author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0043 0.00029 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.026 0.0018 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03762817 chr14:71107039 14 71107039 TTC9 North shore -0.0036 0.00028 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore -0.004 0.00021 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.015 0.0013 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13244312 chr14:71109707 14 71109707 TTC9 South shore -0.003 0.00024 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13244312 chr14:71109707 14 71109707 TTC9 South shore 0.015 0.0015 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg04176452 chr14:71131956 14 71131956 TTC9 Open sea 0.3229 0.00866 4.2e-90 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.19798 0.0077 3.2e-64 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg13244312 chr14:71109707 14 71109707 TTC9 South shore -0.18819 0.00733 3.5e-64 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.23881 0.00965 9e-62 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg04176452 chr14:71131956 14 71131956 TTC9 Open sea - - 3.88e-50 - 23526956_clear_cell_renal_carcinoma Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.106783 0.00820936 1.811702e-38 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg13244312 chr14:71109707 14 71109707 TTC9 South shore - - 2.25e-32 - 28056824_age_4_vs_age_0 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0942544 0.00821981 2.609634e-30 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg13244312 chr14:71109707 14 71109707 TTC9 South shore -1.4691 0.08953 2.28e-28 - 25282492_fetal_vs_adult_liver Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0879151 0.0082246 1.43101e-26 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg23691406 chr14:71112909 14 71112909 TTC9 South shelf 0.0022 None 2.8e-26 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0853577 0.00822644 3.894388e-25 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0820887 0.00822871 2.3066700000000002e-23 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0795998 0.00823037 4.63898e-22 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg26937852 chr14:71114333 14 71114333 TTC9 Open sea -0.02207 0.00202 5.9e-22 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.0782592 0.00823125 2.2486999999999998e-21 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg03762817 chr14:71107039 14 71107039 TTC9 North shore -0.05962 0.0057 1.4e-20 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea -0.0751296 0.00823324 8.080301e-20 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0716362 0.00823536 3.712305e-18 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea -0.0708757 0.00823581 8.339443e-18 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0902047 0.0105719 1.570675e-17 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.0681408 0.00823738 1.428029e-16 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.067578 0.0082377 2.527223e-16 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.0671798 0.00823792 3.774309e-16 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11812810 chr14:71107693 14 71107693 TTC9 North shore 0.0018 None 0.0000000000000015 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore -0.0652726 0.00823896 0.000000000000002495713 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19839909 chr14:71113592 14 71113592 TTC9 Open sea 0.0637297 0.00823979 0.00000000000001106463 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0634647 0.00823993 0.00000000000001423876 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0634012 0.00823996 0.00000000000001512371 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0627795 0.00824028 0.0000000000000272071 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0625637 0.0082404 0.00000000000003331528 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0797034 0.0105307 0.00000000000003994111 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0791035 0.010557 0.00000000000007117973 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.061432 0.00824098 0.00000000000009527855 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3570556 (gene symbol: MED6) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3570556 (gene symbol: MED6) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg08280368 chr14:71110536 14 71110536 TTC9 South shore None None 0.00000000000014 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3570556__gene_symbol__med6__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea -0.060813 0.00824129 0.0000000000001679626 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04536689 chr14:71108024 14 71108024 TTC9 Island 0.0015 None 0.0000000000002 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0590632 0.00824216 0.0000000000008090849 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.31393 0.0442 0.00000000000129 - 25650246_gestational_age Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg08280368 chr14:71110536 14 71110536 TTC9 South shore -0.00924 0.0013 0.0000000000014 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3570556 (gene symbol: MED6) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3570556 (gene symbol: MED6) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg13244312 chr14:71109707 14 71109707 TTC9 South shore None None 0.0000000000026 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3570556__gene_symbol__med6__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19839909 chr14:71113592 14 71113592 TTC9 Open sea -0.0667433 0.00955517 0.000000000002970149 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19839909 chr14:71113592 14 71113592 TTC9 Open sea -0.0658819 0.00957533 0.000000000006211348 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19839909 chr14:71113592 14 71113592 TTC9 Open sea -0.065279 0.00955948 0.000000000008904576 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.00099486 0.00014599 0.0000000000158 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore -0.1752131 0.0262721 0.00000000002573 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.0549526 0.0082441 0.0000000000272827 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 TTC9B protein levels (SeqId = 9386-42) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TTC9B protein levels (SeqId = 9386-42) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tetratricopeptide repeat protein 9B 774 1 Adults (18-65 years) Both European cg13244312 chr14:71109707 14 71109707 TTC9 South shore -0.56 0.084 0.000000000028 None Gadd-DA_ttc9b_protein_levels__seqid___9386-42__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19839909 chr14:71113592 14 71113592 TTC9 Open sea -0.0636071 0.00957403 0.00000000003166686 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_3 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3570556 (gene symbol: MED6) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3570556 (gene symbol: MED6) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg01634544 chr14:71128147 14 71128147 TTC9 Open sea None None 0.000000000035 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3570556__gene_symbol__med6__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0545293 0.00824429 0.00000000003865302 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04905775 chr14:71109040 14 71109040 TTC9 Island 0.00056 0.000084 0.000000000043 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0543827 0.00824435 0.00000000004358125 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore -0.0535975 0.0082447 0.0000000000824557 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea -0.052818 0.00824505 0.0000000001539105 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0527773 0.00824506 0.00000000015897 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0524267 0.00824522 0.0000000002098441 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0672635 0.0105927 0.0000000002217006 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0518596 0.00824546 0.0000000003275736 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 TTC9B protein levels (SeqId = 9386-42) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TTC9B protein levels (SeqId = 9386-42) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tetratricopeptide repeat protein 9B 774 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.97 0.154 0.00000000035 None Gadd-DA_ttc9b_protein_levels__seqid___9386-42__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0511666 0.00824576 0.0000000005609313 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0655688 0.0105713 0.0000000005705109 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0656198 0.0105814 0.0000000005744852 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19839909 chr14:71113592 14 71113592 TTC9 Open sea -0.0510944 0.00824579 0.0000000005930158 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_1 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg01080375 chr14:71109264 14 71109264 TTC9 Island 0.00681 0.0011 0.000000000681 - 23334450_rheumatoid_arthritis Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.210692 0.0341931 0.0000000007349759 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0507804 0.00824592 0.0000000007547436 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0502128 0.00824616 0.00000000116282 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0501554 0.00824618 0.000000001214445 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03199903 chr14:71122637 14 71122637 TTC9 Open sea 0.0500242 0.00824623 0.000000001341015 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore -0.0500102 0.00824624 0.000000001355209 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Zeilinger S - 23691101 2013-05-17 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking discovery Table S1 DNA methylation Smoking Age, sex, body mass index, alcohol consumption and cell counts M values - Illumina HumanMethylation450 Whole blood - 1011 1 60.8 Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore - - 0.00000000136 - 23691101_smoking_current_vs_never_smoking_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09168785 chr14:71123414 14 71123414 TTC9 Open sea -0.0499291 0.00824627 0.000000001440672 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg10392721 chr14:71107931 14 71107931 TTC9 North shore 0.00067 None 0.0000000016 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19839909 chr14:71113592 14 71113592 TTC9 Open sea 0.0492035 0.00824657 0.000000002479171 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0491772 0.00824658 0.000000002528113 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.048741 0.00824676 0.000000003490232 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg17498102 chr14:71108199 14 71108199 TTC9 Island 0.0028 0.00049 0.0000000051 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 1.3 0.216 0.0000000051 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.200322 0.0342751 0.000000005171383 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea 0.0480034 0.00824705 0.000000005983675 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03762817 chr14:71107039 14 71107039 TTC9 North shore -0.0484941 0.00836276 0.000000006816204 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.0477909 0.00824714 0.000000006978897 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg04905775 chr14:71109040 14 71109040 TTC9 Island 0.0032 0.00055 0.0000000072 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0477358 0.00824716 0.000000007262175 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 TTC9B protein levels (SeqId = 9386-42) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TTC9B protein levels (SeqId = 9386-42) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tetratricopeptide repeat protein 9B 774 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore -0.68 0.119 0.00000001 None Gadd-DA_ttc9b_protein_levels__seqid___9386-42__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0471248 0.0082474 0.00000001125616 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0470994 0.00824741 0.00000001146204 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13244312 chr14:71109707 14 71109707 TTC9 South shore -0.0469143 0.00824748 0.00000001307466 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09168785 chr14:71123414 14 71123414 TTC9 Open sea -0.0468397 0.00824751 0.00000001378446 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03762817 chr14:71107039 14 71107039 TTC9 North shore -0.0467966 0.00824753 0.00000001421246 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04176452 chr14:71131956 14 71131956 TTC9 Open sea -0.0467428 0.00824755 0.00000001476393 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0466676 0.00824758 0.00000001556981 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19839909 chr14:71113592 14 71113592 TTC9 Open sea 0.0464734 0.00824765 0.00000001785438 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Li S - 28811542 2017-08-15 Age EFO_0000246 - Table S1 DNA methylation Age Cell counts M values years Illumina HumanMethylation450 Whole blood - 1366 2 73 Missing European cg03762817 chr14:71107039 14 71107039 TTC9 North shore -0.0253 0.00459375 0.0000000182 - 28811542_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0464259 0.00824767 0.00000001846082 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03762817 chr14:71107039 14 71107039 TTC9 North shore -0.0465672 0.00830718 0.00000002112085 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg01634544 chr14:71128147 14 71128147 TTC9 Open sea None None 0.000000022 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0460801 0.0082478 0.00000002351906 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0457839 0.00824791 0.00000002890139 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0583055 0.0105646 0.00000003468586 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0560563 0.0101885 0.00000003820259 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 TTC9B protein levels (SeqId = 9386-42) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TTC9B protein levels (SeqId = 9386-42) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tetratricopeptide repeat protein 9B 774 1 Adults (18-65 years) Both European cg03199903 chr14:71122637 14 71122637 TTC9 Open sea -0.5 0.091 0.00000004 None Gadd-DA_ttc9b_protein_levels__seqid___9386-42__somascan_protein_measurement Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg17498102 chr14:71108199 14 71108199 TTC9 Island 0.162334 0.0296234 0.00000004311682 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Kyung WK None 32795589 11-08-2020 atopy EFO_0002686 discovery Table E4 DNA methylation atopy None Beta values None Illumina HumanMethylationEPIC nasal polyp None 108 1 Adults Both East Asian cg27232014 chr14:71136523 14 71136523 TTC9 Open sea 0.017 0.0029 0.000000046 None 32795589_Kyung-WK_atopy_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09168785 chr14:71123414 14 71123414 TTC9 Open sea -0.044896 0.00824825 0.00000005320225 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0574821 0.0105913 0.00000005812116 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.044529 0.00824838 0.000000068242 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.044415 0.00824842 0.00000007369682 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.182937 0.0341756 0.00000008767606 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Gadd DA Generation Scotland 35945220 31/07/2022 TTC9B protein levels (SeqId = 9386-42) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TTC9B protein levels (SeqId = 9386-42) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tetratricopeptide repeat protein 9B 774 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea -0.72 0.135 0.000000093 None Gadd-DA_ttc9b_protein_levels__seqid___9386-42__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore -0.0439266 0.0082486 0.0000001022498 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0438365 0.00824863 0.0000001085755 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14929883 chr14:71140452 14 71140452 TTC9 Open sea -0.00918 0.00166 0.00000011 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0563505 0.0106123 0.000000111283 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0437045 0.00824868 0.0000001185376 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.0434444 0.00824878 0.0000001408098 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0551176 0.010489 0.0000001502475 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea 0.0433438 0.00824881 0.0000001504672 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03199903 chr14:71122637 14 71122637 TTC9 Open sea 0.0432802 0.00824883 0.0000001568999 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03199903 chr14:71122637 14 71122637 TTC9 Open sea -0.0431508 0.00824888 0.0000001708093 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.155489 0.0297758 0.0000001790717 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea -0.042977 0.00824894 0.0000001913972 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.0428991 0.00824897 0.0000002013824 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0548954 0.0105785 0.0000002138769 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.201273 0.0388198 0.0000002186894 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19839909 chr14:71113592 14 71113592 TTC9 Open sea 0.0426604 0.00824905 0.0000002352205 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.98 0.19 0.00000027 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg17498102 chr14:71108199 14 71108199 TTC9 Island 0.00038 0.000075 0.00000029 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea 0.04228 0.00824919 0.00000030076 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.053976 0.010602 0.0000003603603 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.053499 0.0105183 0.0000003696838 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0416587 0.0082494 0.0000004473309 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0533678 0.0105978 0.0000004816259 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19839909 chr14:71113592 14 71113592 TTC9 Open sea 0.0415066 0.00824946 0.0000004925672 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19839909 chr14:71113592 14 71113592 TTC9 Open sea -0.0414518 0.00824948 0.0000005099417 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.052226 0.0104091 0.0000005300985 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.0413194 0.00824952 0.0000005543601 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea 0.0412336 0.00824955 0.0000005850864 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 TTC9B protein levels (SeqId = 9386-42) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TTC9B protein levels (SeqId = 9386-42) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tetratricopeptide repeat protein 9B 774 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -1 0.202 0.0000007 None Gadd-DA_ttc9b_protein_levels__seqid___9386-42__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13244312 chr14:71109707 14 71109707 TTC9 South shore -0.04078 0.0082497 0.0000007769696 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.189776 0.0385728 0.000000873631 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13244312 chr14:71109707 14 71109707 TTC9 South shore -0.0422822 0.00859705 0.0000008827856 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19839909 chr14:71113592 14 71113592 TTC9 Open sea -0.0521173 0.0106197 0.0000009317569 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03199903 chr14:71122637 14 71122637 TTC9 Open sea -0.0402927 0.00824987 0.00000105029 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.145523 0.029847 0.000001094159 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13244312 chr14:71109707 14 71109707 TTC9 South shore -0.0418269 0.00860071 0.00000116703 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0505104 0.0103967 0.000001196077 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0400119 0.00824996 0.000001247589 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13244312 chr14:71109707 14 71109707 TTC9 South shore 0.0397937 0.00825003 0.000001425098 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.0397027 0.00825006 0.000001506013 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0575705 0.0119744 0.000001541298 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0396426 0.00825008 0.000001561954 P02747 41361833_Josephine_Robertson_P02747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0506135 0.0105865 0.00000176159 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore -0.0393684 0.00825017 0.00000184319 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH29 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH29 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.0392775 0.0082502 0.000001946754 A0A0C4DH29 41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg23900759 chr14:71108106 14 71108106 TTC9 Island 0.001 None 0.0000023 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.00017985 3.83e-05 0.00000262 - 27843151_alcohol_consumption_per_day_european_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea -0.0387634 0.00825037 0.000002646141 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09168785 chr14:71123414 14 71123414 TTC9 Open sea -0.0386408 0.00825041 0.000002845413 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0495415 0.0105809 0.000002864033 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0008476 0.00018132 0.00000332 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea 0.0383156 0.00825051 0.000003446496 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13244312 chr14:71109707 14 71109707 TTC9 South shore -0.0399653 0.00861018 0.000003486682 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03199903 chr14:71122637 14 71122637 TTC9 Open sea 0.0381037 0.00825058 0.000003901678 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea 0.0427835 0.00927705 0.000004026515 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.0379944 0.00825061 0.000004158487 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Inkster A Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827 34044884 03-08-2021 Sex PATO_0001894 Discovery Supplementary Table 1 DNA methylation Sex Ancestry (genomic PCs), Gestational age, Dataset M values None Illumina HumanMethylation450 Placenta None 585 4 Infants Both European, East Asian, African, Admixed cg08280368 chr14:71110536 14 71110536 TTC9 South shore 3.9 None 0.0000042 None 34044884_Inkster-A_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0484928 0.0105589 0.000004413683 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.0477711 0.0104178 0.000004565891 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea 0.0378196 0.00825066 0.000004603171 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0378055 0.00825067 0.00000464086 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea -0.0422124 0.00926945 0.000005307708 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13244312 chr14:71109707 14 71109707 TTC9 South shore -0.0392452 0.00861929 0.000005326409 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.037442 0.00825078 0.000005724249 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MT89 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0A0MT89 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea 0.0374327 0.00825078 0.000005754915 A0A0A0MT89 41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea 0.0419916 0.00927608 0.000006033515 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.037328 0.00825082 0.000006111104 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14929883 chr14:71140452 14 71140452 TTC9 Open sea -0.0373175 0.00825082 0.000006148255 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0373118 0.00825082 0.000006168297 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0372981 0.00825083 0.000006216844 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0477082 0.0105699 0.000006423298 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.037179 0.00825086 0.000006654701 P02747 41361833_Josephine_Robertson_P02747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea 0.0371758 0.00825086 0.000006667128 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0370579 0.0082509 0.000007130379 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0474577 0.0105953 0.000007550945 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O95445 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O95445 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0369323 0.00825094 0.000007657818 O95445 41361833_Josephine_Robertson_O95445_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13244312 chr14:71109707 14 71109707 TTC9 South shore 0.0369254 0.00825094 0.000007688148 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 TTC9B protein levels (SeqId = 9386-42) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TTC9B protein levels (SeqId = 9386-42) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tetratricopeptide repeat protein 9B 774 1 Adults (18-65 years) Both European cg19839909 chr14:71113592 14 71113592 TTC9 Open sea -0.62 0.139 0.0000085 None Gadd-DA_ttc9b_protein_levels__seqid___9386-42__somascan_protein_measurement Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 CD4+ T-cells Table S2 DNA methylation HIV infection Age - - Illumina HumanMethylation450 CD4+ T-cells - 60 1 46.5 Males European cg13244312 chr14:71109707 14 71109707 TTC9 South shore 0.31475 0.0711 0.00000959 None 27105112_hiv_infection_cd4_tcells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea 0.0365023 0.00825107 0.000009761116 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea -0.0410163 0.00927641 0.000009869257 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03199903 chr14:71122637 14 71122637 TTC9 Open sea 0.0364641 0.00825108 0.000009972624 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0446282 0.0100985 0.000009974538 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13244312 chr14:71109707 14 71109707 TTC9 South shore -0.0364399 0.00825109 0.00001010907 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0364019 0.0082511 0.0000103265 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11812810 chr14:71107693 14 71107693 TTC9 North shore 0.00096 0.00022 0.000011 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18005 1 Adults (18-65y) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.071 0.0161 0.000011 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04176452 chr14:71131956 14 71131956 TTC9 Open sea -0.0378864 0.00861838 0.00001110363 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09168785 chr14:71123414 14 71123414 TTC9 Open sea -0.0361752 0.00825117 0.00001171975 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19839909 chr14:71113592 14 71113592 TTC9 Open sea -0.0465616 0.010647 0.00001232817 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea -0.0359973 0.00825122 0.0000129364 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14929883 chr14:71140452 14 71140452 TTC9 Open sea -0.00038 0.000087 0.000013 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg13244312 chr14:71109707 14 71109707 TTC9 South shore - - 0.0000138 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.035844 0.00825127 0.00001408109 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0358112 0.00825128 0.00001433813 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04176452 chr14:71131956 14 71131956 TTC9 Open sea -0.0374983 0.0086475 0.00001458565 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0357609 0.00825129 0.00001474137 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0459281 0.0105978 0.00001475689 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.167564 0.0386879 0.00001491565 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0357153 0.0082513 0.00001511626 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05160 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05160 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore -0.0356675 0.00825132 0.00001551877 P05160 41361833_Josephine_Robertson_P05160_OSCA_model_1 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg04536689 chr14:71108024 14 71108024 TTC9 Island -1.077212 0.2496 0.000016 - 27105112_hiv_infection_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0495939 0.0114978 0.00001618543 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0355405 0.00825136 0.00001663847 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.0442167 0.0103125 0.00001817165 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0352972 0.00825143 0.00001900186 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MT89 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0A0MT89 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03199903 chr14:71122637 14 71122637 TTC9 Open sea 0.0349411 0.00825153 0.00002304519 A0A0A0MT89 41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.122714 0.0289926 0.00002321533 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0349253 0.00825153 0.00002324221 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0348876 0.00825155 0.00002371972 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0348696 0.00825155 0.00002395016 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CTHRC1 protein levels (SeqId = 15467-10) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CTHRC1 protein levels (SeqId = 15467-10) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Collagen triple helix repeat-containing protein 1 774 1 Adults (18-65 years) Both European cg01080375 chr14:71109264 14 71109264 TTC9 Island 0.82 0.196 0.000027 None Gadd-DA_cthrc1_protein_levels__seqid___15467-10__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea 0.034605 0.00825163 0.00002760318 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0499422 0.0119187 0.00002803068 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05160 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05160 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0345643 0.00825164 0.00002821027 P05160 41361833_Josephine_Robertson_P05160_OSCA_model_1 Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg03762817 chr14:71107039 14 71107039 TTC9 North shore -0.00094 0.00022 0.000029 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MT89 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0A0MT89 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.0345029 0.00825166 0.0000291498 A0A0A0MT89 41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea -0.0344776 0.00825166 0.00002954518 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.0344564 0.00825167 0.00002988041 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea 0.0344199 0.00825168 0.00003046688 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea 0.0343987 0.00825169 0.0000308121 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0343817 0.00825169 0.00003109071 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0440179 0.0105775 0.00003179961 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03199903 chr14:71122637 14 71122637 TTC9 Open sea 0.0341096 0.00821868 0.00003339863 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg04905775 chr14:71109040 14 71109040 TTC9 Island 0.11581 0.0279779 0.00003498572 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Gadd DA Generation Scotland 35945220 31/07/2022 QPCT protein levels (SeqId = 7849-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 QPCT protein levels (SeqId = 7849-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glutaminyl-peptide cyclotransferase 774 1 Adults (18-65 years) Both European cg04905775 chr14:71109040 14 71109040 TTC9 Island -0.72 0.173 0.000035 None Gadd-DA_qpct_protein_levels__seqid___7849-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03199903 chr14:71122637 14 71122637 TTC9 Open sea -0.0340855 0.00825177 0.00003636911 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MT89 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0A0MT89 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0340707 0.00825178 0.00003665403 A0A0A0MT89 41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea 0.0339721 0.00825181 0.00003860454 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea 0.033903 0.00825183 0.00004003159 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13244312 chr14:71109707 14 71109707 TTC9 South shore -0.0371035 0.00903459 0.00004033052 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH29 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH29 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0337965 0.00825185 0.00004233001 A0A0C4DH29 41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17498102 chr14:71108199 14 71108199 TTC9 Island -0.0349533 0.00853553 0.00004243633 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03199903 chr14:71122637 14 71122637 TTC9 Open sea -0.0337105 0.00825188 0.00004427553 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MS15 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0A0MS15 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.0335871 0.00825191 0.00004721528 A0A0A0MS15 41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea -0.0335416 0.00825193 0.0000483442 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0430679 0.0106031 0.00004894188 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0335073 0.00825194 0.00004921361 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03762817 chr14:71107039 14 71107039 TTC9 North shore -0.0403207 0.00993582 0.00004972786 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0430163 0.0106014 0.00004983708 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0334657 0.00825195 0.00005028753 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0426169 0.0105154 0.00005086582 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.0334044 0.00825196 0.00005191013 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.042656 0.0105435 0.00005242855 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH25 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH25 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11527941 chr14:71126160 14 71126160 TTC9 Open sea 0.0333041 0.00825199 0.0000546721 A0A0C4DH25 41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03199903 chr14:71122637 14 71122637 TTC9 Open sea -0.0336609 0.00834794 0.00005552669 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19839909 chr14:71113592 14 71113592 TTC9 Open sea -0.0332722 0.008252 0.0000555812 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26937852 chr14:71114333 14 71114333 TTC9 Open sea 0.0034 0.00084 0.000058 None 33450751_Mulder-RH_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH36 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH36 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg06774142 chr14:71122191 14 71122191 TTC9 Open sea -0.0332917 0.00829953 0.00006069232 A0A0C4DH36 41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17498102 chr14:71108199 14 71108199 TTC9 Island -0.0342193 0.00854215 0.00006207646 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea -0.0422557 0.0105634 0.00006359656 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0423409 0.0106121 0.00006643108 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03199903 chr14:71122637 14 71122637 TTC9 Open sea -0.0332404 0.0083396 0.00006756458 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04536689 chr14:71108024 14 71108024 TTC9 Island -0.0329898 0.0082925 0.00006975344 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Ischemic Heart Disease (Self-report) None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Ischemic Heart Disease (Self-report) Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 14391 1 Adults (18-65y) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.072 0.0181 0.000073 None Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0418959 0.0106069 0.00007856515 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore -0.0325288 0.0082522 0.0000812363 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0414965 0.0105428 0.00008323292 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03199903 chr14:71122637 14 71122637 TTC9 Open sea 0.0322753 0.00820688 0.000084378 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg21070062 chr14:71132266 14 71132266 TTC9 Open sea 0.0415653 0.0105768 0.00008539001 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6J9 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6J9 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore 0.032402 0.00825224 0.00008660122 A0A075B6J9 41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MT89 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0A0MT89 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13244312 chr14:71109707 14 71109707 TTC9 South shore 0.0323943 0.00825224 0.0000869383 A0A0A0MT89 41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 TTC9B protein levels (SeqId = 9386-42) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 TTC9B protein levels (SeqId = 9386-42) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Tetratricopeptide repeat protein 9B 774 1 Adults (18-65 years) Both European cg06774142 chr14:71122191 14 71122191 TTC9 Open sea -0.2 0.051 0.000087 None Gadd-DA_ttc9b_protein_levels__seqid___9386-42__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04536689 chr14:71108024 14 71108024 TTC9 Island -0.0325598 0.00829596 0.00008720663 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08280368 chr14:71110536 14 71110536 TTC9 South shore -0.0323453 0.00825225 0.00008910863 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13244312 chr14:71109707 14 71109707 TTC9 South shore 0.0323391 0.00825225 0.00008938781 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04176452 chr14:71131956 14 71131956 TTC9 Open sea -0.0340335 0.00868927 0.00009016576 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.116539 0.0297629 0.00009053349 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea -0.0414728 0.010603 0.00009217444 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04176452 chr14:71131956 14 71131956 TTC9 Open sea -0.0337462 0.00862845 0.00009231251 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04176452 chr14:71131956 14 71131956 TTC9 Open sea 0.0398184 0.0101852 0.00009293425 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg17498102 chr14:71108199 14 71108199 TTC9 Island -0.0330685 0.00847867 0.00009654367 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01634544 chr14:71128147 14 71128147 TTC9 Open sea 0.0410665 0.0105504 0.00009968604 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2