author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0088	0.00043	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.059	0.002	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05266843	chr8:95961618	8	95961618	TP53INP1	Island	0.00075	0.000083	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg09323728	chr8:95962352	8	95962352	TP53INP1	Island	0.016	0.0011	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13393036	chr8:95962371	8	95962371	TP53INP1	Island	0.02	0.0014	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16049864	chr8:95962084	8	95962084	TP53INP1	Island	0.0019	0.00012	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18059933	chr8:95962463	8	95962463	TP53INP1	South shore	0.018	0.0014	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20039814	chr8:95962383	8	95962383	TP53INP1	South shore	0.018	0.0013	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	0.00075	0.000069	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18059933	chr8:95962463	8	95962463	TP53INP1	South shore	0.31047	0.00782	7.799999999999999e-95	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg01282195	chr8:95952351	8	95952351	TP53INP1	Open sea	0.23059	0.00609	3.2e-91	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	0.00093	None	8.2e-85	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg09323728	chr8:95962352	8	95962352	TP53INP1	Island	0.27233	0.00825	2.4e-81	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg23172400	chr8:95962367	8	95962367	TP53INP1	Island	0.18083	0.00569	1.2e-78	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13393036	chr8:95962371	8	95962371	TP53INP1	Island	0.23289	0.0077	4.1e-75	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg20039814	chr8:95962383	8	95962383	TP53INP1	South shore	0.1962	0.00774	2.7e-63	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	3.8655	0.08814	4.12e-61	-	25282492_fetal_vs_adult_liver
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.12201	0.00596	2.7e-50	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	0.04424	0.00236	2.9e-45	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16049864	chr8:95962084	8	95962084	TP53INP1	Island	0.0825	0.00516	3.3000000000000002e-37	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.0931845	0.00822065	1.163948e-29	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-	-	1.5500000000000001e-27	-	23526956_clear_cell_renal_carcinoma
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08755736	chr8:95957928	8	95957928	TP53INP1	North shelf	0.04932	0.00386	1.8e-27	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.00159243	0.00015762	5.74e-23	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg18059933	chr8:95962463	8	95962463	TP53INP1	South shore	1.58615	0.1253	1.95e-21	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22335238	chr8:95953253	8	95953253	TP53INP1	Open sea	0.0780372	0.00823139	2.913225e-21	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22335238	chr8:95953253	8	95953253	TP53INP1	Open sea	0.0772043	0.00823193	7.643818e-21	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3145149 (gene symbol: TP53INP1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3145149 (gene symbol: TP53INP1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg18059933	chr8:95962463	8	95962463	TP53INP1	South shore	None	None	7.6e-20	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3145149__gene_symbol__tp53inp1__meta-analysis
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg09323728	chr8:95962352	8	95962352	TP53INP1	Island	1.50027	0.12798	1.35e-19	-	25282492_fetal_vs_adult_liver
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.248159	0.0276142	2.792613e-19	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22335238	chr8:95953253	8	95953253	TP53INP1	Open sea	-0.0720875	0.00823509	2.287159e-18	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.0714662	0.00823546	4.451942e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.208049	0.0241201	6.8960310000000004e-18	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3145149 (gene symbol: TP53INP1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3145149 (gene symbol: TP53INP1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg09323728	chr8:95962352	8	95962352	TP53INP1	Island	None	None	7.6e-18	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3145149__gene_symbol__tp53inp1__meta-analysis
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.2384	0.0283187	4.109781000000001e-17	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0685804	0.00823713	9.112414000000001e-17	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23172400	chr8:95962367	8	95962367	TP53INP1	Island	0.011	0.0013	2.2e-16	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3145149 (gene symbol: TP53INP1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3145149 (gene symbol: TP53INP1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg16049864	chr8:95962084	8	95962084	TP53INP1	Island	None	None	0.0000000000000016	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3145149__gene_symbol__tp53inp1__meta-analysis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24434118	chr8:95961556	8	95961556	TP53INP1	Island	0.00061	0.00008	0.000000000000029	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.214126	0.0285142	0.00000000000006226849	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16049864	chr8:95962084	8	95962084	TP53INP1	Island	0.0013	None	0.000000000000098	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.181093	0.0248374	0.00000000000032059	None	39706196_Hannah-M.-Smith_bmi_discovery
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.012	0.0014	0.0000000000004	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0595815	0.0082419	0.0000000000005102226	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22335238	chr8:95953253	8	95953253	TP53INP1	Open sea	0.0589774	0.0082422	0.0000000000008729024	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3145149 (gene symbol: TP53INP1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3145149 (gene symbol: TP53INP1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg23172400	chr8:95962367	8	95962367	TP53INP1	Island	None	None	0.0000000000079	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3145149__gene_symbol__tp53inp1__meta-analysis
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg21701395	chr8:95961492	8	95961492	TP53INP1	Island	-0.78434439	0.1153	0.0000000000105	-	27602958_smoking_packyears_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	-0.0560001	0.00824361	0.00000000001139368	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.165905	0.0249005	0.00000000002768851	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0627703	0.00966902	0.00000000008748567	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0625669	0.00964331	0.00000000008970783	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg19916637	chr8:95961757	8	95961757	TP53INP1	Island	-0.65180825	0.1035	0.000000000304	-	27602958_smoking_packyears_discovery_and_replication
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg20017151	chr8:95954126	8	95954126	TP53INP1	Open sea	-0.018	0.00257	0.00000000034	None	32795589_Kyung-WK_atopy_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg21701395	chr8:95961492	8	95961492	TP53INP1	Island	-1.0492844	0.168	0.000000000417	-	27602958_smoking_packyears_lung_squamous_cell
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	-0.022	0.00323	0.00000000056	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0588492	0.0096296	0.000000001013393	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_2
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg13393036	chr8:95962371	8	95962371	TP53INP1	Island	0.08193	0.0135	0.00000000125	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	-0.0493009	0.00824653	0.000000002306016	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg21701395	chr8:95961492	8	95961492	TP53INP1	Island	0.0046	8e-04	0.00000000239	-	23334450_rheumatoid_arthritis
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24253461	chr8:95940993	8	95940993	TP53INP1	Open sea	-0.02553	0.00416	0.0000000046	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	-0.0482993	0.00824694	0.000000004824505	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	-0.0481837	0.00824698	0.000000005248765	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22335238	chr8:95953253	8	95953253	TP53INP1	Open sea	-0.0480054	0.00824705	0.000000005974856	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05266843	chr8:95961618	8	95961618	TP53INP1	Island	0.0031	0.00054	0.000000007	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	-0.0492155	0.00853157	0.000000008153252	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	-0.0489531	0.00853924	0.00000001007791	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_2
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg13128305	chr8:95961759	8	95961759	TP53INP1	Island	-0.51342601	0.0896	0.0000000101	-	27602958_smoking_packyears_discovery_and_replication
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24434118	chr8:95961556	8	95961556	TP53INP1	Island	0.003	0.00052	0.000000011	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0471511	0.00824739	0.000000011047	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	-0.0471295	0.0082474	0.00000001121825	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.0471158	0.0082474	0.00000001132866	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg13128305	chr8:95961759	8	95961759	TP53INP1	Island	-0.9122143	0.1602	0.0000000123	-	27602958_smoking_packyears_lung_squamous_cell
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg05266843	chr8:95961618	8	95961618	TP53INP1	Island	0.162388	0.0288059	0.00000001752646	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0616146	0.0109397	0.00000001812035	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0540636	0.00962736	0.0000000199414	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Cholesterol esters in small VLDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-3.1	0.54	0.00000002	None	Battram-T_cholesterol_esters_in_small_vldl
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg20039814	chr8:95962383	8	95962383	TP53INP1	South shore	-0.041	0.00677	0.000000021	None	32795589_Kyung-WK_atopy_discovery
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg12838385	chr8:95962078	8	95962078	TP53INP1	Island	-0.017	0.00281	0.000000022	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	-0.0618392	0.0111127	0.00000002671995	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	-0.0473987	0.00852	0.00000002694648	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Total cholesterol in small VLDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-1.91	0.34	0.000000029	None	Battram-T_total_cholesterol_in_small_vldl
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24253461	chr8:95940993	8	95940993	TP53INP1	Open sea	-0.0085	0.0015	0.000000032	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	-0.047061	0.00852237	0.0000000340767	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.0529759	0.00961733	0.00000003682526	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0533442	0.00968681	0.00000003713617	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24253461	chr8:95940993	8	95940993	TP53INP1	Open sea	0.012	0.0022	0.000000041	None	33450751_Mulder-RH_sex_discovery
Battram T	ARIES	None	2020-08-20	Total cholesterol in VLDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	681	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.61	0.111	0.000000043	None	Battram-T_total_cholesterol_in_vldl
Battram T	ARIES	None	2020-08-20	Total lipids in small VLDL	EFO_0004529	None	None	DNA methylation	Total lipids in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	681	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.71	0.128	0.000000046	None	Battram-T_total_lipids_in_small_vldl
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg19916637	chr8:95961757	8	95961757	TP53INP1	Island	-0.9210253	0.1693	0.0000000536	-	27602958_smoking_packyears_lung_squamous_cell
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	-0.0447748	0.00824829	0.00000005777584	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22335238	chr8:95953253	8	95953253	TP53INP1	Open sea	-0.0446207	0.00824835	0.00000006413585	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg24434118	chr8:95961556	8	95961556	TP53INP1	Island	0.150123	0.0279473	0.00000007898243	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Kidney Disease (Estimated)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Kidney Disease (Estimated)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18318	1	Adults (18-65y)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.045	0.00852	0.000000095	None	Robert-F-Hillary_Prevalent_Chronic_Kidney_Disease_(Estimated)_Basic_model
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Kidney Disease (Estimated)	None	Fully-adjusted Model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Kidney Disease (Estimated)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	14315	1	Adults (18-65y)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.047	0.00878	0.00000011	None	Robert-F-Hillary_Prevalent_Chronic_Kidney_Disease_(Estimated)_Fully-adjusted_Model
Battram T	ARIES	None	2020-08-20	Concentration of small VLDL particles	EFO_0008317	None	None	DNA methylation	Concentration of small VLDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	681	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-14000000	None	0.00000011	None	Battram-T_concentration_of_small_vldl_particles
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22335238	chr8:95953253	8	95953253	TP53INP1	Open sea	0.0431654	0.00824888	0.0000001691812	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	-0.00015292	2.92e-05	0.000000196	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22335238	chr8:95953253	8	95953253	TP53INP1	Open sea	-0.042929	0.00824896	0.0000001974934	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Free cholesterol in small VLDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-4.6	0.87	0.0000002	None	Battram-T_free_cholesterol_in_small_vldl
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	0.021	0.0041	0.00000021	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0425149	0.00824911	0.0000002584583	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22335238	chr8:95953253	8	95953253	TP53INP1	Open sea	0.0422027	0.00824922	0.0000003160723	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Phospholipids in small VLDL	EFO_0004639	None	None	DNA methylation	Phospholipids in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-3.1	0.59	0.00000033	None	Battram-T_phospholipids_in_small_vldl
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	1.41917	0.2797	0.00000039	-	27105112_hiv_infection_discovery
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	2.3	0.463	0.00000042	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Battram T	ARIES	None	2020-08-20	Total cholesterol in medium VLDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	675	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-2.02	0.4	0.00000045	None	Battram-T_total_cholesterol_in_medium_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0416482	0.00824941	0.0000004503157	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0487142	0.00965334	0.0000004556969	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Ratio of apolipoprotein B to apolipoprotein A I	EFO_0004615, EFO_0004614	None	None	DNA methylation	Ratio of apolipoprotein B to apolipoprotein A I	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.99	0.19	0.00000049	None	Battram-T_ratio_of_apolipoprotein_b_to_apolipoprotein_a_i
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.0414688	0.00824947	0.0000005044995	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.0484108	0.00963099	0.0000005052327	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	0.0412135	0.00824956	0.0000005925342	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Cholesterol esters in large HDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.89	0.178	0.00000061	None	Battram-T_cholesterol_esters_in_large_hdl
Battram T	ARIES	None	2020-08-20	Cholesterol esters in medium VLDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	677	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-3.5	0.7	0.00000072	None	Battram-T_cholesterol_esters_in_medium_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	-0.0407173	0.00824972	0.0000008078631	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg21701395	chr8:95961492	8	95961492	TP53INP1	Island	-1.0438272	0.2116	0.000000812	-	27602958_smoking_packyears_replication
Battram T	ARIES	None	2020-08-20	Triglycerides in small VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-1.41	0.28	0.00000086	None	Battram-T_triglycerides_in_small_vldl
Battram T	ARIES	None	2020-08-20	Remnant cholesterol (non-HDL, non-LDL -cholesterol)	CHEBI_16113	None	None	DNA methylation	Remnant cholesterol (non-HDL, non-LDL -cholesterol)	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.33	0.067	0.0000009	None	Battram-T_remnant_cholesterol__non-hdl__non-ldl_-cholesterol_
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	-0.0405061	0.0082498	0.0000009208145	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21701395	chr8:95961492	8	95961492	TP53INP1	Island	-0.000039	0.0000079	0.00000095	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	0.002	None	0.000001	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0403603	0.00824984	0.000001007472	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20017151	chr8:95954126	8	95954126	TP53INP1	Open sea	0.0401471	0.00824991	0.000001148521	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0467219	0.00962399	0.000001217927	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.0399204	0.00824999	0.000001319274	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Total lipids in very small VLDL	EFO_0004529	None	None	DNA methylation	Total lipids in very small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.99	0.2	0.0000015	None	Battram-T_total_lipids_in_very_small_vldl
Battram T	ARIES	None	2020-08-20	Total cholesterol in large HDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.66	0.135	0.0000015	None	Battram-T_total_cholesterol_in_large_hdl
Battram T	ARIES	None	2020-08-20	Triglycerides in medium VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	673	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.96	0.197	0.0000015	None	Battram-T_triglycerides_in_medium_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0480431	0.00999813	0.000001561256	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.0502453	0.0104757	0.000001631627	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Phospholipids in medium VLDL	EFO_0004639	None	None	DNA methylation	Phospholipids in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	676	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-2.6	0.55	0.0000017	None	Battram-T_phospholipids_in_medium_vldl
Battram T	ARIES	None	2020-08-20	Total lipids in medium VLDL	EFO_0004529	None	None	DNA methylation	Total lipids in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	676	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.51	0.106	0.0000019	None	Battram-T_total_lipids_in_medium_vldl
Battram T	ARIES	None	2020-08-20	Free cholesterol in large HDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	2.8	0.58	0.0000021	None	Battram-T_free_cholesterol_in_large_hdl
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg19916637	chr8:95961757	8	95961757	TP53INP1	Island	-0.6496862	0.1372	0.0000022	-	27602958_smoking_packyears_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23172400	chr8:95962367	8	95962367	TP53INP1	Island	0.00095	0.0002	0.0000024	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg09323728	chr8:95962352	8	95962352	TP53INP1	Island	-0.095631	0.020304	0.000002497054	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Battram T	ARIES	None	2020-08-20	Total cholesterol in very small VLDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in very small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-1.93	0.41	0.0000025	None	Battram-T_total_cholesterol_in_very_small_vldl
Battram T	ARIES	None	2020-08-20	Total lipids in large HDL	EFO_0004529	None	None	DNA methylation	Total lipids in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.35	0.074	0.0000026	None	Battram-T_total_lipids_in_large_hdl
Battram T	ARIES	None	2020-08-20	Concentration of very small VLDL particles	EFO_0008317	None	None	DNA methylation	Concentration of very small VLDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-14000000	None	0.0000027	None	Battram-T_concentration_of_very_small_vldl_particles
Battram T	ARIES	None	2020-08-20	Concentration of medium VLDL particles	EFO_0008317	None	None	DNA methylation	Concentration of medium VLDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	676	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-17000000	None	0.0000031	None	Battram-T_concentration_of_medium_vldl_particles
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	-0.0452441	0.00970606	0.000003167938	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Free cholesterol in very small VLDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in very small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-5.7	1.22	0.0000032	None	Battram-T_free_cholesterol_in_very_small_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12838385	chr8:95962078	8	95962078	TP53INP1	Island	-0.038365	0.00825049	0.000003347832	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Triglycerides in very small VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides in very small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-3.4	0.74	0.0000037	None	Battram-T_triglycerides_in_very_small_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0446241	0.00965312	0.00000381891	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Concentration of large HDL particles	EFO_0004612	None	None	DNA methylation	Concentration of large HDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	None	None	0.0000039	None	Battram-T_concentration_of_large_hdl_particles
Gadd DA	Generation Scotland	35945220	31/07/2022	GZMA protein levels (SeqId = 3440-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GZMA protein levels (SeqId = 3440-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granzyme A	774	1	Adults (18-65 years)	Both	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	0.6	0.13	0.0000041	None	Gadd-DA_gzma_protein_levels__seqid___3440-7__somascan_protein_measurement
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg21701395	chr8:95961492	8	95961492	TP53INP1	Island	-0.6431522	0.1399	0.00000428	-	27602958_smoking_packyears_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0506141	0.0110076	0.000004299087	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Phospholipids in very large HDL	EFO_0004639	None	None	DNA methylation	Phospholipids in very large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	1	0.22	0.0000043	None	Battram-T_phospholipids_in_very_large_hdl
Battram T	ARIES	None	2020-08-20	Phospholipids in large HDL	EFO_0004639	None	None	DNA methylation	Phospholipids in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.81	0.17	0.0000043	None	Battram-T_phospholipids_in_large_hdl
Battram T	ARIES	None	2020-08-20	VLDL cholesterol	EFO_0008317	fasting	None	DNA methylation	VLDL cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.63	0.136	0.0000043	None	Battram-T_vldl_cholesterol_fasting
Battram T	ARIES	None	2020-08-20	Free cholesterol in medium VLDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	675	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-3.9	0.84	0.0000044	None	Battram-T_free_cholesterol_in_medium_vldl
Battram T	ARIES	None	2020-08-20	Triglycerides	EFO_0004530	fasting	None	DNA methylation	Triglycerides	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.29	0.062	0.0000045	None	Battram-T_triglycerides_fasting
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.0378186	0.00825066	0.00000460594	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	0.256995	0.0561231	0.000004700156	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23172400	chr8:95962367	8	95962367	TP53INP1	Island	-0.0377584	0.00825068	0.000004769398	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Cholesterol esters in very small VLDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in very small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-2.8	0.61	0.0000058	None	Battram-T_cholesterol_esters_in_very_small_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	-0.0384071	0.00847798	0.000005938833	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Triglycerides to total lipids ratio in medium HDL	EFO_0004530	None	None	DNA methylation	Triglycerides to total lipids ratio in medium HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.092	0.02	0.0000063	None	Battram-T_triglycerides_to_total_lipids_ratio_in_medium_hdl
Battram T	ARIES	None	2020-08-20	Triglycerides in VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides in VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	677	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.31	0.068	0.0000066	None	Battram-T_triglycerides_in_vldl
Battram T	ARIES	None	2020-08-20	Cholesterol esters to total lipids ratio in large HDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters to total lipids ratio in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	677	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.048	0.0105	0.0000066	None	Battram-T_cholesterol_esters_to_total_lipids_ratio_in_large_hdl
Antoun E	UPBEAT	33151971	2020-11-05	gestational diabetes milletus	EFO_0004593	Adjusted for gestational age at OGTT	S1 Data Table H	gestational diabetes milletus	DNA methylation	Sex, ethnicity, cell composition (reference based), maternal smoking, maternal age, parity, gestational age at oral glucose tolerance test	None	Beta Values	Illumina HumanMethylationEPIC	Cord blood	None	557	1	Infants	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	1.77	0.389	0.0000068	None	33151971_Antoun-E_gestational_diabetes_milletus_adjusted_for_gestational_age_at_ogtt
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0430653	0.00964709	0.000008101492	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22335238	chr8:95953253	8	95953253	TP53INP1	Open sea	-0.0365833	0.00825104	0.000009326732	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16049864	chr8:95962084	8	95962084	TP53INP1	Island	0.0032	0.00073	0.0000099	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Antoun E	UPBEAT	33151971	2020-11-05	gestational diabetes milletus	EFO_0004593	Adjusted for BMI	S1 Data Table D	gestational diabetes milletus	DNA methylation	Sex,ethnicity,cell counts (reference based),maternal smoking,maternal age, parity,maternal BMI	None	Beta Values	Illumina HumanMethylationEPIC	Cord blood	None	557	1	Infants	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	1.39	0.313	0.00001	None	33151971_Antoun-E_gestational_diabetes_milletus_adjusted_for_bmi
Battram T	ARIES	None	2020-08-20	Apolipoprotein B	EFO_0004615	None	None	DNA methylation	Apolipoprotein B	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.57	0.128	0.00001	None	Battram-T_apolipoprotein_b
Battram T	ARIES	None	2020-08-20	Serum total triglycerides	EFO_0004530	None	None	DNA methylation	Serum total triglycerides	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	676	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.26	0.057	0.00001	None	Battram-T_serum_total_triglycerides
Battram T	ARIES	None	2020-08-20	Phospholipids to total lipids ratio in large HDL	EFO_0004639	None	None	DNA methylation	Phospholipids to total lipids ratio in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	682	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.036	0.0082	0.00001	None	Battram-T_phospholipids_to_total_lipids_ratio_in_large_hdl
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age*sex	PATO_0000047,EFO_0000246	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	age*sex	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23172400	chr8:95962367	8	95962367	TP53INP1	Island	0.00096	0.00022	0.00001	None	33450751_Mulder-RH_age_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	-0.0363982	0.0082511	0.0000103476	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0423637	0.0096037	0.000010354	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08755736	chr8:95957928	8	95957928	TP53INP1	North shelf	0.0363069	0.00825113	0.00001088981	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	0.104062	0.0236571	0.00001095108	None	39706196_Hannah-M.-Smith_bmi_discovery
Antoun E	UPBEAT	33151971	2020-11-05	gestational diabetes milletus	EFO_0004593	None	S1 Data Table C	gestational diabetes milletus	DNA methylation	Sex,ethnicity,cell counts (reference based),maternal smoking,maternal age, parity	None	Beta Values	Illumina HumanMethylationEPIC	Cord blood	None	557	1	Infants	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	1.25	0.283	0.000012	None	33151971_Antoun-E_gestational_diabetes_milletus
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18059933	chr8:95962463	8	95962463	TP53INP1	South shore	0.0359679	0.00825123	0.00001314932	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0478528	0.0109922	0.00001349819	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_4
Antoun E	UPBEAT	33151971	2020-11-05	gestational diabetes milletus	EFO_0004593	Adjusted for intervention	S1 Data Table R	gestational diabetes milletus	DNA methylation	Sex,ethnicity,cell counts (reference based),maternal smoking,maternal age, parity,intervention	None	Beta Values	Illumina HumanMethylationEPIC	Cord blood	None	557	1	Infants	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	1.09	0.25	0.000014	None	33151971_Antoun-E_gestational_diabetes_milletus_adjusted_for_intervention
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0358139	0.00825127	0.00001431736	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20017151	chr8:95954126	8	95954126	TP53INP1	Open sea	-0.0357374	0.0082513	0.00001493379	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Total cholesterol to total lipids ratio in large HDL	EFO_0004574	None	None	DNA methylation	Total cholesterol to total lipids ratio in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.032	0.0074	0.000015	None	Battram-T_total_cholesterol_to_total_lipids_ratio_in_large_hdl
Battram T	ARIES	None	2020-08-20	Phospholipids to total lipids ratio in IDL	EFO_0004639	None	None	DNA methylation	Phospholipids to total lipids ratio in IDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	672	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.168	0.039	0.000015	None	Battram-T_phospholipids_to_total_lipids_ratio_in_idl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22335238	chr8:95953253	8	95953253	TP53INP1	Open sea	-0.035645	0.00825132	0.00001571172	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Chen Y	None	34670603	Oct 20, 2021	Body mass index	EFO_0004340	Multi-ethnic Asian meta-analysis	None	Body mass index	DNA methylation	Age, Sex, Smoking, Cell composition (reference free), control probe PCs	kg/m2	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	409	None	Adults (18-65 years)	Both	East Asian, South Asian, Admixed	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-17.9	4.1	0.000016	None	34670603_Chen-Y_body_mass_index_multi-ethnic_asian_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22335238	chr8:95953253	8	95953253	TP53INP1	Open sea	-0.0355563	0.00825135	0.00001649524	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg13128305	chr8:95961759	8	95961759	TP53INP1	Island	-0.4685586	0.1088	0.0000166	-	27602958_smoking_packyears_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	-0.0480471	0.0111659	0.00001695845	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Free cholesterol to total lipids ratio in large HDL	EFO_0008591	None	None	DNA methylation	Free cholesterol to total lipids ratio in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.11	0.025	0.000017	None	Battram-T_free_cholesterol_to_total_lipids_ratio_in_large_hdl
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.76	0.176	0.000017	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Battram T	ARIES	None	2020-08-20	Phospholipids in large VLDL	EFO_0004639	None	None	DNA methylation	Phospholipids in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	669	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-4.4	1.02	0.000018	None	Battram-T_phospholipids_in_large_vldl
Battram T	ARIES	None	2020-08-20	Cholesterol esters in large VLDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	661	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-6.8	1.59	0.000019	None	Battram-T_cholesterol_esters_in_large_vldl
Battram T	ARIES	None	2020-08-20	Total cholesterol in HDL2	EFO_0004574	None	None	DNA methylation	Total cholesterol in HDL2	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.38	0.088	0.000019	None	Battram-T_total_cholesterol_in_hdl2
Battram T	ARIES	None	2020-08-20	Total lipids in chylomicrons and extremely large VLDL	EFO_0004529	None	None	DNA methylation	Total lipids in chylomicrons and extremely large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	662	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-8.3	1.93	0.000019	None	Battram-T_total_lipids_in_chylomicrons_and_extremely_large_vldl
Battram T	ARIES	None	2020-08-20	Mean diameter for HDL particles	EFO_0008592	None	None	DNA methylation	Mean diameter for HDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	nm	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.47	0.11	0.000019	None	Battram-T_mean_diameter_for_hdl_particles
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08755736	chr8:95957928	8	95957928	TP53INP1	North shelf	-0.0086	0.002	0.000019	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23172400	chr8:95962367	8	95962367	TP53INP1	Island	0.0352375	0.00825144	0.00001962954	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.0351987	0.00825146	0.00002004768	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	-0.24007	0.0563256	0.00002034468	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Battram T	ARIES	None	2020-08-20	Total cholesterol in HDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.34	0.08	0.000021	None	Battram-T_total_cholesterol_in_hdl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	-0.0362733	0.0085364	0.00002158111	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.035052	0.0082515	0.00002170618	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PMEL protein levels (SeqId = 6472-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PMEL protein levels (SeqId = 6472-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Melanocyte protein PMEL	774	1	Adults (18-65 years)	Both	European	cg16049864	chr8:95962084	8	95962084	TP53INP1	Island	-0.3	0.071	0.000023	None	Gadd-DA_pmel_protein_levels__seqid___6472-40__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19916637	chr8:95961757	8	95961757	TP53INP1	Island	-0.000023	0.0000056	0.000023	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	ARIES	None	2020-08-20	Phospholipids in very small VLDL	EFO_0004639	None	None	DNA methylation	Phospholipids in very small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-2.7	0.64	0.000025	None	Battram-T_phospholipids_in_very_small_vldl
Gadd DA	Generation Scotland	35945220	31/07/2022	PMEL protein levels (SeqId = 6472-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PMEL protein levels (SeqId = 6472-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Melanocyte protein PMEL	774	1	Adults (18-65 years)	Both	European	cg23172400	chr8:95962367	8	95962367	TP53INP1	Island	-0.57	0.136	0.000026	None	Gadd-DA_pmel_protein_levels__seqid___6472-40__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	LDL cholesterol	EFO_0004195	fasting	None	DNA methylation	LDL cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	692	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.135	0.032	0.000027	None	Battram-T_ldl_cholesterol_fasting
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23172400	chr8:95962367	8	95962367	TP53INP1	Island	0.0345681	0.00825164	0.00002815322	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Total lipids in large VLDL	EFO_0004529	None	None	DNA methylation	Total lipids in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	671	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.77	0.183	0.000029	None	Battram-T_total_lipids_in_large_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	0.0448208	0.0107221	0.00002929254	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Concentration of very large HDL particles	EFO_0004612	None	None	DNA methylation	Concentration of very large HDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	None	None	0.00003	None	Battram-T_concentration_of_very_large_hdl_particles
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09323728	chr8:95962352	8	95962352	TP53INP1	Island	0.0344403	0.00825167	0.00003013739	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23172400	chr8:95962367	8	95962367	TP53INP1	Island	0.0355068	0.00853061	0.00003168786	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Cholesterol esters in IDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in IDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.84	0.2	0.000034	None	Battram-T_cholesterol_esters_in_idl
Battram T	ARIES	None	2020-08-20	Body mass index	EFO_0004340	None	None	DNA methylation	Body mass index	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	714	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.022	0.0052	0.000035	None	Battram-T_body_mass_index
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06542216	chr8:95962175	8	95962175	TP53INP1	Island	0.0341062	0.00825177	0.00003597378	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	-0.0340915	0.00825177	0.00003625438	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Triglycerides in large VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	670	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-1.27	0.3	0.000037	None	Battram-T_triglycerides_in_large_vldl
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.00063803	0.00015421	0.0000379	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Battram T	ARIES	None	2020-08-20	Insulin	None	fasting	None	DNA methylation	Insulin	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	pmol/l	Illumina HumanMethylation450	Whole blood	None	674	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.006	0.0015	0.000047	None	Battram-T_insulin_fasting
Gadd DA	Generation Scotland	35945220	31/07/2022	PMEL protein levels (SeqId = 6472-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PMEL protein levels (SeqId = 6472-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Melanocyte protein PMEL	774	1	Adults (18-65 years)	Both	European	cg13393036	chr8:95962371	8	95962371	TP53INP1	Island	-0.44	0.107	0.000047	None	Gadd-DA_pmel_protein_levels__seqid___6472-40__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	-0.0335687	0.00825192	0.00004766943	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Concentration of large VLDL particles	EFO_0008317	None	None	DNA methylation	Concentration of large VLDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	670	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-45000000	11000000	0.000048	None	Battram-T_concentration_of_large_vldl_particles
Battram T	ARIES	None	2020-08-20	Triglycerides to total lipids ratio in small HDL	EFO_0004530	None	None	DNA methylation	Triglycerides to total lipids ratio in small HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.107	0.026	0.000049	None	Battram-T_triglycerides_to_total_lipids_ratio_in_small_hdl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.0334927	0.00825194	0.00004958947	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0334544	0.00825195	0.00005058371	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Total cholesterol to total lipids ratio in chylomicrons and XXL-VLDL	EFO_0004574	None	None	DNA methylation	Total cholesterol to total lipids ratio in chylomicrons and XXL-VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	653	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.017	0.0042	0.000051	None	Battram-T_total_cholesterol_to_total_lipids_ratio_in_chylomicrons_and_xxl-vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.0334338	0.00825196	0.00005112637	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.0334211	0.00825196	0.00005146272	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0333508	0.00825198	0.0000533699	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Chen Y	None	34670603	Oct 20, 2021	Waist Circumference	EFO_0004342	Multi-ethnic Asian meta-analysis	None	Waist Circumference	DNA methylation	Age, Sex, Smoking, Cell composition (reference free), control probe PCs	cm	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	409	None	Adults (18-65 years)	Both	East Asian, South Asian, Admixed	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-41	10.3	0.000054	None	34670603_Chen-Y_waist_circumference_multi-ethnic_asian_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.0332975	0.00825199	0.00005485787	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Free cholesterol in very large HDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in very large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	3.5	0.87	0.000058	None	Battram-T_free_cholesterol_in_very_large_hdl
Battram T	ARIES	None	2020-08-20	Total lipids in very large HDL	EFO_0004529	None	None	DNA methylation	Total lipids in very large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.45	0.112	0.000058	None	Battram-T_total_lipids_in_very_large_hdl
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg21701395	chr8:95961492	8	95961492	TP53INP1	Island	-0.64806506	0.1614	0.0000592	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg19916637	chr8:95961757	8	95961757	TP53INP1	Island	-0.6528627	0.1626	0.0000593	-	27602958_smoking_packyears_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0387125	0.00963939	0.00005947044	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Cholesterol esters in chylomicrons and extremely large VLDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in chylomicrons and extremely large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	651	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-74	18	0.00006	None	Battram-T_cholesterol_esters_in_chylomicrons_and_extremely_large_vldl
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age*sex	PATO_0000047,EFO_0000246	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	age*sex	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg13393036	chr8:95962371	8	95962371	TP53INP1	Island	0.001	0.00026	0.000063	None	33450751_Mulder-RH_age_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.0386051	0.00965243	0.00006378113	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Free cholesterol in large VLDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	659	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-6.5	1.61	0.000064	None	Battram-T_free_cholesterol_in_large_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0329913	0.00825208	0.00006421084	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08185170	chr8:95956476	8	95956476	TP53INP1	Open sea	0.0329846	0.00825208	0.0000644282	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.0329179	0.0082521	0.0000666645	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16049864	chr8:95962084	8	95962084	TP53INP1	Island	-0.0328915	0.0082521	0.00006756877	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09323728	chr8:95962352	8	95962352	TP53INP1	Island	0.0330211	0.00829104	0.00006845223	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Triglycerides in chylomicrons and extremely large VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides in chylomicrons and extremely large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	654	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-11.3	2.8	0.000069	None	Battram-T_triglycerides_in_chylomicrons_and_extremely_large_vldl
Battram T	ARIES	None	2020-08-20	Total cholesterol in large VLDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	664	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-3.3	0.82	0.00007	None	Battram-T_total_cholesterol_in_large_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01282195	chr8:95952351	8	95952351	TP53INP1	Open sea	0.0328197	0.00825212	0.00007008855	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	0.0326396	0.00825217	0.00007680607	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Phospholipids in medium LDL	EFO_0004639	None	None	DNA methylation	Phospholipids in medium LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-2.5	0.62	0.000077	None	Battram-T_phospholipids_in_medium_ldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18059933	chr8:95962463	8	95962463	TP53INP1	South shore	0.0326295	0.00825218	0.00007720204	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26343298	chr8:95960752	8	95960752	TP53INP1	Island	-0.0325349	0.0082522	0.00008098855	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Hip Trochanter T score	EFO_0007702	None	None	DNA methylation	Hip Trochanter T score	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	DXA scan measurement	705	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.087	0.022	0.000081	None	Battram-T_hip_trochanter_t_score
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22335238	chr8:95953253	8	95953253	TP53INP1	Open sea	0.0324867	0.00825221	0.0000829826	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Free cholesterol to total lipids ratio in large LDL	EFO_0008591	None	None	DNA methylation	Free cholesterol to total lipids ratio in large LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.099	0.025	0.000093	None	Battram-T_free_cholesterol_to_total_lipids_ratio_in_large_ldl
Battram T	ARIES	None	2020-08-20	Total cholesterol in IDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in IDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	-0.57	0.14	0.000094	None	Battram-T_total_cholesterol_in_idl
Gadd DA	Generation Scotland	35945220	31/07/2022	PMEL protein levels (SeqId = 6472-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PMEL protein levels (SeqId = 6472-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Melanocyte protein PMEL	774	1	Adults (18-65 years)	Both	European	cg06542216	chr8:95962175	8	95962175	TP53INP1	Island	-0.29	0.073	0.000094	None	Gadd-DA_pmel_protein_levels__seqid___6472-40__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Phospholipids to total lipids ratio in small VLDL	EFO_0004639	None	None	DNA methylation	Phospholipids to total lipids ratio in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg01824466	chr8:95959531	8	95959531	TP53INP1	North shore	0.066	0.017	0.000099	None	Battram-T_phospholipids_to_total_lipids_ratio_in_small_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg20039814	chr8:95962383	8	95962383	TP53INP1	South shore	0.0321336	0.00825231	0.0000990877	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1