author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.0026	0.00028	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0048	0.00013	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0094	0.00084	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0053	0.00014	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0093	0.00085	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.0053	0.00023	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.006	0.00019	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.015	0.0012	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.024	0.0028	0	None	33450751_Mulder-RH_sex_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0032	0.00018	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.011	0.0012	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24331475	chr18:21596915	18	21596915	TTC39C	South shore	0.31147	0.00529	2.4e-125	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.35208	0.00934	6.3e-91	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.162665	0.00814661	1.5418749999999998e-87	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.160553	0.00814946	2.6680289999999996e-85	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.16076	0.00479	1.8999999999999998e-82	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.155002	0.00815678	1.455657e-79	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.154835	0.008157	2.152375e-79	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.30344	0.00957	1.7e-78	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.153371	0.00815889	6.440064999999999e-78	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07205589	chr18:21597456	18	21597456	TTC39C	South shore	-0.08641	0.00296	1.3e-72	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.144207	0.00817027	5.232149e-69	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.142805	0.00817195	1.075714e-67	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.141448	0.00817356	1.947308e-66	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.137899	0.00817769	3.3222349999999996e-63	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.14771	0.00599	1.6e-61	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.132104	0.00818421	4.137471e-58	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.19154	0.00853	1e-55	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.126064	0.0081907	4.875091e-53	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.120362	0.00819655	1.788771e-48	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	3.16825	0.10473	5.99e-48	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.118167	0.00819872	8.966493000000001e-47	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-	-	1.18e-46	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.117379	0.0081995	3.586778e-46	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0019	None	1.2e-45	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.11503	0.00820176	2.120488e-44	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.114806	0.00820198	3.113604e-44	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.113298	0.00820341	4.065938e-43	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18429646	chr18:21594021	18	21594021	TTC39C	Island	0.03481	0.00196	1.4e-42	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.111645	0.00820495	6.535726e-42	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	2.5736	0.10351	2.67e-41	-	25282492_fetal_vs_adult_liver
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	2.65776	0.1098	2.0599999999999997e-40	-	25282492_fetal_vs_adult_liver
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-	-	4.1099999999999995e-40	-	23526956_clear_cell_renal_carcinoma
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.13968	0.00829	8.8e-40	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg06586496	chr18:21715307	18	21715307	TTC39C	North shelf	-0.04854	0.00289	1.1e-39	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-	-	5.04e-39	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.105752	0.00821027	9.285090999999999e-38	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	0.103603	0.00821214	2.666899e-36	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-	-	2.7e-35	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.0970035	0.00821763	5.176478e-32	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.094657	0.0082195	1.4802709999999999e-30	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	0.0924089	0.00822124	3.4042210000000004e-29	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0016	None	1.0000000000000001e-28	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.104832	0.00960597	1.272728e-27	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.089736	0.00822326	1.283315e-27	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0887472	0.00822399	4.7829499999999995e-27	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0884858	0.00822418	6.75606e-27	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0875353	0.00822488	2.351974e-26	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg24331475	chr18:21596915	18	21596915	TTC39C	South shore	-	-	4.47e-26	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0864472	0.00822566	9.646542999999999e-26	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-	-	1.36e-25	-	23526956_clear_cell_renal_carcinoma
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-4.4	0.428	5.099999999999999e-25	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	0.0845457	0.00822701	1.089384e-24	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.0825882	0.00822837	1.2491320000000001e-23	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.684456	0.0682698	1.362524e-23	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0813063	0.00822924	5.984418e-23	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0807607	0.0082296	1.1572360000000002e-22	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Nones K	-	24500968	2014-05-09	Pancreatic ductal adenocarcinoma	EFO_0002517	-	Table S4	DNA methylation	Pancreatic ductal adenocarcinoma	-	Beta values	-	Illumina HumanMethylation450	Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata	-	196	1	-	Missing	None	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-	-	2.08e-22	-	24500968_pancreatic_ductal_adenocarcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0793256	0.00823055	6.420359000000001e-22	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0791397	0.00823068	7.998536000000001e-22	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.0791231	0.00823069	8.15654e-22	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0781875	0.0082313	2.445077e-21	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0912277	0.0096584	4.064272e-21	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.0776998	0.00823161	4.311259e-21	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0766274	0.0082323	1.481919e-20	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.075659	0.00823291	4.453796e-20	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.0756266	0.00823293	4.619646e-20	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-0.502828	0.0549605	6.378146e-20	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0751075	0.00823325	8.283667e-20	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.083029	0.00914051	1.1822449999999998e-19	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg02449778	chr18:21693577	18	21693577	TTC39C	Open sea	-0.3166693	0.0350078	1.487e-19	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0869356	0.00960611	1.6062259999999998e-19	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0832846	0.00927934	3.164506e-19	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-0.0738874	0.008234	3.21697e-19	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-3.1	0.352	4.1e-19	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0736052	0.00823418	4.3890619999999995e-19	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg24242002	chr18:21594044	18	21594044	TTC39C	Island	0.01311	0.00132	4.7e-19	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg03438346	chr18:21692621	18	21692621	TTC39C	Open sea	-0.495413	0.0557967	6.753e-19	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0729991	0.00823454	8.520071e-19	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.0728422	0.00823464	1.010773e-18	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg02449778	chr18:21693577	18	21693577	TTC39C	Open sea	-0.486602	0.0550695	1.079344e-18	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.0725296	0.00823483	1.418919e-18	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0723314	0.00823494	1.758289e-18	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.0721109	0.00823508	2.230257e-18	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.0716789	0.00823533	3.546592e-18	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-0.075046	0.0086742	5.598077e-18	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0710466	0.00823571	6.957677e-18	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0786766	0.00916153	9.754999e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0696172	0.00823654	3.124019e-17	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03469660	chr18:21636266	18	21636266	TTC39C	Open sea	0.0694746	0.00823662	3.6229690000000006e-17	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	-0.0688357	0.00823699	7.011377e-17	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0686223	0.00823711	8.729568000000001e-17	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.0680964	0.00823741	1.494034e-16	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0674804	0.00823775	2.788983e-16	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.0669979	0.00823802	4.530048e-16	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg03964321	chr18:21693002	18	21693002	TTC39C	Open sea	-0.4588143	0.0566568	5.581e-16	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.04194	0.00477	7.8e-16	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0664364	0.00823833	7.931908e-16	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0774752	0.00960904	8.033421e-16	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3781980 (gene symbol: TTC39C)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3781980 (gene symbol: TTC39C)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	None	None	0.0000000000000014	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3781980__gene_symbol__ttc39c__meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.0658215	0.00823867	0.000000000000001457044	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.0657031	0.00823873	0.00000000000000163706	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.013	0.0016	0.0000000000000018	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	2.4	0.301	0.000000000000002	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.061	0.00708	0.0000000000000024	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-1.4494	0.15085	0.00000000000000255	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0646853	0.00823928	0.000000000000004417105	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0645902	0.00823933	0.000000000000004843035	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0644879	0.00823939	0.00000000000000534559	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.0642629	0.00823951	0.000000000000006639523	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.064219	0.00823953	0.000000000000006925447	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0641878	0.00823955	0.000000000000007136586	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0639804	0.00823966	0.000000000000008706828	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.0636603	0.00823982	0.00000000000001182059	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.063334	0.00824	0.00000000000001611937	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.524651	0.0685086	0.00000000000001985078	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0630874	0.00824012	0.00000000000002035672	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.0629804	0.00824018	0.00000000000002251946	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.0627659	0.00824029	0.0000000000000275581	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.517006	0.0683015	0.00000000000003935854	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0623375	0.00824051	0.00000000000004116371	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-0.0656648	0.00868439	0.00000000000004228591	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0621939	0.00824059	0.00000000000004705855	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.3878902	0.051469	0.00000000000004832	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0621599	0.0082406	0.00000000000004857601	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.0620917	0.00824064	0.00000000000005175565	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.404201	0.053658	0.00000000000005193903	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0620071	0.00824068	0.00000000000005598972	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0617058	0.00824084	0.00000000000007401683	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.0614748	0.00824096	0.00000000000009160185	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0612788	0.00824105	0.0000000000001096888	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.014	0.0019	0.00000000000011	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0714595	0.00963936	0.0000000000001299319	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0609541	0.00824122	0.0000000000001476637	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-0.403976	0.055134	0.0000000000002454233	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0603804	0.00824151	0.0000000000002487666	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24782431	chr18:21642931	18	21642931	TTC39C	Open sea	0.0603592	0.00824152	0.0000000000002535935	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-	-	0.000000000000355	-	26857698_primary_sjogrens_syndrome_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0596501	0.00824187	0.0000000000004798812	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0595985	0.00824189	0.0000000000005025573	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.059589	0.0082419	0.0000000000005068475	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0595265	0.00824193	0.0000000000005359288	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24331475	chr18:21596915	18	21596915	TTC39C	South shore	-0.0018	0.00025	0.00000000000058	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.110162	0.015374	0.0000000000008122478	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.116773	0.0164467	0.000000000001303989	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.026	0.00327	0.0000000000014	None	32795589_Kyung-WK_eosinophilia_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.011	0.0015	0.0000000000015	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.082	0.01158	0.0000000000018	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0581005	0.00824262	0.000000000001885352	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0579889	0.00824268	0.000000000002077862	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg13763247	chr18:21693078	18	21693078	TTC39C	Open sea	-0.3598044	0.051301	0.000000000002323	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0578604	0.00824274	0.00000000000232345	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03469660	chr18:21636266	18	21636266	TTC39C	Open sea	0.0577277	0.0082428	0.000000000002606773	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	0.0576834	0.00824282	0.000000000002708752	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24782431	chr18:21642931	18	21642931	TTC39C	Open sea	0.0576275	0.00824285	0.0000000000028429	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0575678	0.00824288	0.000000000002993445	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0575627	0.00824288	0.000000000003006695	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0671009	0.00961157	0.000000000003050916	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0574378	0.00824294	0.000000000003348872	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27166860	chr18:21594461	18	21594461	TTC39C	Island	0.00079	None	0.0000000000042	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0571237	0.00824309	0.000000000004387187	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0568859	0.0082432	0.000000000005377327	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0567848	0.00824325	0.000000000005862124	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.0565646	0.00824335	0.000000000007070332	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	0.0564863	0.00824339	0.000000000007556274	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16441133	chr18:21595161	18	21595161	TTC39C	Island	0.00742	0.00102	0.0000000000082	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	0.0561922	0.00824353	0.000000000009690881	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.2391779	0.0352676	0.00000000001187	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0648639	0.00959902	0.00000000001458411	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.287081	0.0425104	0.00000000001489716	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0555772	0.00824381	0.00000000001624027	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0555109	0.00824384	0.00000000001716491	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg24782431	chr18:21642931	18	21642931	TTC39C	Open sea	0.011	0.00149	0.000000000018	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0554254	0.00824388	0.00000000001843145	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg07179105	chr18:21594232	18	21594232	TTC39C	Island	0.00487	7e-04	0.0000000000193	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.0671905	0.0100421	0.00000000002298196	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.0550576	0.00824405	0.0000000000250142	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0550421	0.00824405	0.00000000002533704	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg20799816	chr18:21594185	18	21594185	TTC39C	Island	0.00482	7e-04	0.0000000000319	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0547549	0.00824419	0.00000000003211279	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0545983	0.00824426	0.00000000003652323	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.0545526	0.00824428	0.00000000003792006	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-0.362383	0.0549815	0.00000000004494811	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0608766	0.00927377	0.00000000005400361	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.2175	0.0332	0.0000000000592	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0539925	0.00824453	0.00000000005989773	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0629875	0.00962289	0.00000000006123003	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.0539024	0.00824457	0.00000000006444045	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16441133	chr18:21595161	18	21595161	TTC39C	Island	0.00033	0.00005	0.000000000065	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0600853	0.0091945	0.00000000006574651	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0537358	0.00824464	0.00000000007374066	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0537213	0.00824465	0.00000000007461494	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.0536749	0.00824467	0.00000000007745881	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-	-	0.000000000078	-	26857698_primary_sjogrens_syndrome_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24782431	chr18:21642931	18	21642931	TTC39C	Open sea	-0.0536402	0.00824468	0.00000000007966328	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.310742	0.0478075	0.00000000008258951	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03469660	chr18:21636266	18	21636266	TTC39C	Open sea	0.0535331	0.00824473	0.00000000008684893	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0533283	0.00824482	0.0000000001023897	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0575416	0.00890727	0.000000000107957	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.00081212	0.00012454	0.000000000108	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.0532565	0.00824485	0.0000000001084565	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.0530925	0.00824493	0.0000000001236722	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0530414	0.00824495	0.0000000001288188	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0529686	0.00824498	0.0000000001365215	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0529438	0.00824499	0.0000000001392527	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.0527396	0.00824508	0.000000000163809	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.20282	0.0317	0.000000000166	-	25650246_gestational_age
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg24331475	chr18:21596915	18	21596915	TTC39C	South shore	0.16323	0.0255	0.000000000167	-	25650246_gestational_age
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.2774	0.0435	0.000000000172	-	25650246_gestational_age
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24331475	chr18:21596915	18	21596915	TTC39C	South shore	0.016	0.0025	0.00000000018	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.0524627	0.0082452	0.0000000002039587	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.052382	0.00824524	0.0000000002173856	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0611564	0.0096281	0.0000000002189885	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	0.0523635	0.00824524	0.0000000002205837	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0522633	0.00824529	0.0000000002386863	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.211692	0.03347	0.0000000002597555	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.420142	0.0664775	0.0000000002675141	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0521038	0.00824536	0.0000000002705637	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.187532	0.0297585	0.0000000002942	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0586064	0.00930795	0.000000000313352	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0519029	0.00824544	0.000000000316667	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	-0.0518147	0.00824548	0.0000000003392545	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.044	0.00632	0.00000000034	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.051768	0.0082455	0.0000000003518468	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.0515938	0.00824557	0.0000000004029609	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0513218	0.00824569	0.0000000004975665	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0512952	0.0082457	0.0000000005079049	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07179105	chr18:21594232	18	21594232	TTC39C	Island	-0.000038	0.0000061	0.00000000051	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0512739	0.00824571	0.0000000005163666	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.2251	0.0363	0.000000000535	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.051126	0.00824577	0.0000000005787549	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0508225	0.0082459	0.0000000007307631	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.0505418	0.00824602	0.0000000009056465	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.058975	0.00962347	0.0000000009112874	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Petersen A-K	KORA F4	24014485	2013-09-06	M00054_tryptophan	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M00054_tryptophan	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.37	0.033	0.00000000098	None	24014485_Petersen-A-K_m00054_tryptophan_snps_as_covariates_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.0503027	0.00824612	0.00000000108622	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.00453	0.00074	0.0000000011	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.0502607	0.00824614	0.000000001121334	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-	-	0.00000000113	-	26857698_primary_sjogrens_syndrome_whole_blood
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg27166860	chr18:21594461	18	21594461	TTC39C	Island	1.559919	0.2565	0.00000000119	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.0501428	0.00824619	0.000000001226113	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.0608859	0.0100136	0.000000001229381	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0500891	0.00824621	0.000000001276861	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0500832	0.00824621	0.000000001282568	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.0629661	0.0103708	0.000000001298585	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.0500626	0.00824622	0.000000001302657	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg24331475	chr18:21596915	18	21596915	TTC39C	South shore	0.267448	0.044094	0.000000001343581	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0498278	0.00824632	0.00000000155478	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.0497535	0.00824635	0.000000001644058	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.055264	0.00920225	0.000000001952644	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0494372	0.00824648	0.000000002083178	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.061359	0.0102647	0.000000002316299	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0551337	0.00923169	0.000000002394605	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-	-	0.00000000271	-	26857698_primary_sjogrens_syndrome_whole_blood
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg07205589	chr18:21597456	18	21597456	TTC39C	South shore	0.0876	0.0148	0.00000000287	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-0.0514404	0.00865799	0.000000002890478	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.198883	0.0335514	0.000000003129911	None	39706196_Hannah-M.-Smith_body_fat_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.016	0.0028	0.0000000036	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0486054	0.00824681	0.000000003855876	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.282331	0.0479274	0.000000003914276	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.0484736	0.00824687	0.000000004247187	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0884848	0.0151034	0.000000004768061	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07205589	chr18:21597456	18	21597456	TTC39C	South shore	0.0097	0.0017	0.0000000048	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.048151	0.00824699	0.00000000537492	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.0659508	0.0113299	0.00000000597325	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.0479994	0.00824705	0.000000006000845	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0479266	0.00824708	0.000000006326035	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.0479069	0.00824709	0.000000006416945	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0478373	0.00824712	0.000000006748687	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.0477291	0.00824716	0.00000000729724	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0476817	0.00824718	0.000000007551137	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.0476678	0.00824719	0.000000007626904	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0579403	0.0100278	0.000000007715477	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0555337	0.00961303	0.000000007762667	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0476305	0.0082472	0.000000007834556	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.0893352	0.0154798	0.000000008035484	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.0475475	0.00824723	0.00000000831662	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0472717	0.00824734	0.00000001013532	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0591792	0.0103494	0.00000001097997	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.266116	0.0465635	0.00000001113432	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0471039	0.00824741	0.00000001142548	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0470686	0.00824742	0.00000001171633	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.00406	0.00071	0.000000012	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.261568	0.0459481	0.00000001269943	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.49932	0.0877184	0.00000001272624	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.307522	0.0540525	0.00000001295109	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.0468692	0.0082475	0.00000001349914	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.271282	0.0477841	0.00000001390779	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0588684	0.0103722	0.00000001408053	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0546268	0.00962512	0.00000001409514	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-	-	0.0000000146	-	26857698_primary_sjogrens_syndrome_whole_blood
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg24331475	chr18:21596915	18	21596915	TTC39C	South shore	None	None	0.000000015	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0467149	0.00824756	0.00000001505859	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	-0.046492	0.00824764	0.00000001762241	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.08564	0.0152	0.0000000184	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.0638445	0.0113486	0.00000001880459	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-0.048543	0.00863625	0.00000001934946	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg03469660	chr18:21636266	18	21636266	TTC39C	Open sea	0.04	0.00663	0.00000002	None	32795589_Kyung-WK_eosinophilia_discovery
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg24242002	chr18:21594044	18	21594044	TTC39C	Island	0.00768	0.0014	0.0000000204	-	23334450_rheumatoid_arthritis
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	-0.15041	0.0268632	0.00000002185607	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.0485985	0.00867985	0.00000002194663	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0846183	0.0151262	0.00000002256642	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0461263	0.00824778	0.00000002277299	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0737757	0.0132233	0.00000002458599	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0519327	0.00932288	0.00000002585502	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg07205589	chr18:21597456	18	21597456	TTC39C	South shore	0.02	0.00334	0.000000027	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0457739	0.00824792	0.00000002910245	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0457232	0.00824794	0.00000003014332	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0839069	0.0151437	0.00000003064044	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.013	0.0023	0.000000033	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0455113	0.00824802	0.00000003490004	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0454813	0.00824803	0.00000003562858	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.0454094	0.00824805	0.00000003743799	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	-0.156796	0.0285644	0.0000000409086	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07179105	chr18:21594232	18	21594232	TTC39C	Island	0.00328	0.00058	0.000000046	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.0451076	0.00824817	0.00000004605144	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0450925	0.00824817	0.00000004652657	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.0474063	0.00867666	0.00000004740337	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0829696	0.0152051	0.00000004929986	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0449958	0.00824821	0.00000004970432	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0507559	0.00932786	0.00000005373628	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24331475	chr18:21596915	18	21596915	TTC39C	South shore	-0.0448146	0.00824828	0.00000005623308	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24331475	chr18:21596915	18	21596915	TTC39C	South shore	-0.0671385	0.0123866	0.00000006045308	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0520269	0.00962612	0.0000000659067	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12972164	chr18:21695725	18	21695725	TTC39C	Open sea	-0.0445595	0.00824837	0.00000006684631	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.0445423	0.00824838	0.00000006762994	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.16699	0.0309	0.0000000682	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.044496	0.00824839	0.00000006977827	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	0.0444718	0.0082484	0.00000007092944	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03469660	chr18:21636266	18	21636266	TTC39C	Open sea	-0.0443946	0.00824843	0.0000000747188	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.250423	0.0465427	0.00000007519606	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0512706	0.0095333	0.00000007644921	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0441831	0.00824851	0.00000008613188	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0441258	0.00824853	0.00000008950336	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	-0.0440835	0.00824854	0.00000009207705	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12972164	chr18:21695725	18	21695725	TTC39C	Open sea	-0.0440644	0.00824855	0.00000009325789	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0439839	0.00824858	0.00000009841284	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.046169	0.00867227	0.0000001031484	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0438255	0.00824864	0.000000109375	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12972164	chr18:21695725	18	21695725	TTC39C	Open sea	0.0438085	0.00824864	0.0000001106207	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0493969	0.00930747	0.0000001129247	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0437647	0.00824866	0.0000001138897	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0511357	0.00964009	0.0000001146341	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0436918	0.00824869	0.0000001195396	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.1909	0.0361	0.000000123	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0492028	0.00929916	0.0000001233318	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.0811989	0.0153647	0.0000001276565	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.221202	0.0420395	0.0000001442869	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.0433861	0.0082488	0.0000001463321	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-0.0452006	0.00859605	0.0000001474373	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.0433428	0.00824881	0.0000001505654	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0781597	0.0148824	0.0000001526973	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0885549	0.0168707	0.0000001550219	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24782431	chr18:21642931	18	21642931	TTC39C	Open sea	0.0432883	0.00824883	0.0000001560583	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.245265	0.046755	0.0000001573788	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.0452552	0.00865369	0.0000001722297	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0430792	0.00824891	0.0000001790213	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0430475	0.00824892	0.0000001827796	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24782431	chr18:21642931	18	21642931	TTC39C	Open sea	0.0429891	0.00824894	0.000000189884	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0428286	0.008249	0.0000002108567	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0772906	0.0148876	0.0000002112693	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0427069	0.00824904	0.00000022822	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0581592	0.0112469	0.0000002357632	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0426379	0.00824906	0.0000002386666	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0426318	0.00824907	0.0000002396229	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.0425731	0.00824909	0.0000002489072	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg12337761	chr18:21705593	18	21705593	TTC39C	Open sea	-0.1486802	0.0288374	0.0000002525	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.042513	0.00824911	0.0000002587795	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0493572	0.00957994	0.0000002608761	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03469660	chr18:21636266	18	21636266	TTC39C	Open sea	0.0424928	0.00824911	0.0000002621845	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0479033	0.00930353	0.0000002653519	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03469660	chr18:21636266	18	21636266	TTC39C	Open sea	0.0424304	0.00824914	0.0000002729655	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg25801517	chr18:21685889	18	21685889	TTC39C	Open sea	-0.223285	0.0434948	0.0000002843	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0423453	0.00824917	0.000000288378	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	1.8	0.35	0.00000029	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0423256	0.00824917	0.0000002920583	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0422332	0.0082492	0.0000003099397	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0672236	0.0131432	0.0000003182018	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0421842	0.00824922	0.0000003198568	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.1442308	0.0282525	0.0000003307	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0749042	0.0146895	0.0000003454144	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0492408	0.0096669	0.0000003553963	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0419674	0.0082493	0.0000003675047	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.0419377	0.00824931	0.0000003745437	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0417978	0.00824936	0.0000004094937	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0571119	0.0112767	0.0000004142035	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0473061	0.00934911	0.0000004244237	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0417275	0.00824938	0.0000004282233	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0416079	0.00824942	0.0000004619804	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.0415974	0.00824943	0.0000004650568	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24331475	chr18:21596915	18	21596915	TTC39C	South shore	-0.0627016	0.0124422	0.0000004725298	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0750628	0.0148958	0.0000004730258	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0740601	0.0147317	0.0000005034132	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06586496	chr18:21715307	18	21715307	TTC39C	North shelf	-0.0414196	0.00824949	0.0000005204259	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	0.0413726	0.0082495	0.0000005360825	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-0.0434744	0.00867	0.0000005383635	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0467168	0.00932009	0.0000005435702	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0683981	0.0136548	0.000000553287	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12972164	chr18:21695725	18	21695725	TTC39C	Open sea	-0.0413213	0.00824952	0.0000005536725	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	0.0412992	0.00824953	0.0000005614289	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0411834	0.00824957	0.0000006038493	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.0410689	0.00824961	0.000000648761	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20799816	chr18:21594185	18	21594185	TTC39C	Island	-0.000048	0.0000097	0.00000065	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0410319	0.00824962	0.0000006639701	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0409872	0.00824963	0.0000006828123	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-0.047	0.00947	0.0000007	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02449778	chr18:21693577	18	21693577	TTC39C	Open sea	-0.0409171	0.00824966	0.0000007133586	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.0408735	0.00824967	0.0000007330226	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.0407414	0.00824972	0.0000007958119	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.0407338	0.00824972	0.000000799611	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0474881	0.00962007	0.0000008047043	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0407124	0.00824973	0.000000810288	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0833302	0.0168857	0.0000008104466	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg06586496	chr18:21715307	18	21715307	TTC39C	North shelf	0.00203	0.00041	0.00000084	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0490705	0.00997829	0.0000008850525	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0405602	0.00824978	0.0000008904647	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg06878786	chr18:21693037	18	21693037	TTC39C	Open sea	-0.3488744	0.071023	0.0000009009	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0405223	0.00824979	0.0000009115908	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.0424997	0.00865246	0.0000009118501	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0405141	0.00824979	0.0000009162329	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0486453	0.00991105	0.0000009291081	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg24331475	chr18:21596915	18	21596915	TTC39C	South shore	-0.0041	0.0008	0.00000094	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0404698	0.00824981	0.0000009416971	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0476373	0.00971452	0.0000009504491	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	0.0404353	0.00824982	0.0000009619609	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0403858	0.00824984	0.000000991752	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0403627	0.00824984	0.000001006006	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0402181	0.00824989	0.000001099553	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.045531	0.00934101	0.000001103318	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	-0.0401338	0.00824992	0.000001157924	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.0401283	0.00824992	0.000001161802	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.072344	0.0148899	0.000001194541	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0400579	0.00824994	0.00000121297	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0400491	0.00824995	0.000001219525	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02449778	chr18:21693577	18	21693577	TTC39C	Open sea	0.273289	0.0563031	0.000001221246	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.0400368	0.00824995	0.000001228711	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.0421175	0.00868103	0.000001236852	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0399616	0.00824998	0.000001286518	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02449778	chr18:21693577	18	21693577	TTC39C	Open sea	-0.0401568	0.00829349	0.000001298741	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg20530339	chr18:21594203	18	21594203	TTC39C	Island	0.00148	0.0003	0.0000013	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.32447	0.0670772	0.000001316	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0399108	0.00824999	0.000001326978	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.0543062	0.0112308	0.000001341745	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.0398682	0.00825001	0.000001361903	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07205589	chr18:21597456	18	21597456	TTC39C	South shore	-0.0398464	0.00825001	0.0000013801	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0463034	0.00959654	0.000001414069	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.039792	0.00825003	0.000001426578	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0397918	0.00825003	0.000001426667	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0397566	0.00825004	0.000001457515	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.039756	0.00825004	0.000001458045	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0397494	0.00825005	0.00000146393	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-0.054	0.01115	0.0000015	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0397053	0.00825006	0.000001503634	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.0396935	0.00825006	0.000001514489	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0553272	0.0115103	0.000001549364	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_4
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.00080654	0.00016696	0.00000156	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0396076	0.00825009	0.000001595349	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0395322	0.00825012	0.000001669865	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0459965	0.00963114	0.000001807139	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0471291	0.00988679	0.000001889006	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07205589	chr18:21597456	18	21597456	TTC39C	South shore	-0.0392909	0.0082502	0.000001931175	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0392747	0.0082502	0.000001949984	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0459591	0.00965492	0.0000019527	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.039226	0.00825022	0.000002007853	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0806053	0.0169551	0.000002012909	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0459179	0.00965971	0.000002017738	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07205589	chr18:21597456	18	21597456	TTC39C	South shore	0.0391832	0.00825023	0.000002060097	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_1
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0055	0.0012	0.0000021	-	27651444_smoking_current_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0391187	0.00825025	0.000002141154	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0434368	0.00916702	0.000002174518	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.045512	0.00960965	0.000002199377	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0390475	0.00825027	0.000002234371	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0390442	0.00825028	0.000002238688	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0440966	0.00931954	0.000002247992	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg02449778	chr18:21693577	18	21693577	TTC39C	Open sea	-0.306779	0.0648428	0.000002249703	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0458747	0.00971858	0.000002376715	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03469660	chr18:21636266	18	21636266	TTC39C	Open sea	0.0389399	0.00825031	0.000002382479	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0388128	0.00825035	0.000002569544	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07205589	chr18:21597456	18	21597456	TTC39C	South shore	0.0387957	0.00825036	0.000002595785	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0387625	0.00825037	0.000002647498	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0387481	0.00825037	0.000002670209	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.00056157	0.00011922	0.0000028	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0386395	0.00825041	0.000002847534	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0698394	0.0149282	0.000002917862	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.0404766	0.00866718	0.000003037232	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0385183	0.00825044	0.000003059025	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03469660	chr18:21636266	18	21636266	TTC39C	Open sea	-0.0384996	0.00825045	0.000003092958	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0432624	0.00927355	0.000003111391	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_3
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg10902394	chr18:21692412	18	21692412	TTC39C	Open sea	-0.31674	0.067948	0.000003139	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.044811	0.00961892	0.000003211221	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17871682	chr18:21612339	18	21612339	TTC39C	Open sea	0.0384024	0.00825048	0.000003275162	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0481559	0.0103535	0.000003329341	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.0383741	0.00825049	0.000003330118	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0382225	0.00825054	0.000003639917	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0705757	0.0152391	0.000003666317	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.0382077	0.00825054	0.000003671505	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.14	0.0304	0.0000038	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.0381181	0.00825057	0.000003868994	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0380449	0.00825059	0.000004037851	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0429519	0.00931488	0.00000403912	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.0379522	0.00825062	0.000004261948	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0626233	0.0136302	0.000004374872	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0378969	0.00825064	0.00000440129	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.037896	0.00825064	0.000004403387	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0378876	0.00825064	0.000004425128	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0418446	0.0091257	0.000004569482	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0475416	0.0103709	0.000004596547	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_2
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg24331475	chr18:21596915	18	21596915	TTC39C	South shore	-0.3669864	0.0802148	0.000004761	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0438255	0.00958089	0.000004818077	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.259182	0.0566721	0.000004832725	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0688025	0.0150634	0.000004975123	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0665587	0.014586	0.000005078747	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0442325	0.00969758	0.000005127748	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24782431	chr18:21642931	18	21642931	TTC39C	Open sea	-0.037625	0.00825073	0.000005151748	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12972164	chr18:21695725	18	21695725	TTC39C	Open sea	0.0375993	0.00825073	0.00000522868	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0045	0.001	0.0000053	-	27651444_smoking_current_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0782143	0.0171774	0.000005323024	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.152169	0.0334626	0.000005467412	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.0375152	0.00825076	0.000005488395	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0434561	0.00957741	0.000005741527	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0497184	0.0109623	0.000005795043	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.0374094	0.00825079	0.000005832523	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.0374023	0.00825079	0.000005856199	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Inkster A	Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827	34044884	03-08-2021	Sex	PATO_0001894	Discovery	Supplementary Table 1	DNA methylation	Sex	Ancestry (genomic PCs), Gestational age, Dataset	M values	None	Illumina HumanMethylation450	Placenta	None	585	4	Infants	Both	European, East Asian, African, Admixed	cg07205589	chr18:21597456	18	21597456	TTC39C	South shore	3.6	None	0.0000059	None	34044884_Inkster-A_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	-0.0373883	0.0082508	0.000005903704	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0597446	0.0131916	0.000005973919	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07205589	chr18:21597456	18	21597456	TTC39C	South shore	-0.037339	0.00825081	0.000006072853	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0373323	0.00825082	0.00000609622	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0673263	0.0148829	0.000006123104	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg05805973	chr18:21594575	18	21594575	TTC39C	Island	0.00186	0.0004	0.0000062	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Inkster A	Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827	34044884	03-08-2021	Sex	PATO_0001894	Discovery	Supplementary Table 1	DNA methylation	Sex	Ancestry (genomic PCs), Gestational age, Dataset	M values	None	Illumina HumanMethylation450	Placenta	None	585	4	Infants	Both	European, East Asian, African, Admixed	cg24331475	chr18:21596915	18	21596915	TTC39C	South shore	3.5	None	0.0000062	None	34044884_Inkster-A_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.0372983	0.00825083	0.000006215966	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.076977	0.0170418	0.000006322406	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07205589	chr18:21597456	18	21597456	TTC39C	South shore	-0.0372661	0.00825084	0.000006331537	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.043346	0.00959991	0.000006373582	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0438015	0.00970578	0.000006443538	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0421487	0.00934228	0.000006483763	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0372116	0.00825085	0.000006532217	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12972164	chr18:21695725	18	21695725	TTC39C	Open sea	-0.0372116	0.00825085	0.000006532243	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.0664968	0.0147747	0.00000682451	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0673794	0.0149731	0.000006846866	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0437258	0.00972352	0.000006947769	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_3
Kazmi N	PACE	31230546	2019-06-24	Preeclampsia	EFO_0000668	Meta analysis unadjusted model	Table S5	DNA methylation	Preeclampsia	Cell composition (reference based), batch effects, age, smoking, parity, diabetes, body mass index, sex	Beta Values	None	Illumina HumanMethylation450	Cord blood	None	3460	6	Infants	Both	Unclear	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.0258	0.0057	0.000007	None	31230546_Kazmi-N_preeclampsia_meta_analysis_unadjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0370657	0.0082509	0.000007098914	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0420883	0.00937236	0.000007153639	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0691706	0.015404	0.000007162084	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0370486	0.0082509	0.000007168247	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0370405	0.00825091	0.00000720128	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg24331475	chr18:21596915	18	21596915	TTC39C	South shore	-0.00522	0.00116	0.0000073	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.0370043	0.00825092	0.000007351323	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.031	0.00686	0.0000074	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0430571	0.0096122	0.000007541109	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	-0.0369485	0.00825093	0.000007587827	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.0369444	0.00825093	0.000007605509	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0877967	0.0196201	0.000007704604	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0653378	0.0146163	0.000007872792	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0430037	0.00962929	0.000008031758	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0646529	0.0144833	0.000008105421	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg02449778	chr18:21693577	18	21693577	TTC39C	Open sea	0.052	0.01164	0.0000082	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.076125	0.017091	0.000008487001	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0685682	0.0153977	0.000008524605	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.247524	0.0556319	0.000008667891	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.069964	0.0157242	0.000008672742	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.210161	0.0472483	0.000008718311	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24782431	chr18:21642931	18	21642931	TTC39C	Open sea	-0.0366064	0.00825104	0.000009206597	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0425999	0.0096075	0.00000931604	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02449778	chr18:21693577	18	21693577	TTC39C	Open sea	0.250177	0.0564384	0.00000936125	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.0656052	0.014803	0.000009409709	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0649157	0.0146536	0.00000949061	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base plus BMI	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects, body mass index	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg06586496	chr18:21715307	18	21715307	TTC39C	North shelf	-1.96	0.44	0.0000097	4808	31197173_Liu-J_fasting_glucose_base_plus_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0759333	0.0171735	0.00000987035	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0363985	0.0082511	0.00001034569	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0411462	0.00932748	0.00001034906	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0409606	0.00929297	0.00001052202	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24782431	chr18:21642931	18	21642931	TTC39C	Open sea	-0.039154	0.0088866	0.00001060645	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17871682	chr18:21612339	18	21612339	TTC39C	Open sea	-0.0363215	0.00825112	0.00001080106	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg20530339	chr18:21594203	18	21594203	TTC39C	Island	-0.000021	0.0000048	0.000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.036254	0.00825114	0.00001121576	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0646137	0.014706	0.00001122294	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.050522	0.011519	0.00001162756	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0361662	0.00825117	0.00001177862	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.0361248	0.00825118	0.00001205244	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0420617	0.00961347	0.00001221107	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0420336	0.0096271	0.00001273086	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0451401	0.0103403	0.00001277263	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.036019	0.00825121	0.00001278175	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0360002	0.00825122	0.0000129159	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0657553	0.0150804	0.00001307558	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	0.0359672	0.00825123	0.00001315443	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0429575	0.00986299	0.00001337148	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0422029	0.00969504	0.00001351733	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0358917	0.00825125	0.00001371537	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04308838	chr18:21651322	18	21651322	TTC39C	Open sea	-0.0358736	0.00825126	0.00001385264	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0358474	0.00825126	0.00001405465	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0358468	0.00825126	0.00001405922	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.0357713	0.00825129	0.0000146575	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0419907	0.00969984	0.00001507735	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0419228	0.00968725	0.00001517218	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.0375892	0.00868755	0.00001522988	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg06586496	chr18:21715307	18	21715307	TTC39C	North shelf	0.861093	0.1991	0.0000153	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.0489336	0.0113228	0.0000155856	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0705209	0.0163267	0.00001575185	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.0356272	0.00825133	0.0000158659	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PTGR2 protein levels (SeqId = 18943-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PTGR2 protein levels (SeqId = 18943-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Prostaglandin reductase 2	774	1	Adults (18-65 years)	Both	European	cg01465361	chr18:21594964	18	21594964	TTC39C	Island	-0.93	0.216	0.000016	None	Gadd-DA_ptgr2_protein_levels__seqid___18943-4__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.0498589	0.0115585	0.0000161648	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.035572	0.00825135	0.00001635389	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.0355203	0.00825136	0.00001682316	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.0636953	0.0147971	0.00001683798	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0355102	0.00825136	0.00001691649	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07205589	chr18:21597456	18	21597456	TTC39C	South shore	0.0354624	0.00825138	0.00001736461	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06586496	chr18:21715307	18	21715307	TTC39C	North shelf	-0.0043	0.001	0.000018	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0637678	0.0148729	0.00001818354	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0629512	0.0147123	0.00001890861	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.23676	0.0553472	0.00001897783	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24331475	chr18:21596915	18	21596915	TTC39C	South shore	-0.0352103	0.00825145	0.00001992203	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.138585	0.0324857	0.00001999637	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.049307	0.0115573	0.00001999888	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.049214	0.0115488	0.00002044254	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0410542	0.00963848	0.0000206253	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0441476	0.010367	0.00002071154	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.0490932	0.011532	0.00002083456	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43251	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43251	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0351257	0.00825148	0.00002085692	P43251	41361833_Josephine_Robertson_P43251_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TNFSF4 protein levels (SeqId = 2839-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNFSF4 protein levels (SeqId = 2839-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tumor necrosis factor ligand superfamily member 4	774	1	Adults (18-65 years)	Both	European	cg01465361	chr18:21594964	18	21594964	TTC39C	Island	-0.92	0.216	0.000021	None	Gadd-DA_tnfsf4_protein_levels__seqid___2839-2__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CBX3 protein levels (SeqId = 18868-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CBX3 protein levels (SeqId = 18868-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Chromobox protein homolog 3	774	1	Adults (18-65 years)	Both	European	cg01465361	chr18:21594964	18	21594964	TTC39C	Island	-0.92	0.215	0.000021	None	Gadd-DA_cbx3_protein_levels__seqid___18868-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0351114	0.00825148	0.00002101977	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.0485264	0.0114125	0.00002131301	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0632247	0.0148711	0.00002136531	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0716257	0.0168515	0.00002147077	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	-0.0350329	0.0082515	0.00002193151	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.058	0.01362	0.000022	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0564412	0.0132998	0.00002211546	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.0367704	0.00867785	0.00002276393	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.0349341	0.00825153	0.00002313276	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0349309	0.00825153	0.00002317297	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01009	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01009	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0349171	0.00825154	0.00002334565	P01009	41361833_Josephine_Robertson_P01009_OSCA_model_1
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg20742075	chr18:21669758	18	21669758	TTC39C	Open sea	-0.2939362	0.0695292	0.00002363	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.0348646	0.00825155	0.00002401469	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17871682	chr18:21612339	18	21612339	TTC39C	Open sea	-0.0348284	0.00825156	0.00002448693	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02449778	chr18:21693577	18	21693577	TTC39C	Open sea	0.034822	0.00825156	0.00002457191	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	RUNX3 protein levels (SeqId = 11138-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RUNX3 protein levels (SeqId = 11138-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Runt-related transcription factor 3	774	1	Adults (18-65 years)	Both	European	cg01465361	chr18:21594964	18	21594964	TTC39C	Island	-0.91	0.215	0.000026	None	Gadd-DA_runx3_protein_levels__seqid___11138-16__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PACAP protein levels (SeqId = 16322-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PACAP protein levels (SeqId = 16322-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Marginal zone B- and B1-cell-specific protein	774	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-1.45	0.344	0.000026	None	Gadd-DA_pacap_protein_levels__seqid___16322-10__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	-0.0346484	0.00825161	0.00002696959	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07205589	chr18:21597456	18	21597456	TTC39C	South shore	0.0346466	0.00825161	0.00002699571	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0346452	0.00825161	0.00002701583	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.034609	0.00825163	0.00002754379	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18429646	chr18:21594021	18	21594021	TTC39C	Island	-0.00021	0.000051	0.000028	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0345191	0.00825165	0.00002889793	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.135561	0.032409	0.00002892803	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.0344778	0.00825166	0.00002954149	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.0478035	0.0114491	0.00002992875	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.0018	None	0.00003	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	0.0425926	0.0102035	0.00003006293	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0344377	0.00825167	0.00003017849	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0642345	0.0153951	0.00003031284	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.034419	0.00825168	0.00003048146	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	-0.0473858	0.0113651	0.00003071172	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-0.0343668	0.00825169	0.00003133867	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.856852	0.2059	0.0000316	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0428971	0.010326	0.00003281957	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0342776	0.00825172	0.00003285786	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16441133	chr18:21595161	18	21595161	TTC39C	Island	0.0014	0.00033	0.000033	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0555718	0.0133834	0.00003310371	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0477024	0.01149	0.00003319616	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24782431	chr18:21642931	18	21642931	TTC39C	Open sea	0.034254	0.00825173	0.00003326978	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.0342523	0.00825173	0.00003330077	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0342077	0.00825174	0.000034095	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0617641	0.0149014	0.00003419302	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.0557879	0.0134718	0.00003475874	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24782431	chr18:21642931	18	21642931	TTC39C	Open sea	0.0341541	0.00825175	0.00003507517	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.196884	0.047596	0.00003542132	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0341078	0.00825177	0.00003594351	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0340968	0.00825177	0.0000361519	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0340608	0.00825178	0.00003684407	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	IGFLR1 protein levels (SeqId = 7244-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IGFLR1 protein levels (SeqId = 7244-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: IGF-like family receptor 1	774	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.98	0.237	0.000037	None	Gadd-DA_igflr1_protein_levels__seqid___7244-16__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CAMP protein levels (SeqId = 9384-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CAMP protein levels (SeqId = 9384-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cathelicidin antimicrobial peptide	774	1	Adults (18-65 years)	Both	European	cg03438346	chr18:21692621	18	21692621	TTC39C	Open sea	-0.67	0.162	0.000037	None	Gadd-DA_camp_protein_levels__seqid___9384-17__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0602805	0.0146316	0.00003811465	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg20563827	chr18:21686208	18	21686208	TTC39C	Open sea	0.175902	0.0427812	0.00003946314	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0339071	0.00825182	0.00003994546	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	STARD5 protein levels (SeqId = 17383-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STARD5 protein levels (SeqId = 17383-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: StAR-related lipid transfer protein 5	774	1	Adults (18-65 years)	Both	European	cg01465361	chr18:21594964	18	21594964	TTC39C	Island	-0.881	0.214	0.00004	None	Gadd-DA_stard5_protein_levels__seqid___17383-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	THPO protein levels (SeqId = 5947-90)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	THPO protein levels (SeqId = 5947-90)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thrombopoietin	774	1	Adults (18-65 years)	Both	European	cg01465361	chr18:21594964	18	21594964	TTC39C	Island	-0.89	0.216	0.00004	None	Gadd-DA_thpo_protein_levels__seqid___5947-90__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25359467	chr18:21606798	18	21606798	TTC39C	Open sea	0.0336536	0.00819177	0.00004008948	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.069931	0.0170232	0.00004012986	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0611173	0.0148885	0.00004064946	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24782431	chr18:21642931	18	21642931	TTC39C	Open sea	0.0338561	0.00825184	0.00004102843	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.0548081	0.0133702	0.00004166831	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0608745	0.0148669	0.00004251224	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0337843	0.00825186	0.00004259935	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0421343	0.0102921	0.00004265176	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0337616	0.00825186	0.00004310965	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0371997	0.00909577	0.00004340788	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.0546841	0.0133717	0.00004345405	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.0422935	0.010344	0.00004360779	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P22792	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P22792	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.0381352	0.00933147	0.00004398194	P22792	41361833_Josephine_Robertson_P22792_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24782431	chr18:21642931	18	21642931	TTC39C	Open sea	0.0337055	0.00825188	0.00004439144	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0337044	0.00825188	0.000044415	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.186793	0.0457682	0.00004497758	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Battram T	GEO	23334450	2020-09-15	Rheumatoid arthritis	EFO_0000685	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE42861	None	DNA methylation	Rheumatoid arthritis	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	689	1	Adults	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	0.0105	0.00255	0.000045	None	23334450_Battram-T_rheumatoid_arthritis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse42861
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.0353689	0.00866915	0.00004530025	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	-0.0620372	0.015211	0.00004557585	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12972164	chr18:21695725	18	21695725	TTC39C	Open sea	0.0336424	0.0082519	0.00004587441	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.068902	0.016903	0.00004599511	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0335696	0.00825192	0.00004764714	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.0335431	0.00825193	0.00004830645	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0378443	0.00931487	0.00004874454	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg20799816	chr18:21594185	18	21594185	TTC39C	Island	0.00153	0.00037	0.000049	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.0350829	0.00864285	0.00004950082	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0334701	0.00825195	0.00005017211	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0334494	0.00825195	0.000050714	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12972164	chr18:21695725	18	21695725	TTC39C	Open sea	-0.0317964	0.00784427	0.0000507269	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0551035	0.0135973	0.0000509279	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0334412	0.00825195	0.00005093025	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SGK3 protein levels (SeqId = 10042-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SGK3 protein levels (SeqId = 10042-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine/threonine-protein kinase Sgk3	774	1	Adults (18-65 years)	Both	European	cg01465361	chr18:21594964	18	21594964	TTC39C	Island	-0.873	0.215	0.000051	None	Gadd-DA_sgk3_protein_levels__seqid___10042-8__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.0405986	0.0100195	0.00005105132	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12972164	chr18:21695725	18	21695725	TTC39C	Open sea	-0.033432	0.00825196	0.00005117472	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04308838	chr18:21651322	18	21651322	TTC39C	Open sea	0.033431	0.00825196	0.00005119938	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-0.0351108	0.00867445	0.00005201024	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0667077	0.0164912	0.00005257835	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-0.0333795	0.00825197	0.00005258459	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.0417196	0.0103217	0.00005328452	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0597192	0.0147887	0.00005414785	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24782431	chr18:21642931	18	21642931	TTC39C	Open sea	-0.0357219	0.00884657	0.00005419629	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.0333016	0.00825199	0.00005474445	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.033276	0.008252	0.00005547096	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0551614	0.0136841	0.00005580555	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_4
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg06586496	chr18:21715307	18	21715307	TTC39C	North shelf	0.143868	0.0357	0.0000559	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.0332588	0.008252	0.00005596413	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0332419	0.00825201	0.00005645613	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_1
Inkster A	Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827	34044884	03-08-2021	Sex	PATO_0001894	Discovery	Supplementary Table 1	DNA methylation	Sex	Ancestry (genomic PCs), Gestational age, Dataset	M values	None	Illumina HumanMethylation450	Placenta	None	585	4	Infants	Both	European, East Asian, African, Admixed	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	1.4	None	0.000057	None	34044884_Inkster-A_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.0603707	0.0149997	0.00005731313	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	WDR5 protein levels (SeqId = 17760-128)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	WDR5 protein levels (SeqId = 17760-128)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: WD repeat-containing protein 5	774	1	Adults (18-65 years)	Both	European	cg01465361	chr18:21594964	18	21594964	TTC39C	Island	-0.87	0.216	0.000059	None	Gadd-DA_wdr5_protein_levels__seqid___17760-128__somascan_protein_measurement
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg06586496	chr18:21715307	18	21715307	TTC39C	North shelf	0.0019	5e-04	0.000059	-	27651444_smoking_current_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0593972	0.0147911	0.00005955666	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07357	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07357	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06878786	chr18:21693037	18	21693037	TTC39C	Open sea	-0.0331244	0.00825204	0.0000599747	P07357	41361833_Josephine_Robertson_P07357_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0596757	0.0148694	0.0000601666	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0330974	0.00825205	0.00006081077	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age*sex	PATO_0000047,EFO_0000246	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	age*sex	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.001	0.00025	0.000061	None	33450751_Mulder-RH_age_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0330772	0.00825205	0.00006144573	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.0330616	0.00825206	0.00006193819	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0329571	0.00825209	0.00006534291	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0401028	0.0100423	0.00006545349	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	-0.0329496	0.00825209	0.00006559352	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0614753	0.015399	0.00006579639	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	TPSG1 protein levels (SeqId = 3404-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TPSG1 protein levels (SeqId = 3404-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tryptase gamma	774	1	Adults (18-65 years)	Both	European	cg01465361	chr18:21594964	18	21594964	TTC39C	Island	-0.86	0.215	0.000066	None	Gadd-DA_tpsg1_protein_levels__seqid___3404-51__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0329314	0.00825209	0.0000662082	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	-0.0329245	0.0082521	0.00006644143	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0329208	0.0082521	0.0000665659	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.0329123	0.0082521	0.0000668557	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TREM1 protein levels (SeqId = 9266-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TREM1 protein levels (SeqId = 9266-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Triggering receptor expressed on myeloid cells 1	774	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.95	0.237	0.000067	None	Gadd-DA_trem1_protein_levels__seqid___9266-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0328795	0.00825211	0.00006798572	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	0.0328778	0.00825211	0.00006804524	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.0455413	0.0114461	0.00006960974	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	-0.0382945	0.00963284	0.00007059492	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0606645	0.0152608	0.00007066505	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0327943	0.00825213	0.00007100174	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-0.03446	0.00867385	0.00007135561	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01009	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01009	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.0327654	0.00825214	0.00007205318	P01009	41361833_Josephine_Robertson_P01009_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18719665	chr18:21572656	18	21572656	TTC39C	Open sea	0.032755	0.00825214	0.00007243404	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	0.0569377	0.0143452	0.00007248568	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	-0.0394195	0.00993319	0.00007268282	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Colorectal Cancer	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Colorectal Cancer	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14297	1	Adults (18-65y)	Both	European	cg20563827	chr18:21686208	18	21686208	TTC39C	Open sea	0.016	0.00408	0.000073	None	Robert-F-Hillary_Incident_Colorectal_Cancer_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.053554	0.013499	0.00007305086	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	0.0327269	0.00825215	0.00007347841	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q14520	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q14520	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	0.0628699	0.0158575	0.00007384424	Q14520	41361833_Josephine_Robertson_Q14520_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07205589	chr18:21597456	18	21597456	TTC39C	South shore	-0.0349593	0.00881779	0.00007385716	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05401069	chr18:21572634	18	21572634	TTC39C	Open sea	0.0610437	0.0153972	0.00007386809	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CXCL14 protein levels (SeqId = 5730-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXCL14 protein levels (SeqId = 5730-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-X-C motif chemokine 14	774	1	Adults (18-65 years)	Both	European	cg01465361	chr18:21594964	18	21594964	TTC39C	Island	-0.85	0.215	0.000075	None	Gadd-DA_cxcl14_protein_levels__seqid___5730-60__somascan_protein_measurement
Fragoso-Bargas Nicolas	EPIPREG (Epigenetics in pregnancy)	39844050	Jan 22, 2025	Sedentary behaviour	EFO:0000001	discovery (stp adjusted)	None	DNA methylation	Sedentary behaviour	Age,Smoking,Cell composition (reference based)	M values	hours/day	Illumina HumanMethylationEPIC	Whole blood	analysis of pregnant women (gestational week 28)	353	1	Adults (18-65 years)	Females	European,South Asian	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.019742489	0.004927973	0.0000758	None	39844050_Fragoso-Bargas-Nicolas_sedentary_behaviour_discovery_(stp_adjusted)
Gadd DA	Generation Scotland	35945220	31/07/2022	SYN3 protein levels (SeqId = 7199-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SYN3 protein levels (SeqId = 7199-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Synapsin-3	774	1	Adults (18-65 years)	Both	European	cg01465361	chr18:21594964	18	21594964	TTC39C	Island	-0.85	0.215	0.000077	None	Gadd-DA_syn3_protein_levels__seqid___7199-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07357	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07357	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06878786	chr18:21693037	18	21693037	TTC39C	Open sea	-0.0327315	0.00827707	0.00007706384	P07357	41361833_Josephine_Robertson_P07357_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	SSU72 protein levels (SeqId = 13566-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SSU72 protein levels (SeqId = 13566-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: RNA polymerase II subunit A C-terminal domain phosphatase SSU72	774	1	Adults (18-65 years)	Both	European	cg16441133	chr18:21595161	18	21595161	TTC39C	Island	0.32	0.081	0.000078	None	Gadd-DA_ssu72_protein_levels__seqid___13566-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0378666	0.00959332	0.00007944671	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07357	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07357	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06878786	chr18:21693037	18	21693037	TTC39C	Open sea	-0.0326329	0.00827666	0.00008092195	P07357	41361833_Josephine_Robertson_P07357_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.032489	0.00825221	0.00008288742	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg27600766	chr18:21594250	18	21594250	TTC39C	Island	0.00475	0.00118	0.000083	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0570535	0.0144994	0.00008362202	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.224455	0.0570485	0.00008370783	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Gadd DA	Generation Scotland	35945220	31/07/2022	STAU2 protein levels (SeqId = 12970-35)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STAU2 protein levels (SeqId = 12970-35)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Double-stranded RNA-binding protein Staufen homolog 2	774	1	Adults (18-65 years)	Both	European	cg01465361	chr18:21594964	18	21594964	TTC39C	Island	-0.85	0.215	0.000084	None	Gadd-DA_stau2_protein_levels__seqid___12970-35__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CHST14 protein levels (SeqId = 7262-191)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CHST14 protein levels (SeqId = 7262-191)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Carbohydrate sulfotransferase 14	774	1	Adults (18-65 years)	Both	European	cg01465361	chr18:21594964	18	21594964	TTC39C	Island	-0.85	0.216	0.000084	None	Gadd-DA_chst14_protein_levels__seqid___7262-191__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FOLR2 protein levels (SeqId = 15587-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FOLR2 protein levels (SeqId = 15587-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Folate receptor beta	774	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.93	0.237	0.000084	None	Gadd-DA_folr2_protein_levels__seqid___15587-20__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0324524	0.00825222	0.00008443158	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1
Inkster A	Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827	34044884	03-08-2021	Sex	PATO_0001894	Discovery	Supplementary Table 1	DNA methylation	Sex	Ancestry (genomic PCs), Gestational age, Dataset	M values	None	Illumina HumanMethylation450	Placenta	None	585	4	Infants	Both	European, East Asian, African, Admixed	cg00287012	chr18:21593174	18	21593174	TTC39C	North shore	1.1	None	0.000085	None	34044884_Inkster-A_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.0324367	0.00825223	0.0000851011	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	0.033997	0.00866227	0.00008722629	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-0.0323813	0.00825224	0.00008751127	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	-0.182343	0.0464746	0.00008759148	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0323776	0.00825224	0.00008767399	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	XRCC6 protein levels (SeqId = 2835-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	XRCC6 protein levels (SeqId = 2835-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: X-ray repair cross-complementing protein 6	774	1	Adults (18-65 years)	Both	European	cg01465361	chr18:21594964	18	21594964	TTC39C	Island	-0.84	0.215	0.000088	None	Gadd-DA_xrcc6_protein_levels__seqid___2835-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HNRNPAB protein levels (SeqId = 8894-80)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HNRNPAB protein levels (SeqId = 8894-80)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Heterogeneous nuclear ribonucleoprotein A/B	774	1	Adults (18-65 years)	Both	European	cg01465361	chr18:21594964	18	21594964	TTC39C	Island	-0.84	0.214	0.000088	None	Gadd-DA_hnrnpab_protein_levels__seqid___8894-80__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg24331475	chr18:21596915	18	21596915	TTC39C	South shore	-0.0488141	0.0124456	0.00008814309	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17205313	chr18:21572748	18	21572748	TTC39C	Open sea	-0.0525336	0.0134046	0.00008929756	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	-0.0373374	0.00952824	0.0000894668	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22330625	chr18:21597505	18	21597505	TTC39C	South shelf	-0.032337	0.00825225	0.00008948248	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg27166860	chr18:21594461	18	21594461	TTC39C	Island	0.164237	0.0419	0.0000897	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0323294	0.00825226	0.00008982612	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27399348	chr18:21572366	18	21572366	TTC39C	Open sea	0.0530048	0.0135303	0.00008987943	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26719867	chr18:21683463	18	21683463	TTC39C	Open sea	0.0323255	0.00825226	0.00009000041	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0637488	0.0162915	0.00009155983	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0451972	0.0115607	0.00009288141	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_4
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg07205589	chr18:21597456	18	21597456	TTC39C	South shore	1.32	0.34	0.000093	4807	31197173_Liu-J_fasting_glucose_base
Gadd DA	Generation Scotland	35945220	31/07/2022	CEACAM8 protein levels (SeqId = 18873-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CEACAM8 protein levels (SeqId = 18873-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Carcinoembryonic antigen-related cell adhesion molecule 8	774	1	Adults (18-65 years)	Both	European	cg03438346	chr18:21692621	18	21692621	TTC39C	Open sea	-0.64	0.164	0.000094	None	Gadd-DA_ceacam8_protein_levels__seqid___18873-8__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg08471447	chr18:21634257	18	21634257	TTC39C	Open sea	-0.0322296	0.00825228	0.00009443598	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12639429	chr18:21572622	18	21572622	TTC39C	Open sea	-0.0322172	0.00825229	0.00009502727	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	FBXL4 protein levels (SeqId = 9951-36)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FBXL4 protein levels (SeqId = 9951-36)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: F-box/LRR-repeat protein 4	774	1	Adults (18-65 years)	Both	European	cg01465361	chr18:21594964	18	21594964	TTC39C	Island	-0.84	0.216	0.000096	None	Gadd-DA_fbxl4_protein_levels__seqid___9951-36__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0321865	0.00825229	0.00009649999	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg06586496	chr18:21715307	18	21715307	TTC39C	North shelf	-1.76	0.45	0.000097	4808	31197173_Liu-J_fasting_glucose_base
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	-0.0321654	0.0082523	0.00009752105	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg25952192	chr18:21656374	18	21656374	TTC39C	Open sea	-0.0321637	0.0082523	0.00009760719	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04754304	chr18:21693298	18	21693298	TTC39C	Open sea	-0.0339009	0.00870192	0.00009831229	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18334660	chr18:21590132	18	21590132	TTC39C	North shelf	0.0321373	0.00825231	0.00009890006	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18697351	chr18:21693242	18	21693242	TTC39C	Open sea	0.0321185	0.00825231	0.00009983347	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1