author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	3187	2	65.7	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.055	0.004	0	-	28173150_serum_triglycerides_discovery_and_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for surrogate variables	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	3187	2	65.7	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.075	0.005	0	-	28173150_serum_triglycerides_discovery_and_replication_adjusted_for_surrogate_variables
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.872949	0.029524	1.78362e-187	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.839935	0.0297801	3.795307e-171	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.719402	0.0277898	5.290316e-145	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.698554	0.0278866	4.6247799999999995e-136	None	39706196_Hannah-M.-Smith_body_fat_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.674508	0.0299103	5.228487e-111	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.166012	0.008142	3.7794499999999997e-91	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.165651	0.00828292	8.276476e-88	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.557257	0.027982	2.874157e-87	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.160427	0.00814963	3.6202109999999995e-85	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.151861	0.00828115	2.773307e-74	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.138065	0.0081775	2.3581139999999998e-63	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.136485	0.00830819	4.163023e-60	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4261	5	65	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0098643	0.0006066	1.8700000000000001e-59	-	28213390_serum_triglycerides_discovery_and_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication adjusted for surrogate variables	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	2542	1	66.3	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.08	0.005	4.2e-56	-	28173150_serum_triglycerides_replication_adjusted_for_surrogate_variables
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.459653	0.0293744	7.796318000000001e-55	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	Discovery and replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	Weighted Z-test meta-analysis	10238	13	54.5	Both	European,South Asian	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-	-	6.799999999999999e-49	-	28002404_body_mass_index_discovery_and_replication
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.399642	0.0274162	7.332934e-48	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.06406	0.00328	1.6e-47	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Meta-analysis	Table 2	DNA methylation	Body mass index	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Leukocytes, whole blood and CD4+ T cells	Regression coefficient per 1 SD of body mass index	5464	4	59.6	Both	European,African	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-	-	3.44e-47	-	25935004_body_mass_index_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.13162	0.00909869	4.207767e-47	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.119333	0.00833825	3.795788e-46	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	2542	1	66.3	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.063	0.004	1e-44	-	28173150_serum_triglycerides_replication
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.412968	0.0295344	3.366027e-44	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-7.9	0.565	4.8e-44	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for BMI	Table S9	DNA methylation	Serum triglycerides	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4261	5	65	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0086	6e-04	2.4199999999999998e-42	-	28213390_serum_triglycerides_discovery_and_replication_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.109134	0.00820726	4.100038e-40	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.360979	0.0273828	1.6724140000000002e-39	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	sensitivity	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.393048	0.0301224	9.760323e-39	None	39706196_Hannah-M.-Smith_glucose_sensitivity
Sayols-Baixeras S	REGICOR, Framingham Offspring Study	29099282	2017-11-27	Waist circumference	EFO_0004342	Meta-analysis model 2	Supplementary table 4	Waist circumference	DNA methylation	Age, sex, smoking, cell composition (reference based), batch effects	cm	M Values	Illumina HumanMethylation450	Whole blood	Removed individuals with BMI < 18.5	3156	2	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-3.9	0.3	1.2e-38	None	29099282_Sayols-Baixeras-S_waist_circumference_meta-analysis_model_2
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Replication	Table 2	DNA methylation	Body mass index	Age, sex, smoking, study centre and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood and CD4+ T cells	Regression coefficient per 1 SD of body mass index	3368	3	61.7	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-	-	5.77e-38	-	25935004_body_mass_index_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.10627	0.00825674	1.053202e-37	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Aslibekyan S	-	26110892	2015-07-01	Body mass index	EFO_0004340	Meta-analysis	Table 2	DNA methylation	Body mass index	Age, sex, smoking, study centre and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	CD4+ T-cells, leukocytes and whole blood	-	5474	4	59.1	Both	European,African	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-	-	3.5e-37	-	26110892_body_mass_index_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.104768	0.00821113	4.359226e-37	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.103805	0.00817336	9.188539e-37	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.104553	0.00832237	5.1756919999999997e-36	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.119545	0.00952013	5.573358e-36	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Sayols-Baixeras S	REGICOR, Framingham Offspring Study	29099282	2017-11-27	Waist circumference	EFO_0004342	Meta-analysis model 1	Supplementary table 4	Waist circumference	DNA methylation	Age, sex, smoking, cell composition (reference based)	cm	M Values	Illumina HumanMethylation450	Whole blood	Removed individuals with BMI < 18.5	3156	2	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-2.5	0.2	7.5e-36	None	29099282_Sayols-Baixeras-S_waist_circumference_meta-analysis_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.102907	0.00821274	7.79427e-36	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.104504	0.00835532	1.034358e-35	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0089987	0.0007236	1.65e-35	-	28213390_serum_triglycerides_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.113198	0.00932124	8.964567e-34	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry discovery	Table S3	Body mass index	DNA mehtylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	5387	4	54.5	Both	European,South Asian	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-40.2	3.1	3.3e-33	-	28002404_body_mass_index_all_ancestry_discovery
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-LDL-TG	None	Meta-analysis	Table S2	DNA methylation	S-LDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in small LDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-4.1	0.35	4.3e-33	None	33413638_Gomez-Alonso-MDC_s-ldl-tg_meta-analysis
Sayols-Baixeras S	REGICOR, Framingham Offspring Study	29099282	2017-11-27	Body mass index	EFO_0004340	Meta-analysis model 2	Supplementary table 3	Body mass index	DNA methylation	Age, sex, smoking, cell composition (reference based), batch effects	Kg/m2	M Values	Illumina HumanMethylation450	Whole blood	Removed individuals with BMI < 18.5	3156	2	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-1.3	0.11	3.1e-32	None	29099282_Sayols-Baixeras-S_body_mass_index_meta-analysis_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.097264	0.00821742	3.549202e-32	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.068	0.00583	8.999999999999999e-32	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0976644	0.00834172	1.603044e-31	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0970556	0.00831916	2.598762e-31	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0957774	0.00821861	3.016145e-31	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0955353	0.00821881	4.260152000000001e-31	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	discovery	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.322506	0.0278913	8.170955e-31	None	39706196_Hannah-M.-Smith_glucose_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.108995	0.00951123	2.832644e-30	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Meta-analysis	Table S1	DNA methylation	Body mass index	Age, sex, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood	Weighted Z-test meta-analysis	3743	4	69.2	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-	-	2.2e-29	-	28095459_body_mass_index_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0914373	0.00822198	1.289217e-28	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0951057	0.0086344	4.182803000000001e-28	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0897553	0.00822325	1.2505199999999999e-27	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0927844	0.00850893	1.4020250000000001e-27	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.084266	0.0077415	1.731822e-27	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	European ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2707	3	57.9	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-42.08	3.9	3.5e-27	-	28002404_body_mass_index_european_ancestry_discovery
Irvin MR	-	24920721	2014-08-12	Triglycerides	EFO_0004530	Discovery	Table 1	DNA methylation	Triglycerides	Age, sex and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	CD4+ T-cells	Triglycerides levels were log-transformed	991	1	49	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.032	0.00299	1.5600000000000002e-26	-	24920721_triglycerides
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	1955	3	61	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0119788	0.0011262	2.01e-26	-	28213390_serum_triglycerides_replication
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-TG_pct	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-TG_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Triglycerides to total lipids ratio in small VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-1.8	0.17	2.1e-26	None	33413638_Gomez-Alonso-MDC_s-vldl-tg_pct_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0889331	0.00836273	2.569193e-26	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for lipid-lowering medication use	Table 3	DNA methylation	Triglycerides	Age, sex, smoking, lipid-lowering medication use, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0142	0.0013	2.6e-26	-	28194238_triglycerides_discovery_and_replication_lipidlowering_medication_use_adjusted
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication	Table S1	DNA methylation	Triglycerides	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0139	0.0013	5.07e-26	-	28194238_triglycerides_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery adjusted for BMI	Table S9	DNA methylation	Serum triglycerides	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0079025	0.00075	5.810000000000001e-26	-	28213390_serum_triglycerides_discovery_adjusted_for_bmi
Sun D	Bogalusa Heart Study, Georgia Stress and Heart Study	31510868	2019-09-12	body mass index	EFO_0004340	meta-analysis in Europeans	Online Table I	DNA methylation	body mass index	age, sex, smoking, cell composition (reference based), batch effects	Beta Values	kg/m2	Illumina HumanMethylation450	Whole blood	None	1247	2	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.00088	None	1.9e-25	None	31510868_Sun-D_body_mass_index_meta-analysis_in_europeans
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0873471	0.00836733	2.01874e-25	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0857756	0.00822614	2.285e-25	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0978966	0.00939146	2.36346e-25	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0853618	0.00822644	3.87429e-25	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0876926	0.00851822	9.03924e-25	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0958326	0.00931273	9.44398e-25	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0846464	0.00822694	9.594391e-25	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.13	0.013	1.0999999999999998e-24	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Framingham Heart Study Batch 2	Table S1	DNA methylation	Body mass index	Age, sex and technical covariates	-	kg/m2	Illumina HumanMethylation450	Whole blood	DNA methylation was inverse normally rank transformed	1935	1	67	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0422	0.00403	1.18e-24	-	28095459_body_mass_index_framingham_heart_study_batch_2
Aslibekyan S	-	26110892	2015-07-01	Body mass index	EFO_0004340	FHS 1	Table 2	DNA methylation	Body mass index	Age, sex and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood	-	1935	1	65	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.04	0.004	2.4e-24	-	26110892_body_mass_index_fhs_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0844875	0.00836655	6.732687e-24	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-LDL-TG_pct	None	Meta-analysis	Table S2	DNA methylation	S-LDL-TG_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Triglycerides to total lipids ratio in small LDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-2.52	0.25	1.1e-23	None	33413638_Gomez-Alonso-MDC_s-ldl-tg_pct_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0837603	0.00835107	1.34206e-23	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Lai CQ	-	27777315	2016-12-01	Postprandial lipemia	EFO_0007632	Discovery and replication	Table S2	Postprandial lipemia	DNA methylation	Age, sex, study centre and technical covariates	-	Beta values	Illumina HumanMethylation450	CD4+ T-cells	Postprandial lipemia measured using the area under the curve	979	1	48.3	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-38.5	3.77	2.69e-23	-	27777315_postprandial_lipemia_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0836405	0.00840914	3.098101e-23	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0921251	0.00929092	4.210794e-23	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0825975	0.00834379	4.951445e-23	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0808774	0.00822952	1.005308e-22	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for other lipids	Table 3	DNA methylation	Triglycerides	Age, sex, smoking, other lipids, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0161	0.0016	1.5000000000000002e-22	-	28194238_triglycerides_discovery_and_replication_other_lipids_adjusted
Sayols-Baixeras S	REGICOR, Framingham Offspring Study	29099282	2017-11-27	Body mass index	EFO_0004340	Meta-analysis model 1	Supplementary table 3	Body mass index	DNA methylation	Age, sex, smoking, cell composition (reference based)	Kg/m2	M Values	Illumina HumanMethylation450	Whole blood	Removed individuals with BMI < 18.5	3156	2	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.87	0.09	4.2e-22	None	29099282_Sayols-Baixeras-S_body_mass_index_meta-analysis_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0807552	0.00835146	4.724758e-22	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Irvin MR	-	24920721	2014-08-12	Very low-density lipoprotein cholesterol	EFO_0008317	Discovery	Table 1	DNA methylation	Very low-density lipoprotein cholesterol	Age, sex and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	CD4+ T-cells	Very low-density lipoprotein cholesterol levels were log-transformed	991	1	49	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.022	0.00228	1.79e-21	-	24920721_very_lowdensity_lipoprotein_cholesterol
Sun D	Bogalusa Heart Study	31510868	2019-09-12	body mass index	EFO_0004340	Discovery in Europeans	Online Table I	DNA methylation	body mass index	age, sex, smoking, cell composition (reference based), batch effects	Beta Values	kg/m2	Illumina HumanMethylation450	Whole blood	None	995	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.00092	None	3e-21	None	31510868_Sun-D_body_mass_index_discovery_in_europeans
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0766797	0.00823226	1.3959959999999998e-20	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0771144	0.00832308	2.214525e-20	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.075701	0.00828996	7.613181e-20	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0737939	0.00823406	3.566259e-19	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0747788	0.0083764	4.874962e-19	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0841394	0.0094292	5.055869e-19	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0734366	0.00823428	5.28123e-19	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0744104	0.00835566	5.935608999999999e-19	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0744242	0.00836174	6.197796999999999e-19	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication adjusted for BMI	Table S9	DNA methylation	Serum triglycerides	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	1955	3	61	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0104012	0.0011766	9.59e-19	-	28213390_serum_triglycerides_replication_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0807599	0.00912725	9.896369e-19	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.072642	0.00823476	1.25626e-18	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_1
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	4851	9	54.5	Both	European,South Asian	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-21.3	2.4	2.8e-18	-	28002404_body_mass_index_all_ancestry_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0730242	0.00836813	2.907142e-18	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0718505	0.00823523	2.950675e-18	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0716829	0.00823533	3.531326e-18	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.071615	0.00823537	3.797288e-18	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0723469	0.00837393	6.220386e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0718541	0.00835658	8.884245e-18	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0718057	0.00838164	1.1665860000000001e-17	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Dhana K	Rotterdam study	29762635	2018-05-14	Waist Circumference	EFO_0004342	Discovery	Table 3	DNA methylation	Waist Circumference	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Leukocytes	None	1450	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0005	0.000058	1.2e-17	None	29762635_Dhana-K_waist_circumference_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0697857	0.00823644	2.621161e-17	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1
Cardona A	FHS	31506343	2019-09-10	Type II diabetes	EFO_0001360	Replication in Europeans	Table 3	DNA methylation	Type II diabetes	Age, sex, cell composition (reference based), batch effects, body mass index	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2607	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0067	0.00079	4.8e-17	None	31506343_Cardona-A_type_ii_diabetes_replication_in_europeans
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0691178	0.00823683	5.242381000000001e-17	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Demerath EW	-	25935004	2015-08-01	Waist circumference	EFO_0004342	Discovery	Table S5	DNA methylation	Waist circumference	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	cm	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of waist circumference	2097	1	56.2	Both	African	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0034	4e-04	5.79e-17	-	25935004_waist_circumference_discovery
Dhana K	Atherosclerosis Risk in Communities	29762635	2018-05-14	Waist Circumference	EFO_0004342	Replication	Table 3	DNA methylation	Waist Circumference	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Leukocytes	None	2097	1	Adults	Both	Admixed	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0034	0.00041	5.8e-17	None	29762635_Dhana-K_waist_circumference_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.079291	0.00950159	7.750933000000001e-17	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	None	None	8.3e-17	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0796709	0.00958223	1.002276e-16	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0684765	0.00823719	1.013617e-16	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0691757	0.00836568	1.46603e-16	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_2
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for waist circumference	Table 3	DNA methylation	Triglycerides	Age, sex, smoking, waist circumference, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0114	0.0014	1.9e-16	-	28194238_triglycerides_discovery_and_replication_waist_circumference_adjusted
Aslibekyan S	-	26110892	2015-07-01	Waist circumference	EFO_0004342	Meta-analysis	Table 3	DNA methylation	Waist circumference	Age, sex, smoking, study centre and technical covariates	Beta values	cm	Illumina HumanMethylation450	CD4+ T-cells and leukocytes	-	3097	2	53.8	Both	European,African	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-	-	2.2e-16	-	26110892_waist_circumference_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0699365	0.00852578	2.539137e-16	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0717828	0.00875953	2.716128e-16	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.068057	0.00835026	3.922388e-16	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0669805	0.00823803	4.609609e-16	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0774732	0.00953312	4.760315e-16	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_4
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	South Asian ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2680	1	51.0	Both	South Asian	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-37.77	4.07	4.9e-16	-	28002404_body_mass_index_south_asian_ancestry_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.076917	0.00949447	5.866981e-16	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0741234	0.00922869	0.000000000000001032947	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0763246	0.00950916	0.000000000000001079377	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_4
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table 2	DNA methylation	Triglycerides	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	725	1	60	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0206	0.0026	0.00000000000000123	-	28194238_triglycerides_discovery
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting insulin	EFO_0004466	Base	Supplementary Data 1	DNA methylation	fasting insulin	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	log pmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-3.12	0.39	0.0000000000000013	4739	31197173_Liu-J_fasting_insulin_base
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0656651	0.00822664	0.000000000000001545943	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0656978	0.00823873	0.000000000000001645501	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Mamtani M	-	26798409	2016-01-20	Hypertriglyceridemic waist	EFO_0004342, EFO_0004530	-	Table S2	Liability function of hypertriglyceridemic waist	DNA methylation	Age, sex, use of statin, use of anti-hypertensive, use of diabetic medications, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	850	1	46.8	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.4826574	0.06064	0.00000000000000173	-	26798409_hypertriglyceridemic_waist
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0657758	0.00826927	0.000000000000001933286	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0674824	0.00848886	0.000000000000002008116	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0755163	0.00950279	0.000000000000002053546	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0662125	0.0083469	0.000000000000002300772	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0671291	0.00848826	0.000000000000002790874	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-PL_pct	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-PL_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Phospholipids to total lipids ratio in medium VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.36	0.046	0.0000000000000032	None	33413638_Gomez-Alonso-MDC_m-vldl-pl_pct_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0657769	0.00836815	0.000000000000004095022	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0657543	0.0083712	0.000000000000004280179	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0646175	0.00823932	0.000000000000004716705	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Dhana K	Rotterdam study	29762635	2018-05-14	Body mass index	EFO_0004340	Discovery	Table 2	DNA methylation	Body mass index	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Leukocytes	None	1450	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0011	0.00014	0.0000000000000062	None	29762635_Dhana-K_body_mass_index_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0650263	0.00837161	0.000000000000008535285	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0638075	0.00823975	0.00000000000001027279	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Lai CQ	-	27777315	2016-12-01	Postprandial lipemia	EFO_0007632	Replication	Table S2	Postprandial lipemia	DNA methylation	Age, sex, study centre and technical covariates	-	Beta values	Illumina HumanMethylation450	CD4+ T-cells	Postprandial lipemia measured using the area under the curve	326	1	48.8	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-50.84	6.27	0.0000000000000118	-	27777315_postprandial_lipemia_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0732709	0.00951641	0.00000000000001453963	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_4
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-2.67	0.35	0.000000000000025	4807	31197173_Liu-J_fasting_glucose_base
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0596855	0.0078456	0.00000000000002963873	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0626837	0.00824033	0.00000000000002976793	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0644977	0.00850407	0.00000000000003542362	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3
Petersen A-K	KORA F4	24014485	2013-09-06	M33871_1-eicosadienoylglycerophosphocholine*	EFO_0004727, EFO_0004725	no snps model	Table S2	M33871_1-eicosadienoylglycerophosphocholine*	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-1	0.51	0.000000000000068	None	24014485_Petersen-A-K_m33871_1-eicosadienoylglycerophosphocholine__no_snps_model
Aslibekyan S	-	28139377	2016-11-23	Plasma adiponectin	EFO_0004502	Discovery adjusted for smoking and alcohol consumption	Table 4	DNA methylation	Plasma adiponectin	Age, sex, smoking, alcohol consumption and technical covariates	Beta values	ug/dl	Illumina HumanMethylation450	CD4+ T-cells	Plasma adiponectin levels were log transformed	991	1	49	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.01	0.001	0.000000000000074	-	28139377_plasma_adiponectin_discovery_adjusted_for_smoking_and_alcohol
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0635435	0.00851754	0.00000000000009115666	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Petersen A-K	KORA F4	24014485	2013-09-06	M33871_1-eicosadienoylglycerophosphocholine*	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M33871_1-eicosadienoylglycerophosphocholine*	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-1	0.51	0.000000000000092	None	24014485_Petersen-A-K_m33871_1-eicosadienoylglycerophosphocholine__snps_as_covariates_model
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Lifetime consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	None	None	0.000000000000096	None	31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery
Richard MA	CHARGE	29198723	2019-11-25	Systolic Blood Pressure	EFO_0006335	Meta-analysis	Table S4	DNA methylation	Systolic Blood Pressure	Age, sex, smoking, batch effects, ancestry, body mass index, blood cell counts	Beta Values	mmHg	Illumina HumanMethylation450	Whole blood, CD4+ T cells	Overall meta-analysis of discovery and replication cohorts	17010	14	Adults	Both	African, Admixed, European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.00005	None	0.00000000000012	None	29198723_Richard-MA_systolic_blood_pressure_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0621311	0.00838205	0.0000000000001308076	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0620801	0.00838225	0.0000000000001371188	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0632392	0.0085518	0.0000000000001492473	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0604661	0.00824146	0.000000000000230203	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_1
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	European ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	4195	8	54.6	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-18.44	2.52	0.00000000000027	-	28002404_body_mass_index_european_ancestry_replication
Fernández-Sanlés A.	REGICOR, Framingham Offspring Cohort	29326313	2018-01-11	Cardiovascular risk	EFO_0003919, EFO_0004298	Age-independent cardiovascular risk was determined via the delta age approach, results meta-analysesd across discovery and replicaton cohorts	Table 2	DNA methylation	Cardiovascular risk	Sex, age, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole Blood	None	2746	2	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0182	0.0025	0.00000000000028	None	29326313_Fernández-Sanlés-A._cardiovascular_risk_age-independent_cardiovascular_risk_was_determined_via_the_delta_age_approach__results_meta-analysesd_across_discovery_and_replicaton_cohorts
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0602018	0.0082416	0.0000000000002923598	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_1
Pfeiffer L	-	25583993	2015-01-12	Triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table 2	Triglycerides	DNA methylation	Age, sex, smoking, body mass index, alcohol consumption, physical activity, hypertension, history of MI, hemoglobin A1c, C-reactive protein, lipid-lowering drugs intake and cell counts	mg/dl	Beta values	Illumina HumanMethylation450	Whole blood	-	1776	1	61	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.118	0.016	0.000000000000315	-	25583993_triglycerides_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0611433	0.00838945	0.0000000000003303454	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_2
Aslibekyan S	-	28139377	2016-11-14	Plasma adiponectin	EFO_0004502	Discovery	Table 2	DNA methylation	Plasma adiponectin	Age, sex and technical covariates	Beta values	ug/dl	Illumina HumanMethylation450	CD4+ T-cells	Plasma adiponectin levels were log transformed	991	1	49	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.01	0.001	0.00000000000034	-	28139377_plasma_adiponectin_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0599811	0.00824171	0.0000000000003566501	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0610008	0.00839033	0.000000000000376616	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0595842	0.0082419	0.0000000000005089985	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1
Justice AE	ARIC study	32901515	09-09-2020	waist circumference-to-hip ratio	None	discovery	Table 1	waist circumference-to-hip ratio	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Body mass index, Education	cm	Beta values	Illumina HumanMethylation450	Whole blood	None	2684	1	Adults	Both	African, Other	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.44	0.061	0.00000000000058	None	32901515_Justice-AE_waist_circumference-to-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0680831	0.00944171	0.0000000000005831261	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_4
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Replication	Table 2	DNA methylation	Triglycerides	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	760	1	68	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0114	0.0016	0.000000000000724	-	28194238_triglycerides_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0677451	0.00950396	0.000000000001065291	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0595153	0.00837706	0.000000000001262768	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0580389	0.00824265	0.000000000001989348	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.059757	0.00853885	0.000000000002704162	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0595561	0.00852237	0.000000000002904242	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0583612	0.00835229	0.000000000002919972	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0585007	0.00838507	0.00000000000314979	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_2
Dhana K	Atherosclerosis Risk in Communities	29762635	2018-05-14	Body mass index	EFO_0004340	Replication	Table 2	DNA methylation	Body mass index	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Leukocytes	None	2097	1	Adults	Both	Admixed	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0029	0.00042	0.0000000000032	None	29762635_Dhana-K_body_mass_index_replication
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Discovery	Table S4	DNA methylation	Body mass index	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of body mass index	2096	1	56.2	Both	African	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0029	4e-04	0.00000000000323	-	25935004_body_mass_index_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0574794	0.00824292	0.000000000003230775	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0579408	0.00836123	0.000000000004393501	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0579898	0.00838577	0.000000000004862993	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous decade consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	None	None	0.0000000000054	None	31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0564417	0.00824341	0.000000000007846944	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0640523	0.00936548	0.000000000008279656	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0563566	0.00824345	0.000000000008433597	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0569031	0.00837301	0.00000000001116954	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0645344	0.00952856	0.00000000001311907	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0557924	0.00824371	0.00000000001356404	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0564667	0.00835405	0.00000000001439939	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0556576	0.00824377	0.00000000001518488	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0555068	0.00824384	0.00000000001722347	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0628007	0.00933365	0.00000000001778846	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0561892	0.00836249	0.00000000001894782	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.00095	0.00014	0.000000000019	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Liu C	CHARGE+	27843151	2016-12-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	European ancestry	Table S5	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g der day	Illumina HumanMethylation450	Whole blood	-	9643	10	64.2	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.00010127	1.51e-05	0.0000000000209	-	27843151_alcohol_consumption_per_day_european_ancestry
Justice AE	ARIC study	32901515	09-09-2020	waist circumference-to-height	None	discovery	Table 1	waist circumference-to-height	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Body mass index, Education	cm	Beta values	Illumina HumanMethylation450	Whole blood	None	2684	1	Adults	Both	African, Other	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.267	0.04	0.000000000023	None	32901515_Justice-AE_waist_circumference-to-height_discovery
Ma J	FHS, RS, CARDIA, MESA	30936141	2020-05-22	Hepatic Fat	EFO_0006506, EFO_0008421	Meta-analysis model 1	Table 1	DNA methylation	Hepatic Fat	Age, sex	Beta Values	Hounsfield units	Illumina HumanMethylation450	Whole blood	Model 1 = adjusted for sex + age	3400	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	None	None	0.00000000003	None	30936141_Ma-J_hepatic_fat_meta-analysis_model_1
Lai CQ	-	27777315	2016-12-01	Postprandial lipemia	EFO_0007632	Discovery	Table S2	Postprandial lipemia	DNA methylation	Age, sex, study centre and technical covariates	-	Beta values	Illumina HumanMethylation450	CD4+ T-cells	Postprandial lipemia measured using the area under the curve	653	1	48	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-33.24	4.91	0.0000000000302	-	27777315_postprandial_lipemia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0564091	0.0084939	0.00000000003222368	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0546988	0.00824421	0.00000000003363012	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0553293	0.00837461	0.00000000004062675	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0551568	0.00837772	0.0000000000474308	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0541426	0.00824446	0.00000000005301447	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Ma J	FHS, RS, CARDIA, MESA	30936141	2020-05-22	Hepatic Fat	EFO_0006506, EFO_0008421	Meta-analysis model 2	Table 1	DNA methylation	Hepatic Fat	Age, sex	Beta Values	Hounsfield units	Illumina HumanMethylation450	Whole blood	Model 2 = model 1 + smoking + physical activity + alcohol consumption	3400	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	None	None	0.000000000063	None	30936141_Ma-J_hepatic_fat_meta-analysis_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0620451	0.00950108	0.0000000000677935	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_4
Aslibekyan S	-	26110892	2015-07-01	Body mass index	EFO_0004340	Discovery GOLDN	Table 2	DNA methylation	Body mass index	Age, sex, smoking, study centre and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	CD4+ T-cells	-	991	1	49	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-9e-04	1e-04	0.000000000076	-	26110892_body_mass_index_discovery_goldn
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0618098	0.00950735	0.00000000008222321	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0535289	0.00824473	0.00000000008714132	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-C_pct	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-C_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Total cholesterol to total lipids ratio in medium VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	1.2	0.18	0.000000000091	None	33413638_Gomez-Alonso-MDC_m-vldl-c_pct_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0548645	0.00851355	0.0000000001197014	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0614868	0.00955596	0.0000000001278278	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0538293	0.00837456	0.0000000001335376	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0527415	0.00824508	0.0000000001635518	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14350	1	Adults (18-65y)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.088	0.0138	0.00000000019	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.053963	0.00847122	0.0000000001944715	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0541148	0.00849881	0.0000000001980573	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0524354	0.00824521	0.0000000002084196	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1
Aslibekyan S	-	26110892	2015-07-01	Waist circumference	EFO_0004342	Discovery GOLDN	Table 3	DNA methylation	Waist circumference	Age, sex, smoking, study centre and technical covariates	Beta values	cm	Illumina HumanMethylation450	CD4+ T-cells	-	991	1	49	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-3e-04	5e-05	0.00000000026	-	26110892_waist_circumference_discovery_goldn
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0528889	0.00836552	0.0000000002652528	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0521151	0.00824535	0.0000000002681707	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Richard MA	CHARGE	29198723	2019-11-25	Diastolic Blood Pressure	EFO_0006336	Meta-analysis	Table S4	DNA methylation	Diastolic Blood Pressure	Age, sex, smoking, batch effects, ancestry, body mass index, blood cell counts	Beta Values	mmHg	Illumina HumanMethylation450	Whole blood, CD4+ T cells	Overall meta-analysis of discovery and replication cohorts	17010	14	Adults	Both	African, Admixed, European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.000075	None	0.0000000003	None	29198723_Richard-MA_diastolic_blood_pressure_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0527719	0.00837571	0.0000000003049863	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0536551	0.00853087	0.0000000003274799	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_3
Jiantao Ma	FHS	30796027	Feb 22, 2019	hepatic fat	EFO_0010821	Discovery	Table 1	DNA methylation	hepatic fat	Age, Sex, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylation450	whole blood	None	1496	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	None	None	0.00000000033	None	30796027_Jiantao-Ma_hepatic_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0515537	0.0081993	0.0000000003315984	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0517824	0.00824549	0.0000000003479339	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	13971	1	Adults (18-65y)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.039	0.00627	0.00000000035	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0593341	0.00949056	0.000000000416717	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0594212	0.00951953	0.0000000004438201	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0517832	0.00837679	0.0000000006507722	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0509011	0.00824587	0.0000000006880197	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0586217	0.00950822	0.0000000007216408	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0520289	0.00847197	0.0000000008396609	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0519434	0.00850074	0.000000001018619	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0509633	0.00838887	0.000000001269654	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0500111	0.00824624	0.000000001354304	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0499774	0.00824625	0.000000001389148	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0516928	0.00853272	0.000000001410354	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0507254	0.00837563	0.000000001426874	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0507264	0.00837693	0.000000001434102	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.051739	0.00854523	0.000000001440907	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0508373	0.00840607	0.000000001505151	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0496914	0.00827334	0.000000001944023	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0567278	0.00944887	0.000000001974851	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0501714	0.00838157	0.000000002201867	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0492027	0.00824657	0.000000002480545	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	APOC3 protein levels (SeqId = 6461-54)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APOC3 protein levels (SeqId = 6461-54)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Apolipoprotein C-III	774	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.93	0.156	0.0000000029	None	Gadd-DA_apoc3_protein_levels__seqid___6461-54__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0563016	0.00948723	0.00000000301465	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0563658	0.00954364	0.000000003580343	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0486963	0.00824678	0.000000003606759	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0486568	0.00824679	0.000000003713001	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0495055	0.00839196	0.000000003734001	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0499406	0.00848227	0.00000000400314	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_3
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.00027262	4.6e-05	0.0000000042	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	L-LDL-FC_pct	None	Meta-analysis	Table S2	DNA methylation	L-LDL-FC_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Free cholesterol to total lipids ratio in large LDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.58	0.098	0.0000000043	None	33413638_Gomez-Alonso-MDC_l-ldl-fc_pct_meta-analysis
Cardona A	EPIC-Norfolk	31506343	2019-09-10	Type II diabetes	EFO_0001360	Discovery	Table 2	Type II diabetes	DNA methylation	Age, sex, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1264	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.37	None	0.0000000052	None	31506343_Cardona-A_type_ii_diabetes_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0490186	0.00838932	0.000000005236209	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0557643	0.0095486	0.000000005329159	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0489676	0.00838629	0.000000005362336	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0556418	0.00954356	0.000000005649258	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	SCUBE1 protein levels (SeqId = 8989-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SCUBE1 protein levels (SeqId = 8989-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Signal peptide, CUB and EGF-like domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.91	0.156	0.0000000058	None	Gadd-DA_scube1_protein_levels__seqid___8989-40__somascan_protein_measurement
Sun D	Bogalusa Heart Study Follow up	31510868	2019-09-12	body mass index	EFO_0004340	follow up in Europeans	Online Table III	DNA methylation	body mass index	age, sex, smoking, cell composition (reference based), batch effects	Beta Values	kg/m2	Illumina HumanMethylation450	Whole blood	None	439	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.00092	None	0.0000000059	None	31510868_Sun-D_body_mass_index_follow_up_in_europeans
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0496867	0.0085353	0.000000005960684	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0552435	0.00956482	0.000000007818743	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0544992	0.0094787	0.000000009121332	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0481413	0.00838143	0.00000000944069	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_2
Juvinao-Quintero DL	ALSPAC, LBC1936, RSIII-1, RS-Bios	33622391	2021-02-23	Type 2 diabetes	EFO_0001360	meta-analysis	Table 2	DNA methylation	Type 2 diabetes	age, sex, batch effects, cell composition (reference based), smoking	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	3428	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.007	0.00125	0.000000012	None	33622391_Juvinao-Quintero-DL_type_2_diabetes_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0469845	0.00824745	0.00000001243885	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0469075	0.00824748	0.00000001313785	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0541937	0.00955998	0.00000001465088	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.046675	0.00824757	0.00000001548891	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0480484	0.00849069	0.00000001551438	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_3
Nano J	-	28624579	2017-06-15	Gamma-glutamyl transferase	EFO_0004532	Meta-analysis	Table S2	DNA methylation	Gamma-glutamyl transferase	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	1450	2	63.5	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.006	0.001	0.000000016	-	28624579_gammaglutamyl_transferase_metaanalysis
Aslibekyan S	-	28139377	2016-11-14	Plasma adiponectin	EFO_0004502	Discovery adjusted for BMI	Table 3	DNA methylation	Plasma adiponectin	Age, sex, body mass index and technical covariates	Beta values	ug/dl	Illumina HumanMethylation450	CD4+ T-cells	Plasma adiponectin levels were log transformed	991	1	49	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.008	0.001	0.000000019	-	28139377_plasma_adiponectin_discovery_adjusted_for_bmi
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	L-VLDL-TG	None	Meta-analysis	Table S2	DNA methylation	L-VLDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in large VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-13.2	2.34	0.000000019	None	33413638_Gomez-Alonso-MDC_l-vldl-tg_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.053321	0.00949755	0.00000002010863	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_4
Aslibekyan S	-	26110892	2015-07-01	Waist circumference	EFO_0004342	ARIC	Table 3	DNA methylation	Waist circumference	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	cm	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of waist circumference	2106	1	56	Both	African	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.004	7e-04	0.000000021	-	26110892_waist_circumference_aric
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base plus BMI	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects, body mass index	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-1.89	0.34	0.000000022	4807	31197173_Liu-J_fasting_glucose_base_plus_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0530751	0.00951666	0.00000002489288	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.046684	0.00838363	0.00000002614923	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0473488	0.00852957	0.00000002887389	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0467897	0.0084412	0.00000003024401	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0463162	0.00838648	0.00000003394667	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0462265	0.00838339	0.00000003565925	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Demerath EW	-	25935004	2015-08-01	Body mass index change	EFO_0004340, EFO_0005937	-	Table S3	DNA methylation	Body mass index change	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of body mass index change	2096	1	56.2	Both	African	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0024	4e-04	0.000000043	-	25935004_body_mass_index_change
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0522492	0.00953287	0.00000004300343	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0457983	0.00838598	0.00000004803654	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.045511	0.00833481	0.00000004829288	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0456958	0.00838214	0.00000005073454	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0448418	0.00824827	0.00000005520408	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0458295	0.00849664	0.00000007003619	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0459574	0.00855102	0.00000007797419	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_3
Albao D.	None	31691802	2019-12-15	Type II diabetes mellitus	EFO_0001360	Linear regression	Table 3	DNA methylation	Type II diabetes mellitus	Age, sex	M Values	None	Illumina HumanMethylationEPIC	Whole Blood	None	365	2	Adults	Both	South Asian	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	None	None	0.000000082	Type 2 diabetes, p-value	31691802_Albao-D._type_ii_diabetes_mellitus_linear_regression
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0512178	0.00954778	0.0000000824692	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0456092	0.00851118	0.00000008506861	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0440922	0.00824854	0.00000009154307	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0447418	0.00837495	0.00000009312582	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_2
Kriebel J	-	27019061	2016-03-28	Fasting glucose	EFO_0004465	-	Table 3	Fasting glucose	DNA methylation	Age, sex, smoking, cell counts and technical covariates	SD	Beta values	Illumina HumanMethylation450	Whole blood	Regression coefficients are per 1% increase in DNA methylation	1448	1	59	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.097	0.0182	0.000000098	-	27019061_fasting_glucose
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0456129	0.00855833	0.00000009986068	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0447266	0.00839366	0.0000001004254	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0453203	0.0085341	0.000000110926	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0506935	0.0095805	0.000000123184	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_4
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.00029065	5.47e-05	0.000000131	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0448398	0.00850949	0.0000001388173	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0434372	0.00824878	0.0000001414773	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0434221	0.00824878	0.0000001428904	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	TotFA	EFO_0005110, EFO_0005110	Meta-analysis	Table S2	DNA methylation	TotFA	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Total fatty acids	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-1.9	0.36	0.00000017	None	33413638_Gomez-Alonso-MDC_totfa_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0445241	0.00852573	0.0000001791093	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_3
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-TG	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in medium VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-7.1	1.37	0.00000018	None	33413638_Gomez-Alonso-MDC_m-vldl-tg_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0445966	0.00854462	0.0000001820875	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0495727	0.00953792	0.0000002047768	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0491876	0.00948824	0.0000002199972	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0438681	0.00847009	0.0000002258163	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0431476	0.00839154	0.0000002756318	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0422442	0.0082492	0.0000003077535	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0421658	0.00824923	0.0000003236533	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0436774	0.00856026	0.0000003396688	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0436252	0.00855102	0.0000003407314	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0419191	0.00824931	0.0000003790177	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0469729	0.00925278	0.0000003889029	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0467716	0.00927064	0.0000004586399	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0423202	0.00839486	0.000000468144	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0415824	0.00824943	0.0000004695174	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0422636	0.00838521	0.0000004704489	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0414782	0.00824947	0.0000005014893	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0411567	0.00824958	0.0000006140437	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PSAT1 protein levels (SeqId = 18342-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PSAT1 protein levels (SeqId = 18342-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphoserine aminotransferase	774	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.78	0.156	0.00000067	None	Gadd-DA_psat1_protein_levels__seqid___18342-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.042178	0.00855217	0.0000008234998	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0468174	0.00957382	0.000001018296	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_4
Cardona A	LOLIPOP	31506343	2019-09-10	Type II diabetes	EFO_0001360	Replication in Indians	Table 3	Type II diabetes	DNA methylation	Cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	2664	1	Adults	Both	South Asian	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.223	None	0.0000011	None	31506343_Cardona-A_type_ii_diabetes_replication_in_indians
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	L-VLDL-P	None	Meta-analysis	Table S2	DNA methylation	L-VLDL-P	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mol/L	Illumina HumanMethylation450	Whole blood	Concentration of large VLDL particles	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-12.3	2.54	0.0000012	None	33413638_Gomez-Alonso-MDC_l-vldl-p_meta-analysis
Gadd DA	Generation Scotland	35945220	31/07/2022	WNT5A protein levels (SeqId = 13268-45)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	WNT5A protein levels (SeqId = 13268-45)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein Wnt-5a	774	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.76	0.156	0.0000012	None	Gadd-DA_wnt5a_protein_levels__seqid___13268-45__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0463686	0.0095463	0.000001202695	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0412248	0.00851872	0.000001316127	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0460383	0.00952701	0.00000136263	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_4
Xu K	-	27826092	2018-01-01	Body mass index	EFO_0004340	-	Table 2	DNA methylation	Body mass index	Age, sex, ethnicity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMehtylation450	Whole blood	-	510	1	29	Both	European,African,Other	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-7e-04	0.00015	0.00000152	-	27826092_body_mass_index
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0459716	0.00957143	0.000001578502	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0458286	0.00958186	0.000001745135	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P23142	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P23142	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0394245	0.00825015	0.000001781917	P23142	41361833_Josephine_Robertson_P23142_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0396554	0.00831237	0.000001853973	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	L-VLDL-PL	None	Meta-analysis	Table S2	DNA methylation	L-VLDL-PL	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Phospholipids in large VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-12.2	2.56	0.0000019	None	33413638_Gomez-Alonso-MDC_l-vldl-pl_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0439392	0.0092399	0.000001999686	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_4
Fernández-Sanlés A.	REGICOR, Framingham Offspring Cohort	29326313	2018-01-11	Cardiovascular risk	EFO_0003919, EFO_0004298	Age-independent cardiovascular risk was determined via the residuals approach, results meta-analysesd across discovery and replicaton cohorts	Table 2	DNA methylation	Cardiovascular risk	Sex, age, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole Blood	None	2746	2	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-5	1.05	0.000002	None	29326313_Fernández-Sanlés-A._cardiovascular_risk_age-independent_cardiovascular_risk_was_determined_via_the_residuals_approach__results_meta-analysesd_across_discovery_and_replicaton_cohorts
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0451426	0.00952345	0.000002155685	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_4
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	MUFA	EFO_0006823	Meta-analysis	Table S2	DNA methylation	MUFA	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Monounsaturated fatty acids 16:1, 18:1	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-2.86	0.6	0.0000022	None	33413638_Gomez-Alonso-MDC_mufa_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0451816	0.00955386	0.000002275694	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0401961	0.00850315	0.000002297575	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Isoleucine	EFO_0009793	None	None	DNA methylation	Isoleucine	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	679	1	Adults	Females	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-15.7	3.3	0.0000024	None	Battram-T_isoleucine
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0394755	0.00837343	0.000002446771	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0389652	0.00829045	0.00000262513	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0400657	0.0085342	0.000002693927	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0386044	0.00825042	0.000002907361	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0382891	0.00825052	0.00000350049	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	L-VLDL-L	None	Meta-analysis	Table S2	DNA methylation	L-VLDL-L	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Total lipids in large VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-12.3	2.67	0.0000039	None	33413638_Gomez-Alonso-MDC_l-vldl-l_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0439845	0.0095486	0.000004131826	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0385747	0.00838224	0.000004220556	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0392461	0.00853657	0.000004313419	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	DEFB1 protein levels (SeqId = 6629-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DEFB1 protein levels (SeqId = 6629-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-defensin 1	774	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.716	0.156	0.0000046	None	Gadd-DA_defb1_protein_levels__seqid___6629-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0438306	0.00956244	0.000004607641	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_4
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery adjusted for surrogate variables	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	645	1	63.2	Both	None	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.05	0.011	0.0000047	-	28173150_serum_triglycerides_discovery_adjusted_for_surrogate_variables
Gadd DA	Generation Scotland	35945220	31/07/2022	ACY1 protein levels (SeqId = 3343-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACY1 protein levels (SeqId = 3343-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aminoacylase-1	774	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.72	0.156	0.0000047	None	Gadd-DA_acy1_protein_levels__seqid___3343-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0381951	0.00839385	0.000005398144	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0388388	0.00854462	0.000005526559	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0374497	0.00825078	0.000005699149	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0385109	0.00851192	0.000006105565	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0372836	0.00825083	0.000006268603	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	ALDOB protein levels (SeqId = 18185-118)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ALDOB protein levels (SeqId = 18185-118)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fructose-bisphosphate aldolase B	774	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.7	0.156	0.0000066	None	Gadd-DA_aldob_protein_levels__seqid___18185-118__somascan_protein_measurement
Aslibekyan S	-	26110892	2015-07-01	Body mass index	EFO_0004340	ARIC	Table 2	DNA methylation	Body mass index	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of body mass index	2106	1	56	Both	African	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.003	7e-04	0.0000072	-	26110892_body_mass_index_aric
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0375856	0.00838345	0.000007405075	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0382122	0.00854342	0.000007781645	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_3
Pfeiffer L	-	25583993	2015-01-12	Triglycerides	EFO_0004530, CHEBI_17855	Replication	Table 2	Triglycerides	DNA methylation	Age, sex, smoking, body mass index, alcohol consumption, physical activity, hypertension, history of MI, hemoglobin A1c, C-reactive protein, lipid-lowering drugs intake and cell counts	mg/dl	Beta values	Illumina HumanMethylation450	Whole blood	-	971	2	62	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-	-	0.00000788	-	25583993_triglycerides_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	D6RF35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	D6RF35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0375181	0.00839904	0.000007993669	D6RF35	41361833_Josephine_Robertson_D6RF35_OSCA_model_2
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-TG	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in small VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-5.6	1.25	0.000008	None	33413638_Gomez-Alonso-MDC_s-vldl-tg_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P23142	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P23142	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0372778	0.00839269	0.000008990546	P23142	41361833_Josephine_Robertson_P23142_OSCA_model_2
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-CE_pct	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-CE_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Cholesterol esters to total lipids ratio in small VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	2.02	0.455	0.000009	None	33413638_Gomez-Alonso-MDC_s-vldl-ce_pct_meta-analysis
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery	Supplementary Table 2	DNA methylation	HOMA-IR	Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (cross ancestry)	456	1	Adults (18-65 years)	Females	European,South Asian	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.122234925	0.027229568	0.00000912	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	XS-VLDL-TG	None	Meta-analysis	Table S2	DNA methylation	XS-VLDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in very small VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-4	0.9	0.0000097	None	33413638_Gomez-Alonso-MDC_xs-vldl-tg_meta-analysis
Jiantao Ma	RS, MESA, CARDIA	30796027	Feb 22, 2019	hepatic fat	EFO_0010821	Replication	Table 1	DNA methylation	hepatic fat	Age, Sex, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylation450	whole blood	None	1904	3	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	None	None	0.0000099	None	30796027_Jiantao-Ma_hepatic_fat_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0422717	0.00958903	0.00001049061	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_4
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-PL	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-PL	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Phospholipids in small VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-3.6	0.83	0.000011	None	33413638_Gomez-Alonso-MDC_s-vldl-pl_meta-analysis
Battram T	ARIES	None	2020-08-20	Conjugated linoleic acid	EFO_0006807	None	None	DNA methylation	Conjugated linoleic acid	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	666	1	Adults	Females	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-10.2	2.3	0.000011	None	Battram-T_conjugated_linoleic_acid
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0419507	0.00955503	0.00001139218	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0368006	0.00838418	0.00001145189	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_2
Aslibekyan S	-	26110892	2015-07-01	Body mass index	EFO_0004340	FHS 2	Table 2	DNA methylation	Body mass index	Age, sex and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood	-	442	1	71	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.04	0.01	0.000012	-	26110892_body_mass_index_fhs_2
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.00202	0.00046	0.000012	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0365143	0.00836166	0.00001269032	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_2
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Framingham Heart Study Batch 1	Table S1	DNA methylation	Body mass index	Age, sex and technical covariates	-	kg/m2	Illumina HumanMethylation450	Whole blood	DNA methylation was inverse normally rank transformed	442	1	67	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0429	0.00956	0.000014	-	28095459_body_mass_index_framingham_heart_study_batch_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0361972	0.00833465	0.00001415091	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_3
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	VLDL-TG	None	Meta-analysis	Table S2	DNA methylation	VLDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-6.7	1.55	0.000015	None	33413638_Gomez-Alonso-MDC_vldl-tg_meta-analysis
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-2.5	0.59	0.000016	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-C_pct	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-C_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Total cholesterol to total lipids ratio in small VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	1.33	0.311	0.000019	None	33413638_Gomez-Alonso-MDC_s-vldl-c_pct_meta-analysis
Gadd DA	Generation Scotland	35945220	31/07/2022	FTH1 protein levels (SeqId = 5934-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FTH1 protein levels (SeqId = 5934-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ferritin heavy chain|Ferritin light chain	774	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.67	0.156	0.000019	None	Gadd-DA_fth1_protein_levels__seqid___5934-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.035864	0.00838907	0.00001922741	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0395676	0.00927137	0.00001987266	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	PCYOX1 protein levels (SeqId = 6431-68)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PCYOX1 protein levels (SeqId = 6431-68)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Prenylcysteine oxidase 1	774	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.66	0.156	0.000021	None	Gadd-DA_pcyox1_protein_levels__seqid___6431-68__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.036389	0.00855289	0.00002107393	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	D6RF35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	D6RF35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0350942	0.00825149	0.00002121614	D6RF35	41361833_Josephine_Robertson_D6RF35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0355535	0.00838194	0.00002232198	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0347228	0.00825159	0.00002591535	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Triglycerides in medium HDL	EFO_0004530	None	None	DNA methylation	Triglycerides in medium HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-10.9	2.6	0.000026	None	Battram-T_triglycerides_in_medium_hdl
Gadd DA	Generation Scotland	35945220	31/07/2022	FTL protein levels (SeqId = 15324-58)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FTL protein levels (SeqId = 15324-58)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ferritin light chain	774	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.65	0.156	0.000028	None	Gadd-DA_ftl_protein_levels__seqid___15324-58__somascan_protein_measurement
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting insulin	EFO_0004466	Base plus BMI	Supplementary Data 1	DNA methylation	fasting insulin	Age, sex, smoking, cell composition (reference based), batch effects, body mass index	Beta Values	log pmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-1.44	0.35	0.00003	4739	31197173_Liu-J_fasting_insulin_base_plus_bmi
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-P	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-P	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mol/L	Illumina HumanMethylation450	Whole blood	Concentration of small VLDL particles	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-3.9	0.93	0.000032	None	33413638_Gomez-Alonso-MDC_s-vldl-p_meta-analysis
Battram T	ARIES	None	2020-08-20	Leucine	EFO_0009770	None	None	DNA methylation	Leucine	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-17.3	4.1	0.000034	None	Battram-T_leucine
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-L	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-L	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Total lipids in small VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-3.7	0.89	0.000035	None	33413638_Gomez-Alonso-MDC_s-vldl-l_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0341501	0.00825176	0.00003514997	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0395933	0.00958474	0.00003633963	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_4
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-P	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-P	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mol/L	Illumina HumanMethylation450	Whole blood	Concentration of medium VLDL particles	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-6.1	1.47	0.000037	None	33413638_Gomez-Alonso-MDC_m-vldl-p_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0351705	0.00854556	0.00003881977	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0338722	0.00825183	0.00004068432	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (european)	Supplementary Table 3	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (europeans)	294	1	Adults (18-65 years)	Females	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.157998698	0.038068085	0.0000407	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european)
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0343738	0.00839033	0.00004210854	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_2
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-L	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-L	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Total lipids in medium VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-6	1.46	0.000045	None	33413638_Gomez-Alonso-MDC_m-vldl-l_meta-analysis
Battram T	GEO	25282492	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE61278. Compared fetal liver tissue to adult liver tissue of different individuals	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Fetal liver, adult liver	None	110	1	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.275	0.064	0.000047	None	25282492_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse61278__compared_fetal_liver_tissue_to_adult_liver_tissue_of_different_individuals
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0387856	0.00954594	0.00004868858	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_4
Lai CQ	-	27777315	2016-12-01	Postprandial lipemia	EFO_0007632	Replication adjusted for baseline triglycerides	Table S1	Postprandial lipemia	DNA methylation	Age, sex, study centre and technical covariates	-	Beta values	Illumina HumanMethylation450	CD4+ T-cells	Postprandial lipemia measured using the area under the curve	326	1	48.8	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-13.99	3.4	0.00005	-	27777315_postprandial_lipemia_replication_adjusted_for_baseline_triglycerides
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-FC	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-FC	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Free cholesterol in small VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-3.6	0.9	0.000051	None	33413638_Gomez-Alonso-MDC_s-vldl-fc_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01762	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01762	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0339462	0.0083933	0.00005271697	P01762	41361833_Josephine_Robertson_P01762_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0333337	0.00825198	0.00005384351	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-FC	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-FC	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Free cholesterol in medium VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-7	1.73	0.000054	None	33413638_Gomez-Alonso-MDC_m-vldl-fc_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0332165	0.00825202	0.00005719771	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.0383263	0.00956257	0.00006155214	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.038252	0.00956498	0.00006387557	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0342284	0.00855902	0.0000638936	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_3
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-C	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-C	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Total cholesterol in medium VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-4.8	1.21	0.00007	None	33413638_Gomez-Alonso-MDC_m-vldl-c_meta-analysis
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	Ile	EFO_0009793	Meta-analysis	Table S2	DNA methylation	Ile	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Isoleucine	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-1.47	0.371	0.000071	None	33413638_Gomez-Alonso-MDC_ile_meta-analysis
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	Serum-TG	EFO_0004530	Meta-analysis	Table S2	DNA methylation	Serum-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Serum total triglycerides	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-5.1	1.28	0.000072	None	33413638_Gomez-Alonso-MDC_serum-tg_meta-analysis
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-PL	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-PL	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Phospholipids in medium VLDL	5414	4	Adults	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-5.7	1.43	0.000076	None	33413638_Gomez-Alonso-MDC_m-vldl-pl_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0337452	0.00854024	0.0000780846	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Inflammatory Bowel Disease	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Inflammatory Bowel Disease	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17959	1	Adults (18-65y)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.016	0.00395	0.000079	None	Robert-F-Hillary_Incident_Inflammatory_Bowel_Disease_Basic_model
Battram T	ARIES	None	2020-08-20	Saturated fatty acids	EFO_0005110	None	None	DNA methylation	Saturated fatty acids	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	669	1	Adults	Females	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.187	0.047	0.000079	None	Battram-T_saturated_fatty_acids
Gadd DA	Generation Scotland	35945220	31/07/2022	KAZALD1 protein levels (SeqId = 7144-234)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KAZALD1 protein levels (SeqId = 7144-234)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Kazal-type serine protease inhibitor domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.61	0.156	0.000091	None	Gadd-DA_kazald1_protein_levels__seqid___7144-234__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Glycoprotein acetyls	EFO_0004555	None	None	DNA methylation	Glycoprotein acetyls	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-0.91	0.23	0.000093	None	Battram-T_glycoprotein_acetyls
Battram T	ARIES	None	2020-08-20	Arm region fat	EFO_0005409	None	None	DNA methylation	Arm region fat	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	-1.73	0.44	0.000094	None	Battram-T_arm_region_fat
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00574958	chr11:68607622	11	68607622	CPT1A	North shore	0.0321466	0.00825243	0.00009846967	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_3