author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea 0.227112 0.0100934 2.972753e-110 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea 0.17232 0.00915079 3.49916e-78 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea 0.169471 0.00912339 3.791846e-76 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea 0.138364 0.00817716 1.2677739999999998e-63 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_1 Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea -0.0653 0.00467 3.8e-31 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3667858 (gene symbol: HP) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3667858 (gene symbol: HP) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea None None 1e-19 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3667858__gene_symbol__hp__meta-analysis Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea 2.1 0.357 0.000000004 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Fully-adjusted model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 14040 1 Adults Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea 2 0.367 0.000000097 Fully_Adjusted_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea -0.0481573 0.00923477 0.0000001865411 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea -0.0424398 0.00824913 0.0000002713176 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea -0.0471002 0.00924727 0.0000003560316 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea -0.0406566 0.00824974 0.0000008388693 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea -0.0445581 0.009192 0.000001263148 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea -0.0447343 0.00923204 0.000001275491 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea 0.0436052 0.00920342 0.00000217931 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea 0.0428781 0.00908338 0.000002374445 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea 0.0387635 0.00825037 0.000002645954 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea -0.0386382 0.00825041 0.000002849749 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 HP protein levels (SeqId = 3054-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HP protein levels (SeqId = 3054-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Haptoglobin 774 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea 1.23 0.265 0.0000032 None Gadd-DA_hp_protein_levels__seqid___3054-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea 0.0414285 0.00907086 0.000004983024 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea 0.0360524 0.0082512 0.00001254744 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea 0.0390495 0.00909466 0.00001768693 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea -0.0350516 0.0082515 0.0000217104 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea 0.0346965 0.0082516 0.00002628331 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea 0.037495 0.00906164 0.00003526429 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea -0.0377376 0.00923399 0.00004396682 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea 0.0369232 0.00913216 0.00005299372 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea None None 0.000063 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg04170065 chr16:72153204 16 72153204 PMFBP1 Open sea -0.0324752 0.00825222 0.0000834638 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1