author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.669966	0.032069	9.732384e-96	None	39706196_Hannah-M.-Smith_bmi_discovery
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	4.2	0.204	2.5e-91	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.638376	0.0321814	1.313707e-86	None	39706196_Hannah-M.-Smith_body_fat_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.654696	0.0339665	6.334349000000001e-82	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.621533	0.0342272	5.198674e-73	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.563319	0.0321618	4.248618e-68	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.147487	0.00908925	1.061668e-58	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.144702	0.00910193	1.939354e-56	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.476571	0.0312907	4.647276e-52	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.137755	0.00912123	3.772506e-51	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.49645	0.0342189	2.04768e-47	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.112769	0.0082039	9.937304000000001e-43	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.449317	0.0333355	3.294509e-41	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.115425	0.00911375	1.4386929999999999e-36	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.103228	0.00821246	4.7533209999999996e-36	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0934786	0.00822042	7.730205e-30	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0928623	0.00822089	1.819855e-29	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0909667	0.00822234	2.4450540000000003e-28	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0903082	0.00822283	5.953104000000001e-28	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.100385	0.00915801	7.513285e-28	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0968636	0.00892454	2.435002e-27	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0945588	0.00912781	4.627748e-25	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0850599	0.00822665	5.685419e-25	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.068	0.00665	1.7999999999999997e-24	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0874638	0.009164	1.582735e-21	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0928315	0.00982221	3.848784e-21	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0859075	0.00916426	7.971106e-21	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0844115	0.00914858	3.1644899999999997e-20	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0843733	0.00914953	3.318891e-20	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0744122	0.00823368	1.7995739999999997e-19	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0732831	0.00823437	6.248364999999999e-19	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0714124	0.00823549	4.714708e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0734864	0.00854943	9.120859e-18	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0689799	0.0082369	6.043804000000001e-17	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.12	0.0147	1.2e-16	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0752298	0.0090813	1.292912e-16	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0676453	0.00823766	2.361159e-16	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0674116	0.00823779	2.989132e-16	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0661264	0.0082385	0.000000000000001078475	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	1.7	0.215	0.0000000000000012	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0714106	0.00917736	0.000000000000007663351	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0714058	0.00918116	0.000000000000007892281	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0637806	0.00823976	0.00000000000001054007	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0635852	0.00823986	0.00000000000001269682	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.07042	0.00916161	0.00000000000001608799	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0632648	0.00824003	0.00000000000001721212	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0695372	0.00912827	0.00000000000002738096	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Ischemic Heart Disease	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Ischemic Heart Disease	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17483	1	Adults (18-65y)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.048	0.00636	0.000000000000033	None	Robert-F-Hillary_Incident_Ischemic_Heart_Disease_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0694733	0.0091853	0.00000000000004155353	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0638344	0.00845819	0.0000000000000471411	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0602685	0.00824156	0.0000000000002752666	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0598322	0.00824178	0.000000000000407658	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.035	0.0042	0.00000000000052	None	32795589_Kyung-WK_eosinophilia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.067234	0.00942302	0.000000000001012743	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	discovery	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.227549	0.0319138	0.00000000000104108	None	39706196_Hannah-M.-Smith_glucose_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0722414	0.0102553	0.000000000001946759	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.071213	0.0102549	0.000000000003963729	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0612379	0.00887522	0.000000000005418356	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0630959	0.00917839	0.000000000006476649	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0561494	0.00824355	0.00000000001004721	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0604471	0.00907759	0.0000000000285626	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0548822	0.00824413	0.00000000002891484	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0544005	0.00824435	0.00000000004295113	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0604672	0.00916986	0.00000000004424156	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.054363	0.00824436	0.0000000000442892	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0589455	0.00913794	0.0000000001148744	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0628066	0.00982567	0.0000000001685834	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0584915	0.0091734	0.0000000001869597	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0588015	0.00930828	0.0000000002741821	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0576982	0.00916259	0.0000000003118233	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0577924	0.00918051	0.0000000003159122	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.057902	0.00920675	0.0000000003284021	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0579736	0.00930934	0.0000000004869895	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0569851	0.00916959	0.0000000005285329	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.05122	0.00824573	0.0000000005383137	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0500569	0.00824622	0.000000001308337	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0564093	0.00929576	0.000000001324643	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0545104	0.00903469	0.000000001643491	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0542554	0.00918029	0.000000003497339	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0532582	0.00915922	0.000000006200543	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0581485	0.0100391	0.000000007089258	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	sensitivity	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.197504	0.0341373	0.000000007346935	None	39706196_Hannah-M.-Smith_glucose_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0529379	0.00918572	0.000000008426237	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0525528	0.00917831	0.00000001049934	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0563637	0.00993315	0.00000001418963	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0508722	0.00916085	0.00000002853445	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0561362	0.0102254	0.00000004088921	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0502345	0.0091737	0.00000004424072	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0548794	0.0101692	0.00000006896548	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.044085	0.00824854	0.00000009198119	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0489132	0.00915727	0.00000009357554	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0483729	0.00916985	0.0000001344886	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.043098	0.0082489	0.0000001768321	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	13971	1	Adults (18-65y)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.037	0.0072	0.0000002	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0460411	0.00894368	0.0000002668394	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18059	1	Adults (18-65y)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.082	0.0158	0.00000027	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Basic_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.17255	0.0335879	0.0000002816411	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0469326	0.00918734	0.0000003289794	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0512845	0.0100765	0.0000003633971	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0493784	0.00975837	0.0000004240902	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	GPX1 protein levels (SeqId = 15591-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GPX1 protein levels (SeqId = 15591-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glutathione peroxidase 1	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.8	0.159	0.00000059	None	Gadd-DA_gpx1_protein_levels__seqid___15591-28__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0455604	0.00916719	0.0000006772641	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0507375	0.0102377	0.0000007277631	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0496648	0.0101667	0.000001044876	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.04438	0.00908931	0.000001057664	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	DDX58 protein levels (SeqId = 12382-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DDX58 protein levels (SeqId = 12382-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Probable ATP-dependent RNA helicase DDX58	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.77	0.159	0.0000013	None	Gadd-DA_ddx58_protein_levels__seqid___12382-2__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14350	1	Adults (18-65y)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.076	0.0158	0.0000014	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Ischemic Heart Disease	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Ischemic Heart Disease	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	13797	1	Adults (18-65y)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.034	0.00715	0.0000015	None	Robert-F-Hillary_Incident_Ischemic_Heart_Disease_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0442211	0.00918974	0.000001509121	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0443623	0.00923613	0.000001577555	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	PF4V1 protein levels (SeqId = 5663-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PF4V1 protein levels (SeqId = 5663-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Platelet factor 4 variant	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.76	0.16	0.0000017	None	Gadd-DA_pf4v1_protein_levels__seqid___5663-18__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0438355	0.00918949	0.000001858403	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0392944	0.00825019	0.000001927113	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0390448	0.00825028	0.00000223796	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43251	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43251	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0389649	0.0082503	0.000002347241	P43251	41361833_Josephine_Robertson_P43251_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0381056	0.00825057	0.000003897406	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	18413	1	Adults (18-65y)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.15	0.0337	0.0000044	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0464522	0.0101642	0.00000491304	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.045993	0.0100649	0.000004925491	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0453749	0.00993488	0.000004982301	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0454895	0.00996891	0.000005080353	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0465621	0.0102317	0.000005388026	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0416162	0.00915224	0.000005482423	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0374866	0.00825077	0.000005579382	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0408656	0.00902523	0.000006003321	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	PRSS8 protein levels (SeqId = 15513-108)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRSS8 protein levels (SeqId = 15513-108)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Prostasin	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.72	0.159	0.0000062	None	Gadd-DA_prss8_protein_levels__seqid___15513-108__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	F3 protein levels (SeqId = 4931-59)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	F3 protein levels (SeqId = 4931-59)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tissue factor	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.72	0.159	0.0000067	None	Gadd-DA_f3_protein_levels__seqid___4931-59__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GUSB protein levels (SeqId = 15562-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GUSB protein levels (SeqId = 15562-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-glucuronidase	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.71	0.159	0.0000074	None	Gadd-DA_gusb_protein_levels__seqid___15562-24__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LGALS4 protein levels (SeqId = 2982-82)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LGALS4 protein levels (SeqId = 2982-82)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Galectin-4	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.71	0.159	0.0000079	None	Gadd-DA_lgals4_protein_levels__seqid___2982-82__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0411305	0.00920683	0.000007977224	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	MRAP protein levels (SeqId = 7895-108)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MRAP protein levels (SeqId = 7895-108)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Melanocortin-2 receptor accessory protein	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.71	0.159	0.000008	None	Gadd-DA_mrap_protein_levels__seqid___7895-108__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0367936	0.00825098	0.000008283627	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0413016	0.00927389	0.000008509152	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.040535	0.00916586	0.000009831571	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	GFAP protein levels (SeqId = 3034-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GFAP protein levels (SeqId = 3034-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glial fibrillary acidic protein	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.702	0.159	0.000011	None	Gadd-DA_gfap_protein_levels__seqid___3034-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KIAA1467 protein levels (SeqId = 7892-132)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KIAA1467 protein levels (SeqId = 7892-132)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein FAM234B	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.7	0.159	0.000012	None	Gadd-DA_kiaa1467_protein_levels__seqid___7892-132__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0393573	0.00899642	0.00001223984	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14391	1	Adults (18-65y)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.074	0.0171	0.000013	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0400132	0.00917616	0.00001306169	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	VAV3 protein levels (SeqId = 9830-109)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VAV3 protein levels (SeqId = 9830-109)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Guanine nucleotide exchange factor VAV3	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.69	0.159	0.000016	None	Gadd-DA_vav3_protein_levels__seqid___9830-109__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	VCAN protein levels (SeqId = 9561-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VCAN protein levels (SeqId = 9561-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Versican core protein	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.69	0.16	0.000016	None	Gadd-DA_vcan_protein_levels__seqid___9561-21__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UBE2G2 protein levels (SeqId = 9199-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBE2G2 protein levels (SeqId = 9199-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-conjugating enzyme E2 G2	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.69	0.16	0.000016	None	Gadd-DA_ube2g2_protein_levels__seqid___9199-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ADIPOQ protein levels (SeqId = 3554-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADIPOQ protein levels (SeqId = 3554-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Adiponectin	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.68	0.159	0.000016	None	Gadd-DA_adipoq_protein_levels__seqid___3554-24__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0355957	0.00825134	0.00001614301	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0354883	0.00825137	0.00001712034	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.043692	0.0102061	0.00001872584	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.024	0.00565	0.000019	None	Robert-F-Hillary_Incident_COPD_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	ADAM19 protein levels (SeqId = 8948-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADAM19 protein levels (SeqId = 8948-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Disintegrin and metalloproteinase domain-containing protein 19	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.68	0.159	0.000019	None	Gadd-DA_adam19_protein_levels__seqid___8948-13__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0392353	0.00917733	0.00001921421	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0387129	0.00906439	0.00001959316	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0426571	0.0100164	0.00002068901	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0391105	0.00919304	0.0000210948	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0350637	0.00825149	0.00002156964	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0436604	0.0102834	0.00002192293	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	TREM1 protein levels (SeqId = 9266-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TREM1 protein levels (SeqId = 9266-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Triggering receptor expressed on myeloid cells 1	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.67	0.159	0.000024	None	Gadd-DA_trem1_protein_levels__seqid___9266-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0348628	0.00825155	0.00002403796	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	BMPER protein levels (SeqId = 15368-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BMPER protein levels (SeqId = 15368-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: BMP-binding endothelial regulator protein	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.67	0.159	0.000027	None	Gadd-DA_bmper_protein_levels__seqid___15368-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CREBBP protein levels (SeqId = 13614-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CREBBP protein levels (SeqId = 13614-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CREB-binding protein	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.67	0.16	0.00003	None	Gadd-DA_crebbp_protein_levels__seqid___13614-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KLRK1 protein levels (SeqId = 14095-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KLRK1 protein levels (SeqId = 14095-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NKG2-D type II integral membrane protein	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.67	0.159	0.00003	None	Gadd-DA_klrk1_protein_levels__seqid___14095-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02765	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02765	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0344475	0.00825167	0.00003002232	P02765	41361833_Josephine_Robertson_P02765_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	HNF4A protein levels (SeqId = 10041-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HNF4A protein levels (SeqId = 10041-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hepatocyte nuclear factor 4-alpha	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.66	0.159	0.000035	None	Gadd-DA_hnf4a_protein_levels__seqid___10041-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0382819	0.00925658	0.0000355934	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	WFDC8 protein levels (SeqId = 7147-35)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	WFDC8 protein levels (SeqId = 7147-35)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: WAP four-disulfide core domain protein 8	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.655	0.159	0.000036	None	Gadd-DA_wfdc8_protein_levels__seqid___7147-35__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0384379	0.00930828	0.00003656861	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CD86 protein levels (SeqId = 5337-64)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD86 protein levels (SeqId = 5337-64)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-lymphocyte activation antigen CD86	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.65	0.159	0.000038	None	Gadd-DA_cd86_protein_levels__seqid___5337-64__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NOG protein levels (SeqId = 8778-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NOG protein levels (SeqId = 8778-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Noggin	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.655	0.159	0.000039	None	Gadd-DA_nog_protein_levels__seqid___8778-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CD3G protein levels (SeqId = 7924-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD3G protein levels (SeqId = 7924-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-cell surface glycoprotein CD3 gamma chain	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.65	0.159	0.000043	None	Gadd-DA_cd3g_protein_levels__seqid___7924-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.037393	0.00918383	0.00004693341	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.0370965	0.00913772	0.0000493875	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CHST12 protein levels (SeqId = 6626-81)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CHST12 protein levels (SeqId = 6626-81)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Carbohydrate sulfotransferase 12	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.65	0.16	0.00005	None	Gadd-DA_chst12_protein_levels__seqid___6626-81__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0413015	0.0102049	0.00005209911	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	DEFB110 protein levels (SeqId = 8340-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DEFB110 protein levels (SeqId = 8340-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-defensin 110	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.64	0.159	0.000056	None	Gadd-DA_defb110_protein_levels__seqid___8340-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ZBTB33 protein levels (SeqId = 12785-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZBTB33 protein levels (SeqId = 12785-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transcriptional regulator Kaiso	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.642	0.159	0.000057	None	Gadd-DA_zbtb33_protein_levels__seqid___12785-49__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CARD17 protein levels (SeqId = 18267-74)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CARD17 protein levels (SeqId = 18267-74)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Caspase recruitment domain-containing protein 17	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.64	0.159	0.000057	None	Gadd-DA_card17_protein_levels__seqid___18267-74__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ALKBH2 protein levels (SeqId = 18400-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ALKBH2 protein levels (SeqId = 18400-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DNA oxidative demethylase ALKBH2	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.64	0.16	0.000057	None	Gadd-DA_alkbh2_protein_levels__seqid___18400-52__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Lung Cancer	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Lung Cancer	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18364	1	Adults (18-65y)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.012	0.00301	0.000064	None	Robert-F-Hillary_Incident_Lung_Cancer_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0412178	0.0103109	0.00006432697	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	PGM2 protein levels (SeqId = 18330-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PGM2 protein levels (SeqId = 18330-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphoglucomutase-2	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.64	0.16	0.000065	None	Gadd-DA_pgm2_protein_levels__seqid___18330-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FGF20 protein levels (SeqId = 2763-66)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FGF20 protein levels (SeqId = 2763-66)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fibroblast growth factor 20	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.64	0.159	0.000065	None	Gadd-DA_fgf20_protein_levels__seqid___2763-66__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KYNU protein levels (SeqId = 4559-64)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KYNU protein levels (SeqId = 4559-64)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Kynureninase	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.63	0.159	0.000068	None	Gadd-DA_kynu_protein_levels__seqid___4559-64__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SORBS3 protein levels (SeqId = 12976-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SORBS3 protein levels (SeqId = 12976-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Vinexin	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.63	0.16	0.000069	None	Gadd-DA_sorbs3_protein_levels__seqid___12976-49__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.036391	0.00915528	0.00007075838	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	ALDOC protein levels (SeqId = 9876-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ALDOC protein levels (SeqId = 9876-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fructose-bisphosphate aldolase C	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.63	0.159	0.000072	None	Gadd-DA_aldoc_protein_levels__seqid___9876-20__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PARVA protein levels (SeqId = 13434-172)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PARVA protein levels (SeqId = 13434-172)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Alpha-parvin	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.63	0.159	0.000074	None	Gadd-DA_parva_protein_levels__seqid___13434-172__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DDX39B protein levels (SeqId = 9742-59)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DDX39B protein levels (SeqId = 9742-59)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Spliceosome RNA helicase DDX39B	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.63	0.159	0.000075	None	Gadd-DA_ddx39b_protein_levels__seqid___9742-59__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AURKA protein levels (SeqId = 3091-70)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AURKA protein levels (SeqId = 3091-70)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aurora kinase A	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.63	0.159	0.000077	None	Gadd-DA_aurka_protein_levels__seqid___3091-70__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ICAM1 protein levels (SeqId = 4342-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ICAM1 protein levels (SeqId = 4342-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Intercellular adhesion molecule 1	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.63	0.159	0.000081	None	Gadd-DA_icam1_protein_levels__seqid___4342-10__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ITGB2 protein levels (SeqId = 12750-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ITGB2 protein levels (SeqId = 12750-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Integrin beta-2	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.62	0.159	0.000084	None	Gadd-DA_itgb2_protein_levels__seqid___12750-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NOTCH2 protein levels (SeqId = 5106-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NOTCH2 protein levels (SeqId = 5106-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neurogenic locus notch homolog protein 2	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.63	0.16	0.000085	None	Gadd-DA_notch2_protein_levels__seqid___5106-52__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	POLR3F protein levels (SeqId = 11444-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	POLR3F protein levels (SeqId = 11444-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DNA-directed RNA polymerase III subunit RPC6	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.626	0.16	0.000088	None	Gadd-DA_polr3f_protein_levels__seqid___11444-49__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SPOCK3 protein levels (SeqId = 9906-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SPOCK3 protein levels (SeqId = 9906-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Testican-3	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.62	0.159	0.000088	None	Gadd-DA_spock3_protein_levels__seqid___9906-21__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0360378	0.00919457	0.00008914868	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	-0.0358904	0.0091762	0.00009223321	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	PATE1 protein levels (SeqId = 8386-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PATE1 protein levels (SeqId = 8386-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Prostate and testis expressed protein 1	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.62	0.16	0.000095	None	Gadd-DA_pate1_protein_levels__seqid___8386-11__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RFXAP protein levels (SeqId = 12726-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RFXAP protein levels (SeqId = 12726-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Regulatory factor X-associated protein	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.62	0.16	0.000096	None	Gadd-DA_rfxap_protein_levels__seqid___12726-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PPARGC1A protein levels (SeqId = 11825-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PPARGC1A protein levels (SeqId = 11825-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.62	0.159	0.000097	None	Gadd-DA_ppargc1a_protein_levels__seqid___11825-27__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IL17F protein levels (SeqId = 14026-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL17F protein levels (SeqId = 14026-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-17F	774	1	Adults (18-65 years)	Both	European	cg00683922	chr1:207242569	1	207242569	PFKFB2	Open sea	0.617	0.159	0.000099	None	Gadd-DA_il17f_protein_levels__seqid___14026-24__somascan_protein_measurement