author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.009 0.00029 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.042 0.0015 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.32247 0.00663 2.8e-110 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.116828 0.00820003 9.419691e-46 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea - - 1.18e-35 - 23526956_clear_cell_renal_carcinoma Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0969565 0.00821767 5.540279e-32 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0892305 0.00822364 2.519076e-27 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0779225 0.00823147 3.329113e-21 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0733568 0.00823433 5.764041999999999e-19 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 2902326 (gene symbol: HCP5) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 2902326 (gene symbol: HCP5) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg01082299 chr6:31431969 6 31431969 HCP5 Open sea None None 6.6e-18 None 33752734_Yao-C_gene_expression_of_affymetrix_id__2902326__gene_symbol__hcp5__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.104268 0.0123173 2.798947e-17 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0684474 0.00823721 1.044249e-16 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.092067 0.0117204 0.000000000000004264301 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0909311 0.0116402 0.000000000000006018598 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0840387 0.0117205 0.0000000000007843388 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0836048 0.0117212 0.000000000001029621 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0586892 0.00824234 0.000000000001125703 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0071 0.00089 0.0000000000017 None 33564054_Kashima-K_gestational_age Imgenberg-Kreuz J - 26857698 2016-11-01 Primary Sjogrens syndrome EFO_0000699 Whole blood Table S1 DNA methylation Primary Sjogrens syndrome Age, sex and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 500 1 - Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea - - 0.00000000000366 - 26857698_primary_sjogrens_syndrome_whole_blood Mendelson MM FHS 29740313 2018-04-24 Soluble tumor necrosis factor receptor 2 EFO_0008384, NCIT_C117749 None Table S1 DNA methylation Soluble tumor necrosis factor receptor 2 Age, sex, body mass index, smoking, batch effects Beta Values pg/ml Illumina HumanMethylation450 Whole blood None 2468 1 Adults Both Unclear cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0166 0.00244 0.000000000015 None 29740313_Mendelson-MM_soluble_tumor_necrosis_factor_receptor_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0801518 0.0122402 0.00000000006016194 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0785333 0.0123113 0.0000000001836516 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0520711 0.00824537 0.0000000002775994 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0517392 0.00824551 0.0000000003598389 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0769642 0.0123379 0.0000000004553215 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0511733 0.00824575 0.0000000005580687 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0750702 0.012128 0.0000000006184609 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0721379 0.0116917 0.0000000007007398 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0507262 0.00824594 0.0000000007866916 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0716274 0.0116559 0.0000000008193574 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH34 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH34 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0756862 0.0123206 0.000000000830338 A0A0C4DH34 41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0716813 0.0117107 0.0000000009534604 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0742813 0.0121699 0.000000001062694 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0496785 0.00824638 0.000000001739296 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0706288 0.0117327 0.000000001787873 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0700045 0.0117344 0.000000002490926 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0698989 0.0117263 0.000000002566233 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0688175 0.0116243 0.000000003288613 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0690606 0.0117207 0.000000003894625 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0679587 0.0115623 0.000000004252612 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0681098 0.0116833 0.000000005671133 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0708167 0.0123149 0.000000009076255 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02747 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02747 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0700507 0.0123293 0.00000001359612 P02747 41361833_Josephine_Robertson_P02747_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0468392 0.00824751 0.00000001379006 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0675816 0.0122125 0.00000003187225 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0642409 0.0117297 0.0000000440264 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0673278 0.0122979 0.00000004453261 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04430 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04430 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0673637 0.0123448 0.00000004925018 P04430 41361833_Josephine_Robertson_P04430_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH34 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH34 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.063901 0.0117265 0.00000005139719 A0A0C4DH34 41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0638264 0.0117214 0.00000005255607 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0447184 0.00824831 0.00000006002967 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01602 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01602 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0667855 0.0123283 0.00000006147725 P01602 41361833_Josephine_Robertson_P01602_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH34 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH34 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0634108 0.0117329 0.00000006600401 A0A0C4DH34 41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01602 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01602 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.063035 0.0117314 0.00000007854995 P01602 41361833_Josephine_Robertson_P01602_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0442389 0.00824849 0.00000008296349 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04430 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04430 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0626421 0.0117391 0.00000009632203 P04430 41361833_Josephine_Robertson_P04430_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01602 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01602 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0625333 0.0117198 0.00000009659676 P01602 41361833_Josephine_Robertson_P01602_OSCA_model_3 Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -1.843201 0.3467 0.000000106 - 27105112_hiv_infection_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04430 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04430 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0622783 0.0117403 0.000000114515 P04430 41361833_Josephine_Robertson_P04430_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01602 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01602 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.04339 0.0082488 0.0000001459495 P01602 41361833_Josephine_Robertson_P01602_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04430 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04430 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0428972 0.00824897 0.0000002016301 P04430 41361833_Josephine_Robertson_P04430_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0427567 0.00824902 0.0000002209522 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.060562 0.0117264 0.0000002441446 P02747 41361833_Josephine_Robertson_P02747_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 GBP1 protein levels (SeqId = 15326-64) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GBP1 protein levels (SeqId = 15326-64) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Guanylate-binding protein 1 774 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.93 0.182 0.00000031 None Gadd-DA_gbp1_protein_levels__seqid___15326-64__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0592742 0.0117419 0.0000004515887 P02747 41361833_Josephine_Robertson_P02747_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 FCGR3B protein levels (SeqId = 3311-27) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 FCGR3B protein levels (SeqId = 3311-27) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Low affinity immunoglobulin gamma Fc region receptor III-B 774 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.929 0.186 0.00000056 None Gadd-DA_fcgr3b_protein_levels__seqid___3311-27__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.041189 0.00824956 0.0000006017245 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg01082299 chr6:31431969 6 31431969 HCP5 Open sea None None 0.00000061 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0579972 0.0117076 0.0000007359285 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0580319 0.0117227 0.0000007487985 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01762 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01762 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0577577 0.0117436 0.0000008827741 P01762 41361833_Josephine_Robertson_P01762_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01762 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01762 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0605749 0.0123464 0.0000009381966 P01762 41361833_Josephine_Robertson_P01762_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0404035 0.00824983 0.000000980973 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01762 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01762 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0571305 0.0117397 0.000001148174 P01762 41361833_Josephine_Robertson_P01762_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0588315 0.0123066 0.000001765769 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0584872 0.0122753 0.000001910347 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0392368 0.00825021 0.000001994932 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0390729 0.00825027 0.000002200594 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 MICB protein levels (SeqId = 5102-55) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MICB protein levels (SeqId = 5102-55) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: MHC class I polypeptide-related sequence B 774 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.87 0.186 0.0000025 None Gadd-DA_micb_protein_levels__seqid___5102-55__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0550263 0.011728 0.000002731445 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0562403 0.0120431 0.000003040111 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0539547 0.0116817 0.000003893393 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0380232 0.0082506 0.000004089342 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0535881 0.011727 0.000004925411 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0374632 0.00825078 0.000005655071 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0006552 0.00014381 0.00000581 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0546514 0.0122508 0.000008217417 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0522083 0.0117323 0.00000865265 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.050715 0.0114617 0.000009726462 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0515817 0.0117201 0.0000108442 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0362405 0.00825115 0.00001130055 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0360764 0.0082512 0.00001238126 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0533801 0.0122351 0.00001292499 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0538506 0.0123473 0.00001301512 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0534525 0.0122866 0.00001367769 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0358472 0.00825126 0.00001405643 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0358333 0.00825127 0.00001416497 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.00017412 4.01e-05 0.0000142 - 27843151_alcohol_consumption_per_day_european_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.050229 0.0115934 0.00001483661 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH34 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH34 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0355051 0.00825137 0.00001696378 A0A0C4DH34 41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0354669 0.00825138 0.00001732265 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JRQ6 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0G2JRQ6 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0528809 0.0123099 0.00001752005 A0A0G2JRQ6 41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0354304 0.00825139 0.00001767094 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 CD48 protein levels (SeqId = 3292-75) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CD48 protein levels (SeqId = 3292-75) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: CD48 antigen 774 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.8 0.186 0.000018 None Gadd-DA_cd48_protein_levels__seqid___3292-75__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0498468 0.0116439 0.00001872792 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0500416 0.0116901 0.00001875105 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0500606 0.0117167 0.00001944287 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0499332 0.0117123 0.00002026779 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0351734 0.00825146 0.00002032464 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0497589 0.0117016 0.00002128711 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0493182 0.0116839 0.00002446556 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0491322 0.0116634 0.00002540349 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.006 0.0014 0.00003 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0479135 0.011498 0.00003102319 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0486678 0.0117179 0.00003295892 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg01082299 chr6:31431969 6 31431969 HCP5 Open sea None None 0.000034 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0505658 0.0123211 0.00004082728 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0495391 0.0121963 0.00004894966 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH29 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH29 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0500215 0.0123544 0.00005172984 A0A0C4DH29 41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 GZMA protein levels (SeqId = 3440-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GZMA protein levels (SeqId = 3440-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Granzyme A 774 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.75 0.185 0.000054 None Gadd-DA_gzma_protein_levels__seqid___3440-7__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P19827 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P19827 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0499019 0.0123737 0.00005537485 P19827 41361833_Josephine_Robertson_P19827_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 CD5L protein levels (SeqId = 3293-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CD5L protein levels (SeqId = 3293-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: CD5 antigen-like 774 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.74 0.185 0.000057 None Gadd-DA_cd5l_protein_levels__seqid___3293-2__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0466851 0.0116226 0.00005929694 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0488691 0.0121908 0.0000613559 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0330354 0.00825206 0.00006277563 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0468984 0.0117226 0.00006346999 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea 0.0329771 0.00825208 0.00006467698 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0325648 0.00825219 0.00007977308 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 LAG3 protein levels (SeqId = 9950-229) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LAG3 protein levels (SeqId = 9950-229) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Lymphocyte activation gene 3 protein 774 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.73 0.185 0.000083 None Gadd-DA_lag3_protein_levels__seqid___9950-229__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01082299 chr6:31431969 6 31431969 HCP5 Open sea -0.0323265 0.00825226 0.00008995605 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1