author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	0.0039	0.00011	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	0.07822	0.00257	1.3e-75	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Marttila S	-	25888029	2015-03-14	Ageing	GO_0007568	-	Additional file 1	DNA methylation	Age group	Sex and cell counts	Beta values	-	Illumina HumanMethylation450	Peripheral blood mononuclear cells	Variable dispersion beta regression model	143	1	58.5	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	0.86356024	0.0571	1.36e-51	-	25888029_ageing
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg00748589	chr12:11653486	12	11653486	-	Island	0.0014	0.000098	1.1999999999999999e-41	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg00748589	chr12:11653486	12	11653486	-	Island	-2.28509	0.11639	1.02e-33	-	25282492_fetal_vs_adult_liver
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	0.0011	None	4.899999999999999e-31	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Reynolds LM	-	25404168	2014-11-18	Age	EFO_0000246	Monocytes	Additional file 1	DNA methylation	Age	Sex, ethnicity and technical covariates	M values	years	Illumina HumanMethylation450	Monocytes	-	1264	1	60	Both	European,African,Admixed	cg00748589	chr12:11653486	12	11653486	-	Island	-	-	3.7200000000000004e-26	-	25404168_age_monocytes
Tajuddin SM	HANDLS	31426852	2019-08-19	Age	EFO_0001799	In African American individuals	Table 2, Table S1	DNA methylation	Age	Sex, ancestry (other), socioeconomic position, cell composition (reference based)	Beta Values	years	Illumina HumanMethylationEPIC	Whole Blood	Not all sites reported	237	1	Adults	Both	African	cg00748589	chr12:11653486	12	11653486	-	Island	0.016	0.0018	2.5e-19	None	31426852_Tajuddin-SM_age_in_african_american_individuals
Li S	-	28811542	2017-08-15	Age	EFO_0000246	-	Table S1	DNA methylation	Age	Cell counts	M values	years	Illumina HumanMethylation450	Whole blood	-	1366	2	73	Missing	European	cg00748589	chr12:11653486	12	11653486	-	Island	0.0113	0.00159931	0.0000000000008	-	28811542_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	-0.0636071	0.00898063	0.000000000001478119	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Reynolds LM	-	25404168	2014-11-18	Age	EFO_0000246	T cells	Additional file 1	DNA methylation	Age	Sex, ethnicity and technical covariates	M values	Years	Illumina HumanMethylation450	T cells	-	227	1	-	Missing	None	cg00748589	chr12:11653486	12	11653486	-	Island	-	-	0.00000000000396	-	25404168_age_t_cells
Tajuddin SM	HANDLS	31426852	2019-08-19	Age	EFO_0001799	In white individuals	Table 2, Table S1	DNA methylation	Age	Sex, ancestry (other), socioeconomic position, cell composition (reference based)	Beta Values	years	Illumina HumanMethylationEPIC	Whole Blood	Not all sites reported	233	1	Adults	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	0.017	0.0026	0.00000000003	None	31426852_Tajuddin-SM_age_in_white_individuals
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	-0.0519463	0.00867002	0.000000002127911	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	0.248495	0.0423038	0.000000004330373	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	-0.047491	0.00824726	0.000000008661727	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	0.179281	0.0328287	0.00000004796525	None	39706196_Hannah-M.-Smith_bmi_discovery
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	-0.0038	0.00071	0.000000065	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Battram T	GEO	29383109	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE101961	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Breast	None	121	1	Adults	Females	European, African	cg00748589	chr12:11653486	12	11653486	-	Island	0.00124	0.00022	0.00000013	None	29383109_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse101961
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	0.0466333	0.00902594	0.0000002415383	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	-0.0453842	0.00900279	0.000000468312	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	-0.0431021	0.00901588	0.000001763901	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	0.0032	0.00069	0.0000028	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	0.0414376	0.00899864	0.000004161795	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_2
Battram T	GEO	25888029	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE58888. Compared nonagenarians to adults aged 19-30	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	143	1	Geriatrics	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	-0.113	0.0238	0.0000059	None	25888029_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse58888__compared_nonagenarians_to_adults_aged_19-30
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	-0.0363964	0.0082511	0.00001035833	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Fernandez-Jimenez N	Pregnancy And Childhood Epigenetics (PACE)	None	None	maternal pre-pregnancy body mass index	EFO_0004340	inverse variance-weighted fixed effects meta-analysis	https://doi.org/10.5281/zenodo.7314534	DNA methylation	maternal pre-pregnancy body mass index	Maternal age, parity, maternal education, maternal smoking	Beta values	kg/m2	Illumina HumanMethylation450	Placenta	None	2631	10	Infants	Both	European, Unclear	cg00748589	chr12:11653486	12	11653486	-	Island	0.0017	0.00038	0.000011	None	Fernandez-Jimenez-N_maternal_pre-pregnancy_body_mass_index_inverse_variance-weighted_fixed_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	0.0355255	0.00825136	0.00001677615	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	0.0385393	0.00901157	0.00001909263	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	0.0348526	0.00825156	0.00002417053	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	-0.0352774	0.00875313	0.0000559958	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	-0.0330997	0.00825205	0.00006073881	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	0.035883	0.0089614	0.00006254239	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	0.0330371	0.00825206	0.00006272013	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	1.3	0.333	0.000071	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	-0.0357035	0.00902047	0.00007592087	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	0.168178	0.0426013	0.00007921188	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg00748589	chr12:11653486	12	11653486	-	Island	-0.0489417	0.0124897	0.00008948316	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Fernandez-Jimenez N	Pregnancy And Childhood Epigenetics (PACE)	None	None	maternal pre-pregnancy body mass index	EFO_0004340	inverse variance-weighted fixed effects meta-analysis adjusted by cellular heterogeneity	https://doi.org/10.5281/zenodo.7314534	DNA methylation	maternal pre-pregnancy body mass index	Cell composition (reference free), maternal age, parity, maternal education, maternal smoking	Beta values	kg/m2	Illumina HumanMethylation450	Placenta	None	2631	10	Infants	Both	European, Unclear	cg00748589	chr12:11653486	12	11653486	-	Island	0.0014	0.00037	0.000092	None	Fernandez-Jimenez-N_maternal_pre-pregnancy_body_mass_index_inverse_variance-weighted_fixed_effects_meta-analysis_adjusted_by_cellular_heterogeneity