author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11998703	chr19:58446669	19	58446669	ZNF418	Island	0.00076	0.000079	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	0.0024	0.0002	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	0.28503	0.00477	1.7e-126	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg21759268	chr19:58446988	19	58446988	ZNF418	South shore	0.15558	0.00373	1.5e-98	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18673377	chr19:58446898	19	58446898	ZNF418	South shore	0.16092	0.00409	3.8e-94	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11788523	chr19:58446770	19	58446770	ZNF418	Island	0.13958	0.00403	8.4e-85	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg21444693	chr19:58446787	19	58446787	ZNF418	Island	0.13252	0.0047	2.3e-70	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg15060012	chr19:58446783	19	58446783	ZNF418	Island	0.13063	0.00488	6.3e-67	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07474494	chr19:58446600	19	58446600	ZNF418	Island	0.04951	0.00256	4e-47	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11998703	chr19:58446669	19	58446669	ZNF418	Island	0.03777	0.00225	1.1e-39	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	-	-	3.08e-39	-	23526956_clear_cell_renal_carcinoma
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg26671652	chr19:58446312	19	58446312	ZNF418	North shore	0.0315	0.00196	2.3e-37	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg12961842	chr19:58446758	19	58446758	ZNF418	Island	0.03753	0.00273	2.1e-30	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg13668618	chr19:58446745	19	58446745	ZNF418	Island	0.02516	0.00194	4.400000000000001e-28	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	-0.0865706	0.00822557	8.227170000000001e-26	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3872542 (gene symbol: ZNF418)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3872542 (gene symbol: ZNF418)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg26671652	chr19:58446312	19	58446312	ZNF418	North shore	None	None	8.5e-22	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3872542__gene_symbol__znf418__meta-analysis
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3872380 (gene symbol: ZNF154)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3872380 (gene symbol: ZNF154)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	None	None	2.3e-21	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3872380__gene_symbol__znf154__meta-analysis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11998703	chr19:58446669	19	58446669	ZNF418	Island	0.00074	None	3.2e-21	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg15060012	chr19:58446783	19	58446783	ZNF418	Island	-	-	9.56e-21	-	23526956_clear_cell_renal_carcinoma
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07474494	chr19:58446600	19	58446600	ZNF418	Island	0.00079	None	2.6e-20	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	-0.0733681	0.00823432	5.693357999999999e-19	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg08648727	chr19:58446436	19	58446436	ZNF418	Island	0.01989	0.00221	2.1e-16	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11998703	chr19:58446669	19	58446669	ZNF418	Island	-0.0659576	0.00823859	0.000000000000001274096	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	-0.0657222	0.00823872	0.000000000000001606566	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21759268	chr19:58446988	19	58446988	ZNF418	South shore	0.0017	0.00021	0.000000000000002	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18673377	chr19:58446898	19	58446898	ZNF418	South shore	-0.061114	0.00824114	0.0000000000001275823	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	-0.01	0.0014	0.00000000000037	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03304654	chr19:58446911	19	58446911	ZNF418	South shore	-0.0595576	0.00824192	0.0000000000005212629	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Marttila S	-	25888029	2015-03-14	Ageing	GO_0007568	-	Additional file 1	DNA methylation	Age group	Sex and cell counts	Beta values	-	Illumina HumanMethylation450	Peripheral blood mononuclear cells	Variable dispersion beta regression model	143	1	58.5	Both	European	cg11998703	chr19:58446669	19	58446669	ZNF418	Island	0.67068696	0.0934	0.000000000000707	-	25888029_ageing
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21759268	chr19:58446988	19	58446988	ZNF418	South shore	0.0018	None	0.0000000000009	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg15060012	chr19:58446783	19	58446783	ZNF418	Island	0.0014	None	0.00000000000095	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	-0.0586067	0.00824238	0.000000000001210445	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21444693	chr19:58446787	19	58446787	ZNF418	Island	0.0011	None	0.0000000000013	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3872380 (gene symbol: ZNF154)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3872380 (gene symbol: ZNF154)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg18673377	chr19:58446898	19	58446898	ZNF418	South shore	None	None	0.0000000000016	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3872380__gene_symbol__znf154__meta-analysis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07724487	chr19:58442865	19	58442865	ZNF418	North shelf	-0.0013	0.00019	0.0000000000024	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11788523	chr19:58446770	19	58446770	ZNF418	Island	-0.0572374	0.00824304	0.000000000003979148	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12961842	chr19:58446758	19	58446758	ZNF418	Island	-0.0571633	0.00824307	0.000000000004240865	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03304654	chr19:58446911	19	58446911	ZNF418	South shore	-0.0559282	0.00824365	0.000000000012104	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Marttila S	-	25888029	2015-03-14	Ageing	GO_0007568	-	Additional file 1	DNA methylation	Age group	Sex and cell counts	Beta values	-	Illumina HumanMethylation450	Peripheral blood mononuclear cells	Variable dispersion beta regression model	143	1	58.5	Both	European	cg15060012	chr19:58446783	19	58446783	ZNF418	Island	0.69571077	0.1027	0.0000000000126	-	25888029_ageing
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18673377	chr19:58446898	19	58446898	ZNF418	South shore	0.001	0.00015	0.000000000023	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11788523	chr19:58446770	19	58446770	ZNF418	Island	0.00091	0.00014	0.000000000027	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3872398 (gene symbol: ZNF671)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3872398 (gene symbol: ZNF671)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg18673377	chr19:58446898	19	58446898	ZNF418	South shore	None	None	0.000000000062	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3872398__gene_symbol__znf671__meta-analysis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26671652	chr19:58446312	19	58446312	ZNF418	North shore	0.00027	None	0.000000000073	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15060012	chr19:58446783	19	58446783	ZNF418	Island	-0.0534558	0.00824477	0.00000000009242366	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18673377	chr19:58446898	19	58446898	ZNF418	South shore	0.0013	None	0.0000000001	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18673377	chr19:58446898	19	58446898	ZNF418	South shore	-0.0527491	0.00824508	0.0000000001625782	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11788523	chr19:58446770	19	58446770	ZNF418	Island	0.0012	None	0.00000000018	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11788523	chr19:58446770	19	58446770	ZNF418	Island	-0.0523245	0.00824526	0.0000000002274707	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg08648727	chr19:58446436	19	58446436	ZNF418	Island	-1.537042	0.2482	0.000000000596	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11998703	chr19:58446669	19	58446669	ZNF418	Island	-0.0508228	0.0082459	0.000000000730626	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08648727	chr19:58446436	19	58446436	ZNF418	Island	0.00072	0.00012	0.0000000013	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3872560 (gene symbol: ZNF256)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3872560 (gene symbol: ZNF256)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg15060012	chr19:58446783	19	58446783	ZNF418	Island	None	None	0.0000000014	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3872560__gene_symbol__znf256__meta-analysis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16048904	chr19:58448067	19	58448067	ZNF418	South shore	-0.0008	0.00013	0.0000000014	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21444693	chr19:58446787	19	58446787	ZNF418	Island	-0.0497349	0.00824635	0.000000001667167	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03304654	chr19:58446911	19	58446911	ZNF418	South shore	-0.048266	0.00824695	0.00000000494313	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18673377	chr19:58446898	19	58446898	ZNF418	South shore	-0.0482537	0.00824695	0.000000004987598	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11998703	chr19:58446669	19	58446669	ZNF418	Island	-0.0463596	0.00824769	0.00000001934076	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12961842	chr19:58446758	19	58446758	ZNF418	Island	-0.0460728	0.0082478	0.00000002363879	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg26671652	chr19:58446312	19	58446312	ZNF418	North shore	0.01149	0.0021	0.0000000254	-	23334450_rheumatoid_arthritis
Marzi SJ	E-Risk	29325449	2018-01-12	Childhood sexual victimization	None	None	S3	DNA methylation	Childhood sexual victimization	sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	Analysis of twins	1658	1	Adults	Both	Unclear	cg11788523	chr19:58446770	19	58446770	ZNF418	Island	-0.002	0.00036	0.000000028	None	29325449_Marzi-SJ_childhood_sexual_victimization
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03304654	chr19:58446911	19	58446911	ZNF418	South shore	-0.0450756	0.00824818	0.00000004706935	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	-0.0450605	0.00824818	0.00000004755814	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07724487	chr19:58442865	19	58442865	ZNF418	North shelf	0.0014	None	0.00000005	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	-0.0449821	0.00824821	0.00000005017016	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Kyung WK	None	32795589	11-08-2020	atopy	EFO_0002686	discovery	Table E4	DNA methylation	atopy	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	108	1	Adults	Both	East Asian	cg12961842	chr19:58446758	19	58446758	ZNF418	Island	-0.014	0.00247	0.000000058	None	32795589_Kyung-WK_atopy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11788523	chr19:58446770	19	58446770	ZNF418	Island	-0.0447589	0.0082483	0.00000005840269	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Marzi SJ	E-Risk	29325449	2018-01-12	Childhood sexual victimization	None	None	S3	DNA methylation	Childhood sexual victimization	sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	Analysis of twins	1658	1	Adults	Both	Unclear	cg18673377	chr19:58446898	19	58446898	ZNF418	South shore	-0.012	0.00223	0.000000089	None	29325449_Marzi-SJ_childhood_sexual_victimization
Li S	-	28811542	2017-08-15	Age	EFO_0000246	-	Table S1	DNA methylation	Age	Cell counts	M values	years	Illumina HumanMethylation450	Whole blood	-	1366	2	73	Missing	European	cg08648727	chr19:58446436	19	58446436	ZNF418	Island	0.00763	0.00147155	0.000000108	-	28811542_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18673377	chr19:58446898	19	58446898	ZNF418	South shore	-0.0438357	0.00824863	0.0000001086327	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15060012	chr19:58446783	19	58446783	ZNF418	Island	-0.0438137	0.00824864	0.0000001102387	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13668618	chr19:58446745	19	58446745	ZNF418	Island	-0.0432274	0.00824885	0.0000001624339	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	0.0428859	0.00824898	0.0000002031241	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11788523	chr19:58446770	19	58446770	ZNF418	Island	-0.0047	0.00092	0.00000025	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13668618	chr19:58446745	19	58446745	ZNF418	Island	-0.0422432	0.0082492	0.0000003079522	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg21759268	chr19:58446988	19	58446988	ZNF418	South shore	0.0047	0.00088	0.00000035	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18673377	chr19:58446898	19	58446898	ZNF418	South shore	-0.0416573	0.0082494	0.0000004477319	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03304654	chr19:58446911	19	58446911	ZNF418	South shore	-0.041453	0.00824947	0.000000509546	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg13668618	chr19:58446745	19	58446745	ZNF418	Island	-1.110675	0.2223	0.000000584	-	27105112_hiv_infection_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00242039	chr19:58447434	19	58447434	ZNF418	South shore	0.00062	None	0.00000073	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15060012	chr19:58446783	19	58446783	ZNF418	Island	-0.0404064	0.00824983	0.0000009792279	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15060012	chr19:58446783	19	58446783	ZNF418	Island	-0.039957	0.00824998	0.000001290159	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	-0.0393024	0.00825019	0.000001917811	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18673377	chr19:58446898	19	58446898	ZNF418	South shore	-0.0390637	0.00825027	0.000002212808	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12961842	chr19:58446758	19	58446758	ZNF418	Island	-0.0390462	0.00825028	0.000002236015	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11788523	chr19:58446770	19	58446770	ZNF418	Island	-0.0389247	0.00825031	0.000002404161	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13668618	chr19:58446745	19	58446745	ZNF418	Island	-0.0388815	0.00825033	0.000002466729	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11998703	chr19:58446669	19	58446669	ZNF418	Island	-0.0388735	0.00825033	0.000002478526	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07474494	chr19:58446600	19	58446600	ZNF418	Island	0.00038	0.00008	0.0000026	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18673377	chr19:58446898	19	58446898	ZNF418	South shore	-0.0387777	0.00825036	0.000002623729	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg13668618	chr19:58446745	19	58446745	ZNF418	Island	-0.0385096	0.00825045	0.000003074679	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21759268	chr19:58446988	19	58446988	ZNF418	South shore	-0.0067	0.0014	0.0000031	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11998703	chr19:58446669	19	58446669	ZNF418	Island	-0.0426638	0.00916652	0.000003279121	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12961842	chr19:58446758	19	58446758	ZNF418	Island	-0.0382698	0.00825052	0.00000354029	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15060012	chr19:58446783	19	58446783	ZNF418	Island	-0.0382551	0.00825053	0.000003570965	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21444693	chr19:58446787	19	58446787	ZNF418	Island	-0.0381001	0.00825058	0.000003909792	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00242039	chr19:58447434	19	58447434	ZNF418	South shore	-0.00905	0.00192	0.0000046	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	-0.0377125	0.0082507	0.000004897852	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	-0.037462	0.00825078	0.000005658927	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	0.148022	0.0326173	0.000005713499	None	39706196_Hannah-M.-Smith_bmi_discovery
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg27094156	chr19:58436566	19	58436566	ZNF418	Open sea	-1.109562	0.2449	0.00000587	-	27105112_hiv_infection_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18673377	chr19:58446898	19	58446898	ZNF418	South shore	-0.0047	0.001	0.0000067	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	-0.0371604	0.00825087	0.000006725778	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27094156	chr19:58436566	19	58436566	ZNF418	Open sea	0.00051	None	0.0000077	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07106651	chr19:58447338	19	58447338	ZNF418	South shore	-0.0369014	0.00825095	0.000007793278	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18673377	chr19:58446898	19	58446898	ZNF418	South shore	-0.0367646	0.00825099	0.000008420563	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12961842	chr19:58446758	19	58446758	ZNF418	Island	-0.0367477	0.00825099	0.000008501506	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	-0.00052557	0.00011757	0.00000865	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03304654	chr19:58446911	19	58446911	ZNF418	South shore	-0.0366897	0.00825101	0.000008784594	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	AMIGO1 protein levels (SeqId = 9979-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AMIGO1 protein levels (SeqId = 9979-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Amphoterin-induced protein 1	774	1	Adults (18-65 years)	Both	European	cg11788523	chr19:58446770	19	58446770	ZNF418	Island	0.47	0.105	0.0000088	None	Gadd-DA_amigo1_protein_levels__seqid___9979-13__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11788523	chr19:58446770	19	58446770	ZNF418	Island	-0.0365871	0.00825104	0.000009307015	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	0.0365434	0.00825106	0.000009538376	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11788523	chr19:58446770	19	58446770	ZNF418	Island	-0.0362913	0.00825113	0.00001098509	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15060012	chr19:58446783	19	58446783	ZNF418	Island	-0.0362185	0.00825115	0.0000114405	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Ambatipudi S	-	26864933	2016-05-01	Smoking	EFO_0005671, EFO_0004318	Former vs never smoking	Table S2	DNA methylation	Smoking	Age, breast cancer status, menopausal status, use of contraceptive pill, use of hormone replacement therapy and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	717	1	53.4	Females	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	-	-	0.0000132	-	26864933_smoking_former_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11788523	chr19:58446770	19	58446770	ZNF418	Island	-0.0357901	0.00825128	0.00001450594	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11998703	chr19:58446669	19	58446669	ZNF418	Island	-0.0357592	0.00825129	0.00001475533	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03304654	chr19:58446911	19	58446911	ZNF418	South shore	-0.0357027	0.00825131	0.00001522107	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11998703	chr19:58446669	19	58446669	ZNF418	Island	0.109357	0.0253712	0.00001639376	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15060012	chr19:58446783	19	58446783	ZNF418	Island	-0.0355478	0.00825135	0.00001657205	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	0.0057	0.0013	0.000018	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21444693	chr19:58446787	19	58446787	ZNF418	Island	-0.0352278	0.00825145	0.0000197334	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	LY9 protein levels (SeqId = 3324-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LY9 protein levels (SeqId = 3324-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-lymphocyte surface antigen Ly-9	774	1	Adults (18-65 years)	Both	European	cg12961842	chr19:58446758	19	58446758	ZNF418	Island	0.45	0.105	0.00002	None	Gadd-DA_ly9_protein_levels__seqid___3324-51__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AMH protein levels (SeqId = 4923-79)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AMH protein levels (SeqId = 4923-79)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Muellerian-inhibiting factor	774	1	Adults (18-65 years)	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	0.63	0.148	0.000022	None	Gadd-DA_amh_protein_levels__seqid___4923-79__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26671652	chr19:58446312	19	58446312	ZNF418	North shore	0.00015	0.000036	0.000022	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18673377	chr19:58446898	19	58446898	ZNF418	South shore	-0.0349847	0.00825152	0.00002251034	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	-0.0349378	0.00825153	0.00002308724	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12961842	chr19:58446758	19	58446758	ZNF418	Island	0.0825943	0.0196258	0.00002584261	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11998703	chr19:58446669	19	58446669	ZNF418	Island	-0.0345873	0.00825163	0.00002786586	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11998703	chr19:58446669	19	58446669	ZNF418	Island	0.129352	0.0309506	0.00002938599	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Gadd DA	Generation Scotland	35945220	31/07/2022	C1QL1 protein levels (SeqId = 6404-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C1QL1 protein levels (SeqId = 6404-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C1q-related factor	774	1	Adults (18-65 years)	Both	European	cg07106651	chr19:58447338	19	58447338	ZNF418	South shore	0.936	0.225	0.000031	None	Gadd-DA_c1ql1_protein_levels__seqid___6404-20__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12961842	chr19:58446758	19	58446758	ZNF418	Island	-0.0343443	0.0082517	0.00003171498	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21444693	chr19:58446787	19	58446787	ZNF418	Island	-0.0341315	0.00825176	0.00003549619	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CXCL12 protein levels (SeqId = 3516-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXCL12 protein levels (SeqId = 3516-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Stromal cell-derived factor 1	774	1	Adults (18-65 years)	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	0.61	0.148	0.000036	None	Gadd-DA_cxcl12_protein_levels__seqid___3516-60__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NLGN2 protein levels (SeqId = 9772-153)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NLGN2 protein levels (SeqId = 9772-153)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neuroligin-2	774	1	Adults (18-65 years)	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	0.61	0.148	0.000041	None	Gadd-DA_nlgn2_protein_levels__seqid___9772-153__somascan_protein_measurement
Ambatipudi S	-	26864933	2016-05-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Age, breast cancer status, menopausal status, use of contraceptive pill, use of hormone replacement therapy and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	721	1	52.6	Females	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	-	-	0.0000427	-	26864933_smoking_current_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03304654	chr19:58446911	19	58446911	ZNF418	South shore	-0.0336805	0.00825189	0.00004497362	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg08648727	chr19:58446436	19	58446436	ZNF418	Island	0.0032	0.00078	0.000045	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11998703	chr19:58446669	19	58446669	ZNF418	Island	-0.0335999	0.00825191	0.00004690184	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15060012	chr19:58446783	19	58446783	ZNF418	Island	-0.0334491	0.00825195	0.00005072231	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CTRB1 protein levels (SeqId = 5671-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CTRB1 protein levels (SeqId = 5671-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Chymotrypsinogen B	774	1	Adults (18-65 years)	Both	European	cg07106651	chr19:58447338	19	58447338	ZNF418	South shore	0.91	0.224	0.000051	None	Gadd-DA_ctrb1_protein_levels__seqid___5671-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TGFBR2 protein levels (SeqId = 5133-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TGFBR2 protein levels (SeqId = 5133-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: TGF-beta receptor type-2	774	1	Adults (18-65 years)	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	0.6	0.148	0.000056	None	Gadd-DA_tgfbr2_protein_levels__seqid___5133-17__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PNLIP protein levels (SeqId = 15613-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PNLIP protein levels (SeqId = 15613-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pancreatic triacylglycerol lipase	774	1	Adults (18-65 years)	Both	European	cg07106651	chr19:58447338	19	58447338	ZNF418	South shore	0.9	0.224	0.000056	None	Gadd-DA_pnlip_protein_levels__seqid___15613-16__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg26356061	chr19:58446960	19	58446960	ZNF418	South shore	-0.0330103	0.00825207	0.00006358872	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21444693	chr19:58446787	19	58446787	ZNF418	Island	-0.0329751	0.00825208	0.00006474305	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03304654	chr19:58446911	19	58446911	ZNF418	South shore	-0.0328418	0.00825212	0.00006930437	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11788523	chr19:58446770	19	58446770	ZNF418	Island	-0.0328311	0.00825212	0.00006968446	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18673377	chr19:58446898	19	58446898	ZNF418	South shore	0.0328237	0.00825212	0.00006994783	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21759268	chr19:58446988	19	58446988	ZNF418	South shore	0.0328188	0.00825212	0.0000701214	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	RNF150 protein levels (SeqId = 9774-59)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RNF150 protein levels (SeqId = 9774-59)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: RING finger protein 150	774	1	Adults (18-65 years)	Both	European	cg12961842	chr19:58446758	19	58446758	ZNF418	Island	0.42	0.105	0.000072	None	Gadd-DA_rnf150_protein_levels__seqid___9774-59__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21444693	chr19:58446787	19	58446787	ZNF418	Island	-0.0326695	0.00825216	0.00007565247	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18673377	chr19:58446898	19	58446898	ZNF418	South shore	-0.0325305	0.0082522	0.00008116807	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11788523	chr19:58446770	19	58446770	ZNF418	Island	-0.0325129	0.00825221	0.00008189079	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11998703	chr19:58446669	19	58446669	ZNF418	Island	-0.0357323	0.00911849	0.00008944357	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11998703	chr19:58446669	19	58446669	ZNF418	Island	0.0322549	0.00825228	0.00009324661	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	AMIGO1 protein levels (SeqId = 9979-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AMIGO1 protein levels (SeqId = 9979-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Amphoterin-induced protein 1	774	1	Adults (18-65 years)	Both	European	cg03304654	chr19:58446911	19	58446911	ZNF418	South shore	0.54	0.139	0.000095	None	Gadd-DA_amigo1_protein_levels__seqid___9979-13__somascan_protein_measurement