author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03234186 chr19:58220657 19 58220657 ZNF154 South shore 0.0014 0.00007 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08668790 chr19:58220662 19 58220662 ZNF154 South shore 0.0011 0.000063 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11294513 chr19:58220295 19 58220295 ZNF154 Island 0.0014 0.000067 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12506930 chr19:58220718 19 58220718 ZNF154 South shore 0.0017 0.000086 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26465391 chr19:58220773 19 58220773 ZNF154 South shore 0.0022 0.00011 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island 0.00059 0.000042 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27324426 chr19:58220837 19 58220837 ZNF154 South shore 0.0012 0.0001 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11294513 chr19:58220295 19 58220295 ZNF154 Island 0.0014 None 1.3e-310 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03234186 chr19:58220657 19 58220657 ZNF154 South shore 0.0015 None 3.6000000000000005e-282 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08668790 chr19:58220662 19 58220662 ZNF154 South shore 0.0012 None 8.6e-261 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island 0.00082 None 2.9999999999999996e-243 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12506930 chr19:58220718 19 58220718 ZNF154 South shore 0.0016 None 1e-197 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26465391 chr19:58220773 19 58220773 ZNF154 South shore 0.0017 None 1.8e-110 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27324426 chr19:58220837 19 58220837 ZNF154 South shore 0.0013 None 2.9e-64 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg26465391 chr19:58220773 19 58220773 ZNF154 South shore 0.07564 0.00331 8.3e-57 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg27324426 chr19:58220837 19 58220837 ZNF154 South shore 0.06078 0.0034 7.6e-43 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg01268824 chr19:58220818 19 58220818 ZNF154 South shore 0.06238 0.00372 1.7e-39 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island 0.002 None 2.6000000000000002e-37 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03234186 chr19:58220657 19 58220657 ZNF154 South shore 0.0029 None 7e-35 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08668790 chr19:58220662 19 58220662 ZNF154 South shore 0.0027 None 6.800000000000001e-28 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg26465391 chr19:58220773 19 58220773 ZNF154 South shore - - 8.58e-28 - 23526956_clear_cell_renal_carcinoma Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg11294513 chr19:58220295 19 58220295 ZNF154 Island - - 1.18e-27 - 24500968_pancreatic_ductal_adenocarcinoma Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg21790626 chr19:58220494 19 58220494 ZNF154 Island - - 1.5500000000000002e-26 - 23526956_clear_cell_renal_carcinoma Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg05661282 chr19:58220370 19 58220370 ZNF154 Island - - 1.88e-26 - 24500968_pancreatic_ductal_adenocarcinoma Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg11294513 chr19:58220295 19 58220295 ZNF154 Island - - 2.24e-24 - 23526956_clear_cell_renal_carcinoma Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11294513 chr19:58220295 19 58220295 ZNF154 Island 0.0028 None 8.3e-23 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg21790626 chr19:58220494 19 58220494 ZNF154 Island - - 2.5600000000000003e-22 - 24500968_pancreatic_ductal_adenocarcinoma Marttila S - 25888029 2015-03-14 Ageing GO_0007568 - Additional file 1 DNA methylation Age group Sex and cell counts Beta values - Illumina HumanMethylation450 Peripheral blood mononuclear cells Variable dispersion beta regression model 143 1 58.5 Both European cg26465391 chr19:58220773 19 58220773 ZNF154 South shore 0.7434262 0.0773 6.45e-22 - 25888029_ageing Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island - - 2.6900000000000002e-21 - 23526956_clear_cell_renal_carcinoma Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3872398 (gene symbol: ZNF671) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3872398 (gene symbol: ZNF671) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg12506930 chr19:58220718 19 58220718 ZNF154 South shore None None 5.2e-21 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3872398__gene_symbol__znf671__meta-analysis Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg03142586 chr19:58220080 19 58220080 ZNF154 North shore - - 2.56e-20 - 23526956_clear_cell_renal_carcinoma Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg01268824 chr19:58220818 19 58220818 ZNF154 South shore - - 8.68e-20 - 23526956_clear_cell_renal_carcinoma Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg12506930 chr19:58220718 19 58220718 ZNF154 South shore 0.0341 0.00337 1.3e-19 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg27049766 chr19:58220516 19 58220516 ZNF154 Island - - 1.56e-19 - 24500968_pancreatic_ductal_adenocarcinoma Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg08668790 chr19:58220662 19 58220662 ZNF154 South shore - - 2.01e-19 - 24500968_pancreatic_ductal_adenocarcinoma Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg12506930 chr19:58220718 19 58220718 ZNF154 South shore 0.0029 None 2.7e-19 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01268824 chr19:58220818 19 58220818 ZNF154 South shore 0.0011 None 1.3e-18 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Marttila S - 25888029 2015-03-14 Ageing GO_0007568 - Additional file 1 DNA methylation Age group Sex and cell counts Beta values - Illumina HumanMethylation450 Peripheral blood mononuclear cells Variable dispersion beta regression model 143 1 58.5 Both European cg11294513 chr19:58220295 19 58220295 ZNF154 Island 1.00934442 0.1173 7.58e-18 - 25888029_ageing Marttila S - 25888029 2015-03-14 Ageing GO_0007568 - Additional file 1 DNA methylation Age group Sex and cell counts Beta values - Illumina HumanMethylation450 Peripheral blood mononuclear cells Variable dispersion beta regression model 143 1 58.5 Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island 1.19161282 0.1391 1.06e-17 - 25888029_ageing Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg05661282 chr19:58220370 19 58220370 ZNF154 Island - - 1.33e-16 - 23526956_clear_cell_renal_carcinoma Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01268824 chr19:58220818 19 58220818 ZNF154 South shore 0.001 0.00012 2.2e-16 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Marttila S - 25888029 2015-03-14 Ageing GO_0007568 - Additional file 1 DNA methylation Age group Sex and cell counts Beta values - Illumina HumanMethylation450 Peripheral blood mononuclear cells Variable dispersion beta regression model 143 1 58.5 Both European cg21790626 chr19:58220494 19 58220494 ZNF154 Island 1.07818799 0.1316 2.57e-16 - 25888029_ageing Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island - - 7.51e-16 - 26500701_sex_kora_f4 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg12506930 chr19:58220718 19 58220718 ZNF154 South shore - - 0.00000000000000173 - 26500701_sex_kora_f4 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3872398 (gene symbol: ZNF671) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3872398 (gene symbol: ZNF671) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg03234186 chr19:58220657 19 58220657 ZNF154 South shore None None 0.0000000000000018 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3872398__gene_symbol__znf671__meta-analysis Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3872560 (gene symbol: ZNF256) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3872560 (gene symbol: ZNF256) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg27049766 chr19:58220516 19 58220516 ZNF154 Island None None 0.0000000000000043 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3872560__gene_symbol__znf256__meta-analysis Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg03234186 chr19:58220657 19 58220657 ZNF154 South shore - - 0.0000000000000078 - 24500968_pancreatic_ductal_adenocarcinoma Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg26465391 chr19:58220773 19 58220773 ZNF154 South shore - - 0.00000000000000929 - 24500968_pancreatic_ductal_adenocarcinoma Marttila S - 25888029 2015-03-14 Ageing GO_0007568 - Additional file 1 DNA methylation Age group Sex and cell counts Beta values - Illumina HumanMethylation450 Peripheral blood mononuclear cells Variable dispersion beta regression model 143 1 58.5 Both European cg08668790 chr19:58220662 19 58220662 ZNF154 South shore 0.95133936 0.1246 0.0000000000000221 - 25888029_ageing Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg03234186 chr19:58220657 19 58220657 ZNF154 South shore - - 0.0000000000000415 - 26500701_sex_kora_f4 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03142586 chr19:58220080 19 58220080 ZNF154 North shore 0.00064 None 0.000000000000043 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Marttila S - 25888029 2015-03-14 Ageing GO_0007568 - Additional file 1 DNA methylation Age group Sex and cell counts Beta values - Illumina HumanMethylation450 Peripheral blood mononuclear cells Variable dispersion beta regression model 143 1 58.5 Both European cg27324426 chr19:58220837 19 58220837 ZNF154 South shore 0.84140663 0.1122 0.0000000000000649 - 25888029_ageing Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg26465391 chr19:58220773 19 58220773 ZNF154 South shore 0.001 0.00013 0.000000000000088 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg08668790 chr19:58220662 19 58220662 ZNF154 South shore - - 0.000000000000193 - 26500701_sex_kora_f4 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3872398 (gene symbol: ZNF671) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3872398 (gene symbol: ZNF671) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg26465391 chr19:58220773 19 58220773 ZNF154 South shore None None 0.00000000000027 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3872398__gene_symbol__znf671__meta-analysis Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg11294513 chr19:58220295 19 58220295 ZNF154 Island - - 0.000000000000687 - 26500701_sex_kora_f4 Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg12506930 chr19:58220718 19 58220718 ZNF154 South shore - - 0.00000000000071 - 24500968_pancreatic_ductal_adenocarcinoma Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg01268824 chr19:58220818 19 58220818 ZNF154 South shore - - 0.00000000000133 - 24500968_pancreatic_ductal_adenocarcinoma Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg05661282 chr19:58220370 19 58220370 ZNF154 Island 0.00022 None 0.0000000000014 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3872398 (gene symbol: ZNF671) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3872398 (gene symbol: ZNF671) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg27324426 chr19:58220837 19 58220837 ZNF154 South shore None None 0.0000000000022 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3872398__gene_symbol__znf671__meta-analysis Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3872560 (gene symbol: ZNF256) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3872560 (gene symbol: ZNF256) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg03234186 chr19:58220657 19 58220657 ZNF154 South shore None None 0.0000000000027 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3872560__gene_symbol__znf256__meta-analysis Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3872380 (gene symbol: ZNF154) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3872380 (gene symbol: ZNF154) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg21790626 chr19:58220494 19 58220494 ZNF154 Island None None 0.0000000000029 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3872380__gene_symbol__znf154__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14969744 chr19:58220955 19 58220955 ZNF154 South shore -0.0574552 0.00824293 0.000000000003299174 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg26465391 chr19:58220773 19 58220773 ZNF154 South shore - - 0.0000000000052 - 26500701_sex_kora_f4 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3872398 (gene symbol: ZNF671) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3872398 (gene symbol: ZNF671) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg21790626 chr19:58220494 19 58220494 ZNF154 Island None None 0.0000000000062 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3872398__gene_symbol__znf671__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14969744 chr19:58220955 19 58220955 ZNF154 South shore -0.0560842 0.00824358 0.00000000001061496 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3872560 (gene symbol: ZNF256) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3872560 (gene symbol: ZNF256) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg21790626 chr19:58220494 19 58220494 ZNF154 Island None None 0.000000000011 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3872560__gene_symbol__znf256__meta-analysis Marttila S - 25888029 2015-03-14 Ageing GO_0007568 - Additional file 1 DNA methylation Age group Sex and cell counts Beta values - Illumina HumanMethylation450 Peripheral blood mononuclear cells Variable dispersion beta regression model 143 1 58.5 Both European cg03142586 chr19:58220080 19 58220080 ZNF154 North shore 0.69386134 0.105 0.0000000000383 - 25888029_ageing Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg12506930 chr19:58220718 19 58220718 ZNF154 South shore 0.0016 0.00024 0.000000000048 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Marttila S - 25888029 2015-03-14 Ageing GO_0007568 - Additional file 1 DNA methylation Age group Sex and cell counts Beta values - Illumina HumanMethylation450 Peripheral blood mononuclear cells Variable dispersion beta regression model 143 1 58.5 Both European cg05661282 chr19:58220370 19 58220370 ZNF154 Island 0.87457273 0.1348 0.0000000000875 - 25888029_ageing Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3872398 (gene symbol: ZNF671) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3872398 (gene symbol: ZNF671) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg08668790 chr19:58220662 19 58220662 ZNF154 South shore None None 0.00000000012 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3872398__gene_symbol__znf671__meta-analysis Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3843188 (gene symbol: TRAPPC2P1) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3843188 (gene symbol: TRAPPC2P1) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg27324426 chr19:58220837 19 58220837 ZNF154 South shore None None 0.00000000014 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3843188__gene_symbol__trappc2p1__meta-analysis Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg03234186 chr19:58220657 19 58220657 ZNF154 South shore 0.0014 0.00022 0.00000000016 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg11294513 chr19:58220295 19 58220295 ZNF154 Island 0.0011 0.00017 0.00000000018 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg08668790 chr19:58220662 19 58220662 ZNF154 South shore 0.0012 0.00019 0.00000000045 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26465391 chr19:58220773 19 58220773 ZNF154 South shore 0.0039 None 0.00000000046 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg27324426 chr19:58220837 19 58220837 ZNF154 South shore 0.0013 0.0002 0.00000000059 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg27049766 chr19:58220516 19 58220516 ZNF154 Island 0.00096 0.00015 0.00000000071 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3872398 (gene symbol: ZNF671) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3872398 (gene symbol: ZNF671) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg27049766 chr19:58220516 19 58220516 ZNF154 Island None None 0.0000000012 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3872398__gene_symbol__znf671__meta-analysis Marttila S - 25888029 2015-03-14 Ageing GO_0007568 - Additional file 1 DNA methylation Age group Sex and cell counts Beta values - Illumina HumanMethylation450 Peripheral blood mononuclear cells Variable dispersion beta regression model 143 1 58.5 Both European cg12506930 chr19:58220718 19 58220718 ZNF154 South shore 0.76199638 0.1283 0.0000000029 - 25888029_ageing Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3872560 (gene symbol: ZNF256) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3872560 (gene symbol: ZNF256) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg05661282 chr19:58220370 19 58220370 ZNF154 Island None None 0.0000000063 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3872560__gene_symbol__znf256__meta-analysis Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg05661282 chr19:58220370 19 58220370 ZNF154 Island - - 0.00000000703 - 26500701_sex_kora_f4 Liu Y - 23334450 2013-01-20 Rheumatoid arthritis EFO_0000685 - Table S3 DNA methylation Rheumatoid arthritis Age, sex, smoking and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 691 1 51.9 Both European cg26855136 chr19:58211993 19 58211993 ZNF154 Open sea -0.02698 0.0047 0.00000000741 - 23334450_rheumatoid_arthritis Marttila S - 25888029 2015-03-14 Ageing GO_0007568 - Additional file 1 DNA methylation Age group Sex and cell counts Beta values - Illumina HumanMethylation450 Peripheral blood mononuclear cells Variable dispersion beta regression model 143 1 58.5 Both European cg03234186 chr19:58220657 19 58220657 ZNF154 South shore 0.81469987 0.1439 0.0000000151 - 25888029_ageing Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14969744 chr19:58220955 19 58220955 ZNF154 South shore -0.0466451 0.00824758 0.00000001581895 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg21790626 chr19:58220494 19 58220494 ZNF154 Island - - 0.0000000174 - 26500701_sex_kora_f4 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26855136 chr19:58211993 19 58211993 ZNF154 Open sea -0.0014 0.00026 0.000000045 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Imgenberg-Kreuz J - 26857698 2016-11-01 Primary Sjogrens syndrome EFO_0000699 Whole blood Table S1 DNA methylation Primary Sjogrens syndrome Age, sex and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 500 1 - Both European cg11294513 chr19:58220295 19 58220295 ZNF154 Island - - 0.0000000576 - 26857698_primary_sjogrens_syndrome_whole_blood Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg05661282 chr19:58220370 19 58220370 ZNF154 Island 0.00057 0.0001 0.000000078 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg27324426 chr19:58220837 19 58220837 ZNF154 South shore - - 0.0000000975 - 26500701_sex_kora_f4 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 Meta-analysis Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1999 3 35.7 Both European cg12506930 chr19:58220718 19 58220718 ZNF154 South shore - - 0.000000127 - 26500701_sex_metaanalysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00983956 chr19:58220669 19 58220669 ZNF154 South shore -0.0433079 0.00824882 0.0000001540651 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg01268824 chr19:58220818 19 58220818 ZNF154 South shore 0.0016 0.00029 0.00000017 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14969744 chr19:58220955 19 58220955 ZNF154 South shore -0.0431256 0.00824889 0.0000001736602 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 Meta-analysis Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1999 3 35.7 Both European cg08668790 chr19:58220662 19 58220662 ZNF154 South shore - - 0.00000022 - 26500701_sex_metaanalysis Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg12506930 chr19:58220718 19 58220718 ZNF154 South shore 0.0766275 0.0148607 0.0000002543731 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14969744 chr19:58220955 19 58220955 ZNF154 South shore -0.0425137 0.00824911 0.0000002586635 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14969744 chr19:58220955 19 58220955 ZNF154 South shore -0.0417716 0.00824937 0.000000416368 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26465391 chr19:58220773 19 58220773 ZNF154 South shore -0.0415992 0.00824942 0.0000004645305 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26855136 chr19:58211993 19 58211993 ZNF154 Open sea 0.0017 None 0.00000048 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Singmann P - 26500701 2015-10-19 Sex EFO_0001271 Meta-analysis Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1999 3 35.7 Both European cg11294513 chr19:58220295 19 58220295 ZNF154 Island - - 0.000000518 - 26500701_sex_metaanalysis Singmann P - 26500701 2015-10-19 Sex EFO_0001271 Meta-analysis Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1999 3 35.7 Both European cg03234186 chr19:58220657 19 58220657 ZNF154 South shore - - 0.000000624 - 26500701_sex_metaanalysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14969744 chr19:58220955 19 58220955 ZNF154 South shore -0.0410446 0.00824961 0.0000006587404 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg01268824 chr19:58220818 19 58220818 ZNF154 South shore - - 0.000000987 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03234186 chr19:58220657 19 58220657 ZNF154 South shore -0.0391303 0.00825025 0.000002126424 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg26855136 chr19:58211993 19 58211993 ZNF154 Open sea 0.01196 0.00245 0.0000022 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg00983956 chr19:58220669 19 58220669 ZNF154 South shore 0.0761222 0.0162396 0.000002786488 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14969744 chr19:58220955 19 58220955 ZNF154 South shore 0.0385698 0.00825043 0.000002967431 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg27049766 chr19:58220516 19 58220516 ZNF154 Island None None 0.0000041 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00983956 chr19:58220669 19 58220669 ZNF154 South shore -0.0379331 0.00825063 0.000004309474 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26465391 chr19:58220773 19 58220773 ZNF154 South shore -0.0376871 0.00825071 0.000004970181 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03234186 chr19:58220657 19 58220657 ZNF154 South shore -0.0378536 0.00832228 0.000005447196 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg21790626 chr19:58220494 19 58220494 ZNF154 Island 0.00035 0.000077 0.0000065 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26465391 chr19:58220773 19 58220773 ZNF154 South shore -0.0372079 0.00825085 0.000006545963 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg00983956 chr19:58220669 19 58220669 ZNF154 South shore 0.0762495 0.0169736 0.000007091039 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg08668790 chr19:58220662 19 58220662 ZNF154 South shore 0.0718752 0.0160662 0.000007734872 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg03234186 chr19:58220657 19 58220657 ZNF154 South shore 0.0620859 0.0139467 0.000008571384 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg12506930 chr19:58220718 19 58220718 ZNF154 South shore 0.0682617 0.0153618 0.000008898825 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14969744 chr19:58220955 19 58220955 ZNF154 South shore 0.0365671 0.00825105 0.000009412093 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11294513 chr19:58220295 19 58220295 ZNF154 Island -0.0364066 0.0082511 0.00001029927 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03234186 chr19:58220657 19 58220657 ZNF154 South shore -0.036492 0.00832543 0.00001177617 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg03234186 chr19:58220657 19 58220657 ZNF154 South shore 0.0643069 0.0148096 0.00001417961 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14969744 chr19:58220955 19 58220955 ZNF154 South shore -0.0357707 0.00825129 0.00001466191 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11294513 chr19:58220295 19 58220295 ZNF154 Island None None 0.000019 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14969744 chr19:58220955 19 58220955 ZNF154 South shore -0.0351545 0.00825147 0.00002053428 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age*sex PATO_0000047,EFO_0000246 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation age*sex sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08668790 chr19:58220662 19 58220662 ZNF154 South shore 0.00038 0.000088 0.000021 None 33450751_Mulder-RH_age_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14969744 chr19:58220955 19 58220955 ZNF154 South shore -0.0364649 0.00857021 0.00002104887 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14969744 chr19:58220955 19 58220955 ZNF154 South shore -0.0364768 0.00857425 0.00002110772 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg03142586 chr19:58220080 19 58220080 ZNF154 North shore 0.0019 None 0.000022 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26465391 chr19:58220773 19 58220773 ZNF154 South shore -0.0349309 0.00825153 0.00002317259 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg03142586 chr19:58220080 19 58220080 ZNF154 North shore 0.00041 0.000097 0.000028 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg12506930 chr19:58220718 19 58220718 ZNF154 South shore None None 0.000028 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00983956 chr19:58220669 19 58220669 ZNF154 South shore 0.0699767 0.0167432 0.00002936919 None 39706196_Hannah-M.-Smith_bmi_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg27049766 chr19:58220516 19 58220516 ZNF154 Island None None 0.00003 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14969744 chr19:58220955 19 58220955 ZNF154 South shore 0.0344431 0.00825167 0.00003009326 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14969744 chr19:58220955 19 58220955 ZNF154 South shore -0.0342888 0.00825172 0.00003266225 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11294513 chr19:58220295 19 58220295 ZNF154 Island None None 0.000033 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27324426 chr19:58220837 19 58220837 ZNF154 South shore 0.0033 None 0.000037 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12506930 chr19:58220718 19 58220718 ZNF154 South shore -0.0338672 0.00825184 0.00004079029 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg08668790 chr19:58220662 19 58220662 ZNF154 South shore -0.0337818 0.00825186 0.00004265499 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Joehanes R - 27651444 2016-10-01 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S2 DNA methylation Current versus never smoking Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood, CD4+ T cells or monocytes - 9389 16 60.3 Both European,African cg01268824 chr19:58220818 19 58220818 ZNF154 South shore -0.0069 0.0017 0.000043 - 27651444_smoking_current_vs_never_smoking Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg01268824 chr19:58220818 19 58220818 ZNF154 South shore -0.00695 0.0017 0.000043 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Singmann P - 26500701 2015-10-19 Sex EFO_0001271 Meta-analysis Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1999 3 35.7 Both European cg26465391 chr19:58220773 19 58220773 ZNF154 South shore - - 0.0000439 - 26500701_sex_metaanalysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11294513 chr19:58220295 19 58220295 ZNF154 Island -0.0337002 0.00825188 0.00004451277 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island -0.00011151 2.73e-05 0.0000451 - 27843151_alcohol_consumption_per_day_european_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island -0.033393 0.00825197 0.00005221717 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg03234186 chr19:58220657 19 58220657 ZNF154 South shore 0.01246 0.00301 0.000053 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg12506930 chr19:58220718 19 58220718 ZNF154 South shore None None 0.000056 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26465391 chr19:58220773 19 58220773 ZNF154 South shore -0.033053 0.00825206 0.00006221024 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg05661282 chr19:58220370 19 58220370 ZNF154 Island -0.0326696 0.00825216 0.00007564641 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg12506930 chr19:58220718 19 58220718 ZNF154 South shore -0.032729 0.00827757 0.00007723613 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg08668790 chr19:58220662 19 58220662 ZNF154 South shore 0.0660436 0.0167047 0.00007727811 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg12506930 chr19:58220718 19 58220718 ZNF154 South shore None None 0.000078 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Gadd DA Generation Scotland 35945220 31/07/2022 F8 protein levels (SeqId = 13499-30) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 F8 protein levels (SeqId = 13499-30) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Coagulation factor VIII 774 1 Adults (18-65 years) Both European cg06915417 chr19:58215047 19 58215047 ZNF154 Open sea -0.72 0.183 0.000079 None Gadd-DA_f8_protein_levels__seqid___13499-30__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg03234186 chr19:58220657 19 58220657 ZNF154 South shore -0.0325487 0.0082522 0.00008042495 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg03234186 chr19:58220657 19 58220657 ZNF154 South shore None None 0.000084 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14969744 chr19:58220955 19 58220955 ZNF154 South shore -0.0383807 0.00977851 0.00008712455 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_4 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11294513 chr19:58220295 19 58220295 ZNF154 Island None None 0.000089 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island 0.0570618 0.014588 0.00009203962 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00983956 chr19:58220669 19 58220669 ZNF154 South shore -0.0322459 0.00825228 0.00009366938 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Liver Cirrhosis None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Liver Cirrhosis Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18325 1 Adults (18-65y) Both European cg01268824 chr19:58220818 19 58220818 ZNF154 South shore -0.0043 0.0011 0.000095 None Robert-F-Hillary_Incident_Liver_Cirrhosis_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island -0.0321989 0.00825229 0.00009589948 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg26465391 chr19:58220773 19 58220773 ZNF154 South shore 0.102695 0.0263401 0.00009701579 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg03234186 chr19:58220657 19 58220657 ZNF154 South shore None None 0.000098 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery