author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00616525 chr17:26646045 17 26646045 TMEM97 Island -0.000061 0.0000073 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03772856 chr17:26645865 17 26645865 TMEM97 Island 0.0004 0.000046 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07078622 chr17:26645920 17 26645920 TMEM97 Island -0.000083 0.0000075 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.0012 0.00013 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10494684 chr17:26645200 17 26645200 TMEM97 North shore 0.0021 0.00023 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10494684 chr17:26645200 17 26645200 TMEM97 North shore -0.025 0.0024 0 None 33450751_Mulder-RH_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01697541 chr17:26645932 17 26645932 TMEM97 Island 0.00048 None 4.4e-167 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg20687875 chr17:26647213 17 26647213 TMEM97 South shore 0.32644 0.00635 1.5999999999999999e-114 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg06692120 chr17:26646884 17 26646884 TMEM97 South shore 0.12477 0.00425 3.7e-73 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.174095 0.0104419 7.688305e-62 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_4 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01697541 chr17:26645932 17 26645932 TMEM97 Island 0.0015 None 4.1e-52 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island 0.124876 0.0085799 1.176019e-47 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island 0.115239 0.00820156 1.4788119999999998e-44 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island 0.116486 0.0082943 1.625311e-44 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island 0.115971 0.00829885 4.2840200000000003e-44 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.115743 0.00860489 5.328973e-41 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.115279 0.0086105 1.227036e-40 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.10976 0.00820669 1.473229e-40 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.0015 None 5.1000000000000004e-36 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06692120 chr17:26646884 17 26646884 TMEM97 South shore 0.107837 0.00860658 7.846469e-36 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06692120 chr17:26646884 17 26646884 TMEM97 South shore 0.100991 0.00821436 1.435187e-34 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg10494684 chr17:26645200 17 26645200 TMEM97 North shore 0.10047 0.00681 1.7e-33 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06692120 chr17:26646884 17 26646884 TMEM97 South shore 0.0991171 0.00823296 3.177003e-33 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06692120 chr17:26646884 17 26646884 TMEM97 South shore 0.0986749 0.00822789 5.533472000000001e-33 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_3 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.0544 0.00374 6.7e-33 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg10494684 chr17:26645200 17 26645200 TMEM97 North shore -1.55685 0.09868 2.9700000000000004e-27 - 25282492_fetal_vs_adult_liver Gadd DA Generation Scotland 35945220 31/07/2022 TMPRSS6 protein levels (SeqId = 11239-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMPRSS6 protein levels (SeqId = 11239-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transmembrane protease serine 6 774 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island -1.66 0.163 3.4e-24 None Gadd-DA_tmprss6_protein_levels__seqid___11239-49__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06692120 chr17:26646884 17 26646884 TMEM97 South shore 0.0024 None 5.2e-22 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Gadd DA Generation Scotland 35945220 31/07/2022 TMPRSS6 protein levels (SeqId = 11239-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMPRSS6 protein levels (SeqId = 11239-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transmembrane protease serine 6 774 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island -1.25 0.135 1.6e-20 None Gadd-DA_tmprss6_protein_levels__seqid___11239-49__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01438829 chr17:26646651 17 26646651 TMEM97 South shore 0.00069 None 5.5e-20 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Gadd DA Generation Scotland 35945220 31/07/2022 TMPRSS6 protein levels (SeqId = 11239-49) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TMPRSS6 protein levels (SeqId = 11239-49) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Transmembrane protease serine 6 774 1 Adults (18-65 years) Both European cg06692120 chr17:26646884 17 26646884 TMEM97 South shore -1.12 0.123 6.4e-20 None Gadd-DA_tmprss6_protein_levels__seqid___11239-49__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island 0.0717581 0.00824023 3.4115300000000003e-18 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.0862475 0.0100516 1.0383170000000001e-17 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_4 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21784498 chr17:26645922 17 26645922 TMEM97 Island 0.000056 None 5.7e-17 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg21222244 chr17:26646473 17 26646473 TMEM97 Island 3.676382 0.4399 6.43e-17 - 27105112_hiv_infection_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12694510 chr17:26646013 17 26646013 TMEM97 Island -0.000091 0.000011 4.4e-16 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21784498 chr17:26645922 17 26645922 TMEM97 Island -0.000051 0.0000062 4.4e-16 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island 0.0652135 0.00831428 0.000000000000004680391 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island 0.060235 0.00799932 0.0000000000000536894 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.062175 0.00829446 0.00000000000006957065 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10494684 chr17:26645200 17 26645200 TMEM97 North shore 0.0021 None 0.00000000000007 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island 0.01369 0.0017 0.000000000000076 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg01438829 chr17:26646651 17 26646651 TMEM97 South shore 0.01197 0.0015 0.00000000000011 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.0634427 0.00862401 0.0000000000001987786 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg21784498 chr17:26645922 17 26645922 TMEM97 Island 0.00468 6e-04 0.000000000000429 - 23334450_rheumatoid_arthritis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20687875 chr17:26647213 17 26647213 TMEM97 South shore 0.0632264 0.00901183 0.000000000002384469 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island 0.0572133 0.00824305 0.000000000004062555 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 MBD1 protein levels (SeqId = 14294-61) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MBD1 protein levels (SeqId = 14294-61) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Methyl-CpG-binding domain protein 1 774 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.92 0.136 0.00000000001 None Gadd-DA_mbd1_protein_levels__seqid___14294-61__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01273840 chr17:26645861 17 26645861 TMEM97 Island 0.00034 0.000051 0.000000000018 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Li M None 33279932 2020-12-14 Schizophrenia EFO_0000692 main Table 1 DNA methylation Schizophrenia age, sex, batch effects Beta Values None Illumina HumanMethylationEPIC Whole blood None 999 None Adults Both East Asian cg08959305 chr17:26646465 17 26646465 TMEM97 Island 0.00179 0.00027 0.00000000004 None 33279932_Li-M_schizophrenia_main Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06692120 chr17:26646884 17 26646884 TMEM97 South shore 0.0520218 0.00826074 0.0000000003111796 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20687875 chr17:26647213 17 26647213 TMEM97 South shore 0.0517979 0.00830018 0.0000000004479581 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20687875 chr17:26647213 17 26647213 TMEM97 South shore 0.0514464 0.00829554 0.0000000005735699 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.0647784 0.0105315 0.000000000790386 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_4 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg21222244 chr17:26646473 17 26646473 TMEM97 Island 0.01137 0.0018 0.0000000018 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10494684 chr17:26645200 17 26645200 TMEM97 North shore -0.009 0.0015 0.0000000025 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06711110 chr17:26645523 17 26645523 TMEM97 Island -0.000088 0.000015 0.0000000027 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg20687875 chr17:26647213 17 26647213 TMEM97 South shore 0.0479383 0.00824708 0.000000006272914 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06692120 chr17:26646884 17 26646884 TMEM97 South shore 0.0460567 0.00792718 0.000000006378043 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_3 Li M None 33279932 2020-12-14 Schizophrenia EFO_0000692 adjusted for cell composition Table 1 DNA methylation Schizophrenia age, sex, batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylationEPIC Whole blood None 999 None Adults Both East Asian cg08959305 chr17:26646465 17 26646465 TMEM97 Island None None 0.000000014 None 33279932_Li-M_schizophrenia_adjusted_for_cell_composition Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg01697541 chr17:26645932 17 26645932 TMEM97 Island 0.00443 8e-04 0.0000000402 - 23334450_rheumatoid_arthritis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08959305 chr17:26646465 17 26646465 TMEM97 Island -0.000057 0.00001 0.000000046 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06692120 chr17:26646884 17 26646884 TMEM97 South shore 0.0445778 0.00824836 0.00000006602734 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island -0.0442828 0.00824847 0.00000008055719 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island 0.0460762 0.0086371 0.00000009713293 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06692120 chr17:26646884 17 26646884 TMEM97 South shore 0.0438248 0.00826979 0.0000001178754 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island 0.0442468 0.00835013 0.0000001181691 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06692120 chr17:26646884 17 26646884 TMEM97 South shore 0.0456256 0.00864813 0.0000001340771 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island 0.0440303 0.00834787 0.0000001350587 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06692120 chr17:26646884 17 26646884 TMEM97 South shore 0.0434553 0.00824373 0.0000001373707 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06692120 chr17:26646884 17 26646884 TMEM97 South shore 0.0435152 0.00826616 0.0000001427442 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_3 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg01273840 chr17:26645861 17 26645861 TMEM97 Island 0.00573 0.00106 0.00000021 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg06711110 chr17:26645523 17 26645523 TMEM97 Island 1.518585 0.297 0.000000318 - 27105112_hiv_infection_discovery Gadd DA Generation Scotland 35945220 31/07/2022 CPN2 protein levels (SeqId = 6415-90) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CPN2 protein levels (SeqId = 6415-90) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Carboxypeptidase N subunit 2 774 1 Adults (18-65 years) Both European cg06692120 chr17:26646884 17 26646884 TMEM97 South shore 0.63 0.12 0.00000032 None Gadd-DA_cpn2_protein_levels__seqid___6415-90__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 MBD1 protein levels (SeqId = 14294-61) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MBD1 protein levels (SeqId = 14294-61) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Methyl-CpG-binding domain protein 1 774 1 Adults (18-65 years) Both European cg06692120 chr17:26646884 17 26646884 TMEM97 South shore 0.63 0.123 0.00000033 None Gadd-DA_mbd1_protein_levels__seqid___14294-61__somascan_protein_measurement Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg20687875 chr17:26647213 17 26647213 TMEM97 South shore 0.015 0.0029 0.00000047 None 33450751_Mulder-RH_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01438829 chr17:26646651 17 26646651 TMEM97 South shore 0.0017 None 0.00000062 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03772856 chr17:26645865 17 26645865 TMEM97 Island 0.00029 None 0.00000064 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island -0.0409671 0.00824964 0.0000006914414 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island 0.040869 0.00824967 0.0000007350668 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg04929665 chr17:26652175 17 26652175 TMEM97 Open sea 0.01252 0.00245 0.00000077 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01273840 chr17:26645861 17 26645861 TMEM97 Island 0.0398606 0.00825001 0.000001368197 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06711110 chr17:26645523 17 26645523 TMEM97 Island 0.0454407 0.00944847 0.00000152952 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 MBD1 protein levels (SeqId = 14294-61) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MBD1 protein levels (SeqId = 14294-61) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Methyl-CpG-binding domain protein 1 774 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island 0.78 0.165 0.000002 None Gadd-DA_mbd1_protein_levels__seqid___14294-61__somascan_protein_measurement Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg21784498 chr17:26645922 17 26645922 TMEM97 Island 0.0015 0.00031 0.000002 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06692120 chr17:26646884 17 26646884 TMEM97 South shore 0.0386674 0.0082504 0.000002800938 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03772856 chr17:26645865 17 26645865 TMEM97 Island 0.0014 0.0003 0.0000033 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01273840 chr17:26645861 17 26645861 TMEM97 Island 0.0015 0.00034 0.0000064 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03772856 chr17:26645865 17 26645865 TMEM97 Island 0.00099 None 0.0000069 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.0029 None 0.000007 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.0369693 0.00825093 0.000007498893 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CPN2 protein levels (SeqId = 6415-90) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CPN2 protein levels (SeqId = 6415-90) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Carboxypeptidase N subunit 2 774 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island 0.74 0.16 0.0000077 None Gadd-DA_cpn2_protein_levels__seqid___6415-90__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg18463993 chr17:26653167 17 26653167 TMEM97 Open sea 0.0367953 0.00825098 0.000008276085 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg07078622 chr17:26645920 17 26645920 TMEM97 Island 0.00213 0.00046 0.0000083 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Lu X Lifelines DEEP 32916427 2020-09-09 BPA None None ST5 DNA methylation BPA Age, Sex, body mass index, cell composition (reference based), batch effects Beta Values ng/24h Illumina HumanMethylation450 Whole blood The trait is a phthalate metabolite 622 1 Adults Both European cg03772856 chr17:26645865 17 26645865 TMEM97 Island 0.003 0.00067 0.0000092 None 32916427_Lu-X_bpa Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island -0.0362721 0.00825114 0.00001110317 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06692120 chr17:26646884 17 26646884 TMEM97 South shore 0.0051 None 0.000015 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg16929041 chr17:26648951 17 26648951 TMEM97 South shelf -0.227219 0.0525062 0.00001516376 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg20687875 chr17:26647213 17 26647213 TMEM97 South shore -0.0088 0.002 0.000016 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Gadd DA Generation Scotland 35945220 31/07/2022 HS3ST5 protein levels (SeqId = 10731-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HS3ST5 protein levels (SeqId = 10731-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Heparan sulfate glucosamine 3-O-sulfotransferase 5 774 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island -0.7 0.165 0.000019 None Gadd-DA_hs3st5_protein_levels__seqid___10731-10__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CPN2 protein levels (SeqId = 6415-90) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CPN2 protein levels (SeqId = 6415-90) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Carboxypeptidase N subunit 2 774 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.58 0.14 0.000021 None Gadd-DA_cpn2_protein_levels__seqid___6415-90__somascan_protein_measurement Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg10494684 chr17:26645200 17 26645200 TMEM97 North shore 0.009 0.002 0.0000214 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns Gadd DA Generation Scotland 35945220 31/07/2022 MVK protein levels (SeqId = 11391-69) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MVK protein levels (SeqId = 11391-69) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Mevalonate kinase 774 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island -0.692 0.164 0.000025 None Gadd-DA_mvk_protein_levels__seqid___11391-69__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island -0.0346896 0.0082516 0.00002638188 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg06711110 chr17:26645523 17 26645523 TMEM97 Island 0.000088 None 0.000028 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg21222244 chr17:26646473 17 26646473 TMEM97 Island 0.00026 0.000062 0.000028 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island -0.0345408 0.00825164 0.00002856608 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.0361642 0.00865877 0.00002976111 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_3 Sikdar S PACE 31536415 2019-09-19 Prenatal smoke exposure EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318 Inverse varience-weighted fixed-effects meta-analysis Table S1 DNA methylation Prenatal smoke exposure Maternal age, socioeconomic position, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Cord blood, whole blood None 5648 9 Infants Both European, African, Unclear cg10494684 chr17:26645200 17 26645200 TMEM97 North shore 0.0085 0.002 0.00003 None 31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity, white blood cell counts and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg10494684 chr17:26645200 17 26645200 TMEM97 North shore 0.009 0.002 0.0000301 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts Fragoso-Bargas Nicolas EPIPREG (Epigenetics in pregnancy) 39844050 Jan 22, 2025 Moderate physical activity EFO:0000001 discovery (step adjusted) None DNA methylation Moderate physical activity Age,Smoking,Cell composition (reference based) M values hours/day Illumina HumanMethylationEPIC Whole blood analysis of pregnant women (gestational week 28) 353 1 Adults (18-65 years) Females European,South Asian cg08959305 chr17:26646465 17 26646465 TMEM97 Island -0.070901646 0.01682713 0.0000322 None 39844050_Fragoso-Bargas-Nicolas_moderate_physical_activity_discovery_(step_adjusted) Gadd DA Generation Scotland 35945220 31/07/2022 HN1 protein levels (SeqId = 19335-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HN1 protein levels (SeqId = 19335-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Jupiter microtubule associated homolog 1 774 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.56 0.136 0.000037 None Gadd-DA_hn1_protein_levels__seqid___19335-2__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.0355789 0.00866233 0.00004024521 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 CPN2 protein levels (SeqId = 6415-90) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CPN2 protein levels (SeqId = 6415-90) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Carboxypeptidase N subunit 2 774 1 Adults (18-65 years) Both European cg19478260 chr17:26651787 17 26651787 TMEM97 Open sea 0.58 0.14 0.000046 None Gadd-DA_cpn2_protein_levels__seqid___6415-90__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH36 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH36 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07097636 chr17:26646373 17 26646373 TMEM97 Island -0.0334663 0.00825195 0.00005027111 A0A0C4DH36 41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19026207 chr17:26645466 17 26645466 TMEM97 Island -0.0333767 0.00825197 0.00005266008 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12694510 chr17:26646013 17 26646013 TMEM97 Island 0.0329937 0.00825208 0.00006412919 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04929665 chr17:26652175 17 26652175 TMEM97 Open sea 0.032987 0.00825208 0.00006435084 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH36 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH36 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07097636 chr17:26646373 17 26646373 TMEM97 Island -0.0329051 0.00826316 0.0000686256 A0A0C4DH36 41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P22792 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P22792 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10494684 chr17:26645200 17 26645200 TMEM97 North shore 0.0349442 0.00883294 0.00007653571 P22792 41361833_Josephine_Robertson_P22792_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH36 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH36 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07097636 chr17:26646373 17 26646373 TMEM97 Island -0.0324296 0.00823769 0.0000829797 A0A0C4DH36 41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.0322958 0.00825226 0.000091354 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00616525 chr17:26646045 17 26646045 TMEM97 Island 0.0321851 0.00825229 0.00009656636 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P15169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P15169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg10342447 chr17:26645325 17 26645325 TMEM97 Island 0.0321236 0.00825231 0.00009958011 P15169 41361833_Josephine_Robertson_P15169_OSCA_model_1