author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore 0.0025 0.00014 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore 0.0016 None 1.7e-33 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore - - 2.03e-18 - 26500701_sex_kora_f4 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 2540157 (gene symbol: ODC1) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 2540157 (gene symbol: ODC1) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore None None 0.0000000000000058 None 33752734_Yao-C_gene_expression_of_affymetrix_id__2540157__gene_symbol__odc1__meta-analysis Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore 0.198408 0.0255767 0.000000000000009150406 None 39706196_Hannah-M.-Smith_bmi_sensitivity Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore -0.0061 0.00093 0.000000000067 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore -0.158075 0.024953 0.0000000002430804 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore 0.157235 0.0257595 0.000000001056745 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore -0.03203 0.00567 0.000000058 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore 0.131212 0.0256742 0.0000003244645 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore -0.019 0.00372 0.00000036 None Robert-F-Hillary_Incident_COPD_Basic_model Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore -0.00012878 2.63e-05 0.000000946 - 27843151_alcohol_consumption_per_day_european_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore -0.0470202 0.00967654 0.000001190813 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_4 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18005 1 Adults (18-65y) Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore 0.046 0.0098 0.000003 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore None None 0.0000038 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore -0.037969 0.00825071 0.000004221442 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore -0.0376287 0.00825072 0.000005140604 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore -0.0374984 0.00825076 0.000005541563 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore -0.0370499 0.00828396 0.000007789785 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore -0.0361318 0.00824919 0.00001194765 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore -0.0352432 0.00825144 0.00001956909 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore -0.0346729 0.00826843 0.00002764041 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore -0.0345424 0.00824895 0.00002837015 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore -0.0337626 0.00826448 0.00004425984 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore 0.0334896 0.00825194 0.00004966708 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 14350 1 Adults (18-65y) Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore 0.042 0.0103 0.000051 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore -0.0332949 0.00825199 0.00005493334 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore -0.0328394 0.00825212 0.00006938915 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore 0.0328616 0.00827784 0.00007226662 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01381586 chr2:10587627 2 10587627 ODC1;SNORA80B North shore -0.0325889 0.00826738 0.00008122775 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3