author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02873098	chr16:4524103	16	4524103	NMRAL1;HMOX2	North shore	0.0035	0.00018	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3678147 (gene symbol: NMRAL1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3678147 (gene symbol: NMRAL1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg02873098	chr16:4524103	16	4524103	NMRAL1;HMOX2	North shore	None	None	1.7e-99	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3678147__gene_symbol__nmral1__meta-analysis
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg02873098	chr16:4524103	16	4524103	NMRAL1;HMOX2	North shore	0.27033	0.00712	1.9e-91	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg02873098	chr16:4524103	16	4524103	NMRAL1;HMOX2	North shore	-	-	7.18e-44	-	28056824_age_4_vs_age_0
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02873098	chr16:4524103	16	4524103	NMRAL1;HMOX2	North shore	-0.0079	0.0012	0.000000000043	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg02873098	chr16:4524103	16	4524103	NMRAL1;HMOX2	North shore	-0.026	0.0041	0.00000000016	None	Robert-F-Hillary_Incident_COPD_Basic_model
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg02873098	chr16:4524103	16	4524103	NMRAL1;HMOX2	North shore	-0.01031	0.00167	0.00000000063	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg02873098	chr16:4524103	16	4524103	NMRAL1;HMOX2	North shore	-0.0111	0.0021	0.00000023	-	27651444_smoking_current_vs_never_smoking
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age*sex	PATO_0000047,EFO_0000246	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	age*sex	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg02873098	chr16:4524103	16	4524103	NMRAL1;HMOX2	North shore	0.00082	0.00019	0.000015	None	33450751_Mulder-RH_age_sex_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	KRT20 protein levels (SeqId = 12975-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KRT20 protein levels (SeqId = 12975-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Keratin, type I cytoskeletal 20	774	1	Adults (18-65 years)	Both	European	cg02873098	chr16:4524103	16	4524103	NMRAL1;HMOX2	North shore	-0.5	0.126	0.000077	None	Gadd-DA_krt20_protein_levels__seqid___12975-11__somascan_protein_measurement