author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0054 0.00026 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea 0.025 0.0015 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.25479 0.00528 1e-109 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea - - 5.52e-39 - 23526956_clear_cell_renal_carcinoma Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.263343 0.0279207 4.527602e-21 None 39706196_Hannah-M.-Smith_bmi_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.270305 0.0307701 1.7130200000000001e-18 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea 0.0717513 0.00823529 3.281932e-18 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.01695 0.00195 3.9e-18 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -1.6 0.18 4.3e-18 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea - - 2.41e-17 - 24500968_pancreatic_ductal_adenocarcinoma Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.236396 0.0279988 3.3328520000000005e-17 None 39706196_Hannah-M.-Smith_body_fat_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.25033 0.0309802 6.882674e-16 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.217932 0.0308814 0.000000000001765094 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Joehanes R - 27651444 2016-10-01 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S2 DNA methylation Current versus never smoking Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood, CD4+ T cells or monocytes - 9389 16 60.3 Both European,African cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.017 0.0024 0.0000000000031 - 27651444_smoking_current_vs_never_smoking Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.188519 0.0279338 0.00000000001538344 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0612483 0.00918309 0.00000000002655325 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Dugue PA Melbourne Collaborative Cohort Study 31552803 2019-09-25 Smoking EFO_0006527, EFO_0004318 Current vs never smoking Supplementary table 1 DNA methylation Smoking Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects M Values None Illumina HumanMethylation450 Whole blood None 1851 1 Adults Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.14 0.0216 0.000000000086 None 31552803_Dugue-PA_smoking_current_vs_never_smoking Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.018 0.0028 0.000000000095 None 33450751_Mulder-RH_sex_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.031 0.00478 0.00000000014 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0520837 0.00824537 0.0000000002748727 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Imboden M Aging Lungs in European Cohorts project 31073081 2019-07-01 FEV1 EFO_0004314 Meta-analysis Supplementary table 4 DNA methylation FEV1 Batch effects, age, age squared, height, squared deviation from the mean height, sex, education, body mass index, cell composition (reference based) Beta Values L Illumina HumanMethylation450 Whole blood Meta-analyses were conducted across time points 5370 8 Adults Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea 0.7 0.114 0.0000000008 None 31073081_Imboden-M_fev1_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea 0.0489062 0.00824669 0.000000003089783 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0460214 0.00824782 0.00000002450199 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0515119 0.00925592 0.00000002663104 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea 0.164465 0.030048 0.00000004473231 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0495969 0.0092865 0.00000009394286 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea 0.0478664 0.00923744 0.000000222686 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea 0.0427316 0.00824903 0.0000002245883 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0473198 0.00926711 0.0000003327989 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea 0.0471314 0.0092733 0.0000003771203 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0419268 0.00824931 0.000000377158 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea None None 0.00000052 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0462369 0.00926247 0.0000006048885 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Li S - 28811542 2017-08-15 Age EFO_0000246 - Table S1 DNA methylation Age Cell counts M values years Illumina HumanMethylation450 Whole blood - 1366 2 73 Missing European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0123 0.00257978 0.000000931 - 28811542_age Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea 0.12519 0.0271602 0.000004067282 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Reynolds LM - 25404168 2014-11-18 Age EFO_0000246 T cells Additional file 1 DNA methylation Age Sex, ethnicity and technical covariates M values Years Illumina HumanMethylation450 T cells - 227 1 - Missing None cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea - - 0.0000042 - 25404168_age_t_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0378683 0.00825065 0.000004474919 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0408238 0.00912496 0.000007739825 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Reynolds LM - 25404168 2014-11-18 Age EFO_0000246 Monocytes Additional file 1 DNA methylation Age Sex, ethnicity and technical covariates M values years Illumina HumanMethylation450 Monocytes - 1264 1 60 Both European,African,Admixed cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea - - 0.0000154 - 25404168_age_monocytes Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea 0.0398941 0.00927292 0.00001701923 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0395259 0.00928599 0.00002089315 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea None None 0.000024 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0385446 0.00926715 0.00003210848 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea 0.033962 0.00825181 0.00003881018 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_1 Battram T GEO 24559495 2020-09-15 Smoking EFO_0004318, EFO_0005671, EFO_0006527 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE53045 None DNA methylation Smoking Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Peripheral blood mononuclear cells None 111 1 Adults Females African cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.068 0.0159 0.000049 None 24559495_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse53045 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0331385 0.00825204 0.00005953905 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0329626 0.00825208 0.00006515754 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea 0.0369009 0.00927827 0.0000700873 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0367233 0.00923629 0.00007042587 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0052 0.0013 0.000072 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg00073460 chr6:149806502 6 149806502 ZC3H12D Open sea -0.0323037 0.00825226 0.00009099047 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_1