author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.012	0.0003	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.046	0.0012	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.64	0	0	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg01940273	chr2:233284934	2	233284934	-	Island	-0.08545	0.00131	0	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.12	0.00428	1.6000000000000002e-158	None	Robert-F-Hillary_Incident_COPD_Basic_model
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-	-	1.43e-137	-	28056824_age_4_vs_age_0
Zeilinger S	-	23691101	2013-05-17	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking discovery	Table S1	DNA methylation	Smoking	Age, sex, body mass index, alcohol consumption and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	1011	1	60.8	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-	-	9.28e-114	-	23691101_smoking_current_vs_never_smoking_discovery
Christiansen C	TwinsUK, NSHD, NCDS1, NCDS2, BCS70	33593402	2021-02-16	Smoking	EFO_0004318, EFO_0006527	Current vs never smoking meta-analysis in European samples	Table S1	DNA methylation	Smoking	Sex, cell composition (reference based), body mass index, batch effects, relatedness	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	912	5	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	None	None	1.1e-109	None	33593402_Christiansen-C_smoking_current_vs_never_smoking_meta-analysis_in_european_samples
Dogan MV	-	28686328	2017-07-07	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S1	DNA methylation	Smoking	Age, sex and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	1597	1	67	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-1.80094117	0.0886	6.78e-92	-	28686328_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Former vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	156	1	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.23	0.0117	1.1e-85	None	31552803_Dugue-PA_smoking_former_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.160285	0.00814982	5.1049259999999997e-85	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.156651	0.00815683	3.338495e-81	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.17728	0.0054	5.6e-81	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.15631	0.00815508	6.759769000000001e-81	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Ambatipudi S	-	26864933	2016-05-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Age, breast cancer status, menopausal status, use of contraceptive pill, use of hormone replacement therapy and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	721	1	52.6	Females	European	cg01940273	chr2:233284934	2	233284934	-	Island	-	-	1.75e-78	-	26864933_smoking_current_vs_never_smoking
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.61	0.0336	7.44e-74	-	25556184_smoking_current_vs_never_smoking
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0005671, EFO_0004318	Former vs never smoking	Table S5	DNA methylation	Former versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	13474	16	62.9	Both	European,African	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0234	0.0013	9.6e-73	-	27651444_smoking_former_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.148071	0.00817194	1.384344e-72	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Barcelona V	GENOA	30915882	2019-03-27	Smoking	EFO_0004318, EFO_0006527	Replication	Table 2	DNA methylation	Smoking	Age, batch effects, cell composition (reference based)	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	1100	1	Adults	Females	African	cg01940273	chr2:233284934	2	233284934	-	Island	-0.083	0.004	2.5000000000000003e-67	None	30915882_Barcelona-V_smoking_replication
Chatziioannou A	EnviroGenomarkers project consortium	28225026	2017-02-22	Tobacco smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S2	DNA methylation	Current vs never smoking	Age, sex, body mass index, study centre and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	454	2	52	Both	None	cg01940273	chr2:233284934	2	233284934	-	Island	-	-	1.3800000000000002e-64	-	28225026_tobacco_smoking
Domingo-Relloso A	Strong Heart Study	32484362	2020-06-02	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	Current vs never	Table S2	DNA methylation	Smoking	Age, sex, batch effects, body mass index, cell composition (reference based), ancestry (genomic PCs)	M Values	None	Illumina HumanMethylationEPIC	Whole blood	None	2325	1	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	-0.218	0.0135	1.4e-58	None	32484362_Domingo-Relloso-A_smoking_current_vs_never
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.130358	0.00818612	1.2808919999999999e-56	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.128842	0.00818775	2.428746e-55	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.127994	0.00818866	1.2409060000000001e-54	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.140729	0.00932011	3.950519e-51	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Shah S	-	25249537	2014-09-23	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking discovery	Table S2	DNA methylation	Smoking	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	535	1	70	Both	None	cg01940273	chr2:233284934	2	233284934	-	Island	-0.08674823	0.0058	9.999999999999999e-51	-	25249537_smoking_current_vs_never_smoking_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.122921	0.0082175	3.2186869999999998e-50	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.121807	0.00819509	1.307361e-49	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.121436	0.00819547	2.567017e-49	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.1214	0.00821948	5.165498e-49	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.151708	0.0103514	2.720175e-48	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_4
Zhang Y	-	26826776	2016-04-01	Serum cotinine	EFO_0007813	Replication	Table 2	DNA methylation	Serum cotinine	Age, sex, body mass index, physical activity, total cholesterol, systolic blood pressure, prevalence of cardiovascular disease, diabetes, cancer, leukocyte, cell counts and technical covariates	Beta values	ng/ml	Illumina HumanMethylation450	Whole blood	-	500	1	62	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0013	8.9e-05	6.9e-48	-	26826776_serum_cotinine_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.119263	0.00821248	1.870332e-47	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.148126	0.0102243	3.07571e-47	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.115736	0.0082273	1.176929e-44	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.115298	0.00822702	2.454165e-44	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.113288	0.00820342	4.134947e-43	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_1
Zeilinger S	-	23691101	2013-05-17	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking replication	Table S2	DNA methylation	Smoking	Age, sex, body mass index, alcohol consumption and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	468	1	53	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-	-	5.4600000000000005e-43	-	23691101_smoking_current_vs_never_smoking_replication
Sayols-Baixeras S	-	26829059	2015-01-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Smoking status	Table S1	DNA methylation	Smoking	Age, sex, physical activity and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	645	1	63.2	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-	-	5.56e-43	-	26829059_smoking_smoking_status
Sayols-Baixeras S	-	26829059	2015-01-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Age, sex, physical activity and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	449	1	63.1	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-	-	8.7e-42	-	26829059_smoking_current_vs_never_smoking
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Lung Cancer	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Lung Cancer	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18364	1	Adults (18-65y)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.031	0.00232	1.5999999999999998e-41	None	Robert-F-Hillary_Incident_Lung_Cancer_Basic_model
Imboden M	Aging Lungs in European Cohorts project	31073081	2019-07-01	FEV1 / FVC	EFO_0004713	Meta-analysis	Supplementary table 3	DNA methylation	FEV1 / FVC	Batch effects, age, age squared, height, squared deviation from the mean height, sex, education, body mass index, cell composition (reference based)	Beta Values	None	Illumina HumanMethylation450	Whole blood	Meta-analyses were conducted across time points	5370	8	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.206	0.015	4.0999999999999996e-41	None	31073081_Imboden-M_fev1___fvc_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.141023	0.0104796	4.920834999999999e-41	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_4
Sayols-Baixeras S	-	26829059	2015-01-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking adjusted for cell counts	Table S1	DNA methylation	Smoking	Age, sex, physical activity, cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	449	1	63.1	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-	-	2.63e-40	-	26829059_smoking_current_vs_never_smoking_adjusted_for_cell_counts
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.108869	0.00820749	6.303802e-40	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.108126	0.00820817	2.101877e-39	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.108481	0.00824721	2.704769e-39	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.122673	0.00939591	9.655857000000001e-39	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.10524	0.00810455	2.410416e-38	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.105601	0.00821041	1.178877e-37	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.10499	0.00821094	3.08136e-37	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-2	0.156	4.9e-37	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.103964	0.00823598	2.434125e-36	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.129747	0.0104574	3.587872e-35	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_4
Ambatipudi S	-	26864933	2016-05-01	Smoking	EFO_0005671, EFO_0004318	Former vs never smoking	Table S2	DNA methylation	Smoking	Age, breast cancer status, menopausal status, use of contraceptive pill, use of hormone replacement therapy and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	717	1	53.4	Females	European	cg01940273	chr2:233284934	2	233284934	-	Island	-	-	8.020000000000001e-35	-	26864933_smoking_former_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.10174	0.00824927	8.920193e-35	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_2
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0815	0.0067	2.0000000000000003e-34	-	27651444_smoking_current_vs_never_smoking
Imboden M	Aging Lungs in European Cohorts project	31073081	2019-07-01	FEV1	EFO_0004314	Meta-analysis	Supplementary table 4	DNA methylation	FEV1	Batch effects, age, age squared, height, squared deviation from the mean height, sex, education, body mass index, cell composition (reference based)	Beta Values	L	Illumina HumanMethylation450	Whole blood	Meta-analyses were conducted across time points	5370	8	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	1.25	0.103	3.3000000000000003e-34	None	31073081_Imboden-M_fev1_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0999579	0.00824888	1.231794e-33	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.126972	0.0104795	1.255612e-33	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.099383	0.0082157	1.58711e-33	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Zhu X	-	26756918	2016-07-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S1	DNA methylation	Smoking	Age, sex, alcohol consumption, body mass index and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	Regression coefficients are for inverse normally transformed DNA methylation	596	4	53.9	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.539	0.044994	4.5600000000000005e-33	-	26756918_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0985749	0.00821636	5.232848e-33	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.113305	0.00948732	1.0038560000000001e-32	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_3
Tsaprouni LG	CARDIOGENICS	25424692	2014-10-31	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S2	DNA methylation	Smoking	Age, sex, disease status, centre and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	464	1	55.4	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-	-	3.6800000000000003e-32	-	25424692_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0968231	0.00821778	6.717753e-32	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0965256	0.00821802	1.0315530000000002e-31	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0964219	0.0082181	1.197645e-31	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0961796	0.00825659	3.1927280000000003e-31	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Zhang Y	-	26826776	2016-04-01	Serum cotinine	EFO_0007813	Discovery	Table 2	DNA methylation	Serum cotinine	Age, sex and technical covariates	Beta values	ng/ml	Illumina HumanMethylation450	Whole blood	-	500	1	62	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0011	1e-04	7.55e-31	-	26826776_serum_cotinine_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.120802	0.0104786	1.285573e-30	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_4
Petersen A-K	KORA F4	24014485	2013-09-06	M36098_4-vinylphenol_sulfate	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M36098_4-vinylphenol_sulfate	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.98	0.147	1.5000000000000001e-30	None	24014485_Petersen-A-K_m36098_4-vinylphenol_sulfate_snps_as_covariates_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0941713	0.00821988	2.932849e-30	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1
Petersen A-K	KORA F4	24014485	2013-09-06	M36098_4-vinylphenol_sulfate	EFO_0004727, EFO_0004725	no snps model	Table S2	M36098_4-vinylphenol_sulfate	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.98	0.144	4.6000000000000004e-30	None	24014485_Petersen-A-K_m36098_4-vinylphenol_sulfate_no_snps_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0935461	0.00824867	1.095847e-29	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0921368	0.00825628	8.396474e-29	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0919983	0.00826147	1.094157e-28	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0906985	0.00822254	3.515559e-28	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.104288	0.00949324	5.768743e-28	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_3
Battram T	GEO	25424692	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Never vs current smokers	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	201	1	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.1106	0.0085	6.6e-28	None	25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__never_vs_current_smokers
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0905966	0.00825848	6.828401000000001e-28	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.103635	0.0094732	9.515890000000001e-28	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.101876	0.00936534	1.868247e-27	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.114398	0.0105179	1.900881e-27	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0890147	0.0082238	3.3554090000000004e-27	A0A075B6I0	41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0887613	0.00826123	7.931521e-27	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0880358	0.00822451	1.2215429999999999e-26	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.111864	0.0104765	1.6232239999999998e-26	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.112221	0.0105416	2.284151e-26	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.08667	0.0082255	7.235927e-26	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0863814	0.00822571	1.050069e-25	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0849805	0.00816302	2.722188e-25	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I0	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6I0	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0852121	0.00827173	8.418768000000001e-25	A0A075B6I0	41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0845363	0.00822702	1.102303e-24	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.108111	0.0105369	1.289364e-24	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0967531	0.00949251	2.579569e-24	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0838526	0.00822749	2.600802e-24	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0841976	0.00826278	2.648636e-24	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0838236	0.00825892	4.003498e-24	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0921379	0.00917328	1.1624870000000002e-23	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0952163	0.00949501	1.367453e-23	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0953453	0.00952562	1.6496410000000002e-23	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.102003	0.0102773	3.8316070000000004e-23	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0818852	0.00826557	4.5961310000000005e-23	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.10344	0.0105134	9.004092e-23	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_4
Zeilinger S	-	23691101	2013-05-17	Smoking	EFO_0005671, EFO_0004318	Former vs never smoking	Table S1	DNA methylation	Smoking	Age, sex, body mass index, alcohol consumption and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	1531	1	61.5	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-	-	2.01e-22	-	23691101_smoking_former_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.102756	0.0105353	2.085112e-22	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_4
van Dongen J	BIOS	30631468	2018-03-23	Educational attainment	EFO_0004784	model 1	Table S2	DNA methylation	Educational attainment	Sex, age, batch effects, cell composition (reference based)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4152	4	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.03	0.003	1e-21	None	30631468_van-Dongen-J_educational_attainment_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.079004	0.00827102	1.471156e-21	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_2
Sun Y-Q	HUNT study	33729499	17/03/21	smoking	EFO_0004318, EFO_0005671, EFO_0009115, EFO_0006526	None	Table 1	DNA methylation	smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	128	1	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.021	0.00182	1.7e-21	None	33729499_Sun-Y-Q_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0784875	0.0082311	1.7220039999999998e-21	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.078906	0.00828167	1.853854e-21	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Domingo-Relloso A	Strong Heart Study	32484362	2020-06-02	Smoking	EFO_0004318, EFO_0005671, EFO_0006526	Pack years	Table S4	DNA methylation	Smoking	Age, sex, batch effects, body mass index, cell composition (reference based), ancestry (genomic PCs)	M Values	pack-years	Illumina HumanMethylationEPIC	Whole blood	None	2325	1	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	-0.00293	0.0003	2.2e-21	None	32484362_Domingo-Relloso-A_smoking_pack_years
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0778098	0.00824495	4.391279e-21	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18059	1	Adults (18-65y)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.12	0.0123	6.7e-21	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0982624	0.0105	9.259196e-21	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0892675	0.00954057	9.405853e-21	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0985211	0.010534	9.761453e-21	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0972025	0.0105261	2.947632e-20	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0880309	0.00954021	3.1466099999999996e-20	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	18413	1	Adults (18-65y)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.24	0.026	3.5e-20	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0754868	0.00823301	5.4085309999999997e-20	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0756837	0.00826743	6.173264e-20	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent COPD (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent COPD (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18078	1	Adults (18-65y)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.07	0.00763	6.2e-20	None	Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0752146	0.00823318	7.345413e-20	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0949365	0.0104959	1.679674e-19	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.074292	0.00823375	2.05645e-19	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0857583	0.00955074	3.0535109999999995e-19	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_3
Karlsson Linner R	-	29086770	2017-10-31	Educational attainment	EFO_0004784	Basic model	Table S1.6b	DNA methylation	Educational attainment	Age, sex, cell counts and technical covariates	Beta values	years of schooling	Illumina HumanMethylation450	Whole blood	-	10767	27	57	Both	None	cg01940273	chr2:233284934	2	233284934	-	Island	-	-	4.75e-19	-	29086770_educational_attainment_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0898438	0.0101092	6.976984999999999e-19	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0731639	0.00823444	7.117913999999999e-19	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0721966	0.00823503	2.033581e-18	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0719891	0.00823515	2.542636e-18	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0722517	0.00826773	2.603614e-18	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I0	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6I0	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0922832	0.0105719	2.841842e-18	A0A075B6I0	41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0825256	0.00951789	4.74505e-18	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0711713	0.00827649	8.830149e-18	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0814077	0.00949088	1.0660380000000001e-17	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0812615	0.00952548	1.591951e-17	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0698472	0.00819897	1.7640050000000002e-17	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0800287	0.00940375	1.901309e-17	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.069453	0.00823663	3.7051950000000006e-17	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0798661	0.00952082	5.3654870000000005e-17	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3
Marzi SJ	E-Risk	29325449	2018-01-12	Smoking	EFO_0006526	None	S2	DNA methylation	Smoking	sex, cell composition (reference based), batch effects	Beta Values	Pack years	Illumina HumanMethylation450	Whole blood	Analysis of twins	1658	1	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	-0.011	None	8.7e-17	None	29325449_Marzi-SJ_smoking
Battram T	GEO	25424692	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Never vs former smokers	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	442	1	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0385	0.00446	1.1e-16	None	25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__never_vs_former_smokers
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0680373	0.00823744	1.586659e-16	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0868389	0.0105457	1.953397e-16	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0778847	0.00947951	2.276556e-16	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0674734	0.00823776	2.808578e-16	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0781729	0.00954877	2.904617e-16	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0674165	0.00823779	2.974491e-16	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.067345	0.00827393	4.288902e-16	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0858265	0.0105686	4.994973e-16	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0854392	0.0105717	6.874812e-16	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0665984	0.00826978	8.680576e-16	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0666714	0.00828838	9.360691e-16	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0754843	0.00947734	0.000000000000001777215	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0655972	0.00827297	0.000000000000002365834	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0656419	0.0082792	0.000000000000002376622	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0646042	0.00823932	0.000000000000004777607	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0644637	0.0082394	0.0000000000000054717	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0810204	0.0104516	0.00000000000000964247	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0745894	0.00969217	0.0000000000000149524	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0725271	0.00945173	0.00000000000001779875	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0633847	0.00828012	0.00000000000002052827	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0730365	0.00956005	0.00000000000002310612	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_3
Christiansen C	TwinsUK, NSHD, NCDS1, NCDS2, BCS70	33593402	2021-02-16	Smoking	EFO_0004318, EFO_0006527	Former vs never smoking meta-analysis in European samples	Table S3	DNA methylation	Smoking	Sex, cell composition (reference based), body mass index, batch effects, relatedness	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	1140	5	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	None	None	0.000000000000033	None	33593402_Christiansen-C_smoking_former_vs_never_smoking_meta-analysis_in_european_samples
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I0	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6I0	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0725706	0.00955759	0.00000000000003314767	A0A075B6I0	41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0626886	0.00828378	0.00000000000004026767	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0798653	0.0105557	0.00000000000004074819	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0618258	0.00824078	0.00000000000006624136	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0703258	0.00951016	0.000000000000149283	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0780502	0.0105666	0.0000000000001589069	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0610275	0.0082847	0.0000000000001847879	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_2
van Dongen J	BIOS	30631468	2018-03-23	Educational attainment	EFO_0004784	model 3	Table S2	DNA methylation	Educational attainment	Sex, age, batch effects, cell composition (reference based), smoking, body mass index	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4152	4	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.019	0.003	0.0000000000002	None	30631468_van-Dongen-J_educational_attainment_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0680944	0.00930049	0.0000000000002577869	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.060229	0.00824158	0.0000000000002852685	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0598922	0.00824175	0.0000000000003862993	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0679325	0.00944781	0.0000000000006778324	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0592382	0.00824207	0.0000000000006927459	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0626259	0.00878958	0.000000000001089165	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Ma J	CHARGE	32525743	2020-08-01	Mediterranean diet	EFO_0002755	European meta-analysis	Table 1	DNA methylation	Mediterranean diet	Age, sex, energy intake, cell composition (reference based), batch effects	Beta values	Mediterranean-style diet score	Illumina HumanMethylation450	Whole blood, CD4+ T-cells, CD14+ monocytes	See supplement of paper for details on diet scores	6662	5	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.005	0.001	0.0000000000016	None	32525743_Ma-J_mediterranean_diet_european_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0741399	0.0104874	0.00000000000162592	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_4
Shah S	-	25249537	2014-09-23	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking replication	Table S2	DNA methylation	Smoking	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	232	1	79	Both	None	cg01940273	chr2:233284934	2	233284934	-	Island	-0.07325115	0.0104	0.00000000000186	-	25249537_smoking_current_vs_never_smoking_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0743873	0.01059	0.000000000002246336	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0668307	0.00955965	0.000000000002848941	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_3
van Dongen J	BIOS	30631468	2018-03-23	Educational attainment	EFO_0004784	model 2	Table S2	DNA methylation	Educational attainment	Sex, age, batch effects, cell composition (reference based), smoking	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4152	4	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.018	0.003	0.0000000000029	None	30631468_van-Dongen-J_educational_attainment_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0576026	0.00829011	0.000000000003851534	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0575743	0.00829056	0.000000000003956118	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0573818	0.00827502	0.000000000004251838	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_2
Ma J	CHARGE	32525743	2020-08-01	Mediterranean diet	EFO_0002755	Trans-ethnic meta-analysis	Table S13	DNA methylation	Mediterranean diet	Age, sex, energy intake, cell composition (reference based), batch effects	Beta values	Mediterranean-style diet score	Illumina HumanMethylation450	Whole blood, CD4+ T-cells, CD14+ monocytes	See supplement of paper for details on diet scores	9724	7	Adults	Both	European, African, Admixed	cg01940273	chr2:233284934	2	233284934	-	Island	0.005	0.001	0.0000000000045	None	32525743_Ma-J_mediterranean_diet_trans-ethnic_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0570029	0.00824315	0.000000000004865472	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_1
Sun Y-Q	HUNT study	33729499	17/03/21	lung cancer	MONDO_0008903	None	Table 3	lung cancer	DNA methylation	Age, sex, cell composition (reference based)	None	Beta Values	Illumina HumanMethylationEPIC	Whole blood	Potentially adjusted for batch effects, but it wasn't clear	276	1	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-23.9	3.5	0.0000000000058	None	33729499_Sun-Y-Q_lung_cancer
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0727921	0.0105789	0.000000000006190159	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_4
Barcelona V	InterGEN	30915882	2019-03-27	Smoking	EFO_0004318, EFO_0006527	Discovery	Table 2	DNA methylation	Smoking	Age, batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylationEPIC	Saliva	None	156	1	Adults	Females	African	cg01940273	chr2:233284934	2	233284934	-	Island	-0.059	0.008	0.0000000000065	None	30915882_Barcelona-V_smoking_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0568324	0.00829325	0.000000000007528136	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0710463	0.0104681	0.0000000000118943	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_4
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP64	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP64	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	6.5	0.96	0.000000000012	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp64
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP70	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP70	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	-6.4	0.94	0.000000000013	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp70
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP71	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP71	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	-6.4	0.94	0.000000000013	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp71
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0557355	0.00824374	0.00000000001422636	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_1
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP72	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP72	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	6.3	0.94	0.000000000016	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp72
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP62	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP62	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	6.4	0.95	0.000000000017	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp62
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP66	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP66	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	-6.3	0.94	0.000000000017	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp66
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.055449	0.00827932	0.00000000002200506	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0550968	0.00824403	0.00000000002421501	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0636296	0.00954369	0.00000000002700612	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP68	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP68	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	-6.4	0.95	0.000000000028	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp68
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0549386	0.00829355	0.00000000003611722	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0549177	0.00829148	0.00000000003632619	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_2
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-	-	0.0000000000368	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0692419	0.0105157	0.00000000004715915	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0542398	0.00824442	0.00000000004897465	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0541695	0.00824445	0.00000000005186514	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_1
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP40	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP40	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	-5.9	0.91	0.000000000071	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp40
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP39	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP39	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	-5.9	0.91	0.000000000071	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp39
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0620889	0.00955452	0.00000000008381109	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_3
Battram T	GEO	25424692	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Former vs current smokers	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	285	1	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0669	0.00993	0.0000000001	None	25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__former_vs_current_smokers
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0685724	0.0106055	0.0000000001039817	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0665557	0.0103618	0.000000000137568	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Battram T	GEO	24559495	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE53045	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Peripheral blood mononuclear cells	None	111	1	Adults	Females	African	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0923	0.0127	0.00000000014	None	24559495_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse53045
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P23142	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P23142	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0526132	0.00824514	0.0000000001810741	P23142	41361833_Josephine_Robertson_P23142_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0673019	0.0105572	0.000000000188491	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0608671	0.00955459	0.0000000001940899	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.271726	0.0426693	0.0000000001960969	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0524881	0.0082707	0.0000000002270899	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_2
Shenker NS	-	23175441	2013-03-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Breast cancer cohort	Table S3	DNA methylation	Smoking	Age, case-control status and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	184	1	50.5	Females	European	cg01940273	chr2:233284934	2	233284934	-	Island	-	-	0.000000000238	-	23175441_smoking_breast_cancer_cohort
Dogan MV	-	24559495	2014-02-22	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table 2	DNA methylation	Smoking	Cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral Blood	-	111	1	48.4	Females	African	cg01940273	chr2:233284934	2	233284934	-	Island	-	-	0.000000000251	-	24559495_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.060267	0.00955295	0.0000000002894075	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Ischemic Heart Disease	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Ischemic Heart Disease	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17483	1	Adults (18-65y)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.031	0.00491	0.0000000003	None	Robert-F-Hillary_Incident_Ischemic_Heart_Disease_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0518457	0.00824547	0.0000000003311625	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Liu C	CHARGE+	27843151	2016-11-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	African ancestry	Table S6	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g per day	Illumina HumanMethylation450	Whole blood	-	2423	3	56	Both	African	cg01940273	chr2:233284934	2	233284934	-	Island	-9.79e-05	1.56e-05	0.000000000383	-	27843151_alcohol_consumption_per_day_african_ancestry
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0663033	0.0105923	0.0000000003968588	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0515894	0.00824558	0.0000000004043556	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0515343	0.0082456	0.0000000004220161	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0650328	0.0104511	0.000000000502424	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0593223	0.00957354	0.0000000005928015	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0587171	0.00953076	0.0000000007427056	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0648325	0.0105384	0.0000000007849143	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0588089	0.00957072	0.0000000008220251	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.050419	0.00824607	0.0000000009943619	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0506842	0.00829398	0.000000001015377	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0501374	0.00828323	0.000000001457434	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0500421	0.0082852	0.000000001578974	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0634561	0.0105928	0.000000002141324	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.056359	0.00945286	0.000000002547221	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0489261	0.00824668	0.000000003044801	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_1
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - GP10	EFO_0005193	None	Table S3	IgG glycosylation measure - GP10	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	-5.7	0.97	0.0000000033	None	29055820_Wahl-A_igg_glycosylation_measure_-_gp10
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0626181	0.0105827	0.000000003351298	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_4
Colicino E	CHARGE	32697766	07-22-2020	All cause mortality	EFO_0004352	basic model	Table S2	All cause mortality	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	None	M values	Illumina HumanMethylation450	Whole blood	Effect estimates represent hazard ratio per 10% increase in DNA methylation.	12300	12	Adults	Both	European, African	cg01940273	chr2:233284934	2	233284934	-	Island	0.91	None	0.0000000038	None	32697766_Colicino-E_all_cause_mortality_basic_model
Karlsson Linner R	-	29086770	2017-10-31	Educational attainment	EFO_0004784	Adjusted model	Table S1.7b	DNA methylation	Educational attainment	Age, sex, smoking, body mass index, cell counts and technical covariates	Beta values	years of schooling	Illumina HumanMethylation450	Whole blood	-	10767	27	57	Both	None	cg01940273	chr2:233284934	2	233284934	-	Island	-	-	0.00000000384	-	29086770_educational_attainment_adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.062191	0.0105741	0.000000004155712	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P23142	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P23142	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0487334	0.00829335	0.000000004289009	P23142	41361833_Josephine_Robertson_P23142_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0483817	0.0082469	0.000000004542622	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q16610	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q16610	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0484292	0.00829885	0.000000005471046	Q16610	41361833_Josephine_Robertson_Q16610_OSCA_model_2
Shenker NS	-	23175441	2013-03-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Colon cancer cohort	Table S3	DNA methylation	Smoking	Age, case-control status and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	190	1	55	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-	-	0.00000000587	-	23175441_smoking_colon_cancer_cohort
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP63	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP63	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	5.7	0.98	0.0000000061	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp63
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0614798	0.0105868	0.000000006483047	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.047852	0.00827981	0.000000007651025	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.047795	0.00827885	0.000000007937921	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.047807	0.00828972	0.00000000823119	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP49	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP49	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	-5.6	0.97	0.0000000085	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp49
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q16610	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q16610	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0471482	0.00824739	0.00000001106997	Q16610	41361833_Josephine_Robertson_Q16610_OSCA_model_1
Liu C	CHARGE+	27843151	2016-12-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	European ancestry	Table S5	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g der day	Illumina HumanMethylation450	Whole blood	-	9643	10	64.2	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.00045597	7.99e-05	0.0000000113	-	27843151_alcohol_consumption_per_day_european_ancestry
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0545442	0.00957144	0.00000001230835	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_3
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	None	None	0.000000016	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Dogan MV	-	26441693	2015-09-22	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table 2	DNA methylation	Smoking	Ethnicity and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	100	1	-	Males	European,African	cg01940273	chr2:233284934	2	233284934	-	Island	-	-	0.0000000191	-	26441693_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0537135	0.00957357	0.00000002052719	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0531967	0.00948846	0.00000002102295	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0585411	0.0104475	0.00000002139984	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_4
Baselmans BM	-	26619905	2015-12-01	Wellbeing	EFO_0007869	-	Table 3	DNA methylation	Wellbeing	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	2456	1	38.3	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.00101	0.00018	0.0000000233	-	26619905_wellbeing
Domingo-Relloso A	Strong Heart Study	32484362	2020-06-02	Urinary cadmium	CHEBI_22977	None	Table S1	DNA methylation	Urinary cadmium	Age, sex, batch effects, body mass index, cell composition (reference based), ancestry (genomic PCs), smoking, estimated glomerular filtration rate	M Values	ug/g	Illumina HumanMethylationEPIC	Whole blood	None	2325	1	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	-0.044	0.0079	0.000000024	None	32484362_Domingo-Relloso-A_urinary_cadmium
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP74	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP74	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	-5.2	0.93	0.000000027	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp74
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP75	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP75	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	-5.2	0.93	0.000000027	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp75
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP69	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP69	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	-5.2	0.94	0.000000034	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp69
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0456051	0.00829476	0.00000003903946	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0522607	0.00951058	0.0000000397214	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Stroke	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Stroke	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18023	1	Adults (18-65y)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.023	0.00421	0.00000005	None	Robert-F-Hillary_Incident_Stroke_Basic_model
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP67	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP67	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	-5.4	0.98	0.000000051	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp67
Fasanelli F	-	26667048	2015-12-15	Lung cancer	EFO_0001071	-	Table 1	Lung cancer	DNA methylation	Cell counts and technical covariates	-	Beta values	Illumina HumanMethylation450	Whole blood	Regression coefficients are per 1-SD of DNA methylation	250	1	47	Females	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.821	0.1508	0.0000000521	-	26667048_lung_cancer
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0519438	0.00958717	0.00000006120132	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q16610	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q16610	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0517448	0.0095878	0.00000006884263	Q16610	41361833_Josephine_Robertson_Q16610_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0443695	0.00824844	0.00000007599085	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0512541	0.0095542	0.00000008237751	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04180	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04180	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.044089	0.00824854	0.00000009173487	P04180	41361833_Josephine_Robertson_P04180_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0440743	0.00824855	0.00000009264663	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Sharp GC	-	28603561	2017-06-08	Cleft palate vs cleft lip	EFO_0003959, HP_0000175	-	Additional file 5	DNA methylation	Cleft palate vs cleft lip	Sex and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	98	1	0	Both	European,Other	cg01940273	chr2:233284934	2	233284934	-	Island	0.05029649	0.00860927	0.0000000948	-	28603561_cleft_palate_vs_cleft_lip
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0508873	0.00956791	0.0000001061378	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_3
Fernandez-Sanles A	REGICOR	33883000	04-21-2021	Acute myocardial infarction	EFO_0008583	Meta-analysis model1	Additional Table 2	Acute myocardial infarction	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	None	Beta values	Illumina HumanMethylationEPIC	Whole blood	Cases and controls matched by age and sex. Blood samples were drawn within the first 24 hours post-AMI for cases and at follow-up for controls.	595	2	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.72	0.14	0.00000011	None	33883000_Fernandez-Sanles-A_acute_myocardial_infarction_meta-analysis_model1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0437931	0.00824865	0.0000001117623	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.050485	0.00954834	0.0000001259111	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0435269	0.00824875	0.0000001333355	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0434687	0.00824877	0.000000138568	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_1
Domingo-Relloso A	Strong Heart Study	32484362	2020-06-02	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	Former vs never	Table S3	DNA methylation	Smoking	Age, sex, batch effects, body mass index, cell composition (reference based), ancestry (genomic PCs)	M Values	None	Illumina HumanMethylationEPIC	Whole blood	None	2325	1	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	-0.079	0.015	0.00000016	None	32484362_Domingo-Relloso-A_smoking_former_vs_never
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.218028	0.0416136	0.0000001629467	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0433259	0.00829161	0.0000001762846	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0433378	0.00829837	0.0000001789941	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0433184	0.00829916	0.0000001817533	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0432378	0.00828948	0.0000001853332	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg01940273	chr2:233284934	2	233284934	-	Island	0.0031	0.00057	0.00000019	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0429268	0.00824896	0.0000001977736	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0530533	0.0102348	0.0000002205145	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_4
van Dongen J	ALSPAC, Dunedin, E-risk, FinnTwin12, GS:SFHS, GLAKU, HELIX, LLD, NFBC1996, NFBC1986, NTR, SATSA, YFS	33420481	2021-01-08	Aggressive behaviour	EFO_0003015	Meta-analysis in whole blood	eTable 6	DNA methylation	Aggressive behaviour	age, sex, cell compostion (reference based), cell composition (reference free), batch effects	Beta Values	None	Illumina HumanMethylation450, Illumina HumanMethylationEPIC	Whole blood	Age range from 7 - 70	14434	13	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	None	None	0.00000023	None	33420481_van-Dongen-J_aggressive_behaviour_meta-analysis_in_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.049411	0.00955893	0.0000002383177	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0425335	0.0082491	0.000000255367	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0426148	0.00828051	0.0000002689656	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04180	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04180	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0426517	0.00830113	0.0000002811458	P04180	41361833_Josephine_Robertson_P04180_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0489607	0.00958322	0.0000003279207	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0423024	0.00829685	0.0000003464203	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0484952	0.00952107	0.0000003559448	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0419212	0.00824931	0.0000003785115	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0420113	0.00827953	0.0000003940641	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Stroke (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Stroke (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18056	1	Adults (18-65y)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.043	0.00848	0.0000004	None	Robert-F-Hillary_Prevalent_Stroke_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0416288	0.00824941	0.000000455889	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Stephenson M	FinnTwin12, FinnTwin16	33277923	2021-01-02	Alcohol consumption	EFO_0004329, EFO_0007878	discovery	Table 2	DNA methylation	Alcohol consumption	Age, sex, body mass index, smoking, cell composition (reference based), zygosity, twin pair identifier	Beta Values	drinks per week	Illumina HumanMethylation450	Whole blood	sample included twins. zygosity and twin pair identifier were random effects in the ewas model.	1004	1	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.00078	0.00016	0.0000006	None	33277923_Stephenson-M_alcohol_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0414465	0.00830106	0.0000006015625	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0413816	0.0082986	0.0000006216235	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0410659	0.00824961	0.0000006500104	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0410018	0.00824963	0.0000006765959	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0472326	0.00951464	0.0000006975707	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0522227	0.0105255	0.0000007072651	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Chronic Pain	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Chronic Pain	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	11591	1	Adults (18-65y)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.063	0.0127	0.00000075	None	Robert-F-Hillary_Incident_Chronic_Pain_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0521743	0.010577	0.0000008195548	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.051426	0.0104791	0.0000009324349	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Liver Cirrhosis	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Liver Cirrhosis	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18325	1	Adults (18-65y)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0083	0.0017	0.000001	None	Robert-F-Hillary_Incident_Liver_Cirrhosis_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0514369	0.0106	0.000001231592	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Chronic Kidney Disease	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Chronic Kidney Disease	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18000	1	Adults (18-65y)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.013	0.00273	0.0000013	None	Robert-F-Hillary_Incident_Chronic_Kidney_Disease_Basic_model
Battram T	ARIES	None	2020-08-20	Haemoglobin	EFO_0004509	fasting	None	DNA methylation	Haemoglobin	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g/dl	Illumina HumanMethylation450	Whole blood	None	689	1	Adults	Females	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.161	0.033	0.0000014	None	Battram-T_haemoglobin_fasting
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0397772	0.00825004	0.000001439452	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0461256	0.00956893	0.000001447391	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0506653	0.0105682	0.000001649861	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0505893	0.0105995	0.000001834291	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0392573	0.00825021	0.000001970535	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0455311	0.0095719	0.000001986087	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0392569	0.00827425	0.000002110263	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6J9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6J9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0389402	0.00825031	0.000002382063	A0A075B6J9	41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0487953	0.0104787	0.000003242563	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0442135	0.00956402	0.000003816487	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0383124	0.00829077	0.000003849907	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0380423	0.00825059	0.000004044086	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0378809	0.00825065	0.000004442281	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0475171	0.0103553	0.000004497392	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14391	1	Adults (18-65y)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.095	0.0208	0.0000045	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.037731	0.00825069	0.000004845556	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0479873	0.0105676	0.000005643625	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_4
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous decade consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg01940273	chr2:233284934	2	233284934	-	Island	None	None	0.0000058	None	31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0472462	0.0104612	0.000006341697	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0372526	0.00825084	0.000006380628	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0372246	0.00825085	0.000006483904	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0371497	0.00825087	0.000006767102	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.047506	0.0105764	0.000007119613	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0372252	0.00829556	0.000007265867	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0368182	0.00825097	0.000008169579	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07357	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07357	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0367646	0.00825099	0.000008420954	P07357	41361833_Josephine_Robertson_P07357_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.00034802	7.8e-05	0.00000895	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0366179	0.00825103	0.000009147208	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.042124	0.00950646	0.000009443663	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0366875	0.0083012	0.000009961962	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0364416	0.00825109	0.00001009931	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0464085	0.0105284	0.00001051004	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0465617	0.0105783	0.0000108206	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6J9	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6J9	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0364017	0.00830056	0.00001165559	A0A075B6J9	41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_2
Smith AK	Psychiatric Genomics Consortium (PGC) PTSD Epigenetics Workgroup	33235198	2020-11-24	post-traumatic stress disorder	EFO_0001358	Meta-analysis	Supplementary data 2	DNA methylation	post-traumatic stress disorder	Age, sex, smoking, cell composition (reference based), batch effects, ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	Controls had been exposed to trauma but did not have a current diagnosis of PTSD or a prior history of PTSD	1896	10	Adults	Both	European, African	cg01940273	chr2:233284934	2	233284934	-	Island	-0.075	0.0169	0.000012	None	33235198_Smith-AK_post-traumatic_stress_disorder_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0452166	0.0103338	0.000012194	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0361522	0.00829409	0.00001316717	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0417807	0.00959235	0.00001335887	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07357	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07357	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0359876	0.00830498	0.00001478983	P07357	41361833_Josephine_Robertson_P07357_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0434375	0.0100423	0.00001532305	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q16610	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q16610	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0458668	0.0106153	0.00001564837	Q16610	41361833_Josephine_Robertson_Q16610_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0355567	0.00825135	0.00001649159	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07357	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P07357	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0456823	0.0106244	0.00001720847	P07357	41361833_Josephine_Robertson_P07357_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.173725	0.0405261	0.00001822889	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0352039	0.00825145	0.00001999087	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0408362	0.00958184	0.00002040218	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0451659	0.0106025	0.00002057874	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_4
Rebecca Richmond	SEE-Cigs	34583751	Sep 28, 2021	Smoking	EFO_0004318	smoking (vs. non-smoking)	Supplementary Table 2	DNA methylation	Smoking	Age, Sex, Body mass index, Education, household smoking, recreational drug use, 20 surrogate variables	Beta values	None	Illumina HumanMethylationEPIC	Saliva	None	231	1	Adults (18-65 years)	Both	Admixed	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0276	0.00633	0.000021	None	34583751_Rebecca-Richmond_smoking_smoking__vs__non-smoking_
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	discovery	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.169992	0.0399602	0.00002110256	None	39706196_Hannah-M.-Smith_glucose_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0402569	0.00958122	0.00002665462	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P22792	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P22792	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0346588	0.00825161	0.00002681959	P22792	41361833_Josephine_Robertson_P22792_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0345348	0.00829825	0.00003176938	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.176669	0.0425777	0.00003350361	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.03437	0.00829246	0.00003421236	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0393027	0.00948814	0.00003457665	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Rheumatoid Arthritis (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Rheumatoid Arthritis (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18055	1	Adults (18-65y)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.039	0.0094	0.000042	None	Robert-F-Hillary_Prevalent_Rheumatoid_Arthritis_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0388612	0.00954418	0.00004691266	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0387325	0.00956584	0.00005169213	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.042759	0.010582	0.0000535602	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.042072	0.0104489	0.00005691144	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0333679	0.00829626	0.00005798461	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.042535	0.0106163	0.00006191166	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_4
Zhao N	CLUE I, CLUE II	34008478	05-31-2021	Lung cancer	MONDO_0008903	smoking score unadjusted	Supplementary Table 2	Lung cancer	DNA methylation	Age, Sex, Smoking, Batch effects, Body mass index, cell composition (reference based)	None	Beta values	Illumina HumanMethylationEPIC	whole blood	even though they adjust for smoking status, they dont adjust for smoking status score like their other EWAS	430	1	Adults	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.101	0.0251	0.000064	None	34008478_Zhao-N_lung_cancer_smoking_score_unadjusted
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0379283	0.0095474	0.00007142254	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0329658	0.00829873	0.00007149607	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0329089	0.00829708	0.00007333782	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0325384	0.00825364	0.00008107765	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Cronjé HT	Prospective Urban and Rural Epidemiology study	31910897	2020-01-07	Smoking	EFO_0004318, EFO_0006527, EFO_0005670	None	Additional file 2b	DNA methylation	Smoking	Age, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	117	1	Adults	Males	African	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0655	0.0158	0.000088	None	31910897_Cronjé-HT_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0325006	0.00829539	0.00008972556	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0372986	0.00953544	0.00009210993	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P22792	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P22792	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	0.0324375	0.00829838	0.0000931375	P22792	41361833_Josephine_Robertson_P22792_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01009	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01009	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg01940273	chr2:233284934	2	233284934	-	Island	-0.0324345	0.00830108	0.00009376896	P01009	41361833_Josephine_Robertson_P01009_OSCA_model_2
Rebecca Richmond	SEE-Cigs	34583751	Sep 28, 2021	E-cigarette use	NCIT_C173621	e-cigarette use (vs. smoking)	Supplementary Table 3	DNA methylation	E-cigarette use	Age, Sex, Body mass index, Education, household smoking, recreational drug use and 20 surrogate variables	Beta values	None	Illumina HumanMethylationEPIC	Saliva	None	225	1	Adults (18-65 years)	Both	Admixed	cg01940273	chr2:233284934	2	233284934	-	Island	0.0255	0.00643	0.000099	None	34583751_Rebecca-Richmond_e-cigarette_use_e-cigarette_use__vs__smoking_