author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.0051 0.00019 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.49258 0.00781 9.999999999999999e-131 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3428671 (gene symbol: SYCP3) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3428671 (gene symbol: SYCP3) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg01687189 chr12:102225365 12 102225365 GNPTAB South shore None None 2.2999999999999997e-24 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3428671__gene_symbol__sycp3__meta-analysis Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore - - 4.41e-21 - 28056824_age_4_vs_age_0 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.0598161 0.00824179 0.0000000000004135842 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.0594379 0.00824197 0.0000000000005800044 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.0055 0.00077 0.000000000098 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.0530666 0.00824494 0.0000000001262566 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.00025343 4.1e-05 0.000000000639 - 27843151_alcohol_consumption_per_day_european_ancestry Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.00096 0.00016 0.0000000053 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg01687189 chr12:102225365 12 102225365 GNPTAB South shore None None 0.000000019 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.0017 None 0.000000035 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.0439951 0.00824858 0.00000009767851 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.006 0.0011 0.00000017 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg01687189 chr12:102225365 12 102225365 GNPTAB South shore None None 0.00000028 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.0407564 0.00824971 0.0000007884509 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.0059 0.0012 0.00000088 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.0400019 0.00824996 0.000001255251 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg01687189 chr12:102225365 12 102225365 GNPTAB South shore None None 0.0000031 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Ultrasound-estimated gestational age Table S1 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.00054299 0.00011676 0.00000373 - 27717397_gestational_age_ultrasoundestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.037225 0.00825085 0.000006482396 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SMPD1 protein levels (SeqId = 10818-36) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SMPD1 protein levels (SeqId = 10818-36) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sphingomyelin phosphodiesterase 774 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.6 0.135 0.0000091 None Gadd-DA_smpd1_protein_levels__seqid___10818-36__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.0352679 0.00825144 0.00001930782 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.0352611 0.00825144 0.00001937944 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.0350086 0.00825151 0.0000222211 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.0333091 0.00825199 0.0000545316 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg01687189 chr12:102225365 12 102225365 GNPTAB South shore -0.00518 0.00129 0.000059 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg01687189 chr12:102225365 12 102225365 GNPTAB South shore 0.0322736 0.00825227 0.00009237552 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1