author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Discovery	Table S3, Table S4	Total serum IgE	DNA methylation	Age, sex, asthma and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	879	2	12	Both	European,African,Other	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	-6.2	0.5258	4.3000000000000004e-32	-	28069425_total_serum_ige_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG3 protein levels (SeqId = 9015-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG3 protein levels (SeqId = 9015-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proteoglycan 3	774	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	-1.96	0.192	1.8999999999999998e-24	None	Gadd-DA_prg3_protein_levels__seqid___9015-1__somascan_protein_measurement
Chen W	-	28069425	2017-01-06	Total serum IgE	EFO_0004579	Puerto Ricans only	Table E7	Total serum IgE	DNA methylation	Age, sex, asthma and technical covariates	IU/ml	Beta values	Illumina HumanMethylation450	Whole blood	Total serum IgE was log10 transformed	525	2	12	Both	European,African,Other	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	-6.02	0.6024	1.6399999999999998e-23	-	28069425_total_serum_ige_puerto_ricans_only
Gadd DA	Generation Scotland	35945220	31/07/2022	PAPPA protein levels (SeqId = 4148-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PAPPA protein levels (SeqId = 4148-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pappalysin-1	774	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	-1.81	0.191	2.6e-21	None	Gadd-DA_pappa_protein_levels__seqid___4148-49__somascan_protein_measurement
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	-0.01911	0.00188	1e-19	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Xu C-J	MeDALL	29496485	2018-02-26	Asthma	EFO_0000270	Meta-analysis of discovery and replication at age 8	Table 1	DNA methylation	Asthma	Sex, batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	3927	8	Children	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	-0.018	0.0022	2.6e-17	None	29496485_Xu-C-J_asthma_meta-analysis_of_discovery_and_replication_at_age_8
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.002	None	3e-16	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	-0.0690909	0.00881596	0.000000000000004929293	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	-0.0686242	0.00890677	0.00000000000001395036	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	-0.0592369	0.00824207	0.0000000000006935314	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Cardenas A	Project Viva	31300640	Jul 12, 2019	fractional exhaled nitric oxide (FeNO)	EFO_0005536	None	Supplementary Data 2	DNA methylation	fractional exhaled nitric oxide (FeNO)	Age, Sex, Smoking, Cell composition (reference free), Batch effects, Ancestry (other), Body mass index, Education, sine and cosine of season at sample collection	Beta values	ppb	Illumina HumanMethylationEPIC	nasal epithelium	None	517	1	Children	Both	Other	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	-4.2	0.682	0.0000000015	SE manually calculated	31300640_Cardenas-A_fractional_exhaled_nitric_oxide__feno_
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.0502462	0.00855551	0.000000004373492	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.0519918	0.00889431	0.000000005157285	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.049343	0.00868297	0.00000001350783	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.0498427	0.00889943	0.00000002173624	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	MMP10 protein levels (SeqId = 8479-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MMP10 protein levels (SeqId = 8479-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Stromelysin-2	774	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	-0.98	0.191	0.00000029	None	Gadd-DA_mmp10_protein_levels__seqid___8479-4__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.0419533	0.0082493	0.0000003708351	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.0448338	0.00890131	0.0000004790922	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.0445236	0.00890271	0.0000005765341	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.0411427	0.00824958	0.000000619449	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.0406417	0.00824975	0.0000008466448	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Xu C-J	MeDALL	29496485	2018-02-26	Asthma	EFO_0000270	Discovery adjusted for cell composition excluding eosinophils at age 8	Table 1	DNA methylation	Asthma	Sex, batch effects, cell composition (reference based)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	731	2	Children	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	None	None	0.000001	None	29496485_Xu-C-J_asthma_discovery_adjusted_for_cell_composition_excluding_eosinophils_at_age_8
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	-0.0652968	0.0139345	0.000002811249	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	-0.0416282	0.00888895	0.000002850429	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	-0.0414347	0.00887097	0.000003026616	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	KIT protein levels (SeqId = 2475-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KIT protein levels (SeqId = 2475-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mast/stem cell growth factor receptor Kit	774	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	-0.89	0.192	0.0000036	None	Gadd-DA_kit_protein_levels__seqid___2475-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.0409048	0.00887463	0.000004076572	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.0410525	0.0089094	0.00000410437	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	PRG2 protein levels (SeqId = 7258-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRG2 protein levels (SeqId = 7258-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bone marrow proteoglycan	774	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	-0.88	0.192	0.0000042	None	Gadd-DA_prg2_protein_levels__seqid___7258-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.0405321	0.00892701	0.000005659643	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Reese SE	PACE	30579849	2018-12-21	Asthma	EFO_0000270	Meta-analysis with DNAm measured in children	Table 2	Asthma	DNA methylation	Batch effects, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	2862	9	Children	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	-9.3	2	0.0000059	None	30579849_Reese-SE_asthma_meta-analysis_with_dnam_measured_in_children
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.0399288	0.00888828	0.000007099851	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.0061	0.0014	0.000013	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.0629599	0.0152404	0.00003630219	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Witt S	None	32080920	02-02-2020	alcohol withdrawal recovery	None	discovery	Table S1	DNA methylation	alcohol withdrawal recovery	Age, Smoking, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylationEPIC	whole blood	two weeks after vs active withdrawal	99	1	Adults	Males	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	1	0.234	0.000045	None	32080920_Witt-S_alcohol_withdrawal_recovery_discovery
Xu C-J	MeDALL	29496485	2018-02-26	Asthma	EFO_0000270	Discovery adjusted for cell composition including eosinophils at age 8	Table 1	DNA methylation	Asthma	Sex, batch effects, cell composition (reference based)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	731	2	Children	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	None	None	0.000056	None	29496485_Xu-C-J_asthma_discovery_adjusted_for_cell_composition_including_eosinophils_at_age_8
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.035797	0.00890161	0.00005814216	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.0358076	0.00891519	0.00005937203	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01901579	chr14:95615731	14	95615731	DICER1	Open sea	0.00082	0.00021	0.000078	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect