author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.05	0.002	4.1800000000000006e-124	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity, white blood cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.05	0.002	1.99e-123	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts
Sikdar S	PACE	31536415	2019-09-19	Prenatal smoke exposure	EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318	Inverse varience-weighted fixed-effects meta-analysis	Table S1	DNA methylation	Prenatal smoke exposure	Maternal age, socioeconomic position, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Cord blood, whole blood	None	5648	9	Infants	Both	European, African, Unclear	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0497	0.0021	2e-123	None	31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.31371	0.00646	3.7e-110	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Any maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	6685	13	0	Missing	European,East Asian,African,Admixed,Other	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.035	0.002	6.3e-91	-	27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns
Wiklund P.	Northern Finland Birth, IoW Birth Cohort, ALSPAC	31262328	2019-07-01	Maternal smoking	EFO_0006527	Meta-analysis	Table 1	DNA methylation	Maternal smoking	Sex, body mass index, smoking, socioeconomic position, ancestry (genomic PCs), age, maternal age	Beta Values	None	Illumina HumanMethylation450	Whole Blood	Some study specific covariates	2821	3	Adults	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.045	0.003	2.6e-54	None	31262328_Wiklund-P._maternal_smoking_meta-analysis
Markunas CA	-	24906187	2014-10-01	Maternal smoking during pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Model 1	Table S2	DNA methylation	Maternal smoking during pregnancy	Offspring sex, offspring cleft status and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	889	1	0	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.051	0.0038	1.53e-40	-	24906187_maternal_smoking_during_pregnancy_model_1
Markunas CA	-	24906187	2014-10-01	Maternal smoking during pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Model 2	Table S2	DNA methylation	Maternal smoking during pregnancy	Offspring sex, offspring cleft status, birth weight, maternal age, maternal alcohol consumption, maternal education, maternal folic acid, supplement use, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	889	1	0	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.05	0.0039	5.08e-38	-	24906187_maternal_smoking_during_pregnancy_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.042	0.00368	1.6e-30	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0776331	0.00842601	3.577425e-20	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Christiansen C	TwinsUK, NSHD, NCDS1, NCDS2, BCS70	33593402	2021-02-16	Smoking	EFO_0004318, EFO_0006527	Current vs never smoking meta-analysis in European samples	Table S1	DNA methylation	Smoking	Sex, cell composition (reference based), body mass index, batch effects, relatedness	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	912	5	Adults	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	None	None	2.8e-19	None	33593402_Christiansen-C_smoking_current_vs_never_smoking_meta-analysis_in_european_samples
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on older children	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	3049	5	6.8	Missing	European,African,Admixed,Other	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.036	0.004	3.25e-18	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_older_children
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0351	0.0041	1.3e-17	-	27651444_smoking_current_vs_never_smoking
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.196418	0.02312	2.127432e-17	None	39706196_Hannah-M.-Smith_bmi_discovery
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	1.1	0.133	6.1e-17	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0707473	0.00846927	7.220649000000001e-17	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0655884	0.00823879	0.000000000000001832057	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	18413	1	Adults (18-65y)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.17	0.0219	0.0000000000000073	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0657973	0.00848259	0.000000000000009285741	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0638841	0.00823971	0.000000000000009547428	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0637526	0.00823978	0.0000000000000108253	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Zeilinger S	-	23691101	2013-05-17	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking discovery	Table S1	DNA methylation	Smoking	Age, sex, body mass index, alcohol consumption and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	1011	1	60.8	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-	-	0.0000000000000592	-	23691101_smoking_current_vs_never_smoking_discovery
Chatziioannou A	EnviroGenomarkers project consortium	28225026	2017-02-22	Tobacco smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S2	DNA methylation	Current vs never smoking	Age, sex, body mass index, study centre and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	454	2	52	Both	None	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-	-	0.0000000000000849	-	28225026_tobacco_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0616067	0.00846939	0.0000000000003665548	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.15	0.0211	0.0000000000012	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0583366	0.00824251	0.000000000001534095	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Priyanka Choudhary	PACE	38052982	Dec 5, 2023	Maternal education at the time of pregnancy	None	Model1_Cord_European	None	DNA methylation	Maternal education at the time of pregnancy	Sex, Cell composition (reference based), Batch effects	Beta values	years of schooling	Illumina HumanMethylation450	Cord blood	Illumina HumanMethylationEPIC was also used for some cohorts	9501	None	Infants	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0013	0.00018	0.000000000003	None	38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_european
Lee KW	-	25325234	2014-10-17	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Replication at birth	Table 3	DNA methylation	Maternal smoking in pregnancy	Age, sex, maternal education, social class and technical covariates	M values	Cigarettes per day	Illumina HumanMethylation450	Cord blood	-	441	1	0	Missing	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-	-	0.0000000000077	-	25325234_maternal_smoking_in_pregnancy_replication_at_birth
Karlsson Linner R	-	29086770	2017-10-31	Educational attainment	EFO_0004784	Basic model	Table S1.6b	DNA methylation	Educational attainment	Age, sex, cell counts and technical covariates	Beta values	years of schooling	Illumina HumanMethylation450	Whole blood	-	10767	27	57	Both	None	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-	-	0.0000000000122	-	29086770_educational_attainment_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0558509	0.00824368	0.00000000001291481	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Priyanka Choudhary	PACE	38052982	Dec 5, 2023	Maternal education at the time of pregnancy	None	Model1_Cord_All	None	DNA methylation	Maternal education at the time of pregnancy	Sex, Cell composition (reference based), Batch effects	Beta values	years of schooling	Illumina HumanMethylation450	Cord blood	Illumina HumanMethylationEPIC was also used for some cohorts	9881	None	Infants	Both	Admixed	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0012	0.00017	0.000000000019	None	38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_all
Ambatipudi S	-	26864933	2016-05-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Age, breast cancer status, menopausal status, use of contraceptive pill, use of hormone replacement therapy and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	721	1	52.6	Females	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-	-	0.0000000000245	-	26864933_smoking_current_vs_never_smoking
van Dongen J	BIOS	30631468	2018-03-23	Educational attainment	EFO_0004784	model 1	Table S2	DNA methylation	Educational attainment	Sex, age, batch effects, cell composition (reference based)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4152	4	Adults	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.023	0.003	0.00000000003	None	30631468_van-Dongen-J_educational_attainment_model_1
Lee KW	-	25325234	2014-10-17	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Discovery	Table 2	DNA methylation	Maternal smoking in pregnancy	Age, sex, cell counts and technical covariates	M values	Cigarettes per day	Illumina HumanMethylation450	Whole blood	-	132	1	16	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-	-	0.000000000039	-	25325234_maternal_smoking_in_pregnancy_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.152985	0.0231921	0.00000000004332869	None	39706196_Hannah-M.-Smith_body_fat_discovery
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.00378	0.00058	0.0000000001	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Lee KW	-	25325234	2014-10-17	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Discovery adjusted for current participant smoking	Table 2	DNA methylation	Maternal smoking in pregnancy	Age, sex, participant smoking, cell counts and technical covariates	M values	Cigarettes per day	Illumina HumanMethylation450	Whole blood	-	128	1	16	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-	-	0.00000000012	-	25325234_maternal_smoking_in_pregnancy_discovery_adjusted_for_current_participant_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0547251	0.00858793	0.0000000001917429	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent COPD (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent COPD (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18078	1	Adults (18-65y)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.04	0.00646	0.00000000059	None	Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0524468	0.00847606	0.0000000006269679	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Sun Y-Q	HUNT study	33729499	17/03/21	smoking	EFO_0004318, EFO_0005671, EFO_0009115, EFO_0006526	None	Table 1	DNA methylation	smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	128	1	Adults	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.018	0.00269	0.00000000066	None	33729499_Sun-Y-Q_smoking
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0024	None	0.0000000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Zeilinger S	-	23691101	2013-05-17	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking replication	Table S2	DNA methylation	Smoking	Age, sex, body mass index, alcohol consumption and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	468	1	53	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-	-	0.00000000133	-	23691101_smoking_current_vs_never_smoking_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0510778	0.00844407	0.000000001493277	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Ambatipudi S	-	26864933	2016-05-01	Smoking	EFO_0005671, EFO_0004318	Former vs never smoking	Table S2	DNA methylation	Smoking	Age, breast cancer status, menopausal status, use of contraceptive pill, use of hormone replacement therapy and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	717	1	53.4	Females	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-	-	0.00000000234	-	26864933_smoking_former_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0505966	0.00847182	0.000000002392716	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0489487	0.00824667	0.000000002994412	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0495106	0.00846283	0.000000005009711	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0476769	0.00824718	0.000000007577277	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0487183	0.00846247	0.000000008734417	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_2
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0005671, EFO_0004318	Former vs never smoking	Table S5	DNA methylation	Former versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	13474	16	62.9	Both	European,African	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0116	0.002	0.0000000092	-	27651444_smoking_former_vs_never_smoking
van Dongen J	BIOS	30631468	2018-03-23	Educational attainment	EFO_0004784	model 3	Table S2	DNA methylation	Educational attainment	Sex, age, batch effects, cell composition (reference based), smoking, body mass index	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4152	4	Adults	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.019	0.003	0.0000000093	None	30631468_van-Dongen-J_educational_attainment_model_3
Lee KW	-	25325234	2014-10-17	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Discovery adjusted for current participant and parent smoking	Table 2	DNA methylation	Maternal smoking in pregnancy	Age, sex, participant smoking, parent smoking, cell counts and technical covariates	M values	Cigarettes per day	Illumina HumanMethylation450	Whole blood	-	125	1	16	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-	-	0.000000012	-	25325234_maternal_smoking_in_pregnancy_discovery_adjusted_for_current_participant_and_parent_smoking
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Lung Cancer	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Lung Cancer	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18364	1	Adults (18-65y)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.011	0.00196	0.000000018	None	Robert-F-Hillary_Incident_Lung_Cancer_Basic_model
van Dongen J	BIOS	30631468	2018-03-23	Educational attainment	EFO_0004784	model 2	Table S2	DNA methylation	Educational attainment	Sex, age, batch effects, cell composition (reference based), smoking	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4152	4	Adults	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.019	0.003	0.000000021	None	30631468_van-Dongen-J_educational_attainment_model_2
Lee KW	-	25325234	2014-10-17	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Replication at age 7	Table 3	DNA methylation	Maternal smoking in pregnancy	Age, sex, maternal education, social class and technical covariates	M values	Cigarettes per day	Illumina HumanMethylation450	Whole blood	-	447	1	7	Missing	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-	-	0.000000021	-	25325234_maternal_smoking_in_pregnancy_replication_at_age_7
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0470726	0.00861806	0.00000004782232	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0454504	0.00839114	0.00000006174291	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0445761	0.00824836	0.00000006610096	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Karlsson Linner R	-	29086770	2017-10-31	Educational attainment	EFO_0004784	Adjusted model	Table S1.7b	DNA methylation	Educational attainment	Age, sex, smoking, body mass index, cell counts and technical covariates	Beta values	years of schooling	Illumina HumanMethylation450	Whole blood	-	10767	27	57	Both	None	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-	-	0.000000121	-	29086770_educational_attainment_adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0452443	0.0085845	0.0000001380095	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0445572	0.00847441	0.0000001477968	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_2
Portales-Casamar E	-	27358653	2016-06-29	Fetal alcohol spectrum disorder	NCIT_C92780	-	Table S1	DNA methylation	Fetal alcohol spectrum disorder	Technical covariates	M values	-	Illumina HumanMethylation450	Buccal	-	206	1	11.4	Both	European,Other	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-	-	0.000000221	-	27358653_fetal_alcohol_spectrum_disorder
Richmond RC	-	25552657	2014-12-30	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Unadjusted model	Table 3	DNA methylation	Maternal smoking in pregnancy	Technical covariates	M values	-	Illumina HumanMethylation450	Cord blood	-	790	1	0	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.05	0.011	0.000000229	-	25552657_maternal_smoking_in_pregnancy_unadjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0422127	0.00824921	0.0000003140639	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1
Lee KW	-	25325234	2014-10-17	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Replication at age 7 adjusted for current parent smoking	Table 3	DNA methylation	Maternal smoking in pregnancy	Age, sex, parent smoking, maternal education, social class and technical covariates	M values	Cigarettes per day	Illumina HumanMethylation450	Whole blood	-	416	1	7	Missing	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-	-	0.00000049	-	25325234_maternal_smoking_in_pregnancy_replication_at_age_7_adjusted_for_current_parent_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0424922	0.00846968	0.0000005310484	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0424217	0.00847428	0.0000005623596	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0411198	0.00824959	0.0000006284053	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Chronic Pain	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Chronic Pain	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	11591	1	Adults (18-65y)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.052	0.0107	0.000001	None	Robert-F-Hillary_Incident_Chronic_Pain_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0413818	0.00845716	0.000001003082	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0402406	0.00824988	0.000001084472	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Rzehak P	-	27171005	2016-05-12	Maternal smoking during pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Replication SEED	Table S1	DNA methylation	Maternal smoking during pregnancy	Sex, ancestry, autism spectrum disorder, maternal age, maternal education and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	528	1	5	Both	European,East Asian,African,Admixed,Other	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.06	0.0123	0.0000011	-	27171005_maternal_smoking_during_pregnancy_replication_seed
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0396556	0.00825008	0.000001549691	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Zhu X	-	26756918	2016-07-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S1	DNA methylation	Smoking	Age, sex, alcohol consumption, body mass index and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	Regression coefficients are for inverse normally transformed DNA methylation	596	4	53.9	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.224	0.046634	0.00000156	-	26756918_smoking
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.12203	0.0254928	0.00000170836	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0392196	0.00825022	0.000002015595	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0391603	0.00825024	0.000002088571	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0395891	0.00846775	0.000002961768	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18059	1	Adults (18-65y)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.049	0.0104	0.000003	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0384287	0.00825047	0.000003224863	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0383688	0.00825049	0.000003340332	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Former vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	156	1	Adults	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.07	0.0152	0.000004	None	31552803_Dugue-PA_smoking_former_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0388441	0.00847694	0.000004636313	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0426262	0.00937651	0.000005509635	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0375079	0.00825076	0.000005511523	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0382817	0.00848988	0.000006560923	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
van Dongen J	ALSPAC, Dunedin, E-risk, FinnTwin12, GS:SFHS, GLAKU, HELIX, LLD, NFBC1996, NFBC1986, NTR, SATSA, YFS	33420481	2021-01-08	Aggressive behaviour	EFO_0003015	Meta-analysis in whole blood	eTable 6	DNA methylation	Aggressive behaviour	age, sex, cell compostion (reference based), cell composition (reference free), batch effects	Beta Values	None	Illumina HumanMethylation450, Illumina HumanMethylationEPIC	Whole blood	Age range from 7 - 70	14434	13	Adults	Both	Unclear	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	None	None	0.0000078	None	33420481_van-Dongen-J_aggressive_behaviour_meta-analysis_in_whole_blood
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.102551	0.023137	0.000009378817	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0365239	0.00825106	0.000009643233	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Stroke (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Stroke (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18056	1	Adults (18-65y)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.031	0.00717	0.000012	None	Robert-F-Hillary_Prevalent_Stroke_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0361116	0.00825119	0.00001214162	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0369616	0.00846927	0.00001284606	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0359828	0.00825122	0.00001304093	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.036816	0.00847506	0.00001408254	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Domingo-Relloso A	Strong Heart Study	32484362	2020-06-02	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	Current vs never	Table S2	DNA methylation	Smoking	Age, sex, batch effects, body mass index, cell composition (reference based), ancestry (genomic PCs)	M Values	None	Illumina HumanMethylationEPIC	Whole blood	None	2325	1	Adults	Both	Unclear	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.089	0.0208	0.000019	None	32484362_Domingo-Relloso-A_smoking_current_vs_never
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0351795	0.00825146	0.00002025689	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0351748	0.00825146	0.00002030916	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0355141	0.00833494	0.00002049023	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0360234	0.00846098	0.00002079241	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0404397	0.00952796	0.0000220613	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0347032	0.0082516	0.00002618974	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0355414	0.00845811	0.00002660727	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0402104	0.00960589	0.00002855569	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0345229	0.00825165	0.0000288397	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0352062	0.00846749	0.00003231485	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_2
Christiansen C	TwinsUK, NSHD, NCDS1, NCDS2, BCS70	33593402	2021-02-16	Smoking	EFO_0004318, EFO_0006527	Former vs never smoking meta-analysis in European samples	Table S3	DNA methylation	Smoking	Sex, cell composition (reference based), body mass index, batch effects, relatedness	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	1140	5	Adults	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	None	None	0.000033	None	33593402_Christiansen-C_smoking_former_vs_never_smoking_meta-analysis_in_european_samples
Rzehak P	-	27171005	2016-05-12	Maternal smoking during pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Discovery	Table 1	DNA methylation	Maternal smoking during pregnancy	Age, sex, study centre, maternal education, parental smoking, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	366	1	5.5	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.05	0.01	0.0000382	-	27171005_maternal_smoking_during_pregnancy_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.0349679	0.00849146	0.00003842526	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0348558	0.00849196	0.00004072709	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Richmond RC	-	25552657	2014-12-30	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Adjusted model	Table 3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, social class, paternal smoking, maternal alcohol in pregnancy and technical covariates	M values	-	Illumina HumanMethylation450	Cord blood	-	744	1	30	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.043	0.012	0.0000423	-	25552657_maternal_smoking_in_pregnancy_adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0388271	0.00949593	0.00004359026	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0341855	0.00848346	0.0000561394	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0331829	0.00825202	0.00005819623	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.038	0.0097	0.000072	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	0.017	0.00434	0.000082	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg04180046	chr7:45002736	7	45002736	MYO1G	Island	-0.0334141	0.00848469	0.00008248635	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_2