author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.0954762	0.00821885	4.634153e-31	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.0941821	0.00821987	2.8888919999999998e-30	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.112646	0.0103219	1.271837e-27	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.109338	0.0103072	3.406743e-26	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_2
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.00111249	0.00011171	2.12e-22	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.0774057	0.0082318	6.059113e-21	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-	-	9.380000000000001e-21	-	28056824_age_4_vs_age_0
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.0976407	0.0114303	1.4449040000000003e-17	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0667771	0.00823814	5.649208e-16	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.065299	0.00823895	0.000000000000002432194	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Engel SM	-	24561991	2014-02-20	Birth weight	EFO_0004344	Adjusted for cell counts	Table 2	Birth weight	DNA methylation	Sex, gestational age, season of birth, maternal age, maternal plasma cotinine, parity, dietary folate, asthma, preeclampsia and cell counts	g	M values	Illumina HumanMethylation450	Cord blood	-	1046	1	0	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	726.57	96.34	0.0000000000000464	-	24561991_birth_weight_adjusted_for_cell_counts
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.00079372	0.00011465	0.00000000000768	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.0561235	0.00824356	0.00000000001026888	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.0539974	0.00824453	0.00000000005965858	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.0671727	0.0103638	0.00000000009373508	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0531755	0.00824489	0.0000000001157307	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0689832	0.0109719	0.0000000003323218	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.0515488	0.00824559	0.0000000004173158	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PRSS57 protein levels (SeqId = 8351-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRSS57 protein levels (SeqId = 8351-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine protease 57	774	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-1.68	0.275	0.00000000096	None	Gadd-DA_prss57_protein_levels__seqid___8351-17__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.0628579	0.010355	0.000000001308302	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.0609522	0.0103471	0.000000003928739	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0479775	0.00824706	0.000000006097202	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.047901	0.00824709	0.000000006444379	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.0471998	0.00824737	0.00000001066996	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.057633	0.010298	0.00000002225925	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.060001	0.0110926	0.00000006433067	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Sikdar S	PACE	31536415	2019-09-19	Prenatal smoke exposure	EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318	Inverse varience-weighted fixed-effects meta-analysis	Table S1	DNA methylation	Prenatal smoke exposure	Maternal age, socioeconomic position, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Cord blood, whole blood	None	5648	9	Infants	Both	European, African, Unclear	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.0077	0.0014	0.000000071	None	31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.00455	0.00084	0.000000071	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0595255	0.0112201	0.0000001141583	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0590401	0.0113509	0.000000200527	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.0428807	0.00824898	0.0000002038093	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0427869	0.00824901	0.0000002166562	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0426668	0.00824905	0.0000002342415	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0412078	0.00824956	0.0000005946482	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Engel SM	-	24561991	2014-02-20	Birth weight	EFO_0004344	-	Table 2	Birth weight	DNA methylation	Sex, gestational age, season of birth, maternal age, maternal plasma cotinine, parity, dietary folate, asthma and preeclampsia	g	M values	Illumina HumanMethylation450	Cord blood	-	1046	1	0	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	403	81.84	0.000000847	-	24561991_birth_weight
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.0403438	0.00824985	0.000001017764	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0540072	0.0115058	0.000002704339	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.0519605	0.0114784	0.000006035071	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0501851	0.0112462	0.000008164946	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0461425	0.010345	0.000008243543	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	GP1BA protein levels (SeqId = 4990-87)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GP1BA protein levels (SeqId = 4990-87)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Platelet glycoprotein Ib alpha chain	774	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-1.22	0.275	0.0000095	None	Gadd-DA_gp1ba_protein_levels__seqid___4990-87__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0444814	0.0101423	0.00001164092	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	SELL protein levels (SeqId = 4831-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SELL protein levels (SeqId = 4831-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: L-selectin	774	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-1.18	0.275	0.000017	None	Gadd-DA_sell_protein_levels__seqid___4831-4__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0433691	0.0101303	0.00001871242	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.035199	0.00825146	0.0000200447	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	NOG protein levels (SeqId = 8778-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NOG protein levels (SeqId = 8778-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Noggin	774	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-1.166	0.275	0.000022	None	Gadd-DA_nog_protein_levels__seqid___8778-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CEACAM8 protein levels (SeqId = 18873-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CEACAM8 protein levels (SeqId = 18873-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Carcinoembryonic antigen-related cell adhesion molecule 8	774	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-1.15	0.274	0.000028	None	Gadd-DA_ceacam8_protein_levels__seqid___18873-8__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0433053	0.0103684	0.00002975065	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0429235	0.0103458	0.00003359781	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0472947	0.0114502	0.00003640215	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	IGF1R protein levels (SeqId = 4232-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IGF1R protein levels (SeqId = 4232-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Insulin-like growth factor 1 receptor	774	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-1.12	0.275	0.000044	None	Gadd-DA_igf1r_protein_levels__seqid___4232-19__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.24428	0.060486	0.0000539881	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0332839	0.008252	0.00005524586	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	ELANE protein levels (SeqId = 13671-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ELANE protein levels (SeqId = 13671-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neutrophil elastase	774	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-1.11	0.274	0.000056	None	Gadd-DA_elane_protein_levels__seqid___13671-40__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.0411005	0.0103568	0.00007268111	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	discovery	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	0.224542	0.0571672	0.00008604474	None	39706196_Hannah-M.-Smith_glucose_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.0449013	0.011471	0.00009106734	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.0404033	0.0103361	0.00009311563	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg02194129	chr14:104171313	14	104171313	XRCC3	Open sea	-0.240877	0.0616333	0.00009332957	None	39706196_Hannah-M.-Smith_bmi_sensitivity