author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.0084 0.00024 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea 0.034 0.0012 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14209186 chr4:38980960 4 38980960 TMEM156 Open sea 0.17176 0.00349 2.9000000000000004e-111 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg02198513 chr4:38987121 4 38987121 TMEM156 Open sea -0.30501 0.00828 3.1e-89 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea 0.27019 0.00771 1.3e-85 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea 0.129048 0.00818753 1.6334680000000002e-55 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea -0.10924 0.00494 8.8e-55 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea 0.118244 0.00819865 7.819381e-47 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg10032387 chr4:38988166 4 38988166 TMEM156 Open sea 0.07765 0.00417 5.4000000000000003e-45 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea 0.10727 0.00820893 8.319926e-39 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea 3.09648 0.13645 2.64e-38 - 25282492_fetal_vs_adult_liver Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13344413 chr4:39034272 4 39034272 TMEM156 Open sea 0.099084 0.00821594 2.4706890000000002e-33 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea 0.0970343 0.00821761 4.950465e-32 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea 0.0916714 0.00822181 9.366077e-29 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.0852497 0.00822651 4.467807000000001e-25 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea 0.0847635 0.00822686 8.274588e-25 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea 0.0781097 0.00823135 2.6773789999999998e-21 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea 0.0778301 0.00823153 3.7064999999999995e-21 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 2724154 (gene symbol: KLHL5) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 2724154 (gene symbol: KLHL5) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg02198513 chr4:38987121 4 38987121 TMEM156 Open sea None None 6.3e-18 None 33752734_Yao-C_gene_expression_of_affymetrix_id__2724154__gene_symbol__klhl5__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea 0.0703567 0.00823611 1.441776e-17 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea 0.0019 None 4e-17 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13344413 chr4:39034272 4 39034272 TMEM156 Open sea 0.068566 0.00823714 9.248731e-17 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea 0.0678084 0.00823757 2.001595e-16 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea 0.216042 0.0262921 2.224758e-16 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea 0.0651106 0.00823905 0.000000000000002922913 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea 0.065033 0.00823909 0.000000000000003152157 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea 0.0643048 0.00823948 0.000000000000006377451 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13344413 chr4:39034272 4 39034272 TMEM156 Open sea 0.0641799 0.00823955 0.000000000000007190889 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea 0.0635397 0.00823989 0.00000000000001325855 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02198513 chr4:38987121 4 38987121 TMEM156 Open sea -0.0621008 0.00824064 0.00000000000005131899 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea 0.205848 0.0279353 0.0000000000001795974 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea 0.0593836 0.008242 0.000000000000608725 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.0581431 0.0082426 0.000000000001816547 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13344413 chr4:39034272 4 39034272 TMEM156 Open sea 0.0575852 0.00824287 0.000000000002948726 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea 0.0572273 0.00824304 0.000000000004013936 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea -0.0570947 0.0082431 0.000000000004497851 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Kyung WK None 32795589 08-11-2020 eosinophilia HP_0001880 discovery Table E4 DNA methylation eosinophilia None Beta values None Illumina HumanMethylationEPIC nasal polyp None 129 1 Adults Both East Asian cg01643325 chr4:39027168 4 39027168 TMEM156 Open sea -0.028 0.0036 0.0000000000092 None 32795589_Kyung-WK_eosinophilia_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea 0.056148 0.00824355 0.00000000001005905 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02198513 chr4:38987121 4 38987121 TMEM156 Open sea -0.0547801 0.00824417 0.00000000003145257 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.0542419 0.00824442 0.00000000004889134 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01643325 chr4:39027168 4 39027168 TMEM156 Open sea -0.0534825 0.00824475 0.00000000009045736 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13344413 chr4:39034272 4 39034272 TMEM156 Open sea -0.0533705 0.0082448 0.00000000009897932 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea 0.0531026 0.00824492 0.0000000001226775 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.0528997 0.00824501 0.0000000001442238 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01643325 chr4:39027168 4 39027168 TMEM156 Open sea -0.0527696 0.00824507 0.0000000001599518 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea 0.0526418 0.00824512 0.0000000001770168 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea -0.0525906 0.00824515 0.0000000001843514 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg26827503 chr4:38982037 4 38982037 TMEM156 Open sea -0.03325 0.0053 0.000000000298 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea 0.0519797 0.00824541 0.000000000298205 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14209186 chr4:38980960 4 38980960 TMEM156 Open sea -0.0514503 0.00824564 0.0000000004504465 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10032387 chr4:38988166 4 38988166 TMEM156 Open sea -0.00077 0.00012 0.00000000058 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24012919 chr4:38969699 4 38969699 TMEM156 Open sea 0.0015 None 0.00000000085 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea 0.0505818 0.008246 0.0000000008784296 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea 0.0503166 0.00824611 0.000000001074822 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea -0.0492309 0.00824656 0.000000002429167 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea 0.0490773 0.00834092 0.000000004094108 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10032387 chr4:38988166 4 38988166 TMEM156 Open sea 0.0482781 0.00824694 0.000000004899745 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.0481405 0.008247 0.000000005416234 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea 0.0479528 0.00824707 0.000000006206948 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 PAPPA protein levels (SeqId = 4148-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PAPPA protein levels (SeqId = 4148-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Pappalysin-1 774 1 Adults (18-65 years) Both European cg14209186 chr4:38980960 4 38980960 TMEM156 Open sea -1.1 0.19 0.0000000064 None Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea -0.0485215 0.00835627 0.000000006507518 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea -0.029 0.00496 0.000000008 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.047229 0.00824736 0.0000000104496 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14209186 chr4:38980960 4 38980960 TMEM156 Open sea -0.00054 0.000095 0.000000013 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01643325 chr4:39027168 4 39027168 TMEM156 Open sea -0.0465961 0.0082476 0.00000001637568 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea -0.0470142 0.00836767 0.00000001960612 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea -0.0012 0.00022 0.00000002 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13344413 chr4:39034272 4 39034272 TMEM156 Open sea 0.0461701 0.00824777 0.00000002208571 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg26827503 chr4:38982037 4 38982037 TMEM156 Open sea 0.01628 0.0028 0.000000025 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea -0.0453868 0.00824806 0.00000003802333 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea 0.0451344 0.00824816 0.00000004521298 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg02198513 chr4:38987121 4 38987121 TMEM156 Open sea 0.0013 0.00023 0.000000054 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea 0.0446332 0.00824834 0.00000006359562 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13344413 chr4:39034272 4 39034272 TMEM156 Open sea 0.0468389 0.00866705 0.00000006609664 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea -0.0444087 0.00824843 0.00000007401173 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13344413 chr4:39034272 4 39034272 TMEM156 Open sea -0.0436396 0.00824871 0.0000001237536 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea 0.0435527 0.00824874 0.0000001310774 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea -0.0504338 0.00957276 0.0000001395135 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.200781 0.0385133 0.0000001876472 None 39706196_Hannah-M.-Smith_bmi_discovery Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg24012919 chr4:38969699 4 38969699 TMEM156 Open sea -0.2197891 0.0429426 0.0000003085 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02198513 chr4:38987121 4 38987121 TMEM156 Open sea -0.0416914 0.00824939 0.0000004381363 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13344413 chr4:39034272 4 39034272 TMEM156 Open sea -0.0415388 0.00824945 0.0000004826393 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14209186 chr4:38980960 4 38980960 TMEM156 Open sea 0.0032 0.00063 0.00000052 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea 0.0411665 0.00824957 0.0000006102802 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13344413 chr4:39034272 4 39034272 TMEM156 Open sea 0.0431035 0.00867229 0.0000006762005 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea 0.18597 0.0374991 0.0000007137428 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10032387 chr4:38988166 4 38988166 TMEM156 Open sea 0.0408927 0.00824967 0.0000007243108 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea 0.0408626 0.00824968 0.0000007380183 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 PRG3 protein levels (SeqId = 9015-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRG3 protein levels (SeqId = 9015-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Proteoglycan 3 774 1 Adults (18-65 years) Both European cg14209186 chr4:38980960 4 38980960 TMEM156 Open sea -0.94 0.191 0.00000077 None Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 CD4+ T-cells Table S2 DNA methylation HIV infection Age - - Illumina HumanMethylation450 CD4+ T-cells - 60 1 46.5 Males European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea -0.517711 0.105 0.000000813 None 27105112_hiv_infection_cd4_tcells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.0406776 0.00824974 0.0000008280217 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13344413 chr4:39034272 4 39034272 TMEM156 Open sea -0.0404604 0.00824981 0.0000009471355 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea 0.0504284 0.010308 0.00000100799 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14209186 chr4:38980960 4 38980960 TMEM156 Open sea -0.0402431 0.00824988 0.000001082819 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13344413 chr4:39034272 4 39034272 TMEM156 Open sea 0.0401639 0.00824991 0.000001136718 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea -0.0500916 0.0103082 0.000001189617 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea -0.0400142 0.00824996 0.000001245812 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea 0.0414678 0.0086497 0.000001649843 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.0393621 0.00825017 0.000001850233 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Stephenson M FinnTwin12, FinnTwin16 33277923 2021-01-02 Alcohol consumption EFO_0004329, EFO_0007878 discovery Table 2 DNA methylation Alcohol consumption Age, sex, body mass index, smoking, cell composition (reference based), zygosity, twin pair identifier Beta Values drinks per week Illumina HumanMethylation450 Whole blood sample included twins. zygosity and twin pair identifier were random effects in the ewas model. 1004 1 Adults Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea -0.0005 0.00011 0.000002 None 33277923_Stephenson-M_alcohol_consumption_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea None None 0.0000022 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea -0.0388762 0.00825033 0.000002474545 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea 0.0409009 0.00870394 0.000002636506 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea 0.0387516 0.00825037 0.000002664631 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea 0.0386317 0.00825041 0.000002860789 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02787 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02787 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea 0.047824 0.0102533 0.000003124891 P02787 41361833_Josephine_Robertson_P02787_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10032387 chr4:38988166 4 38988166 TMEM156 Open sea 0.00081 None 0.0000034 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea 0.129855 0.0280498 0.000003691493 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea 0.03663 0.00797887 0.000004450621 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea 0.037772 0.00825068 0.000004731939 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.0376035 0.00825073 0.000005216156 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.0376034 0.00825073 0.00000521625 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea -0.0375007 0.00825076 0.000005534148 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21808433 chr4:39035017 4 39035017 TMEM156 Open sea 0.0374786 0.00825077 0.000005604966 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -1.1 0.253 0.0000061 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01643325 chr4:39027168 4 39027168 TMEM156 Open sea 0.0372519 0.00825084 0.000006383408 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea 0.0370014 0.00825092 0.000007363401 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.031 0.00686 0.0000074 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea -0.0456797 0.0102634 0.000008620123 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10032387 chr4:38988166 4 38988166 TMEM156 Open sea 0.0366757 0.00825102 0.000008853984 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea 0.0364725 0.00825108 0.000009925859 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea 0.0364708 0.00825108 0.000009935235 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea -0.0421803 0.00955131 0.00001011788 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea -0.0364303 0.00825109 0.00001016351 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.0603142 0.0136933 0.00001067105 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13344413 chr4:39034272 4 39034272 TMEM156 Open sea 0.036139 0.00825118 0.00001195811 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01643325 chr4:39027168 4 39027168 TMEM156 Open sea 0.0413275 0.00943718 0.00001199292 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14209186 chr4:38980960 4 38980960 TMEM156 Open sea -0.0360232 0.00825121 0.00001275213 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea -0.0360169 0.00825121 0.00001279692 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea -0.0358817 0.00825125 0.00001379129 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14209186 chr4:38980960 4 38980960 TMEM156 Open sea 0.0403901 0.00933248 0.00001515297 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea -0.0379609 0.00887759 0.00001914542 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.0352357 0.00825144 0.00001964838 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.162682 0.0386119 0.00002529856 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10032387 chr4:38988166 4 38988166 TMEM156 Open sea -0.0347431 0.00825159 0.00002563521 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.0347193 0.00825159 0.00002596404 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13344413 chr4:39034272 4 39034272 TMEM156 Open sea -0.0346908 0.0082516 0.00002636477 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg14209186 chr4:38980960 4 38980960 TMEM156 Open sea 1.2 0.282 0.000028 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13344413 chr4:39034272 4 39034272 TMEM156 Open sea -0.0344702 0.00825166 0.00002966173 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea -0.0364294 0.00872683 0.00003004778 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_4 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Chronic Kidney Disease (Estimated) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Chronic Kidney Disease (Estimated) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18318 1 Adults (18-65y) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea 0.046 0.01105 0.000031 None Robert-F-Hillary_Prevalent_Chronic_Kidney_Disease_(Estimated)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea -0.0345457 0.0083523 0.00003552794 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 GZMA protein levels (SeqId = 3440-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GZMA protein levels (SeqId = 3440-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Granzyme A 774 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.93 0.226 0.000037 None Gadd-DA_gzma_protein_levels__seqid___3440-7__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.0564247 0.013716 0.00003913437 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea 0.0338936 0.00825183 0.00004023018 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea -2.7 0.656 0.000041 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01643325 chr4:39027168 4 39027168 TMEM156 Open sea 0.0385609 0.00943761 0.00004414421 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea -0.0313644 0.00769401 0.00004596521 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_3 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Ischemic Heart Disease (Self-report) None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Ischemic Heart Disease (Self-report) Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 14391 1 Adults (18-65y) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea 0.068 0.0166 0.000046 None Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14209186 chr4:38980960 4 38980960 TMEM156 Open sea 0.0335621 0.00825192 0.00004783212 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea -0.0339207 0.00836151 0.00005001558 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_4 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg02198513 chr4:38987121 4 38987121 TMEM156 Open sea -0.842312 0.208 0.0000513 - 27105112_hiv_infection_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02131853 chr4:39034637 4 39034637 TMEM156 Open sea -0.0332769 0.008252 0.00005544613 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02198513 chr4:38987121 4 38987121 TMEM156 Open sea -0.0332736 0.008252 0.00005554005 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea -0.0332619 0.008252 0.00005587524 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg10032387 chr4:38988166 4 38988166 TMEM156 Open sea -0.886274 0.22 0.0000563 - 27105112_hiv_infection_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14209186 chr4:38980960 4 38980960 TMEM156 Open sea 0.033213 0.00825202 0.00005730229 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14209186 chr4:38980960 4 38980960 TMEM156 Open sea 0.0376403 0.00938812 0.0000611857 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01643325 chr4:39027168 4 39027168 TMEM156 Open sea -0.0330316 0.00825207 0.00006289678 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea 0.0551084 0.0137813 0.00006398155 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea 0.0408681 0.010222 0.00006418116 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg13344413 chr4:39034272 4 39034272 TMEM156 Open sea -0.128052 0.0320304 0.00006418216 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea -0.0329775 0.00825208 0.00006466346 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea 0.0329513 0.00825209 0.0000655357 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Chronic Pain (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Chronic Pain (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood Fully-adjusted model 18413 1 Adults (18-65y) Both European cg14209186 chr4:38980960 4 38980960 TMEM156 Open sea 0.15 0.0383 0.00007 None Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01643325 chr4:39027168 4 39027168 TMEM156 Open sea 0.0327908 0.00825213 0.00007112853 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 EDC4 protein levels (SeqId = 13066-42) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 EDC4 protein levels (SeqId = 13066-42) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Enhancer of mRNA-decapping protein 4 774 1 Adults (18-65 years) Both European cg25246082 chr4:39034284 4 39034284 TMEM156 Open sea 0.65 0.165 0.000082 None Gadd-DA_edc4_protein_levels__seqid___13066-42__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg02561376 chr4:39035483 4 39035483 TMEM156 Open sea 0.0324838 0.00825221 0.00008310231 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01643325 chr4:39027168 4 39027168 TMEM156 Open sea 0.0350257 0.00892802 0.00008780789 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01643325 chr4:39027168 4 39027168 TMEM156 Open sea 0.0350754 0.00894725 0.00008886336 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19606569 chr4:39029049 4 39029049 TMEM156 Open sea -0.0327651 0.00837431 0.00009172959 P02747 41361833_Josephine_Robertson_P02747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21808433 chr4:39035017 4 39035017 TMEM156 Open sea -0.0321485 0.0082523 0.00009835086 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1