	0.000006477423	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.0460017	0.0101959	0.000006478232	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0371883	0.00825086	0.000006619628	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.155553	0.0345205	0.000006646341	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0471558	0.0104656	0.000006663801	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.00355	0.00079	0.0000067	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0371664	0.00825087	0.000006702789	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0371595	0.00825087	0.000006729276	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.0371513	0.00825087	0.000006760823	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	GZMA protein levels (SeqId = 3440-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GZMA protein levels (SeqId = 3440-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granzyme A	774	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.64	0.143	0.0000068	None	Gadd-DA_gzma_protein_levels__seqid___3440-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0821977	0.0182623	0.000006817361	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_4
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg17468459	chr1:92208474	1	92208474	TGFBR3	Open sea	1.019317	0.2267	0.00000691	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.0371112	0.00825088	0.000006917098	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04516138	chr1:92250760	1	92250760	TGFBR3	Open sea	0.0373344	0.00830318	0.000006964461	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	1.3	0.283	0.000007	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Gadd DA	Generation Scotland	35945220	31/07/2022	PPM1D protein levels (SeqId = 11315-148)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPM1D protein levels (SeqId = 11315-148)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein phosphatase 1D	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.000007	None	Gadd-DA_ppm1d_protein_levels__seqid___11315-148__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.0370899	0.00825089	0.000007001704	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.083937	0.0186775	0.000007042522	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0773772	0.0172239	0.000007095001	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	0.0370567	0.0082509	0.000007135307	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25769732	chr1:92295946	1	92295946	TGFBR3	Open sea	-0.0370288	0.00825091	0.000007249304	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.0370169	0.00825091	0.00000729851	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg03003526	chr1:92223917	1	92223917	TGFBR3	Open sea	-1.57	0.35	0.0000073	4804	31197173_Liu-J_fasting_glucose_base
Gadd DA	Generation Scotland	35945220	31/07/2022	SERPINA12 protein levels (SeqId = 6551-94)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SERPINA12 protein levels (SeqId = 6551-94)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serpin A12	774	1	Adults (18-65 years)	Both	European	cg08648138	chr1:92247732	1	92247732	TGFBR3	Open sea	-0.78	0.174	0.0000073	None	Gadd-DA_serpina12_protein_levels__seqid___6551-94__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TMPRSS11D protein levels (SeqId = 6547-83)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TMPRSS11D protein levels (SeqId = 6547-83)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transmembrane protease serine 11D	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.0000073	None	Gadd-DA_tmprss11d_protein_levels__seqid___6547-83__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MCM6 protein levels (SeqId = 9897-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MCM6 protein levels (SeqId = 9897-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DNA replication licensing factor MCM6	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.0000073	None	Gadd-DA_mcm6_protein_levels__seqid___9897-9__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.0440538	0.00982608	0.000007403539	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08624246	chr1:92202987	1	92202987	TGFBR3	Open sea	0.0371279	0.00828229	0.000007422387	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	0.0384521	0.00857956	0.000007456913	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0473419	0.0105641	0.000007472249	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.15788	0.0352343	0.000007481694	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	0.0369541	0.00825093	0.000007563686	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	-0.0369305	0.00825094	0.00000766562	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.0382338	0.00855882	0.000007984879	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.0368811	0.00825668	0.000007998528	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.0434574	0.00975124	0.000008388583	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	CNEP1R1 protein levels (SeqId = 13532-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CNEP1R1 protein levels (SeqId = 13532-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Nuclear envelope phosphatase-regulatory subunit 1	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.0000084	None	Gadd-DA_cnep1r1_protein_levels__seqid___13532-25__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.0370986	0.0083303	0.000008512325	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0469073	0.0105363	0.00000857112	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	0.0367209	0.008251	0.000008631168	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00342358	chr1:92350112	1	92350112	TGFBR3	North shore	0.036715	0.008251	0.0000086601	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02391982	chr1:92256764	1	92256764	TGFBR3	Open sea	-0.0366927	0.00825101	0.000008769709	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08648138	chr1:92247732	1	92247732	TGFBR3	Open sea	0.00049	None	0.0000088	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.189967	0.042741	0.00000886026	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0634638	0.0142898	0.000009011157	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	-0.0366255	0.00825103	0.000009107868	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent COPD (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent COPD (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18078	1	Adults (18-65y)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	-0.046	0.01036	0.0000092	None	Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.218201	0.0491917	0.000009233042	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0365933	0.00825104	0.00000927478	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	IDI2 protein levels (SeqId = 17832-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IDI2 protein levels (SeqId = 17832-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Isopentenyl-diphosphate delta-isomerase 2	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.0000093	None	Gadd-DA_idi2_protein_levels__seqid___17832-12__somascan_protein_measurement
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg00857921	chr1:92257380	1	92257380	TGFBR3	Open sea	0.00049	0.00011	0.0000094	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.0624303	0.0140874	0.000009419615	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	0.0365554	0.00825105	0.000009474132	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	LYPLAL1 protein levels (SeqId = 12428-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LYPLAL1 protein levels (SeqId = 12428-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lysophospholipase-like protein 1	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.0000095	None	Gadd-DA_lyplal1_protein_levels__seqid___12428-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08624246	chr1:92202987	1	92202987	TGFBR3	Open sea	0.0367162	0.00829807	0.000009728932	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg19756345	chr1:92351956	1	92351956	TGFBR3	Island	0.149941	0.0338957	0.000009762775	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03003526	chr1:92223917	1	92223917	TGFBR3	Open sea	0.0364864	0.00825107	0.00000984839	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	-0.0380799	0.00861151	0.000009850387	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0364827	0.00825107	0.000009869061	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	18413	1	Adults (18-65y)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.15	0.0339	0.0000099	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg17080882	chr1:92191625	1	92191625	TGFBR3	Open sea	1.9	0.425	0.0000099	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	-0.0451731	0.0102209	0.0000099556	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0364662	0.00825108	0.000009960596	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	-0.0364634	0.00825108	0.00000997656	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0364512	0.00825108	0.00001004489	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0364342	0.00825109	0.00001014134	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.036414	0.0082511	0.00001025681	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.036412	0.0082511	0.00001026832	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	-0.0364011	0.0082511	0.000010331	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.140085	0.0317576	0.00001034764	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	-0.0383592	0.00869924	0.0000104351	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0363286	0.00825112	0.0000107583	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0468932	0.0106588	0.00001092628	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	-0.212384	0.0483431	0.00001122908	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.046751	0.0106485	0.00001139449	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0394657	0.00899186	0.00001146451	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	-0.0428786	0.00977185	0.00001152121	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0408605	0.00931307	0.00001154958	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0361846	0.00825116	0.00001165858	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0361817	0.00825117	0.00001167742	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.036162	0.00825117	0.00001180597	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.178508	0.0407713	0.00001202934	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	0.0361175	0.00825118	0.00001210149	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.046437	0.0106139	0.00001222012	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08648138	chr1:92247732	1	92247732	TGFBR3	Open sea	-0.0360899	0.00825119	0.00001228878	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.0452689	0.0103548	0.00001240849	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	-0.006	0.001	0.0000127	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.0425153	0.00974268	0.00001286885	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	18413	1	Adults (18-65y)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.16	0.0366	0.000013	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	PDE4A protein levels (SeqId = 18918-86)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDE4A protein levels (SeqId = 18918-86)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: cAMP-specific 3',5'-cyclic phosphodiesterase 4A	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.000013	None	Gadd-DA_pde4a_protein_levels__seqid___18918-86__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17080882	chr1:92191625	1	92191625	TGFBR3	Open sea	-0.0359598	0.00825123	0.00001320824	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	-0.0359311	0.00825124	0.0000134196	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.0451166	0.0103682	0.00001361702	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0487901	0.0112129	0.00001362913	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0463267	0.010648	0.00001366001	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04702101	chr1:92167308	1	92167308	TGFBR3	Open sea	0.0358763	0.00825126	0.00001383219	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	-0.0358672	0.00825126	0.00001390205	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	HECW1 protein levels (SeqId = 12669-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HECW1 protein levels (SeqId = 12669-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: E3 ubiquitin-protein ligase HECW1	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.000014	None	Gadd-DA_hecw1_protein_levels__seqid___12669-30__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CD1D protein levels (SeqId = 8749-194)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD1D protein levels (SeqId = 8749-194)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Antigen-presenting glycoprotein CD1d	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.000014	None	Gadd-DA_cd1d_protein_levels__seqid___8749-194__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.0363406	0.00836607	0.00001409722	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.0372737	0.00858694	0.00001429545	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0620072	0.0142923	0.00001444104	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17080882	chr1:92191625	1	92191625	TGFBR3	Open sea	0.0357782	0.00825129	0.00001460199	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.0357719	0.00825129	0.0000146523	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.035738	0.0082513	0.00001492868	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19756345	chr1:92351956	1	92351956	TGFBR3	Island	0.0016	0.00036	0.000015	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	BAG5 protein levels (SeqId = 12743-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BAG5 protein levels (SeqId = 12743-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: BAG family molecular chaperone regulator 5	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.000015	None	Gadd-DA_bag5_protein_levels__seqid___12743-18__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0356552	0.00825132	0.00001562356	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0619125	0.0143292	0.00001565485	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15983901	chr1:92366037	1	92366037	TGFBR3	Open sea	-0.0356478	0.00825132	0.00001568769	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26659853	chr1:92282206	1	92282206	TGFBR3	Open sea	0.014	0.0033	0.000016	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17080882	chr1:92191625	1	92191625	TGFBR3	Open sea	-0.0356053	0.00825134	0.00001605808	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	0.0399682	0.00926255	0.00001606274	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	0.0355907	0.00825134	0.00001618664	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0441573	0.0102375	0.00001618953	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03003526	chr1:92223917	1	92223917	TGFBR3	Open sea	0.0355873	0.00825134	0.00001621696	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03006077	chr1:92234946	1	92234946	TGFBR3	Open sea	-0.035585	0.00825134	0.0000162379	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0459171	0.0106603	0.00001663391	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0355353	0.00825136	0.00001668642	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0355203	0.00825136	0.00001682347	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	-0.0420083	0.00976374	0.00001699927	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.0354935	0.00825137	0.00001707207	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0354864	0.00825137	0.00001713813	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09023660	chr1:92328495	1	92328495	TGFBR3	Open sea	-0.0354722	0.00825138	0.00001727229	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.0422212	0.00982912	0.00001754018	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0434396	0.0101131	0.00001755138	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	-0.0354403	0.00825138	0.00001757553	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0488802	0.0113859	0.00001773613	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03003526	chr1:92223917	1	92223917	TGFBR3	Open sea	-0.0354198	0.00825139	0.00001777387	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0800571	0.0186535	0.00001783769	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	0.0353989	0.0082514	0.00001797796	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24879809	chr1:92351641	1	92351641	TGFBR3	Island	0.00609	0.00138	0.000018	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Gadd DA	Generation Scotland	35945220	31/07/2022	SLC26A7 protein levels (SeqId = 13979-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SLC26A7 protein levels (SeqId = 13979-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Anion exchange transporter	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.129	0.03	0.000018	None	Gadd-DA_slc26a7_protein_levels__seqid___13979-3__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Lung Cancer	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Lung Cancer	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18364	1	Adults (18-65y)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	-0.014	0.00316	0.000018	None	Robert-F-Hillary_Incident_Lung_Cancer_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16946848	chr1:92167282	1	92167282	TGFBR3	Open sea	0.0353618	0.00825141	0.00001834505	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	-0.035357	0.00825141	0.00001839326	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	-0.0353501	0.00825141	0.00001846216	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.0398177	0.00929518	0.00001849924	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16946848	chr1:92167282	1	92167282	TGFBR3	Open sea	0.0353429	0.00825141	0.00001853498	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08624246	chr1:92202987	1	92202987	TGFBR3	Open sea	0.0355794	0.00830811	0.0000185992	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_2
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base plus BMI	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects, body mass index	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg03003526	chr1:92223917	1	92223917	TGFBR3	Open sea	-1.46	0.34	0.000019	4804	31197173_Liu-J_fasting_glucose_base_plus_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.036655	0.00857319	0.00001918808	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	0.0352424	0.00825144	0.00001957747	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0613162	0.0143572	0.00001960272	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01081930	chr1:92284280	1	92284280	TGFBR3	Open sea	-0.0352169	0.00825145	0.00001985027	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	ANGPTL7 protein levels (SeqId = 6371-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ANGPTL7 protein levels (SeqId = 6371-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Angiopoietin-related protein 7	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.00002	None	Gadd-DA_angptl7_protein_levels__seqid___6371-50__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TNMD protein levels (SeqId = 6578-29)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNMD protein levels (SeqId = 6578-29)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tenomodulin	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.00002	None	Gadd-DA_tnmd_protein_levels__seqid___6578-29__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.0351631	0.00825147	0.00002043802	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.0394023	0.00924623	0.00002043855	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	0.035162	0.00825147	0.00002045115	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	-0.0441016	0.0103575	0.00002075929	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0481339	0.0113055	0.00002079467	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0448717	0.010541	0.00002085853	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0453829	0.0106622	0.00002090101	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	MRAS protein levels (SeqId = 18297-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MRAS protein levels (SeqId = 18297-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related protein M-Ras	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.000021	None	Gadd-DA_mras_protein_levels__seqid___18297-8__somascan_protein_measurement
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg02391982	chr1:92256764	1	92256764	TGFBR3	Open sea	1.5	0.354	0.000021	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	GZMK protein levels (SeqId = 9545-156)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GZMK protein levels (SeqId = 9545-156)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granzyme K	774	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.91	0.215	0.000021	None	Gadd-DA_gzmk_protein_levels__seqid___9545-156__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.0350999	0.00825148	0.00002115061	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	-0.0350961	0.00825148	0.00002119411	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.04462	0.0105022	0.00002164181	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.0388677	0.00914892	0.00002166918	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.0350491	0.0082515	0.00002174028	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.048732	0.0114768	0.00002188397	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	PDGFRA protein levels (SeqId = 10366-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDGFRA protein levels (SeqId = 10366-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Platelet-derived growth factor receptor alpha	774	1	Adults (18-65 years)	Both	European	cg02061431	chr1:92150549	1	92150549	TGFBR3	Open sea	0.81	0.191	0.000022	None	Gadd-DA_pdgfra_protein_levels__seqid___10366-11__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SUV420H2 protein levels (SeqId = 12452-32)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SUV420H2 protein levels (SeqId = 12452-32)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Histone-lysine N-methyltransferase KMT5C	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.000022	None	Gadd-DA_suv420h2_protein_levels__seqid___12452-32__somascan_protein_measurement
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg11855117	chr1:92293627	1	92293627	TGFBR3	Open sea	0.950048	0.2241	0.0000223	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08624246	chr1:92202987	1	92202987	TGFBR3	Open sea	0.0349997	0.00825151	0.0000223285	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	-0.0397275	0.00937409	0.00002268841	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04516138	chr1:92250760	1	92250760	TGFBR3	Open sea	0.0349867	0.00826379	0.00002312475	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0431645	0.0102013	0.00002338012	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	-0.0349115	0.00825154	0.00002341674	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0393172	0.00929344	0.00002344439	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0394183	0.00931971	0.00002355648	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0348751	0.00825155	0.00002388048	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.044438	0.0105146	0.00002389934	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	0.00069	None	0.000024	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Any maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	6685	13	0	Missing	European,East Asian,African,Admixed,Other	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	-0.005	0.001	0.000024	-	27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0556206	0.0131862	0.0000247875	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.0067	0.0016	0.000025	None	33450751_Mulder-RH_sex_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	MST1R protein levels (SeqId = 2640-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MST1R protein levels (SeqId = 2640-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Macrophage-stimulating protein receptor	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.000025	None	Gadd-DA_mst1r_protein_levels__seqid___2640-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.0347668	0.00825158	0.0000253115	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.034764	0.00825158	0.0000253493	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0347526	0.00825158	0.0000255053	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0600693	0.0142665	0.0000256313	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15326069	chr1:92179761	1	92179761	TGFBR3	Open sea	0.0347399	0.00825159	0.00002567914	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	-0.0435092	0.0103366	0.00002577553	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	None	None	0.000026	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	ADSL protein levels (SeqId = 5023-23)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADSL protein levels (SeqId = 5023-23)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Adenylosuccinate lyase	774	1	Adults (18-65 years)	Both	European	cg11855117	chr1:92293627	1	92293627	TGFBR3	Open sea	0.68	0.162	0.000026	None	Gadd-DA_adsl_protein_levels__seqid___5023-23__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	-0.0041	0.00098	0.000026	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	NLRP4 protein levels (SeqId = 12794-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NLRP4 protein levels (SeqId = 12794-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NACHT, LRR and PYD domains-containing protein 4	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.000026	None	Gadd-DA_nlrp4_protein_levels__seqid___12794-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NOV protein levels (SeqId = 2737-22)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NOV protein levels (SeqId = 2737-22)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CCN family member 3	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.000026	None	Gadd-DA_nov_protein_levels__seqid___2737-22__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0346863	0.0082516	0.00002642817	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25769732	chr1:92295946	1	92295946	TGFBR3	Open sea	0.0346787	0.00825161	0.00002653629	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0346574	0.00825161	0.0000268402	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.0346352	0.00825162	0.00002716123	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0441142	0.0105135	0.0000273302	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	-0.157808	0.0376124	0.000027345	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0598664	0.0142687	0.00002737073	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.0345912	0.00825163	0.00002780739	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.034585	0.00825163	0.00002790018	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CNDP1 protein levels (SeqId = 5456-59)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CNDP1 protein levels (SeqId = 5456-59)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-Ala-His dipeptidase	774	1	Adults (18-65 years)	Both	European	cg08648138	chr1:92247732	1	92247732	TGFBR3	Open sea	-0.72	0.173	0.000029	None	Gadd-DA_cndp1_protein_levels__seqid___5456-59__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TBX3 protein levels (SeqId = 13978-122)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TBX3 protein levels (SeqId = 13978-122)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-box transcription factor TBX3	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.000029	None	Gadd-DA_tbx3_protein_levels__seqid___13978-122__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26659853	chr1:92282206	1	92282206	TGFBR3	Open sea	-0.0095	0.0023	0.000029	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02391982	chr1:92256764	1	92256764	TGFBR3	Open sea	0.0352984	0.00844037	0.00002905213	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	-0.157557	0.0376986	0.00002937401	None	39706196_Hannah-M.-Smith_body_fat_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	CCBL1 protein levels (SeqId = 17365-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CCBL1 protein levels (SeqId = 17365-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Kynurenine--oxoglutarate transaminase 1	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.13	0.03	0.00003	None	Gadd-DA_ccbl1_protein_levels__seqid___17365-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	-0.0344219	0.00825168	0.00003043453	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.0427712	0.0102553	0.00003054825	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	-0.0343924	0.00825169	0.00003091482	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03003526	chr1:92223917	1	92223917	TGFBR3	Open sea	-0.00043	0.0001	0.000031	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	BDH2 protein levels (SeqId = 17329-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BDH2 protein levels (SeqId = 17329-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 3-hydroxybutyrate dehydrogenase type 2	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000031	None	Gadd-DA_bdh2_protein_levels__seqid___17329-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0425247	0.0102122	0.00003143532	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.044315	0.0106452	0.00003160319	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.0343471	0.0082517	0.00003166836	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02391982	chr1:92256764	1	92256764	TGFBR3	Open sea	-0.035001	0.00841219	0.00003190093	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	0.0343302	0.0082517	0.00003195334	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02391982	chr1:92256764	1	92256764	TGFBR3	Open sea	0.0343292	0.0082517	0.00003197084	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	NAALADL1 protein levels (SeqId = 17505-125)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NAALADL1 protein levels (SeqId = 17505-125)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aminopeptidase NAALADL1	774	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	0.68	0.164	0.000032	None	Gadd-DA_naaladl1_protein_levels__seqid___17505-125__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	-0.0343117	0.00825171	0.00003226781	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.00046	0.00011	0.000033	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Hoang	Agricultural Lung Health Study	34516295	Sep 13, 2021	heptachlor	None	discovery	10.5281/zenodo.5156585	DNA methylation	heptachlor	Age, Smoking, Cell composition (reference based), residence,asthma	Beta values	None	Illumina HumanMethylationEPIC	whole blood	None	1131	1	Adults	Males	European	cg19756345	chr1:92351956	1	92351956	TGFBR3	Island	0.00085	0.00021	0.000033	None	34516295_Hoang_heptachlor_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	B3GALT1 protein levels (SeqId = 9541-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	B3GALT1 protein levels (SeqId = 9541-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-1,3-galactosyltransferase 1	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000033	None	Gadd-DA_b3galt1_protein_levels__seqid___9541-15__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.059558	0.0143547	0.00003357946	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.059346	0.0143064	0.00003369602	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0436691	0.0105286	0.00003377869	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	0.0342135	0.00825174	0.00003399064	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg00857921	chr1:92257380	1	92257380	TGFBR3	Open sea	0.0118	0.0028	0.000034	-	27651444_smoking_current_vs_never_smoking
Gadd DA	Generation Scotland	35945220	31/07/2022	AKAP7 protein levels (SeqId = 18399-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AKAP7 protein levels (SeqId = 18399-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: A-kinase anchor protein 7 isoforms alpha and beta	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000034	None	Gadd-DA_akap7_protein_levels__seqid___18399-1__somascan_protein_measurement
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg24879809	chr1:92351641	1	92351641	TGFBR3	Island	0.231766	0.056	0.0000347	-	27105112_hiv_infection_neutrophils
Gadd DA	Generation Scotland	35945220	31/07/2022	RERG protein levels (SeqId = 17822-57)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RERG protein levels (SeqId = 17822-57)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ras-related and estrogen-regulated growth inhibitor	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000035	None	Gadd-DA_rerg_protein_levels__seqid___17822-57__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03003526	chr1:92223917	1	92223917	TGFBR3	Open sea	-0.0341179	0.00825176	0.00003575134	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03003526	chr1:92223917	1	92223917	TGFBR3	Open sea	0.0341156	0.00825177	0.00003579574	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg23721586	chr1:92197531	1	92197531	TGFBR3	Open sea	-0.0004652	0.00011208	0.0000358	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg00857921	chr1:92257380	1	92257380	TGFBR3	Open sea	-0.0033	0.00077	0.000036	None	33564054_Kashima-K_gestational_age
Gadd DA	Generation Scotland	35945220	31/07/2022	SIGLEC11 protein levels (SeqId = 8913-22)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SIGLEC11 protein levels (SeqId = 8913-22)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sialic acid-binding Ig-like lectin 11	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000036	None	Gadd-DA_siglec11_protein_levels__seqid___8913-22__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RPRD1B protein levels (SeqId = 19126-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RPRD1B protein levels (SeqId = 19126-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Regulation of nuclear pre-mRNA domain-containing protein 1B	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000036	None	Gadd-DA_rprd1b_protein_levels__seqid___19126-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NR1H4 protein levels (SeqId = 8946-38)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NR1H4 protein levels (SeqId = 8946-38)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bile acid receptor	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000036	None	Gadd-DA_nr1h4_protein_levels__seqid___8946-38__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PF4V1 protein levels (SeqId = 5663-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PF4V1 protein levels (SeqId = 5663-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Platelet factor 4 variant	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000036	None	Gadd-DA_pf4v1_protein_levels__seqid___5663-18__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	18413	1	Adults (18-65y)	Both	European	cg02391982	chr1:92256764	1	92256764	TGFBR3	Open sea	0.16	0.0398	0.000036	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	SEMA6C protein levels (SeqId = 7202-107)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SEMA6C protein levels (SeqId = 7202-107)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Semaphorin-6C	774	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	0.68	0.16	0.000036	None	Gadd-DA_sema6c_protein_levels__seqid___7202-107__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	-0.0421047	0.0101938	0.00003641235	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.317495	0.0768899	0.00003657135	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	-0.0420754	0.0101913	0.00003670372	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	TNFRSF11B protein levels (SeqId = 8304-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNFRSF11B protein levels (SeqId = 8304-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tumor necrosis factor receptor superfamily member 11B	774	1	Adults (18-65 years)	Both	European	cg09651651	chr1:92208626	1	92208626	TGFBR3	Open sea	0.7	0.169	0.000037	None	Gadd-DA_tnfrsf11b_protein_levels__seqid___8304-50__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.0406861	0.00986491	0.00003738817	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	0.0340255	0.00825179	0.0000375362	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.0384179	0.0093173	0.00003755701	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	0.0431854	0.01048	0.00003797283	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.0339952	0.0082518	0.00003813881	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.291989	0.0709456	0.00003877479	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	-0.033962	0.00825181	0.00003881008	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.0375882	0.00913298	0.00003881899	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	-0.0339568	0.00825181	0.00003891739	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	NAGPA protein levels (SeqId = 11208-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NAGPA protein levels (SeqId = 11208-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	774	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	0.67	0.164	0.000039	None	Gadd-DA_nagpa_protein_levels__seqid___11208-15__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Ischemic Heart Disease	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Ischemic Heart Disease	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17483	1	Adults (18-65y)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.034	0.00816	0.000039	None	Robert-F-Hillary_Incident_Ischemic_Heart_Disease_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.0588705	0.0143113	0.00003917324	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg02796548	chr1:92372096	1	92372096	TGFBR3	Open sea	-0.139796	0.0339937	0.00003932744	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	-0.0339211	0.00825182	0.00003965418	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0339119	0.00825182	0.00003984578	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	-0.0518949	0.012646	0.00004088536	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	GAGE2D protein levels (SeqId = 18273-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GAGE2D protein levels (SeqId = 18273-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: G antigen 2D	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.123	0.03	0.000041	None	Gadd-DA_gage2d_protein_levels__seqid___18273-14__somascan_protein_measurement
Argos M	-	25325195	2014-10-17	Blood arsenic concentration	CHEBI_27563	Discovery	Table 2	DNA methylation	Blood arsenic concentrations	Age, sex and technical covariates	Beta values	ug/l	Illumina HumanMethylation450	Whole blood	-	400	1	43	Both	South Asian	cg00857921	chr1:92257380	1	92257380	TGFBR3	Open sea	0.016	0.004	0.0000412	-	25325195_blood_arsenic_concentration_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0434137	0.0105934	0.00004186452	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_3
Battram T	GEO	27886173	2020-09-15	Crohn's disease	EFO_0000384	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Crohn's disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	161	1	Adults	Both	European	cg17074704	chr1:92350430	1	92350430	TGFBR3	North shore	-0.015	0.00356	0.000042	None	27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Gadd DA	Generation Scotland	35945220	31/07/2022	PSMB3 protein levels (SeqId = 18339-207)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PSMB3 protein levels (SeqId = 18339-207)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteasome subunit beta type-3	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000042	None	Gadd-DA_psmb3_protein_levels__seqid___18339-207__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DEFB107A protein levels (SeqId = 6399-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DEFB107A protein levels (SeqId = 6399-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-defensin 107	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000042	None	Gadd-DA_defb107a_protein_levels__seqid___6399-52__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	BCCIP protein levels (SeqId = 18304-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BCCIP protein levels (SeqId = 18304-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: BRCA2 and CDKN1A-interacting protein	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.123	0.03	0.000042	None	Gadd-DA_bccip_protein_levels__seqid___18304-19__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NDUFB11 protein levels (SeqId = 7747-47)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NDUFB11 protein levels (SeqId = 7747-47)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000042	None	Gadd-DA_ndufb11_protein_levels__seqid___7747-47__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17080882	chr1:92191625	1	92191625	TGFBR3	Open sea	-0.035885	0.00876158	0.00004231095	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09023660	chr1:92328495	1	92328495	TGFBR3	Open sea	0.0337703	0.00825186	0.00004291221	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Starling PS	Healthy Start Study	33356526	24/12/2020	maternal serum perfluorodecanoate (PFDA)	CHEBI_35546	Discovery	Table S5	DNA methylation	maternal serum perfluorodecanoate (PFDA)	gestational age, sex, maternal smoking during pregnancy, maternal age, maternal education, ethnicity, pre-pregnancy BMI, gravidity, cell composition (reference based)	M Values	ln-ng/mL	Illumina HumanMethylation450	cord blood	None	583	1	Infants	Both	European (54%); Hispanic (24%); African American (15%); Other (6%)	cg16382382	chr1:92351047	1	92351047	TGFBR3	Island	-0.0805	None	0.000043	None	33356526_Starling-PS_maternal_serum_perfluorodecanoate__pfda__discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0587018	0.014355	0.00004349932	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.0411356	0.0100612	0.0000436419	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	0.0337352	0.00825187	0.00004370647	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02391982	chr1:92256764	1	92256764	TGFBR3	Open sea	0.162933	0.0398565	0.00004370926	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	-0.0416916	0.0101982	0.00004371609	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.0581765	0.014231	0.00004374174	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	-0.0352137	0.00861392	0.00004374371	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0767534	0.0187771	0.00004381782	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CD72 protein levels (SeqId = 7009-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD72 protein levels (SeqId = 7009-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: B-cell differentiation antigen CD72	774	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	0.67	0.164	0.000044	None	Gadd-DA_cd72_protein_levels__seqid___7009-8__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00976081	chr1:92292815	1	92292815	TGFBR3	Open sea	-0.0337097	0.00825188	0.00004429272	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	0.0382567	0.00937394	0.00004504617	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0461607	0.0113152	0.00004536594	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	-0.0336595	0.00825189	0.00004546852	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08624246	chr1:92202987	1	92202987	TGFBR3	Open sea	0.0338517	0.00830445	0.00004599344	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	TPM1 protein levels (SeqId = 5033-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TPM1 protein levels (SeqId = 5033-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tropomyosin alpha-1 chain	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000046	None	Gadd-DA_tpm1_protein_levels__seqid___5033-27__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg17080882	chr1:92191625	1	92191625	TGFBR3	Open sea	0.157773	0.0387124	0.00004611447	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0615435	0.0151009	0.00004615831	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0336292	0.0082519	0.00004619216	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15326069	chr1:92179761	1	92179761	TGFBR3	Open sea	-0.0336246	0.0082519	0.0000463023	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0584543	0.0143457	0.00004632057	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03613937	chr1:92349104	1	92349104	TGFBR3	North shore	0.033615	0.00825191	0.00004653552	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	0.0350083	0.00859421	0.00004655889	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	0.0336128	0.00825191	0.00004658714	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0336039	0.00825191	0.00004680524	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YY99	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0J9YY99	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0775713	0.0190504	0.00004687788	A0A0J9YY99	41361833_Josephine_Robertson_A0A0J9YY99_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00976081	chr1:92292815	1	92292815	TGFBR3	Open sea	-0.0335955	0.00825191	0.00004700888	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01009	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01009	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	-0.0335757	0.00825192	0.00004749693	P01009	41361833_Josephine_Robertson_P01009_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	RELT protein levels (SeqId = 14112-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RELT protein levels (SeqId = 14112-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tumor necrosis factor receptor superfamily member 19L	774	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	0.66	0.164	0.000048	None	Gadd-DA_relt_protein_levels__seqid___14112-40__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17080882	chr1:92191625	1	92191625	TGFBR3	Open sea	-0.0355028	0.00873117	0.00004803291	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.0335484	0.00825192	0.00004817551	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	HS3ST4 protein levels (SeqId = 8998-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HS3ST4 protein levels (SeqId = 8998-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Heparan sulfate glucosamine 3-O-sulfotransferase 4	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000049	None	Gadd-DA_hs3st4_protein_levels__seqid___8998-15__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0335113	0.00825193	0.00004911233	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	ZNF264 protein levels (SeqId = 9993-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZNF264 protein levels (SeqId = 9993-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Zinc finger protein 264	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000051	None	Gadd-DA_znf264_protein_levels__seqid___9993-11__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	-0.0334355	0.00825196	0.00005108123	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.141261	0.0348761	0.00005136288	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	EFNB2 protein levels (SeqId = 8772-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EFNB2 protein levels (SeqId = 8772-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ephrin-B2	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.121	0.03	0.000052	None	Gadd-DA_efnb2_protein_levels__seqid___8772-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DDIT3 protein levels (SeqId = 19119-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DDIT3 protein levels (SeqId = 19119-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DNA damage-inducible transcript 3 protein	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000052	None	Gadd-DA_ddit3_protein_levels__seqid___19119-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TIMD4 protein levels (SeqId = 15449-33)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TIMD4 protein levels (SeqId = 15449-33)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-cell immunoglobulin and mucin domain-containing protein 4	774	1	Adults (18-65 years)	Both	European	cg13680095	chr1:92372418	1	92372418	TGFBR3	Open sea	-0.89	0.221	0.000052	None	Gadd-DA_timd4_protein_levels__seqid___15449-33__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GZMA protein levels (SeqId = 3440-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GZMA protein levels (SeqId = 3440-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granzyme A	774	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.87	0.215	0.000052	None	Gadd-DA_gzma_protein_levels__seqid___3440-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0333916	0.00825197	0.00005225569	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	-0.041303	0.0102095	0.00005246864	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	RMI1 protein levels (SeqId = 13926-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RMI1 protein levels (SeqId = 13926-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: RecQ-mediated genome instability protein 1	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000053	None	Gadd-DA_rmi1_protein_levels__seqid___13926-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IL36B protein levels (SeqId = 14149-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL36B protein levels (SeqId = 14149-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-36 beta	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000053	None	Gadd-DA_il36b_protein_levels__seqid___14149-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PSG6 protein levels (SeqId = 6456-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PSG6 protein levels (SeqId = 6456-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pregnancy-specific beta-1-glycoprotein 6	774	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	0.66	0.164	0.000053	None	Gadd-DA_psg6_protein_levels__seqid___6456-17__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	-0.0333438	0.00825198	0.00005356234	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04702101	chr1:92167308	1	92167308	TGFBR3	Open sea	0.0333434	0.00825198	0.00005357364	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	MGA protein levels (SeqId = 11587-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MGA protein levels (SeqId = 11587-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: MAX gene-associated protein	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000054	None	Gadd-DA_mga_protein_levels__seqid___11587-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	-0.0333193	0.00825199	0.0000542445	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0429791	0.0106464	0.00005442228	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0447672	0.0110959	0.00005497837	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0428571	0.0106253	0.00005523245	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	0.041996	0.0104174	0.00005574499	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_4
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	None	None	0.000056	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	ITM2A protein levels (SeqId = 7765-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ITM2A protein levels (SeqId = 7765-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Integral membrane protein 2A	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000056	None	Gadd-DA_itm2a_protein_levels__seqid___7765-15__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DNMT3L protein levels (SeqId = 19142-39)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DNMT3L protein levels (SeqId = 19142-39)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DNA (cytosine-5)-methyltransferase 3-like	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000056	None	Gadd-DA_dnmt3l_protein_levels__seqid___19142-39__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.0332465	0.00825201	0.000056321	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23440142	chr1:92195799	1	92195799	TGFBR3	Open sea	0.0332403	0.00825201	0.0000565023	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SLAMF7 protein levels (SeqId = 5487-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SLAMF7 protein levels (SeqId = 5487-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: SLAM family member 7	774	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.79	0.196	0.000057	None	Gadd-DA_slamf7_protein_levels__seqid___5487-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.0332201	0.00825201	0.00005709363	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0428213	0.010639	0.00005727343	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_3
Hoang	Agricultural Lung Health Study	34516295	Sep 13, 2021	heptachlor	None	discovery	10.5281/zenodo.5156585	DNA methylation	heptachlor	Age, Smoking, Cell composition (reference based), residence,asthma	Beta values	None	Illumina HumanMethylationEPIC	whole blood	None	1131	1	Adults	Males	European	cg15083409	chr1:92372179	1	92372179	TGFBR3	Open sea	-0.00322	0.0008	0.000058	None	34516295_Hoang_heptachlor_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.0423569	0.010533	0.00005815556	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	-0.136055	0.0338391	0.00005828422	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	-0.0428078	0.010647	0.0000583262	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	0.0331757	0.00825203	0.00005841364	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	0.0341576	0.0084987	0.00005869971	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_3
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg17284082	chr1:92351487	1	92351487	TGFBR3	Island	-1.195891	0.2977	0.0000588	-	27105112_hiv_infection_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	PXDNL protein levels (SeqId = 11324-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PXDNL protein levels (SeqId = 11324-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peroxidasin-like protein	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000059	None	Gadd-DA_pxdnl_protein_levels__seqid___11324-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PRDX5 protein levels (SeqId = 5017-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRDX5 protein levels (SeqId = 5017-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peroxiredoxin-5, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000059	None	Gadd-DA_prdx5_protein_levels__seqid___5017-19__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RIPPLY1 protein levels (SeqId = 9767-22)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RIPPLY1 protein levels (SeqId = 9767-22)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein ripply1	774	1	Adults (18-65 years)	Both	European	cg16946848	chr1:92167282	1	92167282	TGFBR3	Open sea	-0.78	0.195	0.000059	None	Gadd-DA_ripply1_protein_levels__seqid___9767-22__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0422541	0.0105176	0.00005911744	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09790580	chr1:92171309	1	92171309	TGFBR3	Open sea	-0.0331452	0.00825203	0.00005933626	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0753469	0.0187705	0.00005996531	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_4
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg00342358	chr1:92350112	1	92350112	TGFBR3	North shore	0.00647	0.00161	0.00006	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.042082	0.0104848	0.00006009041	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	0.0344879	0.0085931	0.00006013747	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	ANK2 protein levels (SeqId = 7624-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ANK2 protein levels (SeqId = 7624-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ankyrin-2	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.121	0.03	0.000061	None	Gadd-DA_ank2_protein_levels__seqid___7624-19__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26551819	chr1:92228825	1	92228825	TGFBR3	Open sea	0.0330893	0.00825205	0.00006106512	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0574009	0.0143153	0.00006108074	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-0.0570181	0.0142266	0.00006157845	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0071	0.0018	0.000062	-	27651444_smoking_current_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	0.0330536	0.00825206	0.0000621916	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	0.0330463	0.00825206	0.00006242521	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.0415488	0.0103784	0.00006275026	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Gervin K	-	28785368	2017-08-02	Attention deficit hyperactivity disorder	EFO_0003888	Long-term prenatal exposure to paracetamol versus sporadic prenatal exposure to paracetamol	Table S2	DNA methylation	Long-term prenatal exposure to paracetamol in children with ADHD versus sporadic prenatal exposure to paracetamol in children with ADHD	Sex, smoking, maternal age, gestational age, cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Cord blood	-	96	1	0	Both	European	cg00342358	chr1:92350112	1	92350112	TGFBR3	North shore	-	-	0.0000628	-	28785368_attention_deficit_hyperactivity_disorder_longterm_prenatal_exposure_to_paracetamol_versus_sporadic_prenatal_exposure_to_paracetamol
Gadd DA	Generation Scotland	35945220	31/07/2022	COL25A1 protein levels (SeqId = 7006-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COL25A1 protein levels (SeqId = 7006-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Collagen alpha-1(XXV) chain	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000063	None	Gadd-DA_col25a1_protein_levels__seqid___7006-4__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	-0.0330279	0.00825207	0.00006301589	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.182233	0.0455606	0.00006366142	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0329847	0.00825208	0.0000644262	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	MTPAP protein levels (SeqId = 9028-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MTPAP protein levels (SeqId = 9028-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Poly(A) RNA polymerase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000065	None	Gadd-DA_mtpap_protein_levels__seqid___9028-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.0329597	0.00825209	0.00006525421	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	-0.032941	0.00825209	0.00006588112	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	FBXL4 protein levels (SeqId = 11416-23)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FBXL4 protein levels (SeqId = 11416-23)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: F-box/LRR-repeat protein 4	774	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	0.65	0.164	0.000066	None	Gadd-DA_fbxl4_protein_levels__seqid___11416-23__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ENPP6 protein levels (SeqId = 15579-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ENPP6 protein levels (SeqId = 15579-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 6	774	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	0.65	0.164	0.000066	None	Gadd-DA_enpp6_protein_levels__seqid___15579-26__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04702101	chr1:92167308	1	92167308	TGFBR3	Open sea	0.0329288	0.00825209	0.00006629313	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15983901	chr1:92366037	1	92366037	TGFBR3	Open sea	-0.0329253	0.00825209	0.00006641434	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	0.0329206	0.0082521	0.00006657126	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01081930	chr1:92284280	1	92284280	TGFBR3	Open sea	0.0099	0.0025	0.000067	None	33450751_Mulder-RH_sex_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Ischemic Heart Disease	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Ischemic Heart Disease	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17483	1	Adults (18-65y)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.026	0.00641	0.000067	None	Robert-F-Hillary_Incident_Ischemic_Heart_Disease_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	PAXIP1 protein levels (SeqId = 12894-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAXIP1 protein levels (SeqId = 12894-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: PAX-interacting protein 1	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000067	None	Gadd-DA_paxip1_protein_levels__seqid___12894-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.0418561	0.0104965	0.0000670597	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0329036	0.0082521	0.00006715213	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09023660	chr1:92328495	1	92328495	TGFBR3	Open sea	0.0339976	0.00853104	0.00006775895	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	-0.0328843	0.00825211	0.00006781984	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.0328806	0.00825211	0.00006794478	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0444803	0.0111644	0.0000680566	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02061431	chr1:92150549	1	92150549	TGFBR3	Open sea	0.0331319	0.00831726	0.00006823129	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	0.05	0.01267	0.000069	None	Robert-F-Hillary_Incident_COPD_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	CALCOCO2 protein levels (SeqId = 12534-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CALCOCO2 protein levels (SeqId = 12534-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calcium-binding and coiled-coil domain-containing protein 2	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000069	None	Gadd-DA_calcoco2_protein_levels__seqid___12534-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TSR3 protein levels (SeqId = 7018-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TSR3 protein levels (SeqId = 7018-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ribosome biogenesis protein TSR3 homolog	774	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	0.65	0.164	0.000069	None	Gadd-DA_tsr3_protein_levels__seqid___7018-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PACAP protein levels (SeqId = 16322-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PACAP protein levels (SeqId = 16322-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Marginal zone B- and B1-cell-specific protein	774	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.77	0.194	0.000069	None	Gadd-DA_pacap_protein_levels__seqid___16322-10__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.0328487	0.00825212	0.0000690601	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09790580	chr1:92171309	1	92171309	TGFBR3	Open sea	0.0328464	0.00825212	0.00006914168	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09023660	chr1:92328495	1	92328495	TGFBR3	Open sea	0.0339569	0.0085319	0.00006924726	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_2
Battram T	GEO	30529013	2020-11-01	Melanoma	EFO_0000756	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE120878. Authors assessed methylation differences between melanoma samples and nevi	None	DNA methylation	Melanoma	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Skin	None	162	1	Adults	Both	Unclear	cg18539768	chr1:92149139	1	92149139	TGFBR3	Open sea	-0.114	0.0277	0.00007	None	30529013_Battram-T_melanoma_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse120878__authors_assessed_methylation_differences_between_melanoma_samples_and_nevi
Gadd DA	Generation Scotland	35945220	31/07/2022	THOC1 protein levels (SeqId = 9875-107)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	THOC1 protein levels (SeqId = 9875-107)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: THO complex subunit 1	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.119	0.03	0.00007	None	Gadd-DA_thoc1_protein_levels__seqid___9875-107__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	-0.0371352	0.00933696	0.00007005726	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17080882	chr1:92191625	1	92191625	TGFBR3	Open sea	-0.0328199	0.00825212	0.00007008181	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0570198	0.0143429	0.00007057741	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	-0.0337553	0.00849199	0.00007073032	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.0328012	0.00825213	0.00007075207	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.0327982	0.00825213	0.00007086038	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	IRF9 protein levels (SeqId = 12439-67)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IRF9 protein levels (SeqId = 12439-67)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interferon regulatory factor 9	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000071	None	Gadd-DA_irf9_protein_levels__seqid___12439-67__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FREM2 protein levels (SeqId = 7246-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FREM2 protein levels (SeqId = 7246-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: FRAS1-related extracellular matrix protein 2	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000071	None	Gadd-DA_frem2_protein_levels__seqid___7246-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CCPG1 protein levels (SeqId = 8889-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CCPG1 protein levels (SeqId = 8889-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cell cycle progression protein 1	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000071	None	Gadd-DA_ccpg1_protein_levels__seqid___8889-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CSF2RB protein levels (SeqId = 11137-43)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CSF2RB protein levels (SeqId = 11137-43)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cytokine receptor common subunit beta	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000071	None	Gadd-DA_csf2rb_protein_levels__seqid___11137-43__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	-0.037082	0.00933461	0.00007145472	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	BPTF protein levels (SeqId = 12482-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BPTF protein levels (SeqId = 12482-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Nucleosome-remodeling factor subunit BPTF	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000072	None	Gadd-DA_bptf_protein_levels__seqid___12482-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23113350	chr1:92352404	1	92352404	TGFBR3	South shore	0.0327639	0.00825214	0.00007211007	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	LTA protein levels (SeqId = 4703-87)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LTA protein levels (SeqId = 4703-87)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lymphotoxin-alpha	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000073	None	Gadd-DA_lta_protein_levels__seqid___4703-87__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03003526	chr1:92223917	1	92223917	TGFBR3	Open sea	-0.0327373	0.00825215	0.00007308893	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	-0.0327278	0.00825215	0.00007344361	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SPEF1 protein levels (SeqId = 12876-39)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SPEF1 protein levels (SeqId = 12876-39)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sperm flagellar protein 1	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000074	None	Gadd-DA_spef1_protein_levels__seqid___12876-39__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ITGAL protein levels (SeqId = 11617-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ITGAL protein levels (SeqId = 11617-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Integrin alpha-L	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000074	None	Gadd-DA_itgal_protein_levels__seqid___11617-1__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg08104725	chr1:92177929	1	92177929	TGFBR3	Open sea	0.122243	0.0308459	0.0000743069	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02391982	chr1:92256764	1	92256764	TGFBR3	Open sea	-0.0333815	0.00842631	0.00007480677	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10960253	chr1:92296137	1	92296137	TGFBR3	Open sea	0.0326751	0.00825216	0.00007543724	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01081930	chr1:92284280	1	92284280	TGFBR3	Open sea	-0.001	0.00025	0.000076	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	-0.0439789	0.0111134	0.00007616044	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08624246	chr1:92202987	1	92202987	TGFBR3	Open sea	0.0328456	0.00831008	0.00007770098	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_2
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	-1.05	0.27	0.000078	4808	31197173_Liu-J_fasting_glucose_base
Gadd DA	Generation Scotland	35945220	31/07/2022	SH2D3C protein levels (SeqId = 12704-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SH2D3C protein levels (SeqId = 12704-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: SH2 domain-containing protein 3C	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000078	None	Gadd-DA_sh2d3c_protein_levels__seqid___12704-26__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RIC3 protein levels (SeqId = 11228-37)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RIC3 protein levels (SeqId = 11228-37)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein RIC-3	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000078	None	Gadd-DA_ric3_protein_levels__seqid___11228-37__somascan_protein_measurement
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.00049	0.00012	0.000079	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Gadd DA	Generation Scotland	35945220	31/07/2022	HFE2 protein levels (SeqId = 3332-57)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HFE2 protein levels (SeqId = 3332-57)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hemojuvelin	774	1	Adults (18-65 years)	Both	European	cg09838042	chr1:92351547	1	92351547	TGFBR3	Island	-0.67	0.171	0.000079	None	Gadd-DA_hfe2_protein_levels__seqid___3332-57__somascan_protein_measurement
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Lifetime consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg17074704	chr1:92350430	1	92350430	TGFBR3	North shore	None	None	0.000079	None	31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	PALM protein levels (SeqId = 18306-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PALM protein levels (SeqId = 18306-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Paralemmin-1	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000079	None	Gadd-DA_palm_protein_levels__seqid___18306-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MAPK11 protein levels (SeqId = 5004-69)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAPK11 protein levels (SeqId = 5004-69)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mitogen-activated protein kinase 11	774	1	Adults (18-65 years)	Both	European	cg04333237	chr1:92371472	1	92371472	TGFBR3	Open sea	-0.6	0.151	0.000079	None	Gadd-DA_mapk11_protein_levels__seqid___5004-69__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ZNF175 protein levels (SeqId = 12716-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZNF175 protein levels (SeqId = 12716-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Zinc finger protein 175	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000081	None	Gadd-DA_znf175_protein_levels__seqid___12716-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	-0.0325129	0.00825221	0.00008189062	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	0.0325116	0.00825221	0.00008194729	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10324998	chr1:92338262	1	92338262	TGFBR3	Open sea	-0.036889	0.00936649	0.00008240574	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	-0.0367717	0.00933827	0.00008263446	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0324868	0.00825221	0.00008297785	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	LRRN1 protein levels (SeqId = 11293-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LRRN1 protein levels (SeqId = 11293-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leucine-rich repeat neuronal protein 1	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000083	None	Gadd-DA_lrrn1_protein_levels__seqid___11293-14__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PDIA4 protein levels (SeqId = 7146-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PDIA4 protein levels (SeqId = 7146-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein disulfide-isomerase A4	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000083	None	Gadd-DA_pdia4_protein_levels__seqid___7146-16__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	VAMP8 protein levels (SeqId = 7064-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VAMP8 protein levels (SeqId = 7064-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Vesicle-associated membrane protein 8	774	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	0.64	0.164	0.000083	None	Gadd-DA_vamp8_protein_levels__seqid___7064-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02391982	chr1:92256764	1	92256764	TGFBR3	Open sea	-0.0324631	0.00825222	0.00008397626	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	RGS5 protein levels (SeqId = 16850-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RGS5 protein levels (SeqId = 16850-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Regulator of G-protein signaling 5	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000084	None	Gadd-DA_rgs5_protein_levels__seqid___16850-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GALNT11 protein levels (SeqId = 8700-325)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GALNT11 protein levels (SeqId = 8700-325)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Polypeptide N-acetylgalactosaminyltransferase 11	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000084	None	Gadd-DA_galnt11_protein_levels__seqid___8700-325__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	0.0354831	0.00902224	0.00008433172	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18181593	chr1:92220012	1	92220012	TGFBR3	Open sea	-0.0324497	0.00825222	0.00008454695	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	MDM2 protein levels (SeqId = 13228-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MDM2 protein levels (SeqId = 13228-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: E3 ubiquitin-protein ligase Mdm2	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000085	None	Gadd-DA_mdm2_protein_levels__seqid___13228-75__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GNG11 protein levels (SeqId = 18282-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GNG11 protein levels (SeqId = 18282-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	774	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	0.64	0.164	0.000085	None	Gadd-DA_gng11_protein_levels__seqid___18282-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08106455	chr1:92285197	1	92285197	TGFBR3	Open sea	0.033356	0.00848638	0.00008514739	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04365878	chr1:92311629	1	92311629	TGFBR3	Open sea	-0.0324315	0.00825223	0.00008532344	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	-0.0324179	0.00825223	0.00008591146	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SERF2 protein levels (SeqId = 18274-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SERF2 protein levels (SeqId = 18274-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Small EDRK-rich factor 2	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000086	None	Gadd-DA_serf2_protein_levels__seqid___18274-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17080882	chr1:92191625	1	92191625	TGFBR3	Open sea	0.0324125	0.00825223	0.00008614676	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00563926	chr1:92352481	1	92352481	TGFBR3	South shore	0.1374	0.0349842	0.00008616479	None	39706196_Hannah-M.-Smith_body_fat_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg13178170	chr1:92270513	1	92270513	TGFBR3	Open sea	-1.44	0.367	0.000087	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GAD1 protein levels (SeqId = 11280-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GAD1 protein levels (SeqId = 11280-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glutamate decarboxylase 1	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000087	None	Gadd-DA_gad1_protein_levels__seqid___11280-6__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	0.0323747	0.00825224	0.00008780162	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	KRT7 protein levels (SeqId = 11383-41)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KRT7 protein levels (SeqId = 11383-41)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Keratin, type II cytoskeletal 7	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000089	None	Gadd-DA_krt7_protein_levels__seqid___11383-41__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	0.0397903	0.0101519	0.00008913409	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04702101	chr1:92167308	1	92167308	TGFBR3	Open sea	-0.0355889	0.00908312	0.00008964153	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21382567	chr1:92263858	1	92263858	TGFBR3	Open sea	-0.0364009	0.00929195	0.00008989132	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26542412	chr1:92350568	1	92350568	TGFBR3	North shore	0.003	0.00077	0.00009	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	-0.138363	0.0353474	0.00009098393	None	39706196_Hannah-M.-Smith_body_fat_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg07557690	chr1:92352407	1	92352407	TGFBR3	South shore	0.026	0.00669	0.000091	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	ANXA8 protein levels (SeqId = 18290-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ANXA8 protein levels (SeqId = 18290-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Annexin A8	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000091	None	Gadd-DA_anxa8_protein_levels__seqid___18290-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UBTD2 protein levels (SeqId = 12875-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBTD2 protein levels (SeqId = 12875-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin domain-containing protein 2	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000091	None	Gadd-DA_ubtd2_protein_levels__seqid___12875-28__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CENPW protein levels (SeqId = 8864-59)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CENPW protein levels (SeqId = 8864-59)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Centromere protein W	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000091	None	Gadd-DA_cenpw_protein_levels__seqid___8864-59__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ENTPD1 protein levels (SeqId = 3182-38)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ENTPD1 protein levels (SeqId = 3182-38)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ectonucleoside triphosphate diphosphohydrolase 1	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000091	None	Gadd-DA_entpd1_protein_levels__seqid___3182-38__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12215483	chr1:92342022	1	92342022	TGFBR3	Open sea	-0.0322979	0.00825226	0.00009125807	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	-0.0322928	0.00825227	0.00009149003	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16719359	chr1:92218200	1	92218200	TGFBR3	Open sea	0.0409349	0.0104725	0.00009316682	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15143914	chr1:92196566	1	92196566	TGFBR3	Open sea	0.0322542	0.00825228	0.00009328213	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10197383	chr1:92261514	1	92261514	TGFBR3	Open sea	0.0332899	0.00851914	0.00009361266	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity, white blood cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg00342358	chr1:92350112	1	92350112	TGFBR3	North shore	-0.008	0.002	0.0000938	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts
Sikdar S	PACE	31536415	2019-09-19	Prenatal smoke exposure	EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318	Inverse varience-weighted fixed-effects meta-analysis	Table S1	DNA methylation	Prenatal smoke exposure	Maternal age, socioeconomic position, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Cord blood, whole blood	None	5648	9	Infants	Both	European, African, Unclear	cg00342358	chr1:92350112	1	92350112	TGFBR3	North shore	-0.008	0.002	0.000094	None	31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis
Gadd DA	Generation Scotland	35945220	31/07/2022	PECR protein levels (SeqId = 17776-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PECR protein levels (SeqId = 17776-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peroxisomal trans-2-enoyl-CoA reductase	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000094	None	Gadd-DA_pecr_protein_levels__seqid___17776-15__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CKAP4 protein levels (SeqId = 7221-56)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CKAP4 protein levels (SeqId = 7221-56)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cytoskeleton-associated protein 4	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000094	None	Gadd-DA_ckap4_protein_levels__seqid___7221-56__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12480547	chr1:92179222	1	92179222	TGFBR3	Open sea	-0.0412866	0.0105725	0.00009460802	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	GNLY protein levels (SeqId = 3195-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GNLY protein levels (SeqId = 3195-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granulysin	774	1	Adults (18-65 years)	Both	European	cg16946848	chr1:92167282	1	92167282	TGFBR3	Open sea	-0.75	0.193	0.000095	None	Gadd-DA_gnly_protein_levels__seqid___3195-50__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ANKRD1 protein levels (SeqId = 15361-37)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ANKRD1 protein levels (SeqId = 15361-37)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ankyrin repeat domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.117	0.03	0.000096	None	Gadd-DA_ankrd1_protein_levels__seqid___15361-37__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03203179	chr1:92275181	1	92275181	TGFBR3	Open sea	0.0341521	0.00875459	0.00009620313	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03166702	chr1:92357392	1	92357392	TGFBR3	Open sea	0.0415294	0.0106484	0.00009660051	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19139704	chr1:92198231	1	92198231	TGFBR3	Open sea	-0.0321819	0.00825229	0.0000967201	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Apolipoprotein A-I	EFO_0004614	None	None	DNA methylation	Apolipoprotein A-I	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg23636324	chr1:92351686	1	92351686	TGFBR3	Island	0.67	0.171	0.000097	None	Battram-T_apolipoprotein_a-i
Gadd DA	Generation Scotland	35945220	31/07/2022	GNAS protein levels (SeqId = 5757-45)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GNAS protein levels (SeqId = 5757-45)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neuroendocrine secretory protein 55	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.117	0.03	0.000097	None	Gadd-DA_gnas_protein_levels__seqid___5757-45__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26648031	chr1:92258256	1	92258256	TGFBR3	Open sea	0.0321717	0.0082523	0.00009721459	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08848903	chr1:92352293	1	92352293	TGFBR3	South shore	0.0403616	0.0103596	0.00009820807	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	PYDC1 protein levels (SeqId = 12835-101)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PYDC1 protein levels (SeqId = 12835-101)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pyrin domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg24928141	chr1:92154087	1	92154087	TGFBR3	Open sea	-0.12	0.03	0.000099	None	Gadd-DA_pydc1_protein_levels__seqid___12835-101__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01336162	chr1:92350133	1	92350133	TGFBR3	North shore	-0.0342177	0.00878928	0.00009940214	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21116284	chr1:92216881	1	92216881	TGFBR3	Open sea	0.0326621	0.00839023	0.00009950401	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_2