author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.71297	0.00656	4.2e-175	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	2.60289	0.12443	1.0600000000000001e-35	-	25282492_fetal_vs_adult_liver
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	2.6	0.211	5.5e-35	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0917144	0.00930913	7.903081000000001e-23	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0858266	0.00928006	2.5854909999999998e-20	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.288024	0.0317143	1.180385e-19	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0816045	0.00927292	1.514922e-18	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_3
Liu C	CHARGE+	27843151	2016-11-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	African ancestry	Table S6	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g per day	Illumina HumanMethylation450	Whole blood	-	2423	3	56	Both	African	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.00010688	1.24e-05	5.59e-18	-	27843151_alcohol_consumption_per_day_african_ancestry
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0699369	0.00823635	2.238562e-17	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0660293	0.00823855	0.000000000000001187148	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0724202	0.00933863	0.000000000000009420952	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_2
Petersen A-K	KORA F4	24014485	2013-09-06	M15749_3-phenylpropionate_hydrocinnamate	EFO_0004727, EFO_0004725	no snps model	Table S2	M15749_3-phenylpropionate_hydrocinnamate	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	28.13	0.19	0.000000000000014	None	24014485_Petersen-A-K_m15749_3-phenylpropionate_hydrocinnamate_no_snps_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0700775	0.00917585	0.00000000000002357445	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0809932	0.0107156	0.00000000000004321195	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_4
Petersen A-K	KORA F4	24014485	2013-09-06	M15749_3-phenylpropionate_hydrocinnamate	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M15749_3-phenylpropionate_hydrocinnamate	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	27	0.19	0.000000000000053	None	24014485_Petersen-A-K_m15749_3-phenylpropionate_hydrocinnamate_snps_as_covariates_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0670025	0.00934952	0.0000000000008066331	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.076616	0.010721	0.0000000000009332717	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0767751	0.0107554	0.0000000000009895059	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0588071	0.00824228	0.000000000001014637	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0764891	0.0107744	0.000000000001312887	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0658229	0.00931511	0.000000000001663475	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_2
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-	-	0.00000000000271	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0637645	0.00933863	0.000000000008947294	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0558349	0.00824369	0.00000000001308964	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.044	0.00653	0.000000000017	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0624253	0.00931744	0.00000000002162633	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0548521	0.00824414	0.00000000002964146	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Liver Cirrhosis	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Liver Cirrhosis	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18325	1	Adults (18-65y)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.014	0.00216	0.00000000003	None	Robert-F-Hillary_Incident_Liver_Cirrhosis_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0547122	0.0082442	0.00000000003326159	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.061453	0.00929791	0.00000000003993915	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0614334	0.00932762	0.00000000004666595	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0677881	0.0104978	0.0000000001099166	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Liu C	CHARGE+	27843151	2016-12-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	European ancestry	Table S5	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g der day	Illumina HumanMethylation450	Whole blood	-	9643	10	64.2	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.00022242	3.46e-05	0.000000000127	-	27843151_alcohol_consumption_per_day_european_ancestry
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.093	0.0145	0.00000000015	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	1.4	0.221	0.00000000048	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Nones K	-	24500968	2014-05-09	Pancreatic ductal adenocarcinoma	EFO_0002517	-	Table S4	DNA methylation	Pancreatic ductal adenocarcinoma	-	Beta values	-	Illumina HumanMethylation450	Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata	-	196	1	-	Missing	None	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-	-	0.000000000602	-	24500968_pancreatic_ductal_adenocarcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0573515	0.00932014	0.0000000007776	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_3
Witt S	None	32080920	02-02-2020	alcohol withdrawal recovery	None	discovery	Table S1	DNA methylation	alcohol withdrawal recovery	Age, Smoking, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylationEPIC	whole blood	two weeks after vs active withdrawal	99	1	Adults	Males	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	4.6	0.684	0.0000000012	None	32080920_Witt-S_alcohol_withdrawal_recovery_discovery
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.00782	0.0013	0.0000000016	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0630188	0.0105273	0.000000002197831	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.04901	0.00824665	0.000000002861618	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.188409	0.0317823	0.000000003122428	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0552752	0.0093252	0.000000003144651	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.015	0.0025	0.000000004	None	33450751_Mulder-RH_sex_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0546708	0.00933213	0.00000000477537	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.185847	0.0318561	0.000000005509487	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0540717	0.00933072	0.000000006971973	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0539684	0.00933278	0.00000000750238	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0475588	0.00824723	0.000000008249839	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Nano J	-	28624579	2017-06-15	Gamma-glutamyl transferase	EFO_0004532	Meta-analysis	Table S2	DNA methylation	Gamma-glutamyl transferase	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	1450	2	63.5	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.012	0.002	0.0000000083	-	28624579_gammaglutamyl_transferase_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0608033	0.0107086	0.000000013887	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0528719	0.00932123	0.00000001436346	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0610307	0.0107632	0.00000001452246	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0465638	0.00824762	0.00000001675356	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0599399	0.0106774	0.00000002016104	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.200468	0.0358181	0.00000002214331	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0519008	0.00934661	0.00000002858443	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0590997	0.0107296	0.00000003688114	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0509172	0.00931019	0.00000004600565	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0505323	0.00925532	0.00000004843769	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0508091	0.00932681	0.00000005186525	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Stroke	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Stroke	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18023	1	Adults (18-65y)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.029	0.00534	0.000000054	None	Robert-F-Hillary_Incident_Stroke_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0505579	0.00933709	0.00000006234493	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0458775	0.00851367	0.0000000720706	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Nano J	-	28624579	2017-06-15	Gamma-glutamyl transferase	EFO_0004532	Discovery	Table 2	DNA methylation	Gamma-glutamyl transferase	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	731	1	59.6	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.016	0.003	0.000000075	-	28624579_gammaglutamyl_transferase_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0498877	0.00933461	0.00000009208373	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0499236	0.00936409	0.00000009890805	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0571514	0.0107394	0.0000001043279	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14350	1	Adults (18-65y)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.081	0.0153	0.00000013	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	1.074195	0.2037	0.000000135	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0486769	0.0092538	0.0000001459142	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	13971	1	Adults (18-65y)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.037	0.00699	0.00000015	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0432267	0.00824885	0.0000001625071	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0489377	0.00934066	0.0000001635002	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.190323	0.0365456	0.0000001932497	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Liver Cirrhosis	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Liver Cirrhosis	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14358	1	Adults (18-65y)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.012	0.00235	0.0000002	None	Robert-F-Hillary_Incident_Liver_Cirrhosis_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0560352	0.0108131	0.0000002222361	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0483737	0.0093395	0.0000002254541	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0543687	0.0105325	0.0000002475501	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0474343	0.00924263	0.0000002901619	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0477274	0.00933798	0.0000003242996	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0477399	0.00935348	0.0000003367652	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.047261	0.00934193	0.0000004265062	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	discovery	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.159435	0.0315753	0.0000004476937	None	39706196_Hannah-M.-Smith_glucose_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.047024	0.00934832	0.0000004957473	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.028	0.00553	0.00000057	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.046358	0.00931336	0.0000006511435	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.178487	0.035966	0.0000007016029	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0462355	0.00932616	0.0000007216246	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0458279	0.0093471	0.0000009544147	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0519135	0.0106216	0.000001031859	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0403071	0.00824986	0.00000104103	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0452924	0.00931194	0.000001162884	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0518656	0.0106929	0.000001244365	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0499878	0.0103123	0.000001263726	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0451729	0.0093458	0.000001355117	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0450639	0.00935053	0.0000014544	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0432938	0.00900343	0.000001535085	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0394772	0.00825014	0.000001726219	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0446069	0.00935983	0.000001899234	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0443167	0.00932388	0.000002022874	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0391589	0.00825024	0.000002090262	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0387228	0.00825038	0.000002710493	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0436773	0.00931983	0.00000280431	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0435711	0.00935022	0.000003191483	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0432703	0.00934665	0.000003696972	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0430121	0.00932329	0.000003994742	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0486125	0.010571	0.000004287313	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0428029	0.00933782	0.000004603287	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0378088	0.00825067	0.000004632025	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0424272	0.0092642	0.000004694813	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0425496	0.00934096	0.00000527667	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0425401	0.00935937	0.000005532421	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0487993	0.0107406	0.000005578049	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.037373	0.0082508	0.000005955745	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.042265	0.00934748	0.000006187292	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.041865	0.00934118	0.000007458807	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0367087	0.00825101	0.000008690677	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0365879	0.00825104	0.000009302648	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0360915	0.00825119	0.00001227751	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1
Montano C	-	27074206	2016-05-01	Schizophrenia	EFO_0000692	Discovery	Table S3	DNA methylation	Schizophrenia	Age, sex, smoking, ethnicity, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1334	3	38.6	Both	European,African	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.009	0.0021	0.0000126	-	27074206_schizophrenia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0359927	0.00825122	0.00001296984	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.046834	0.0107555	0.00001343259	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0464223	0.010662	0.00001345869	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0405123	0.00932719	0.00001411959	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0403872	0.00935363	0.00001586176	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.040279	0.00933474	0.00001606828	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.035457	0.00825138	0.0000174158	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0460498	0.0107304	0.00001786052	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0352019	0.00825145	0.00002001279	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0398124	0.00933908	0.0000202967	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0394673	0.00928947	0.00002164334	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0396909	0.00935134	0.00002205222	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0396274	0.00934013	0.0000222205	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0395507	0.00934423	0.00002323802	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0394585	0.00935223	0.00002466898	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.034236	0.00825173	0.00003358833	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0341209	0.00825176	0.00003569522	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0445095	0.0107745	0.00003631951	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19827	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P19827	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0388131	0.00939802	0.00003648901	P19827	41361833_Josephine_Robertson_P19827_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19827	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P19827	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0385106	0.00936016	0.00003904538	P19827	41361833_Josephine_Robertson_P19827_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0385166	0.00937442	0.00004000753	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_3
Antoun E	UPBEAT	33151971	2020-11-05	1-hour glucose	EFO_0004468	Adjusted for gestational age at OGTT	S1 Data Table I	1-hour glucose	DNA methylation	Sex,ethnicity,cell counts (reference based),maternal smoking,maternal age, parity,gestational age at OGTT	None	Beta Values	Illumina HumanMethylationEPIC	Cord blood	None	557	1	Infants	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-1.459	0.3528	0.000041	None	33151971_Antoun-E_1-hour_glucose_adjusted_for_gestational_age_at_ogtt
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0381632	0.00933705	0.00004387746	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0438308	0.0107765	0.00004782001	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Stroke	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Stroke	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14175	1	Adults (18-65y)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.024	0.00584	0.000053	None	Robert-F-Hillary_Incident_Stroke_Fully-adjusted_model
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	18413	1	Adults (18-65y)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.13	0.0331	0.000054	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0376611	0.00936343	0.00005795855	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0331593	0.00825203	0.0000589062	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Antoun E	UPBEAT	33151971	2020-11-05	1-hour glucose	EFO_0004468	Adjusted for intervention	S1 Data Table Q	1-hour glucose	DNA methylation	Sex,ethnicity,cell counts (reference based),maternal smoking,maternal age, parity,intervention	None	Beta Values	Illumina HumanMethylationEPIC	Cord blood	None	557	1	Infants	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-1.816	0.44934	0.000061	None	33151971_Antoun-E_1-hour_glucose_adjusted_for_intervention
Antoun E	UPBEAT	33151971	2020-11-05	1-hour glucose	EFO_0004468	None	S1 Data Table E	1-hour glucose	DNA methylation	Sex,ethnicity,cell counts (reference based),maternal smoking,maternal age, parity	None	Beta Values	Illumina HumanMethylationEPIC	Cord blood	None	557	1	Infants	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-1.85448	0.45998	0.000064	None	33151971_Antoun-E_1-hour_glucose
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.133929	0.0336	0.000067	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0328968	0.0082521	0.0000673859	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	ALDOC protein levels (SeqId = 9876-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ALDOC protein levels (SeqId = 9876-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fructose-bisphosphate aldolase C	774	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.625	0.157	0.000068	None	Gadd-DA_aldoc_protein_levels__seqid___9876-20__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0371109	0.00931662	0.00006829444	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Montano C	-	27074206	2016-05-01	Schizophrenia	EFO_0000692	Replication	Table S3	DNA methylation	Schizophrenia	Age, sex, smoking, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	497	1	35	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.012	0.003	0.00007	-	27074206_schizophrenia_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0342239	0.00861433	0.00007134132	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.041409	0.0104248	0.00007156124	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0371036	0.00934369	0.00007192153	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0387682	0.00977229	0.00007308115	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0327287	0.00825215	0.00007341164	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	0.0360694	0.00911598	0.00007634464	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0326424	0.00825217	0.00007669653	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0369167	0.00935607	0.00007992234	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0366181	0.00932155	0.00008593157	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0364811	0.00930617	0.00008891805	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0062	0.0016	0.00009	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.03661	0.00937749	0.00009502629	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg03497652	chr16:4751569	16	4751569	ANKS3	Open sea	-0.0362676	0.0093157	0.00009938193	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_3