author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0064	0.00031	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05307819	chr1:53236957	1	53236957	ZYG11B	Open sea	-0.0016	0.00016	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11750103	chr1:53238307	1	53238307	ZYG11B	Open sea	-0.0014	0.00016	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21011652	chr1:53192635	1	53192635	ZYG11B	South shore	0.00091	0.00011	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23995459	chr1:53191787	1	53191787	ZYG11B	North shore	-0.0084	0.00028	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg23995459	chr1:53191787	1	53191787	ZYG11B	North shore	0.02	0.0017	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26827702	chr1:53238265	1	53238265	ZYG11B	Open sea	-0.0027	0.00014	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg23995459	chr1:53191787	1	53191787	ZYG11B	North shore	0.23974	0.00598	1.5e-95	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26827702	chr1:53238265	1	53238265	ZYG11B	Open sea	0.0015	None	1.9999999999999998e-50	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	0.106571	0.00820955	2.536154e-38	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.106124	0.00820995	5.161588e-38	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-1.70196	0.0841	1.1599999999999999e-34	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	0.100601	0.00821468	2.580813e-34	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	0.07304	0.00535	3.6e-30	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05307819	chr1:53236957	1	53236957	ZYG11B	Open sea	0.0016	None	4.7000000000000005e-28	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg05307819	chr1:53236957	1	53236957	ZYG11B	Open sea	0.03296	0.00261	4.3e-27	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0839516	0.00822742	2.298021e-24	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	0.0793369	0.00823055	6.335377000000001e-22	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09509462	chr1:53207187	1	53207187	ZYG11B	Open sea	0.0766461	0.00823228	1.450543e-20	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg26827702	chr1:53238265	1	53238265	ZYG11B	Open sea	0.0047	None	6e-17	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09509462	chr1:53207187	1	53207187	ZYG11B	Open sea	0.0654982	0.00823884	0.000000000000002001471	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0641112	0.00823959	0.000000000000007681223	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0632821	0.00824002	0.00000000000001693142	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05307819	chr1:53236957	1	53236957	ZYG11B	Open sea	0.0049	None	0.00000000000061	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2336497 (gene symbol: ZYG11B)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2336497 (gene symbol: ZYG11B)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg16325326	chr1:53192061	1	53192061	ZYG11B	Island	None	None	0.00000000000088	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2336497__gene_symbol__zyg11b__meta-analysis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03935117	chr1:53191150	1	53191150	ZYG11B	North shore	0.00094	None	0.0000000000021	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2336497 (gene symbol: ZYG11B)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2336497 (gene symbol: ZYG11B)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg22166914	chr1:53195759	1	53195759	ZYG11B	South shelf	None	None	0.0000000000026	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2336497__gene_symbol__zyg11b__meta-analysis
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg26827702	chr1:53238265	1	53238265	ZYG11B	Open sea	0.014	0.00194	0.000000000012	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00814357	chr1:53290040	1	53290040	ZYG11B	Open sea	0.02853	0.00397	0.000000000014	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	0.0529935	0.00824497	0.0000000001338395	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.059499	0.00941923	0.0000000002748134	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg24675658	chr1:53192096	1	53192096	ZYG11B	Island	-0.00015	0.000024	0.00000000033	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0591814	0.00942379	0.0000000003481243	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0517247	0.00824552	0.0000000003639255	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09509462	chr1:53207187	1	53207187	ZYG11B	Open sea	0.0514096	0.00824565	0.0000000004648771	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg21011652	chr1:53192635	1	53192635	ZYG11B	South shore	-	-	0.00000000089	-	26857698_primary_sjogrens_syndrome_whole_blood
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg04995860	chr1:53192072	1	53192072	ZYG11B	Island	0.01211	0.002	0.000000000949	-	23334450_rheumatoid_arthritis
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17101920	chr1:53192387	1	53192387	ZYG11B	Island	0.00025	None	0.00000000097	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	-0.0501181	0.0082462	0.000000001249142	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg16325326	chr1:53192061	1	53192061	ZYG11B	Island	0.0284	0.0047	0.00000000183	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0495101	0.00824645	0.000000001972929	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0492471	0.00824655	0.000000002400198	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0560782	0.00943424	0.000000002842607	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0555641	0.00944476	0.000000004115329	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16325326	chr1:53192061	1	53192061	ZYG11B	Island	-0.00063	0.00011	0.0000000045	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09509462	chr1:53207187	1	53207187	ZYG11B	Open sea	0.0477719	0.00824714	0.000000007075395	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	-0.0477679	0.00824715	0.000000007095492	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	0.0477278	0.00824716	0.000000007303911	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg21011652	chr1:53192635	1	53192635	ZYG11B	South shore	0.0039	0.00068	0.0000000098	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0539881	0.00943747	0.00000001082153	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg05307819	chr1:53236957	1	53236957	ZYG11B	Open sea	0.16934	0.0297	0.0000000124	-	25650246_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0528347	0.00937203	0.00000001757315	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.062821	0.0111494	0.00000001788326	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0461582	0.00824777	0.00000002227051	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	-0.0461229	0.00824778	0.0000000228273	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	-0.0460838	0.0082478	0.00000002345809	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	0.0457418	0.00824793	0.00000002975746	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09509462	chr1:53207187	1	53207187	ZYG11B	Open sea	0.0456599	0.00824796	0.00000003149439	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Xu Z	Sister Study	30989176	2019-04-15	breast cancer	EFO_0000305	Case vs Control Discovery	Supplementary Table 1	DNA methylation	breast cancer	cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2443	1	Adults	Females	European	cg03935117	chr1:53191150	1	53191150	ZYG11B	North shore	1.5	0.274	0.000000047	None	30989176_Xu-Z_breast_cancer_case_vs_control_discovery
Yang BZ	-	23332324	2013-02-01	Child abuse	-	-	Appendix B	DNA methylation	Child abuse	Sex, age and ethnicity	Beta values	-	Illumina HumanMethylation450	Saliva	-	192	1	10	Both	European,African,Admixed,Other	cg21011652	chr1:53192635	1	53192635	ZYG11B	South shore	-	-	0.000000047	-	23332324_child_abuse
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	0.0445124	0.00824839	0.00000006900871	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09509462	chr1:53207187	1	53207187	ZYG11B	Open sea	-0.0443119	0.00824846	0.00000007899213	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	0.0440848	0.00824854	0.00000009199761	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	0.0439792	0.00824858	0.000000098724	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0429572	0.00824895	0.0000001938853	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0423476	0.00824916	0.0000002879513	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_1
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg23995459	chr1:53191787	1	53191787	ZYG11B	North shore	-0.0064	0.0012	0.00000032	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09509462	chr1:53207187	1	53207187	ZYG11B	Open sea	-0.0421134	0.00824925	0.000000334731	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	-0.0419681	0.0082493	0.0000003673371	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	0.0412223	0.00824955	0.0000005892543	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	-0.040782	0.0082497	0.0000007760108	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00814357	chr1:53290040	1	53290040	ZYG11B	Open sea	-0.0014	0.00028	0.00000079	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	-0.040557	0.00824978	0.0000008922537	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	0.0404241	0.00824982	0.0000009685994	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg23995459	chr1:53191787	1	53191787	ZYG11B	North shore	0.127698	0.0261347	0.000001037077	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg23995459	chr1:53191787	1	53191787	ZYG11B	North shore	-0.0006368	0.00013067	0.00000126	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	-0.039221	0.00825022	0.000002013938	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0386406	0.00825041	0.000002845765	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	-0.038226	0.00825054	0.000003632333	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	-0.0381952	0.00825055	0.000003698441	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	0.0380849	0.00825058	0.000003944744	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PSMA2 protein levels (SeqId = 4280-47)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PSMA2 protein levels (SeqId = 4280-47)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteasome subunit alpha type-2	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.88	0.192	0.0000048	None	Gadd-DA_psma2_protein_levels__seqid___4280-47__somascan_protein_measurement
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03935117	chr1:53191150	1	53191150	ZYG11B	North shore	-0.01194	0.00256	0.0000056	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Gadd DA	Generation Scotland	35945220	31/07/2022	DES protein levels (SeqId = 12030-82)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DES protein levels (SeqId = 12030-82)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Desmin	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.87	0.192	0.000006	None	Gadd-DA_des_protein_levels__seqid___12030-82__somascan_protein_measurement
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0023	0.0005	0.0000063	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09509462	chr1:53207187	1	53207187	ZYG11B	Open sea	0.0372738	0.00825083	0.000006304021	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0372141	0.00825085	0.00000652262	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	RNF149 protein levels (SeqId = 9773-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RNF149 protein levels (SeqId = 9773-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: E3 ubiquitin-protein ligase RNF149	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.85	0.191	0.0000083	None	Gadd-DA_rnf149_protein_levels__seqid___9773-15__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0093	0.0021	0.0000086	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17101920	chr1:53192387	1	53192387	ZYG11B	Island	0.0089	0.00195	0.0000093	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	-0.0365476	0.00825106	0.000009516183	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Li S	-	28811542	2017-08-15	Age	EFO_0000246	-	Table S1	DNA methylation	Age	Cell counts	M values	years	Illumina HumanMethylation450	Whole blood	-	1366	2	73	Missing	European	cg23995459	chr1:53191787	1	53191787	ZYG11B	North shore	-0.0122	0.00286646	0.0000104	-	28811542_age
Gadd DA	Generation Scotland	35945220	31/07/2022	RAPGEF5 protein levels (SeqId = 9059-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RAPGEF5 protein levels (SeqId = 9059-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Rap guanine nucleotide exchange factor 5	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.84	0.192	0.000013	None	Gadd-DA_rapgef5_protein_levels__seqid___9059-14__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	0.0095	0.0022	0.000014	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	SIRPG protein levels (SeqId = 9241-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SIRPG protein levels (SeqId = 9241-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Signal-regulatory protein gamma	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.83	0.192	0.000015	None	Gadd-DA_sirpg_protein_levels__seqid___9241-40__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CDKN2B protein levels (SeqId = 9874-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CDKN2B protein levels (SeqId = 9874-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cyclin-dependent kinase 4 inhibitor B	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.83	0.192	0.000017	None	Gadd-DA_cdkn2b_protein_levels__seqid___9874-28__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0354196	0.00825139	0.00001777571	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11750103	chr1:53238307	1	53238307	ZYG11B	Open sea	0.0032	None	0.000018	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Prostate Cancer (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Prostate Cancer (Self-report)	Age, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	7406	1	Adults (18-65y)	Males	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	-0.078	0.0182	0.000018	None	Robert-F-Hillary_Prevalent_Prostate_Cancer_(Self-report)_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	GCNT4 protein levels (SeqId = 10842-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GCNT4 protein levels (SeqId = 10842-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.82	0.192	0.000018	None	Gadd-DA_gcnt4_protein_levels__seqid___10842-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09509462	chr1:53207187	1	53207187	ZYG11B	Open sea	0.0352243	0.00825145	0.00001977103	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	-0.0349742	0.00825152	0.00002263801	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	IFNA21 protein levels (SeqId = 15404-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IFNA21 protein levels (SeqId = 15404-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interferon alpha-21	774	1	Adults (18-65 years)	Both	European	cg20201308	chr1:53218931	1	53218931	ZYG11B	Open sea	-0.84	0.198	0.000023	None	Gadd-DA_ifna21_protein_levels__seqid___15404-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05174922	chr1:53291756	1	53291756	ZYG11B	Open sea	-0.0347833	0.00825158	0.00002508801	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09509462	chr1:53207187	1	53207187	ZYG11B	Open sea	0.0346924	0.0082516	0.0000263412	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	RFK protein levels (SeqId = 13059-33)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RFK protein levels (SeqId = 13059-33)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Riboflavin kinase	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.79	0.192	0.000038	None	Gadd-DA_rfk_protein_levels__seqid___13059-33__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PARP1 protein levels (SeqId = 10534-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PARP1 protein levels (SeqId = 10534-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Poly [ADP-ribose] polymerase 1	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.79	0.192	0.000038	None	Gadd-DA_parp1_protein_levels__seqid___10534-40__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	-0.0339931	0.0082518	0.00003818175	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CDH11 protein levels (SeqId = 7763-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CDH11 protein levels (SeqId = 7763-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cadherin-11	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.79	0.192	0.00004	None	Gadd-DA_cdh11_protein_levels__seqid___7763-25__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	VSIG10 protein levels (SeqId = 10825-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VSIG10 protein levels (SeqId = 10825-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: V-set and immunoglobulin domain-containing protein 10	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.79	0.192	0.000043	None	Gadd-DA_vsig10_protein_levels__seqid___10825-12__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg09509462	chr1:53207187	1	53207187	ZYG11B	Open sea	-0.0337541	0.00825187	0.00004327707	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Odintsova VV	Netherlands Twin Register	31744183	2019-11-17	Breastfeeding	EFO_0006864	Discovery, adjusted model, only children younger than 10	Table S14	DNA methylation	Breastfeeding	Sex, age, cell composition (reference based), batch effects, socioeconomic position, maternal smoking, maternal age, maternal body mass index at pregnancy, gestational age	Beta Values	None	Illumina HumanMethylationEPIC	Buccal cells	None	517	1	Children	Both	European	cg23995459	chr1:53191787	1	53191787	ZYG11B	North shore	0.027	0.00661	0.000045	None	31744183_Odintsova-VV_breastfeeding_discovery__adjusted_model__only_children_younger_than_10
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03935117	chr1:53191150	1	53191150	ZYG11B	North shore	-0.0336575	0.00825189	0.00004551673	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	COX4I2 protein levels (SeqId = 7850-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COX4I2 protein levels (SeqId = 7850-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cytochrome c oxidase subunit 4 isoform 2, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.78	0.192	0.00005	None	Gadd-DA_cox4i2_protein_levels__seqid___7850-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05363714	chr1:53191922	1	53191922	ZYG11B	North shore	0.0378158	0.00933795	0.00005154832	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	SGTB protein levels (SeqId = 18837-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SGTB protein levels (SeqId = 18837-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Small glutamine-rich tetratricopeptide repeat-containing protein beta	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.78	0.192	0.000053	None	Gadd-DA_sgtb_protein_levels__seqid___18837-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CALN1 protein levels (SeqId = 10933-107)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CALN1 protein levels (SeqId = 10933-107)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Calcium-binding protein 8	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.78	0.192	0.000054	None	Gadd-DA_caln1_protein_levels__seqid___10933-107__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	0.0333112	0.00825199	0.00005447322	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02205936	chr1:53191046	1	53191046	ZYG11B	North shore	-0.0332685	0.008252	0.00005568643	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0376602	0.00935593	0.0000571943	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	RNF128 protein levels (SeqId = 8633-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RNF128 protein levels (SeqId = 8633-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: E3 ubiquitin-protein ligase RNF128	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.77	0.192	0.000058	None	Gadd-DA_rnf128_protein_levels__seqid___8633-18__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CRIPT protein levels (SeqId = 19294-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CRIPT protein levels (SeqId = 19294-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cysteine-rich PDZ-binding protein	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.77	0.192	0.000059	None	Gadd-DA_cript_protein_levels__seqid___19294-26__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	0.0448279	0.0111952	0.0000625322	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	TNFRSF10D protein levels (SeqId = 14121-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNFRSF10D protein levels (SeqId = 14121-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tumor necrosis factor receptor superfamily member 10D	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.76	0.192	0.000069	None	Gadd-DA_tnfrsf10d_protein_levels__seqid___14121-24__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg15060416	chr1:53272227	1	53272227	ZYG11B	Open sea	0.0328328	0.00825212	0.0000696223	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TNFRSF8 protein levels (SeqId = 2605-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNFRSF8 protein levels (SeqId = 2605-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tumor necrosis factor receptor superfamily member 8	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.76	0.192	0.000072	None	Gadd-DA_tnfrsf8_protein_levels__seqid___2605-49__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GLT8D1 protein levels (SeqId = 8955-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GLT8D1 protein levels (SeqId = 8955-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glycosyltransferase 8 domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.76	0.192	0.000072	None	Gadd-DA_glt8d1_protein_levels__seqid___8955-60__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0373808	0.00942735	0.00007369789	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	VSTM4 protein levels (SeqId = 7242-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VSTM4 protein levels (SeqId = 7242-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: V-set and transmembrane domain-containing protein 4	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.76	0.192	0.000075	None	Gadd-DA_vstm4_protein_levels__seqid___7242-14__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22166914	chr1:53195759	1	53195759	ZYG11B	South shelf	-0.0079	0.002	0.000081	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	ITGA5 protein levels (SeqId = 6932-42)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ITGA5 protein levels (SeqId = 6932-42)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Integrin alpha-5	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.76	0.192	0.000082	None	Gadd-DA_itga5_protein_levels__seqid___6932-42__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RPN1 protein levels (SeqId = 6458-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RPN1 protein levels (SeqId = 6458-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	774	1	Adults (18-65 years)	Both	European	cg24675658	chr1:53192096	1	53192096	ZYG11B	Island	0.46	0.118	0.000084	None	Gadd-DA_rpn1_protein_levels__seqid___6458-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PKDCC protein levels (SeqId = 8664-36)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PKDCC protein levels (SeqId = 8664-36)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Extracellular tyrosine-protein kinase PKDCC	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.76	0.192	0.000084	None	Gadd-DA_pkdcc_protein_levels__seqid___8664-36__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RSPO1 protein levels (SeqId = 6240-70)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RSPO1 protein levels (SeqId = 6240-70)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: R-spondin-1	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.751	0.191	0.000085	None	Gadd-DA_rspo1_protein_levels__seqid___6240-70__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LAYN protein levels (SeqId = 2635-61)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LAYN protein levels (SeqId = 2635-61)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Layilin	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.75	0.192	0.000086	None	Gadd-DA_layn_protein_levels__seqid___2635-61__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg23995459	chr1:53191787	1	53191787	ZYG11B	North shore	-0.0323626	0.00825225	0.00008833546	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P19652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00692173	chr1:53217358	1	53217358	ZYG11B	Open sea	-0.0323587	0.00825225	0.00008851016	P19652	41361833_Josephine_Robertson_P19652_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TNFSF18 protein levels (SeqId = 2708-54)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNFSF18 protein levels (SeqId = 2708-54)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tumor necrosis factor ligand superfamily member 18	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.75	0.192	0.000093	None	Gadd-DA_tnfsf18_protein_levels__seqid___2708-54__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TOP1 protein levels (SeqId = 2876-74)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TOP1 protein levels (SeqId = 2876-74)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DNA topoisomerase 1	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.75	0.192	0.000095	None	Gadd-DA_top1_protein_levels__seqid___2876-74__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TLR1 protein levels (SeqId = 16324-38)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TLR1 protein levels (SeqId = 16324-38)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Toll-like receptor 1	774	1	Adults (18-65 years)	Both	European	cg07472835	chr1:53280203	1	53280203	ZYG11B	Open sea	-0.75	0.192	0.000099	None	Gadd-DA_tlr1_protein_levels__seqid___16324-38__somascan_protein_measurement