author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-1.26	0	0	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.03138	0.00078	0	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.052	0.00161	5.8e-221	None	Robert-F-Hillary_Incident_COPD_Basic_model
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity, white blood cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.066	0.002	1.35e-206	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts
Sikdar S	PACE	31536415	2019-09-19	Prenatal smoke exposure	EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318	Inverse varience-weighted fixed-effects meta-analysis	Table S1	DNA methylation	Prenatal smoke exposure	Maternal age, socioeconomic position, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Cord blood, whole blood	None	5648	9	Infants	Both	European, African, Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0655	0.0021	1.4e-206	None	31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.064	0.002	1.64e-193	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns
Zeilinger S	-	23691101	2013-05-17	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking discovery	Table S1	DNA methylation	Smoking	Age, sex, body mass index, alcohol consumption and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	1011	1	60.8	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	2.54e-182	-	23691101_smoking_current_vs_never_smoking_discovery
Dogan MV	-	28686328	2017-07-07	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S1	DNA methylation	Smoking	Age, sex and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	1597	1	67	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-2.2962761	0.0851	1.58e-160	-	28686328_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Former vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	156	1	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.4	0.0154	3.1e-149	None	31552803_Dugue-PA_smoking_former_vs_never_smoking
Barcelona V	GENOA	30915882	2019-03-27	Smoking	EFO_0004318, EFO_0006527	Replication	Table 2	DNA methylation	Smoking	Age, batch effects, cell composition (reference based)	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	1100	1	Adults	Females	African	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.15	0.004	2.5e-141	None	30915882_Barcelona-V_smoking_replication
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.23453	0.00397	1.3e-125	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.192527	0.00810211	1.661179e-122	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Ambatipudi S	-	26864933	2016-05-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Age, breast cancer status, menopausal status, use of contraceptive pill, use of hormone replacement therapy and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	721	1	52.6	Females	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	8.06e-115	-	26864933_smoking_current_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.18549	0.00820044	2.222874e-111	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.18116	0.00811995	1.845216e-108	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Any maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	6685	13	0	Missing	European,East Asian,African,Admixed,Other	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.036	0.002	1.5e-107	-	27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-1.44	0.0658	3.05e-106	-	25556184_smoking_current_vs_never_smoking
Domingo-Relloso A	Strong Heart Study	32484362	2020-06-02	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	Current vs never	Table S2	DNA methylation	Smoking	Age, sex, batch effects, body mass index, cell composition (reference based), ancestry (genomic PCs)	M Values	None	Illumina HumanMethylationEPIC	Whole blood	None	2325	1	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.957	0.0452	2e-99	None	32484362_Domingo-Relloso-A_smoking_current_vs_never
Christiansen C	TwinsUK, NSHD, NCDS1, NCDS2, BCS70	33593402	2021-02-16	Smoking	EFO_0004318, EFO_0006527	Current vs never smoking meta-analysis in European samples	Table S1	DNA methylation	Smoking	Sex, cell composition (reference based), body mass index, batch effects, relatedness	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	912	5	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	None	None	2.9e-99	None	33593402_Christiansen-C_smoking_current_vs_never_smoking_meta-analysis_in_european_samples
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.169847	0.00822776	2.381248e-93	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Chatziioannou A	EnviroGenomarkers project consortium	28225026	2017-02-22	Tobacco smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S2	DNA methylation	Current vs never smoking	Age, sex, body mass index, study centre and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	454	2	52	Both	None	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	8.1e-87	-	28225026_tobacco_smoking
Sayols-Baixeras S	-	26829059	2015-01-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Smoking status	Table S1	DNA methylation	Smoking	Age, sex, physical activity and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	645	1	63.2	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	1.27e-84	-	26829059_smoking_smoking_status
Sayols-Baixeras S	-	26829059	2015-01-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Age, sex, physical activity and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	449	1	63.1	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	4.11e-84	-	26829059_smoking_current_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.186169	0.0098138	2.675062e-79	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Sayols-Baixeras S	-	26829059	2015-01-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking adjusted for cell counts	Table S1	DNA methylation	Smoking	Age, sex, physical activity, cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	449	1	63.1	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	2.8600000000000003e-79	-	26829059_smoking_current_vs_never_smoking_adjusted_for_cell_counts
Zhang Y	-	26826776	2016-04-01	Serum cotinine	EFO_0007813	Replication	Table 2	DNA methylation	Serum cotinine	Age, sex, body mass index, physical activity, total cholesterol, systolic blood pressure, prevalence of cardiovascular disease, diabetes, cancer, leukocyte, cell counts and technical covariates	Beta values	ng/ml	Illumina HumanMethylation450	Whole blood	-	500	1	62	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.003	0.000161	9.73e-78	-	26826776_serum_cotinine_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.151878	0.00816079	1.994467e-76	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.146661	0.00816729	2.445654e-71	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.190632	0.0106184	2.644684e-71	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.191994	0.0107535	1.501197e-70	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_4
Besingi W	-	24334605	2014-05-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table 2	DNA methylation	Smoking	Age, sex, exposure to snuff, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole Blood	-	421	1	43.8	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.074	0.0042	7.19e-70	-	24334605_smoking
Markunas CA	-	24906187	2014-10-01	Maternal smoking during pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Model 1	Table S2	DNA methylation	Maternal smoking during pregnancy	Offspring sex, offspring cleft status and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	889	1	0	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.046	0.0026	1.45e-69	-	24906187_maternal_smoking_during_pregnancy_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.14457	0.00816983	2.378266e-69	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Ambatipudi S	-	26864933	2016-05-01	Smoking	EFO_0005671, EFO_0004318	Former vs never smoking	Table S2	DNA methylation	Smoking	Age, breast cancer status, menopausal status, use of contraceptive pill, use of hormone replacement therapy and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	717	1	53.4	Females	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	1.96e-68	-	26864933_smoking_former_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.14186	0.00817307	8.119421e-67	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.142317	0.00828114	1.489187e-65	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_2
Markunas CA	-	24906187	2014-10-01	Maternal smoking during pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Model 2	Table S2	DNA methylation	Maternal smoking during pregnancy	Offspring sex, offspring cleft status, birth weight, maternal age, maternal alcohol consumption, maternal education, maternal folic acid, supplement use, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	889	1	0	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0466	0.0027	6.67e-65	-	24906187_maternal_smoking_during_pregnancy_model_2
Zeilinger S	-	23691101	2013-05-17	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking replication	Table S2	DNA methylation	Smoking	Age, sex, body mass index, alcohol consumption and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	468	1	53	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	1.8100000000000003e-64	-	23691101_smoking_current_vs_never_smoking_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.138349	0.00817717	1.3073129999999999e-63	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.136548	0.00817924	5.360806e-62	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Teschendorff AE	-	26181258	2015-07-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Discovery	Table 2	DNA methylation	Smoking	Age, sex and technical covariates	Beta values	-	Illumina HumanMethylation450	Buccal cells	Regression coefficient per 10 pack-years	400	1	53	Females	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.06	0.0037	8.000000000000001e-60	-	26181258_smoking_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.135787	0.00828817	8.5487e-60	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Lung Cancer	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Lung Cancer	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18364	1	Adults (18-65y)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.014	0.00087	5e-59	None	Robert-F-Hillary_Incident_Lung_Cancer_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.131047	0.008162	1.61108e-57	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.132223	0.0082833	7.016177e-57	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.130162	0.00818633	1.879424e-56	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.130738	0.00829643	1.717633e-55	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.155148	0.00991246	8.957384e-55	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.126551	0.00819019	1.9411340000000001e-53	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.127711	0.00829893	5.0445880000000005e-53	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_2
Battram T	GEO	25424692	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Never vs current smokers	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	201	1	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.2384	0.0108	5.299999999999999e-53	None	25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__never_vs_current_smokers
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.12583	0.00819095	7.584551e-53	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-1.2	0.08	4.5e-52	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.164576	0.0108947	3.587807e-51	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_4
Shah S	-	25249537	2014-09-23	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking discovery	Table S2	DNA methylation	Smoking	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	535	1	70	Both	None	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.33317974	0.0222	9.999999999999999e-51	-	25249537_smoking_current_vs_never_smoking_discovery
Shah S	-	25249537	2014-09-23	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking replication	Table S2	DNA methylation	Smoking	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	232	1	79	Both	None	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.30272185	0.0202	9.999999999999999e-51	-	25249537_smoking_current_vs_never_smoking_replication
Imboden M	Aging Lungs in European Cohorts project	31073081	2019-07-01	FEV1 / FVC	EFO_0004713	Meta-analysis	Supplementary table 3	DNA methylation	FEV1 / FVC	Batch effects, age, age squared, height, squared deviation from the mean height, sex, education, body mass index, cell composition (reference based)	Beta Values	None	Illumina HumanMethylation450	Whole blood	Meta-analyses were conducted across time points	5370	8	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.124	0.008	7.2e-50	None	31073081_Imboden-M_fev1___fvc_meta-analysis
Petersen A-K	KORA F4	24014485	2013-09-06	M36098_4-vinylphenol_sulfate	EFO_0004727, EFO_0004725	no snps model	Table S2	M36098_4-vinylphenol_sulfate	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.95	0.086	7.8e-50	None	24014485_Petersen-A-K_m36098_4-vinylphenol_sulfate_no_snps_model
Petersen A-K	KORA F4	24014485	2013-09-06	M36098_4-vinylphenol_sulfate	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M36098_4-vinylphenol_sulfate	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.95	0.087	3.5e-49	None	24014485_Petersen-A-K_m36098_4-vinylphenol_sulfate_snps_as_covariates_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.122563	0.00831477	7.925497999999999e-49	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.120535	0.00819637	1.3102049999999998e-48	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Zhu X	-	26756918	2016-07-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S1	DNA methylation	Smoking	Age, sex, alcohol consumption, body mass index and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	Regression coefficients are for inverse normally transformed DNA methylation	596	4	53.9	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.617	0.042253	2.7099999999999998e-48	-	26756918_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.158935	0.0109133	1.035163e-47	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.143734	0.00987379	1.131579e-47	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Teschendorff AE	-	26181258	2015-07-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004319	Replication	Table 2	DNA methylation	Smoking	Age, sex and technical covariates	Beta values	-	Illumina HumanMethylation450	Buccal cells	Regression coefficient per 10 pack-years	390	1	53	Females	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.05	0.0035	7e-47	-	26181258_smoking_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.120035	0.00832076	7.43861e-47	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.156218	0.0108824	2.043435e-46	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.117687	0.00819919	2.090491e-46	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.118891	0.00831074	4.118615e-46	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.152461	0.0109005	3.620717e-44	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_4
Zhang Y	-	26826776	2016-04-01	Serum cotinine	EFO_0007813	Discovery	Table 2	DNA methylation	Serum cotinine	Age, sex and technical covariates	Beta values	ng/ml	Illumina HumanMethylation450	Whole blood	-	500	1	62	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0027	0.00019	4.57e-44	-	26826776_serum_cotinine_discovery
Imboden M	Aging Lungs in European Cohorts project	31073081	2019-07-01	FEV1	EFO_0004314	Meta-analysis	Supplementary table 4	DNA methylation	FEV1	Batch effects, age, age squared, height, squared deviation from the mean height, sex, education, body mass index, cell composition (reference based)	Beta Values	L	Illumina HumanMethylation450	Whole blood	Meta-analyses were conducted across time points	5370	8	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.79	0.057	1.4999999999999998e-43	None	31073081_Imboden-M_fev1_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.112776	0.0082039	9.818636e-43	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.136384	0.0100184	5.998814e-42	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.11264	0.00831245	1.396171e-41	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.135478	0.0100204	2.105091e-41	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.110923	0.00820562	2.16827e-41	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.11083	0.00820571	2.528643e-41	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.110677	0.00832388	4.148624e-40	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.108157	0.00820814	1.9990280000000003e-39	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.107763	0.00820849	3.7713020000000004e-39	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.140116	0.0106872	4.7535410000000005e-39	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.107242	0.00820896	8.695486000000001e-39	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.130048	0.0100055	2.0553769999999997e-38	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.106762	0.00822888	2.78943e-38	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.107042	0.00832901	1.34302e-37	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.10633	0.00833244	4.266741e-37	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.137512	0.0109049	2.867179e-36	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_4
Sun Y-Q	HUNT study	33729499	17/03/21	smoking	EFO_0004318, EFO_0005671, EFO_0009115, EFO_0006526	None	Table 1	DNA methylation	smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	128	1	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.052	0.00292	2.9999999999999998e-36	None	33729499_Sun-Y-Q_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.103354	0.00821235	3.91532e-36	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1
Zeilinger S	-	23691101	2013-05-17	Smoking	EFO_0005671, EFO_0004318	Former vs never smoking	Table S1	DNA methylation	Smoking	Age, sex, body mass index, alcohol consumption and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	1531	1	61.5	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	4.62e-36	-	23691101_smoking_former_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.104339	0.0083358	9.18546e-36	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent COPD (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent COPD (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18078	1	Adults (18-65y)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.036	0.00288	9.700000000000001e-36	None	Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.102048	0.00821347	2.894155e-35	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.124287	0.0100074	3.07838e-35	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.135581	0.0109517	5.026451e-35	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.102523	0.00832876	1.193075e-34	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0985216	0.0082164	5.659133e-33	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1
Tsaprouni LG	CARDIOGENICS	25424692	2014-10-31	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S2	DNA methylation	Smoking	Age, sex, disease status, centre and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	464	1	55.4	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	3.02e-32	-	25424692_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0986265	0.00833541	3.724837e-32	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0966561	0.00821791	8.548307e-32	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.117526	0.0100297	1.427876e-31	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.127696	0.0109812	4.0414510000000005e-31	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0952389	0.00821904	6.4944470000000005e-31	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.114828	0.00992495	7.989797e-31	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.126893	0.0109739	8.614419e-31	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.115722	0.0100296	1.15094e-30	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_3
Richmond RC	-	25552657	2014-12-30	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Unadjusted model	Table 3	DNA methylation	Maternal smoking in pregnancy	Technical covariates	M values	-	Illumina HumanMethylation450	Cord blood	-	790	1	0	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.081	0.006	1.4099999999999999e-30	-	25552657_maternal_smoking_in_pregnancy_unadjusted_model
Domingo-Relloso A	Strong Heart Study	32484362	2020-06-02	Smoking	EFO_0004318, EFO_0005671, EFO_0006526	Pack years	Table S4	DNA methylation	Smoking	Age, sex, batch effects, body mass index, cell composition (reference based), ancestry (genomic PCs)	M Values	pack-years	Illumina HumanMethylationEPIC	Whole blood	None	2325	1	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.01202	0.0011	2.8000000000000002e-30	None	32484362_Domingo-Relloso-A_smoking_pack_years
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0954062	0.00834041	3.582697e-30	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.124654	0.0109029	3.836375e-30	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.124926	0.0109699	6.408920999999999e-30	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.114084	0.0100649	1.171793e-29	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_3
Karlsson Linner R	-	29086770	2017-10-31	Educational attainment	EFO_0004784	Basic model	Table S1.6b	DNA methylation	Educational attainment	Age, sex, cell counts and technical covariates	Beta values	years of schooling	Illumina HumanMethylation450	Whole blood	-	10767	27	57	Both	None	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	2.0000000000000002e-29	-	29086770_educational_attainment_basic_model
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	18413	1	Adults (18-65y)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.11	0.0098	5.9e-29	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0916688	0.00822181	9.398942000000001e-29	A0A075B6I0	41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.092766	0.00835623	1.60398e-28	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0903962	0.00822277	5.287836e-28	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.119449	0.0108731	5.755636e-28	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.106387	0.00969546	6.624216e-28	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.119848	0.0109514	9.130242e-28	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_4
Teschendorff AE	-	26181258	2015-07-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004320	Whole blood	Table 2	DNA methylation	Smoking	Age, sex and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole Blood	Regression coefficient per 10 pack-years	152	1	53	Females	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.05	0.0046	1e-27	-	26181258_smoking_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.108691	0.00997611	1.551238e-27	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0908996	0.00834692	1.635862e-27	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_2
van Dongen J	BIOS	30631468	2018-03-23	Educational attainment	EFO_0004784	model 1	Table S2	DNA methylation	Educational attainment	Sex, age, batch effects, cell composition (reference based)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4152	4	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.06	0.006	2e-27	None	30631468_van-Dongen-J_educational_attainment_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.109367	0.0100788	2.4999860000000002e-27	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.089698	0.00834301	7.360189999999999e-27	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_2
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0005671, EFO_0004318	Former vs never smoking	Table S5	DNA methylation	Former versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	13474	16	62.9	Both	European,African	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0406	0.0038	8.2e-27	-	27651444_smoking_former_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0891851	0.00832104	1.051981e-26	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_2
Xu R	Boston Birth Cohort	33663600	2021-03-04	maternal smoking	EFO_0004318, EFO_0006527, EFO_0005671, EFO_0002950	Discovery	Table S1	DNA methylation	maternal smoking	gestational age, sex, maternal age, maternal education, race, maternal BMI, maternal alcohol consumption, maternal diabetes, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylationEPIC	Cord blood	None	954	1	Infants	Both	Admixed	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.71	0.065	1.5e-26	None	33663600_Xu-R_maternal_smoking_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0877171	0.00822475	1.8547309999999998e-26	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.1803	0.0171	4.5e-26	-	27651444_smoking_current_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.104563	0.0100079	1.83902e-25	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I0	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6I0	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.087194	0.00835457	2.069613e-25	A0A075B6I0	41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0858333	0.0082261	2.122401e-25	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.113936	0.0109382	2.560096e-25	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0865209	0.00834652	4.3171030000000005e-25	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.113042	0.0109323	5.654072e-25	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0846081	0.00822697	1.006888e-24	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0845412	0.00822701	1.0955559999999999e-24	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.1124	0.0109658	1.431962e-24	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.112416	0.0109749	1.539961e-24	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0847593	0.00835154	4.024537e-24	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.10234	0.0100851	4.075979e-24	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.111124	0.0109807	5.4016419999999996e-24	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0814879	0.00822911	4.8002780000000005e-23	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0799814	0.00823012	2.945537e-22	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_1
Xu R	Boston Birth Cohort	33663600	2021-03-04	maternal smoking	EFO_0004318, EFO_0006527, EFO_0005671, EFO_0002950	Discovery, black only	Table S2	DNA methylation	maternal smoking	gestational age, sex, maternal age, maternal education, race, maternal BMI, maternal alcohol consumption, maternal diabetes, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylationEPIC	Cord blood	None	679	1	Infants	Both	African	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.75	0.075	3e-22	None	33663600_Xu-R_maternal_smoking_discovery__black_only
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.104604	0.0107825	3.472879e-22	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0972765	0.0100969	6.652644e-22	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_3
Colicino E	CHARGE	32697766	07-22-2020	All cause mortality	EFO_0004352	basic model	Table S2	All cause mortality	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	None	M values	Illumina HumanMethylation450	Whole blood	Effect estimates represent hazard ratio per 10% increase in DNA methylation.	12300	12	Adults	Both	European, African	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.88	None	9.500000000000001e-22	None	32697766_Colicino-E_all_cause_mortality_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.100217	0.0105344	2.129223e-21	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0793915	0.00835075	2.258812e-21	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0782536	0.00823125	2.263683e-21	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0952731	0.0100629	3.285779e-21	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.102965	0.0108967	3.921271e-21	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0787992	0.00835593	4.689751e-21	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0780797	0.00834698	9.617353e-21	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0778733	0.00834832	1.2302249999999999e-20	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.102675	0.0110127	1.285281e-20	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0766878	0.00823226	1.383097e-20	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0932018	0.01007	2.4239949999999997e-20	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0926054	0.0100197	2.7368539999999996e-20	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
van Dongen J	BIOS	30631468	2018-03-23	Educational attainment	EFO_0004784	model 3	Table S2	DNA methylation	Educational attainment	Sex, age, batch effects, cell composition (reference based), smoking, body mass index	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4152	4	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.038	0.004	4.3e-20	None	30631468_van-Dongen-J_educational_attainment_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.101173	0.0110106	4.500022e-20	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_4
Priyanka Choudhary	PACE	38052982	Dec 5, 2023	Maternal education at the time of pregnancy	None	Model1_Cord_All	None	DNA methylation	Maternal education at the time of pregnancy	Sex, Cell composition (reference based), Batch effects	Beta values	years of schooling	Illumina HumanMethylation450	Cord blood	Illumina HumanMethylationEPIC was also used for some cohorts	9881	None	Infants	Both	Admixed	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.001	0.00011	4.7e-20	None	38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_all
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0927043	0.0101021	5.025285e-20	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0751215	0.00823324	8.154401e-20	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0995239	0.0109948	1.5791819999999998e-19	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0756325	0.00836064	1.6623779999999998e-19	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0741178	0.00823386	2.494155e-19	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0739831	0.00823394	2.89459e-19	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0902804	0.0100645	3.3144879999999998e-19	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0738454	0.00823403	3.369412e-19	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0985029	0.0110284	4.684281999999999e-19	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0739397	0.00827986	4.755758999999999e-19	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Dogan MV	-	24559495	2014-02-22	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table 2	DNA methylation	Smoking	Cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral Blood	-	111	1	48.4	Females	African	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	6.17e-19	-	24559495_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P23142	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P23142	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0729871	0.00823455	8.632417999999999e-19	P23142	41361833_Josephine_Robertson_P23142_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.173696	0.0196023	8.646706e-19	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Priyanka Choudhary	PACE	38052982	Dec 5, 2023	Maternal education at the time of pregnancy	None	Model1_Cord_European	None	DNA methylation	Maternal education at the time of pregnancy	Sex, Cell composition (reference based), Batch effects	Beta values	years of schooling	Illumina HumanMethylation450	Cord blood	Illumina HumanMethylationEPIC was also used for some cohorts	9501	None	Infants	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0011	0.00012	1e-18	None	38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_european
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0886951	0.0100502	1.214836e-18	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0886648	0.0100955	1.772306e-18	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0720404	0.00823512	2.405953e-18	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Wiklund P.	Northern Finland Birth, IoW Birth Cohort, ALSPAC	31262328	2019-07-01	Maternal smoking	EFO_0006527	Meta-analysis	Table 1	DNA methylation	Maternal smoking	Sex, body mass index, smoking, socioeconomic position, ancestry (genomic PCs), age, maternal age	Beta Values	None	Illumina HumanMethylation450	Whole Blood	Some study specific covariates	2821	3	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.019	0.002	3.5e-18	None	31262328_Wiklund-P._maternal_smoking_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0956531	0.0110076	4.013043e-18	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0953815	0.0109927	4.493162e-18	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_4
Christiansen C	TwinsUK, NSHD, NCDS1, NCDS2, BCS70	33593402	2021-02-16	Smoking	EFO_0004318, EFO_0006527	Former vs never smoking meta-analysis in European samples	Table S3	DNA methylation	Smoking	Sex, cell composition (reference based), body mass index, batch effects, relatedness	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	1140	5	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	None	None	4.8e-18	None	33593402_Christiansen-C_smoking_former_vs_never_smoking_meta-analysis_in_european_samples
van Dongen J	ALSPAC, Dunedin, E-risk, FinnTwin12, GS:SFHS, GLAKU, HELIX, LLD, NFBC1996, NFBC1986, NTR, SATSA, YFS	33420481	2021-01-08	Aggressive behaviour	EFO_0003015	Meta-analysis in whole blood	eTable 6	DNA methylation	Aggressive behaviour	age, sex, cell compostion (reference based), cell composition (reference free), batch effects	Beta Values	None	Illumina HumanMethylation450, Illumina HumanMethylationEPIC	Whole blood	Age range from 7 - 70	14434	13	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	None	None	5e-18	None	33420481_van-Dongen-J_aggressive_behaviour_meta-analysis_in_whole_blood
Richmond RC	-	25552657	2014-12-30	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Adjusted model	Table 3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, social class, paternal smoking, maternal alcohol in pregnancy and technical covariates	M values	-	Illumina HumanMethylation450	Cord blood	-	744	1	30	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.075	0.007	7.64e-18	-	25552657_maternal_smoking_in_pregnancy_adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.07198	0.00836956	8.754001000000001e-18	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I0	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6I0	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0945881	0.0110219	1.0267940000000001e-17	A0A075B6I0	41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.175638	0.0206068	1.670228e-17	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Karlsson Linner R	-	29086770	2017-10-31	Educational attainment	EFO_0004784	Adjusted model	Table S1.7b	DNA methylation	Educational attainment	Age, sex, smoking, body mass index, cell counts and technical covariates	Beta values	years of schooling	Illumina HumanMethylation450	Whole blood	-	10767	27	57	Both	None	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	2.03e-17	-	29086770_educational_attainment_adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.070811	0.00836345	2.7608690000000002e-17	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_2
van Dongen J	BIOS	30631468	2018-03-23	Educational attainment	EFO_0004784	model 2	Table S2	DNA methylation	Educational attainment	Sex, age, batch effects, cell composition (reference based), smoking	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4152	4	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.035	0.004	3e-17	None	30631468_van-Dongen-J_educational_attainment_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0706033	0.00836786	3.5442320000000004e-17	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18059	1	Adults (18-65y)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.039	0.0046	5.4e-17	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0844778	0.0101001	6.604049000000001e-17	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0697467	0.00836073	7.937348000000001e-17	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_2
Marzi SJ	E-Risk	29325449	2018-01-12	Smoking	EFO_0006526	None	S2	DNA methylation	Smoking	sex, cell composition (reference based), batch effects	Beta Values	Pack years	Illumina HumanMethylation450	Whole blood	Analysis of twins	1658	1	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.025	None	8.7e-17	None	29325449_Marzi-SJ_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0693262	0.00835246	1.13025e-16	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0692154	0.00835499	1.289758e-16	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0831101	0.0101152	2.271544e-16	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0822696	0.0100557	3.034511e-16	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0673506	0.00823782	3.178657e-16	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0682877	0.00836886	3.628327e-16	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P23142	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P23142	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0680893	0.00836819	4.386722e-16	P23142	41361833_Josephine_Robertson_P23142_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0749443	0.00929155	7.83217e-16	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0661158	0.00823851	0.00000000000000108984	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0659031	0.00823862	0.000000000000001344502	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0656515	0.00823876	0.000000000000001722113	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0876688	0.0110332	0.000000000000002067995	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_4
Karabegovic I	Airwave, ALSPAC, ESTHER, FHS, KORA, Rotterdam Study, Twins UK, ARIC, CHS, EPIC	33990564	05-14-2021	Coffee and tea consumption	None	Meta-analysis	Table 2	DNA methylation	Coffee and tea consumption	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Alcohol consumption	Beta values	None	Illumina HumanMethylation450	Whole blood	None	15789	15	Adults	Both	European, African	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0016	0.0002	0.0000000000000022	None	33990564_Karabegovic-I_coffee_and_tea_consumption_meta-analysis
Shenker NS	-	23175441	2013-03-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Breast cancer cohort	Table S3	DNA methylation	Smoking	Age, case-control status and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	184	1	50.5	Females	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	0.00000000000000431	-	23175441_smoking_breast_cancer_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0655322	0.00835735	0.000000000000004766111	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0655672	0.00836553	0.000000000000004899645	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0782442	0.00998895	0.000000000000005086119	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.06446	0.0082394	0.000000000000005491651	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0642764	0.0082395	0.000000000000006554106	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0641924	0.00823954	0.000000000000007104797	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0766136	0.00983405	0.00000000000000711219	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0785965	0.0100963	0.000000000000007453327	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0850815	0.0110236	0.00000000000001256946	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0776526	0.010107	0.00000000000001651808	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0834317	0.0108914	0.0000000000000196996	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.083951	0.0110273	0.00000000000002841192	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_4
Battram T	GEO	25424692	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Never vs former smokers	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	442	1	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0682	0.00869	0.000000000000035	None	25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__never_vs_former_smokers
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Stroke	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Stroke	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18023	1	Adults (18-65y)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.012	0.00159	0.000000000000035	None	Robert-F-Hillary_Incident_Stroke_Basic_model
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP64	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP64	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	4.6	0.6	0.000000000000038	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp64
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0633163	0.00837363	0.00000000000004223996	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I0	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6I0	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0763463	0.0101085	0.00000000000004516202	A0A075B6I0	41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0621892	0.00824059	0.00000000000004726865	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0618627	0.00824076	0.00000000000006401447	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP70	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP70	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	-4.4	0.6	0.0000000000001	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp70
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP71	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP71	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	-4.4	0.6	0.0000000000001	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp71
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP68	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP68	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	-4.5	0.6	0.00000000000011	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp68
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0612377	0.00824108	0.0000000000001139113	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Sun Y-Q	HUNT study	33729499	17/03/21	lung cancer	MONDO_0008903	None	Table 3	lung cancer	DNA methylation	Age, sex, cell composition (reference based)	None	Beta Values	Illumina HumanMethylationEPIC	Whole blood	Potentially adjusted for batch effects, but it wasn't clear	276	1	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-11.9	1.6	0.00000000000014	None	33729499_Sun-Y-Q_lung_cancer
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP72	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP72	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	4.4	0.6	0.00000000000014	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp72
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP62	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP62	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	4.4	0.6	0.00000000000018	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp62
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP66	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP66	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	-4.4	0.59	0.0000000000002	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp66
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0742948	0.010101	0.0000000000002007507	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0736453	0.010053	0.0000000000002499936	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Carmona JJ	Normative Aging Study	30343628	2018-10-21	Lung function	EFO_0004313, EFO_0003892	Discovery. FEF25%-75% measurements used to measure lung function	Table S1	Lung function	DNA methylation	Season, follow up time, batch effects, weight, weight squared, log(height), age, vitamin C intake, years of education, taking corticosteroids or beta-2-adrenergic agonists or AHFS or LAMA, smoking	L/min	Beta Values	Illumina HumanMethylation450	Whole blood	None	633	1	Adults	Males	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	1.17	0.16	0.00000000000036	None	30343628_Carmona-JJ_lung_function_discovery__fef25_-75__measurements_used_to_measure_lung_function
Fernández-Sanlés A.	REGICOR, Framingham Offspring Cohort	29326313	2018-01-11	Cardiovascular risk	EFO_0003919, EFO_0004298	Age-independent cardiovascular risk was determined via the delta age approach, results meta-analysesd across discovery and replicaton cohorts	Table 2	DNA methylation	Cardiovascular risk	Sex, age, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole Blood	None	2746	2	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0201	0.0028	0.00000000000046	None	29326313_Fernández-Sanlés-A._cardiovascular_risk_age-independent_cardiovascular_risk_was_determined_via_the_delta_age_approach__results_meta-analysesd_across_discovery_and_replicaton_cohorts
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0605572	0.00836831	0.0000000000004832952	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Philibert RA	-	23070629	2012-10-15	Smoking	EFO_0004318, EFO_0006527, EFO_0005671, EFO_0006526	Males only	Table 2	DNA methylation	Smoking	Technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	181	1	19	Males	None	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	0.000000000000565	-	23070629_smoking_males_only
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0777882	0.0107837	0.0000000000005720772	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - GP10	EFO_0005193	None	Table S3	IgG glycosylation measure - GP10	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	-4.4	0.61	0.00000000000063	None	29055820_Wahl-A_igg_glycosylation_measure_-_gp10
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0592401	0.00824207	0.0000000000006915634	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0601426	0.00837615	0.0000000000007294782	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0599605	0.00837388	0.0000000000008425408	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0588259	0.00824227	0.0000000000009979102	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0586841	0.00824234	0.000000000001130738	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0719345	0.0101053	0.000000000001141569	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0714834	0.0101053	0.00000000000157489	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Discovery	Table S4	DNA methylation	Body mass index	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of body mass index	2096	1	56.2	Both	African	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0125	0.0018	0.00000000000165	-	25935004_body_mass_index_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0774655	0.0109642	0.000000000001674631	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0778228	0.0110376	0.000000000001859526	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_4
Terzikhan N	FHS	33748261	2021-01-07	diffusing capacity of the lung for carbon monoxide per alveolar volume (DLCO/VA)	EFO_0009369	Replication adjusted for weight and height	Table 2	DNA methylation	diffusing capacity of the lung for carbon monoxide per alveolar volume (DLCO/VA)	age, sex, smoking, weight, height, cell composition (reference based), batch effects	Beta Values	mmol/(min x kPa x L)	Illumina HumanMethylation450	Whole blood	None	2114	1	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.04	0.0057	0.0000000000023	None	33748261_Terzikhan-N_diffusing_capacity_of_the_lung_for_carbon_monoxide_per_alveolar_volume__dlco_va__replication_adjusted_for_weight_and_height
Dogan MV	-	26441693	2015-09-22	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table 2	DNA methylation	Smoking	Ethnicity and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	100	1	-	Males	European,African	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	0.00000000000258	-	26441693_smoking
Barcelona V	InterGEN	30915882	2019-03-27	Smoking	EFO_0004318, EFO_0006527	Discovery	Table 2	DNA methylation	Smoking	Age, batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylationEPIC	Saliva	None	156	1	Adults	Females	African	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.152	0.02	0.0000000000026	None	30915882_Barcelona-V_smoking_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0762832	0.010915	0.000000000002890858	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0077	0.0011	0.000000000003	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0583836	0.00836354	0.000000000003062781	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_2
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP49	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP49	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	-4.2	0.61	0.0000000000042	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp49
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0699664	0.0101188	0.000000000004888271	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_3
Battram T	GEO	24559495	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE53045	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Peripheral blood mononuclear cells	None	111	1	Adults	Females	African	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.1306	0.0165	0.0000000000064	None	24559495_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse53045
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP40	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP40	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	-4	0.58	0.0000000000069	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp40
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP39	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP39	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	-4	0.58	0.0000000000069	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp39
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6J9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6J9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0564406	0.00824341	0.000000000007854645	A0A075B6J9	41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0571651	0.00836607	0.00000000000864541	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0562713	0.00824349	0.000000000009064601	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Domingo-Relloso A	Strong Heart Study	32484362	2020-06-02	Urinary cadmium	CHEBI_22977	None	Table S1	DNA methylation	Urinary cadmium	Age, sex, batch effects, body mass index, cell composition (reference based), ancestry (genomic PCs), smoking, estimated glomerular filtration rate	M Values	ug/g	Illumina HumanMethylationEPIC	Whole blood	None	2325	1	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.173	0.0255	0.000000000011	None	32484362_Domingo-Relloso-A_urinary_cadmium
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Ischemic Heart Disease	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Ischemic Heart Disease	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17483	1	Adults (18-65y)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.013	0.00185	0.000000000012	None	Robert-F-Hillary_Incident_Ischemic_Heart_Disease_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0736922	0.0108924	0.00000000001379271	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0680656	0.010099	0.00000000001644994	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0681674	0.0101204	0.00000000001693229	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_3
Terzikhan N	FHS	33748261	2021-01-07	diffusing capacity of the lung for carbon monoxide per alveolar volume (DLCO/VA)	EFO_0009369	Replication not adjusted for weight or height	Table 2	DNA methylation	diffusing capacity of the lung for carbon monoxide per alveolar volume (DLCO/VA)	age, sex, smoking, cell composition (reference based), batch effects	Beta Values	mmol/(min x kPa x L)	Illumina HumanMethylation450	Whole blood	None	2114	1	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.037	0.0055	0.000000000017	None	33748261_Terzikhan-N_diffusing_capacity_of_the_lung_for_carbon_monoxide_per_alveolar_volume__dlco_va__replication_not_adjusted_for_weight_or_height
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0659494	0.00981307	0.00000000001876939	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0562717	0.00837483	0.00000000001895343	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_2
Carmona JJ	Normative Aging Study	30343628	2018-10-21	Lung function	EFO_0004314, EFO_0003892	Discovery. FEV1	Table S1	Lung function	DNA methylation	Season, follow up time, batch effects, weight, weight squared, log(height), age, vitamin C intake, years of education, taking corticosteroids or beta-2-adrenergic agonists or AHFS or LAMA, smoking	L/s	Beta Values	Illumina HumanMethylation450	Whole blood	None	633	1	Adults	Males	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	1.59	0.24	0.000000000023	None	30343628_Carmona-JJ_lung_function_discovery__fev1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0550473	0.00824405	0.00000000002522802	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0559156	0.00837736	0.00000000002567926	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0549773	0.00824408	0.00000000002673071	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0673451	0.0101189	0.00000000002926146	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_3
Fasanelli F	-	26667048	2015-12-15	Lung cancer	EFO_0001071	-	Table 1	Lung cancer	DNA methylation	Cell counts and technical covariates	-	Beta values	Illumina HumanMethylation450	Whole blood	Regression coefficients are per 1-SD of DNA methylation	250	1	47	Females	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.9943	0.1499	0.0000000000333	-	26667048_lung_cancer
Smith AK	Psychiatric Genomics Consortium (PGC) PTSD Epigenetics Workgroup	33235198	2020-11-24	post-traumatic stress disorder	EFO_0001358	Meta-analysis	Supplementary data 2	DNA methylation	post-traumatic stress disorder	Age, sex, smoking, cell composition (reference based), batch effects, ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	Controls had been exposed to trauma but did not have a current diagnosis of PTSD or a prior history of PTSD	1896	10	Adults	Both	European, African	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.218	0.0321	0.00000000004	None	33235198_Smith-AK_post-traumatic_stress_disorder_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0728075	0.011029	0.00000000004210665	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0550882	0.00837476	0.00000000004933628	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0541645	0.00824445	0.00000000005207436	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0658173	0.010026	0.00000000005390937	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Battram T	GEO	25424692	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Former vs current smokers	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	285	1	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.1472	0.02151	0.000000000054	None	25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__former_vs_current_smokers
Rebecca Richmond	SEE-Cigs	34583751	Sep 28, 2021	Smoking	EFO_0004318	smoking (vs. non-smoking)	Supplementary Table 2	DNA methylation	Smoking	Age, Sex, Body mass index, Education, household smoking, recreational drug use, 20 surrogate variables	Beta values	None	Illumina HumanMethylationEPIC	Saliva	None	231	1	Adults (18-65 years)	Both	Admixed	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.082	0.01187	0.000000000054	None	34583751_Rebecca-Richmond_smoking_smoking__vs__non-smoking_
Ligthart S	CHARGE	27955697	2016-12-12	C-reactive protein	EFO_0004458	Discovery	Table S3	DNA methylation	C-reactive protein	Age, sex, smoking, body mass index, cell counts and technical covariates	Beta values	mg/l	Illumina HumanMethylation450	Whole blood	C-reactive protein levels were log-transformed	8863	9	65	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0059	9e-04	0.0000000000544	-	27955697_creactive_protein_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0547705	0.00835836	0.00000000005835981	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Chronic Pain	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Chronic Pain	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	11591	1	Adults (18-65y)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.032	0.0048	0.000000000064	None	Robert-F-Hillary_Incident_Chronic_Pain_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0537905	0.00824462	0.00000000007055147	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.053789	0.00824462	0.0000000000706355	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0545161	0.00836027	0.00000000007219549	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_2
Domingo-Relloso A	Strong Heart Study	32484362	2020-06-02	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	Former vs never	Table S3	DNA methylation	Smoking	Age, sex, batch effects, body mass index, cell composition (reference based), ancestry (genomic PCs)	M Values	None	Illumina HumanMethylationEPIC	Whole blood	None	2325	1	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.314	0.0484	0.000000000093	None	32484362_Domingo-Relloso-A_smoking_former_vs_never
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6J9	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6J9	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0541504	0.00837806	0.0000000001056445	A0A075B6J9	41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0710532	0.0110193	0.0000000001168214	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_4
Demerath EW	-	25935004	2015-08-01	Waist circumference	EFO_0004342	Discovery	Table S5	DNA methylation	Waist circumference	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	cm	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of waist circumference	2097	1	56.2	Both	African	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0112	0.0017	0.00000000013	-	25935004_waist_circumference_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0535289	0.00836414	0.0000000001603007	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Cronjé HT	Prospective Urban and Rural Epidemiology study	31910897	2020-01-07	Smoking	EFO_0004318, EFO_0006527, EFO_0005670	None	Additional file 2b	DNA methylation	Smoking	Age, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	117	1	Adults	Males	African	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.178	0.024	0.00000000017	None	31910897_Cronjé-HT_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0529135	0.00828059	0.0000000001708238	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0526207	0.00824513	0.000000000180001	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0644493	0.0101305	0.0000000002051581	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0642976	0.0101173	0.0000000002143326	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_3
Karabegovic I	Airwave, ALSPAC, ESTHER, FHS, KORA, Rotterdam Study, Twins UK	33990564	05-14-2021	Coffee and tea consumption	None	Discovery	Table 2	DNA methylation	Coffee and tea consumption	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Body mass index, Alcohol consumption	Beta values	None	Illumina HumanMethylation450	Whole blood	None	9612	7	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0014	0.0002	0.00000000023	None	33990564_Karabegovic-I_coffee_and_tea_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0693313	0.0109636	0.0000000002626624	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P22792	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P22792	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0520978	0.00824536	0.0000000002718391	P22792	41361833_Josephine_Robertson_P22792_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0637935	0.0101153	0.0000000002933255	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0527201	0.00836172	0.0000000002965728	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0692425	0.0109853	0.0000000002999288	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0690859	0.011057	0.0000000004267505	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0523298	0.00837938	0.0000000004353053	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0676976	0.0108885	0.0000000005193554	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P23142	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P23142	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0682599	0.0110223	0.0000000006064373	P23142	41361833_Josephine_Robertson_P23142_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0622808	0.010106	0.0000000007337554	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P23142	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P23142	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0621549	0.0101052	0.0000000007908965	P23142	41361833_Josephine_Robertson_P23142_OSCA_model_3
Fernández-Sanlés A.	REGICOR, Framingham Offspring Cohort	29326313	2018-01-11	Cardiovascular risk	EFO_0003919, EFO_0004298	Age-independent cardiovascular risk was determined via the residuals approach, results meta-analysesd across discovery and replicaton cohorts	Table 2	DNA methylation	Cardiovascular risk	Sex, age, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole Blood	None	2746	2	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-7.8	1.26	0.00000000087	None	29326313_Fernández-Sanlés-A._cardiovascular_risk_age-independent_cardiovascular_risk_was_determined_via_the_residuals_approach__results_meta-analysesd_across_discovery_and_replicaton_cohorts
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0668586	0.010981	0.000000001167676	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0505498	0.00837777	0.000000001640009	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.121919	0.0202201	0.00000000167731	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Shenker NS	-	23175441	2013-03-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Colon cancer cohort	Table S3	DNA methylation	Smoking	Age, case-control status and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	190	1	55	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	0.00000000186	-	23175441_smoking_colon_cancer_cohort
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on older children	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	3049	5	6.8	Missing	European,African,Admixed,Other	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.013	0.002	0.00000000187	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_older_children
Portilla-Fernandez	CHARGE	34091768	06-06-2021	carotid intima-media thickness	EFO_0007117	meta-ewas, model2	Table 1	DNA methylation	carotid intima-media thickness	Age, Sex, Smoking, Cell composition (reference based), Batch effects, BMI, HDLC/TC ratio, SBP, antihypertensive, lipid lowering, pDM	Beta values	mm	Illumina HumanMethylationEPIC, Illumina HumanMethylation450	blood	None	6658	10	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.03	None	0.0000000019	None	34091768_Portilla-Fernandez_carotid_intima-media_thickness_meta-ewas__model2
Fernandez-Sanles A	REGICOR	33883000	04-21-2021	Acute myocardial infarction	EFO_0008583	Meta-analysis model1	Additional Table 2	Acute myocardial infarction	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	None	Beta values	Illumina HumanMethylationEPIC	Whole blood	Cases and controls matched by age and sex. Blood samples were drawn within the first 24 hours post-AMI for cases and at follow-up for controls.	595	2	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.75	0.13	0.0000000021	None	33883000_Fernandez-Sanles-A_acute_myocardial_infarction_meta-analysis_model1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0492532	0.00824655	0.000000002389264	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0657514	0.0110198	0.000000002477443	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.065735	0.0110449	0.00000000271583	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0496702	0.00836174	0.000000002911628	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_2
Portilla-Fernandez	CHARGE	34091768	06-06-2021	carotid intima-media thickness	EFO_0007117	meta-ewas, model1	Table 1	DNA methylation	carotid intima-media thickness	Age, Sex, Smoking, Cell composition (reference based), Batch effects	Beta values	mm	Illumina HumanMethylationEPIC, Illumina HumanMethylation450	blood	None	6658	10	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.03	None	0.0000000032	None	34091768_Portilla-Fernandez_carotid_intima-media_thickness_meta-ewas__model1
Ochoa-Rosales C	ESTHER, KORA-F4 , LOLIPOP, SHIP-Trend	32033992	2020-04-01	Statin use	GO_0036273	Discovery	Table 1	Statin use	DNA methylation	sex, age, smoking, body mass index, systolic blood pressure, antihypertensive medication, coronary heart disease, type 2 diabetes, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	Some cohorts used the Illumina HumanMethylationEPIC, but results were restricted to sites measured by the HM450	6820	4	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0132	0.0022	0.0000000032	None	32033992_Ochoa-Rosales-C_statin_use_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0652395	0.0110223	0.00000000331386	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6J9	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6J9	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0653177	0.0110495	0.000000003467688	A0A075B6J9	41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0486326	0.0082468	0.000000003779857	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0485059	0.00824685	0.000000004147838	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0593445	0.0101165	0.000000004557129	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P22792	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P22792	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0491067	0.00837685	0.000000004666025	P22792	41361833_Josephine_Robertson_P22792_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.059356	0.0101376	0.000000004870274	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_3
Philibert RA	-	24120260	2013-10-11	Smoking	EFO_0006527, EFO_0004318	-	Table 2	DNA methylation	Smoking	Technical covariates	Beta values	-	Illumina HumanMethylation450	Lymphocytes	-	101	1	22	Males	African	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	0.00000000492	-	24120260_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0588352	0.0101278	0.000000006403992	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0477743	0.00824714	0.000000007062866	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_1
Imboden M	Aging Lungs in European Cohorts project	31073081	2019-07-01	FVC	EFO_0004312	Meta-analysis	Supplementary table 5	DNA methylation	FVC	Batch effects, age, age squared, height, squared deviation from the mean height, sex, education, body mass index, cell composition (reference based)	Beta Values	L	Illumina HumanMethylation450	Whole blood	Meta-analyses were conducted across time points	5370	8	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.37	0.064	0.0000000088	None	31073081_Imboden-M_fvc_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0474082	0.00824729	0.000000009191693	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0611162	0.0106879	0.00000001097031	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0471456	0.00824739	0.00000001109079	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0573888	0.0100819	0.00000001277508	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.057209	0.0100579	0.00000001309978	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0566177	0.00999875	0.00000001520026	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0559214	0.0099138	0.00000001724314	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0463636	0.00824769	0.00000001928695	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.046214	0.00824775	0.00000002141837	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_1
Portilla-Fernandez	CHARGE	34091768	06-06-2021	carotid intima-media thickness	EFO_0007117	discovery, model2	Table 1	DNA methylation	carotid intima-media thickness	Age, Sex, Smoking, Cell composition (reference based), Batch effects	Beta values	mm	Illumina HumanMethylationEPIC, Illumina HumanMethylation450	blood	None	6407	9	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.02	None	0.000000022	None	34091768_Portilla-Fernandez_carotid_intima-media_thickness_discovery__model2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0609789	0.0108954	0.00000002223468	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0468295	0.0083699	0.00000002245925	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q16610	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q16610	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0468266	0.00838358	0.00000002371486	Q16610	41361833_Josephine_Robertson_Q16610_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0532872	0.00964835	0.00000003390486	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Portilla-Fernandez	CHARGE	34091768	06-06-2021	carotid intima-media thickness	EFO_0007117	discovery, model1	Table 1	DNA methylation	carotid intima-media thickness	Age, Sex, Smoking, Cell composition (reference based), Batch effects	Beta values	mm	Illumina HumanMethylationEPIC, Illumina HumanMethylation450	blood	None	6407	9	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.02	None	0.000000035	None	34091768_Portilla-Fernandez_carotid_intima-media_thickness_discovery__model1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Liver Cirrhosis	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Liver Cirrhosis	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18325	1	Adults (18-65y)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0035	0.00064	0.000000038	None	Robert-F-Hillary_Incident_Liver_Cirrhosis_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0453518	0.00824808	0.00000003895032	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q16610	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q16610	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0452592	0.00824811	0.00000004150841	Q16610	41361833_Josephine_Robertson_Q16610_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0456231	0.00834943	0.00000004725453	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0455591	0.00835733	0.00000005078643	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_2
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP34	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP34	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	-3.3	0.6	0.000000053	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp34
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0579426	0.0106685	0.00000005688037	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_4
Terzikhan N	Rotterdam Study	33748261	2021-01-07	diffusing capacity of the lung for carbon monoxide per alveolar volume (DLCO/VA)	EFO_0009369	Discovery not adjusted for weight or height	Table 2	DNA methylation	diffusing capacity of the lung for carbon monoxide per alveolar volume (DLCO/VA)	age, sex, smoking, cell composition (reference based), batch effects	Beta Values	mmol/(min x kPa x L)	Illumina HumanMethylation450	Whole blood	None	659	1	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.065	0.012	0.000000061	None	33748261_Terzikhan-N_diffusing_capacity_of_the_lung_for_carbon_monoxide_per_alveolar_volume__dlco_va__discovery_not_adjusted_for_weight_or_height
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0445048	0.00824839	0.00000006936565	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04180	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04180	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.044357	0.00824844	0.00000007663503	P04180	41361833_Josephine_Robertson_P04180_OSCA_model_1
Karabegovic I	ARIC, CHS, EPIC	33990564	05-14-2021	Coffee and tea consumption	None	Replication	Table 2	DNA methylation	Coffee and tea consumption	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Body mass index, Alcohol consumption	Beta values	None	Illumina HumanMethylation450	Whole blood	None	6177	3	Adults	Both	European, African	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0027	0.0005	0.000000079	None	33990564_Karabegovic-I_coffee_and_tea_consumption_replication
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - GP23	EFO_0005193	None	Table S3	IgG glycosylation measure - GP23	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	3.2	0.6	0.000000081	None	29055820_Wahl-A_igg_glycosylation_measure_-_gp23
Rebecca Richmond	SEE-Cigs	34583751	Sep 28, 2021	E-cigarette use	NCIT_C173621	e-cigarette use (vs. smoking)	Supplementary Table 3	DNA methylation	E-cigarette use	Age, Sex, Body mass index, Education, household smoking, recreational drug use and 20 surrogate variables	Beta values	None	Illumina HumanMethylationEPIC	Saliva	None	225	1	Adults (18-65 years)	Both	Admixed	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0711	0.0128	0.000000081	None	34583751_Rebecca-Richmond_e-cigarette_use_e-cigarette_use__vs__smoking_
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0536959	0.0100362	0.00000008916256	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Rheumatoid Arthritis (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Rheumatoid Arthritis (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18055	1	Adults (18-65y)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.019	0.0036	0.000000092	None	Robert-F-Hillary_Prevalent_Rheumatoid_Arthritis_(Self-report)_Basic_model
Terzikhan N	Rotterdam Study	33748261	2021-01-07	diffusing capacity of the lung for carbon monoxide per alveolar volume (DLCO/VA)	EFO_0009369	Discovery adjusted for weight and height	Table 2	DNA methylation	diffusing capacity of the lung for carbon monoxide per alveolar volume (DLCO/VA)	age, sex, smoking, weight, height, cell composition (reference based), batch effects	Beta Values	mmol/(min x kPa x L)	Illumina HumanMethylation450	Whole blood	None	659	1	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.064	0.012	0.000000096	None	33748261_Terzikhan-N_diffusing_capacity_of_the_lung_for_carbon_monoxide_per_alveolar_volume__dlco_va__discovery_adjusted_for_weight_and_height
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0446787	0.00837309	0.00000009643793	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Rheumatoid Arthritis	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Rheumatoid Arthritis	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18027	1	Adults (18-65y)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.004	0.00076	0.00000011	None	Robert-F-Hillary_Incident_Rheumatoid_Arthritis_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0444675	0.00838408	0.0000001150617	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Stroke (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Stroke (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18056	1	Adults (18-65y)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.017	0.0032	0.00000014	None	Robert-F-Hillary_Prevalent_Stroke_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0578316	0.0110273	0.0000001589632	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0575883	0.0110631	0.0000001961297	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0435818	0.00837704	0.0000001992352	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_2
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	0.000000224	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q16610	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q16610	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0524175	0.0101411	0.0000002386876	Q16610	41361833_Josephine_Robertson_Q16610_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0522402	0.0101157	0.0000002445259	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0518986	0.0100939	0.0000002759375	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	PRKCG protein levels (SeqId = 5476-66)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRKCG protein levels (SeqId = 5476-66)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein kinase C gamma type	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.58	0.112	0.00000028	None	Gadd-DA_prkcg_protein_levels__seqid___5476-66__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0423027	0.00824918	0.0000002963977	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.042252	0.0082492	0.0000003062137	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.056459	0.0110264	0.0000003088217	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0420804	0.00824926	0.0000003418751	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0561996	0.0110494	0.000000369778	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0509493	0.0100522	0.0000004058718	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0528622	0.0104664	0.0000004456018	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Philibert RA	-	23070629	2012-10-15	Smoking	EFO_0004318, EFO_0006527, EFO_0005671, EFO_0006526	Females only	Table 3	DNA methylation	Smoking	Technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	218	1	19	Females	None	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	0.000000451	-	23070629_smoking_females_only
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6J9	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6J9	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0511146	0.0101371	0.0000004653326	A0A075B6J9	41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0422017	0.00838002	0.0000004810194	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Chronic Kidney Disease	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Chronic Kidney Disease	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18000	1	Adults (18-65y)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0052	0.00103	0.00000049	None	Robert-F-Hillary_Incident_Chronic_Kidney_Disease_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P22792	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P22792	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0509145	0.0101335	0.0000005110692	P22792	41361833_Josephine_Robertson_P22792_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.106438	0.0212005	0.000000520356	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0506617	0.0100912	0.0000005216945	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04180	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04180	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0419565	0.00838546	0.000000569534	P04180	41361833_Josephine_Robertson_P04180_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	HNF4A protein levels (SeqId = 10041-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HNF4A protein levels (SeqId = 10041-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hepatocyte nuclear factor 4-alpha	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.56	0.113	0.00000057	None	Gadd-DA_hnf4a_protein_levels__seqid___10041-3__somascan_protein_measurement
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0012	0.00025	0.0000006	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0506227	0.0101411	0.0000006050251	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_3
Liu C	CHARGE+	27843151	2016-12-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	European ancestry	Table S5	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g der day	Illumina HumanMethylation450	Whole blood	-	9643	10	64.2	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0005272	0.00010572	0.000000614	-	27843151_alcohol_consumption_per_day_european_ancestry
Zhao N	CLUE I, CLUE II	34008478	05-31-2021	Lung cancer	MONDO_0008903	smoking score unadjusted	Supplementary Table 2	Lung cancer	DNA methylation	Age, Sex, Smoking, Batch effects, Body mass index, cell composition (reference based)	None	Beta values	Illumina HumanMethylationEPIC	whole blood	even though they adjust for smoking status, they dont adjust for smoking status score like their other EWAS	430	1	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.072	0.0144	0.00000068	None	34008478_Zhao-N_lung_cancer_smoking_score_unadjusted
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0416235	0.00838368	0.0000006953466	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0499603	0.0100817	0.0000007293793	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0547879	0.0110632	0.0000007417609	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_4
Zaghlool SB	-	25663950	2015-01-22	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table 1	DNA methylation	Smoking	Age, sex, cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	121	1	-	Both	Other	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	0.000000747	-	25663950_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0408175	0.00824969	0.0000007590509	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Carmona JJ	Normative Aging Study	30343628	2018-10-21	Lung function	EFO_0004312, EFO_0003892	Discovery. FVC measurements used to measure lung function	Table S1	Lung function	DNA methylation	Season, follow up time, batch effects, weight, weight squared, log(height), age, vitamin C intake, years of education, taking corticosteroids or beta-2-adrenergic agonists or AHFS or LAMA, smoking	L	Beta Values	Illumina HumanMethylation450	Whole blood	None	633	1	Adults	Males	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	1.3	0.26	0.00000088	None	30343628_Carmona-JJ_lung_function_discovery__fvc_measurements_used_to_measure_lung_function
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0494401	0.0101007	0.0000009948538	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0403674	0.00824984	0.000001003074	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CSF3 protein levels (SeqId = 4840-73)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CSF3 protein levels (SeqId = 4840-73)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granulocyte colony-stimulating factor	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.545	0.113	0.0000013	None	Gadd-DA_csf3_protein_levels__seqid___4840-73__somascan_protein_measurement
Monick MM	-	22232023	2012-01-09	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table 2	DNA methylation	Smoking	Technical covariates	Beta values	-	Illumina HumanMethylation450	Lymphoblasts	-	119	1	45	Females	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-	-	0.00000134	-	22232023_smoking_current_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0533525	0.0110509	0.00000139389	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0525409	0.0109981	0.000001794169	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_4
Stephenson M	FinnTwin12, FinnTwin16	33277923	2021-01-02	Alcohol consumption	EFO_0004329, EFO_0007878	discovery	Table 2	DNA methylation	Alcohol consumption	Age, sex, body mass index, smoking, cell composition (reference based), zygosity, twin pair identifier	Beta Values	drinks per week	Illumina HumanMethylation450	Whole blood	sample included twins. zygosity and twin pair identifier were random effects in the ewas model.	1004	1	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.00125	0.00026	0.0000019	None	33277923_Stephenson-M_alcohol_consumption_discovery
Whitney LD	Women's Health Initiative (WHI), Twins UK	33354722	May 17, 2021	Diet Quality Alternative Healthy Eating Index 2010 (AHEI-2010)	EFO_0002755	discovery	Supplementary Table 1	DNA methylation	Diet Quality Alternative Healthy Eating Index 2010 (AHEI-2010)	Age, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Ancestry (other), Body mass index, study-specific covariates	Beta values	None	Illumina HumanMethylation450	whole blood	None	4355	1	Adults	Females	Other	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.00052	0.00011	0.000002	None	33354722_Whitney-LD_diet_quality_alternative_healthy_eating_index_2010__ahei-2010__discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0481832	0.0101438	0.000002053549	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	ALPP protein levels (SeqId = 7813-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ALPP protein levels (SeqId = 7813-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Alkaline phosphatase, placental type	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.53	0.113	0.0000027	None	Gadd-DA_alpp_protein_levels__seqid___7813-6__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0392699	0.0083771	0.000002786827	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0390577	0.00837485	0.000003133248	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0383557	0.0082505	0.000003366147	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0388913	0.00837228	0.000003426214	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0382953	0.00825052	0.000003487814	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	VAV3 protein levels (SeqId = 9830-109)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VAV3 protein levels (SeqId = 9830-109)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Guanine nucleotide exchange factor VAV3	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.52	0.113	0.000004	None	Gadd-DA_vav3_protein_levels__seqid___9830-109__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14076	1	Adults (18-65y)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.017	0.00364	0.0000047	None	Robert-F-Hillary_Incident_COPD_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0381787	0.00838559	0.000005333983	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0374446	0.00825078	0.000005715616	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0482384	0.0107724	0.000007592975	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	F3 protein levels (SeqId = 4931-59)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	F3 protein levels (SeqId = 4931-59)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tissue factor	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.5	0.113	0.0000076	None	Gadd-DA_f3_protein_levels__seqid___4931-59__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0491205	0.0109967	0.000007997425	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0373929	0.00838393	0.000008254451	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	HNF1A protein levels (SeqId = 11193-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HNF1A protein levels (SeqId = 11193-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hepatocyte nuclear factor 1-alpha	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.5	0.112	0.0000085	None	Gadd-DA_hnf1a_protein_levels__seqid___11193-27__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0448552	0.0101014	0.000009040656	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_3
Logue M	TRACTS	32171335	03-14-2020	Lifetime PTSD	None	Discovery	Additional file 2	DNA methylation	Lifetime PTSD	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs)	M values	None	Illumina HumanMethylationEPIC	Blood	None	513	1	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.134	0.03	0.0000092	None	32171335_Logue-M_lifetime_ptsd_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01009	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01009	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0363154	0.00825113	0.00001083816	P01009	41361833_Josephine_Robertson_P01009_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0478938	0.0109158	0.00001154382	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.804904	0.1838	0.0000119	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q16610	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q16610	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0483	0.0110661	0.00001281705	Q16610	41361833_Josephine_Robertson_Q16610_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01009	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01009	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0365725	0.00838394	0.00001296361	P01009	41361833_Josephine_Robertson_P01009_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	RNASE2 protein levels (SeqId = 8394-56)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RNASE2 protein levels (SeqId = 8394-56)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Non-secretory ribonuclease	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.49	0.113	0.000013	None	Gadd-DA_rnase2_protein_levels__seqid___8394-56__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0362736	0.00837984	0.0000151004	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0361634	0.00835899	0.00001526486	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0472149	0.0109249	0.00001557902	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.036023	0.00833621	0.00001561534	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0436533	0.0101364	0.00001668637	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0474189	0.0110576	0.00001811604	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	TRAPPC5 protein levels (SeqId = 8671-378)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TRAPPC5 protein levels (SeqId = 8671-378)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Trafficking protein particle complex subunit 5	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.48	0.113	0.00002	None	Gadd-DA_trappc5_protein_levels__seqid___8671-378__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P22792	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P22792	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.046733	0.0110465	0.00002345088	P22792	41361833_Josephine_Robertson_P22792_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	PACSIN3 protein levels (SeqId = 14674-63)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PACSIN3 protein levels (SeqId = 14674-63)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein kinase C and casein kinase substrate in neurons protein 3	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.47	0.113	0.000026	None	Gadd-DA_pacsin3_protein_levels__seqid___14674-63__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0462559	0.0110191	0.00002711022	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0351673	0.00838044	0.0000272838	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0422381	0.0101332	0.00003086663	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_3
Priyanka Choudhary	PACE	38052982	Dec 5, 2023	Maternal education at the time of pregnancy	None	Model1_Adolescence	None	DNA methylation	Maternal education at the time of pregnancy	Age, Sex, Cell composition (reference based), Batch effects	Beta values	years of schooling	Illumina HumanMethylation450	Whole blood	Illumina HumanMethylationEPIC was also used for some cohorts	2740	None	Children	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.00068	0.00016	0.000033	None	38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_adolescence
Gadd DA	Generation Scotland	35945220	31/07/2022	EFS protein levels (SeqId = 12572-236)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EFS protein levels (SeqId = 12572-236)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Embryonal Fyn-associated substrate	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.47	0.112	0.000033	None	Gadd-DA_efs_protein_levels__seqid___12572-236__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MAPT protein levels (SeqId = 5854-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MAPT protein levels (SeqId = 5854-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Microtubule-associated protein tau	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.47	0.113	0.000036	None	Gadd-DA_mapt_protein_levels__seqid___5854-60__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SIRT3 protein levels (SeqId = 17495-141)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SIRT3 protein levels (SeqId = 17495-141)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: NAD-dependent protein deacetylase sirtuin-3, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.47	0.113	0.000037	None	Gadd-DA_sirt3_protein_levels__seqid___17495-141__somascan_protein_measurement
Zhao N	1989 CLUE II cohort	34008478	12-01-2020	lung cancer	None	None	Supplemental Table 1	lung cancer	DNA methylation	Age, Sex, Smoking, Body mass index, batch effects, pack-years based smoking methylation score, cell composition (reference based)	None	Other	Illumina HumanMethylationEPIC	whole blood	208 cases and 222 controls. Results are given as logOR corresponding to each 1% increase of methylation beta value	430	1	Adults	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.076	0.0185	0.000037	None	34008478_Zhao-N_lung_cancer
Gadd DA	Generation Scotland	35945220	31/07/2022	SMAD1 protein levels (SeqId = 9838-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SMAD1 protein levels (SeqId = 9838-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mothers against decapentaplegic homolog 1	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.46	0.113	0.000042	None	Gadd-DA_smad1_protein_levels__seqid___9838-4__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0338095	0.00825185	0.00004204279	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CKB protein levels (SeqId = 3800-71)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CKB protein levels (SeqId = 3800-71)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Creatine kinase B-type	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.46	0.112	0.000043	None	Gadd-DA_ckb_protein_levels__seqid___3800-71__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TNFRSF9 protein levels (SeqId = 14025-18)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNFRSF9 protein levels (SeqId = 14025-18)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tumor necrosis factor receptor superfamily member 9	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.46	0.112	0.000043	None	Gadd-DA_tnfrsf9_protein_levels__seqid___14025-18__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0445417	0.0108925	0.00004351808	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0336842	0.00825189	0.0000448853	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	UBE2G2 protein levels (SeqId = 9199-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBE2G2 protein levels (SeqId = 9199-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-conjugating enzyme E2 G2	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.46	0.113	0.000045	None	Gadd-DA_ube2g2_protein_levels__seqid___9199-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LGI3 protein levels (SeqId = 8003-57)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LGI3 protein levels (SeqId = 8003-57)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leucine-rich repeat LGI family member 3	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.459	0.113	0.000047	None	Gadd-DA_lgi3_protein_levels__seqid___8003-57__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LRP12 protein levels (SeqId = 15506-34)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LRP12 protein levels (SeqId = 15506-34)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Low-density lipoprotein receptor-related protein 12	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.46	0.113	0.000051	None	Gadd-DA_lrp12_protein_levels__seqid___15506-34__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.033427	0.00825196	0.00005130606	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0409409	0.0101133	0.00005187403	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0445797	0.0110548	0.00005544296	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0408644	0.0101439	0.00005642747	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CBR3 protein levels (SeqId = 14091-42)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CBR3 protein levels (SeqId = 14091-42)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Carbonyl reductase [NADPH] 3	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.45	0.113	0.000067	None	Gadd-DA_cbr3_protein_levels__seqid___14091-42__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HHIP protein levels (SeqId = 10833-64)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HHIP protein levels (SeqId = 10833-64)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hedgehog-interacting protein	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.45	0.112	0.000069	None	Gadd-DA_hhip_protein_levels__seqid___10833-64__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	THSD7A protein levels (SeqId = 9600-55)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	THSD7A protein levels (SeqId = 9600-55)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thrombospondin type-1 domain-containing protein 7A	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.45	0.113	0.000071	None	Gadd-DA_thsd7a_protein_levels__seqid___9600-55__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CISD2 protein levels (SeqId = 8094-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CISD2 protein levels (SeqId = 8094-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CDGSH iron-sulfur domain-containing protein 2	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.447	0.113	0.000073	None	Gadd-DA_cisd2_protein_levels__seqid___8094-20__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0326216	0.00825218	0.00007751088	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Priyanka Choudhary	PACE	38052982	Dec 5, 2023	Maternal education at the time of pregnancy	None	Model2_Cord_All	None	DNA methylation	Maternal education at the time of pregnancy	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Body mass index, Gestational age	Beta values	years of schooling	Illumina HumanMethylation450	Cord blood	Illumina HumanMethylationEPIC was also used for some cohorts	9881	None	Infants	Both	Admixed	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.00046	0.00012	0.000078	None	38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model2_cord_all
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0436026	0.0110521	0.00008011314	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0330065	0.00837922	0.00008217133	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent COPD (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent COPD (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14391	1	Adults (18-65y)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.026	0.0065	0.000083	None	Robert-F-Hillary_Prevalent_COPD_(Self-report)_Fully-adjusted_model
Gadd DA	Generation Scotland	35945220	31/07/2022	TIMM8A protein levels (SeqId = 19148-58)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TIMM8A protein levels (SeqId = 19148-58)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Mitochondrial import inner membrane translocase subunit Tim8 A	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.44	0.113	0.000084	None	Gadd-DA_timm8a_protein_levels__seqid___19148-58__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02765	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02765	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0434676	0.0110499	0.00008401943	P02765	41361833_Josephine_Robertson_P02765_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.043252	0.0110314	0.00008865046	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
van Dongen J	ALSPAC, GECKO, Generation R, INMA, Poseidon	33420481	2021-01-08	Aggressive behaviour	EFO_0003015	Fully adjusted meta-analysis in cord blood	eTable 7	DNA methylation	Aggressive behaviour	age, sex, cell compostion (reference based), cell composition (reference free), batch effects , body mass index, smoking	Beta Values	None	Illumina HumanMethylation450, Illumina HumanMethylationEPIC	Cord blood	None	2425	5	Infants	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	None	None	0.000089	None	33420481_van-Dongen-J_aggressive_behaviour_fully_adjusted_meta-analysis_in_cord_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P19652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0323158	0.00825226	0.00009044139	P19652	41361833_Josephine_Robertson_P19652_OSCA_model_1
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg05575921	chr5:373378	5	373378	AHRR	North shore	None	None	0.000091	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	ASPA protein levels (SeqId = 18187-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ASPA protein levels (SeqId = 18187-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aspartoacylase	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.44	0.112	0.000091	None	Gadd-DA_aspa_protein_levels__seqid___18187-16__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.0327653	0.00838414	0.00009347738	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	ACRV1 protein levels (SeqId = 15301-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACRV1 protein levels (SeqId = 15301-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Acrosomal protein SP-10	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.44	0.113	0.000094	None	Gadd-DA_acrv1_protein_levels__seqid___15301-24__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GP5 protein levels (SeqId = 7185-29)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GP5 protein levels (SeqId = 7185-29)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Platelet glycoprotein V	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.44	0.113	0.000096	None	Gadd-DA_gp5_protein_levels__seqid___7185-29__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	C17orf78 protein levels (SeqId = 6571-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C17orf78 protein levels (SeqId = 6571-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Uncharacterized protein C17orf78	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.44	0.113	0.000096	None	Gadd-DA_c17orf78_protein_levels__seqid___6571-75__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TCEAL8 protein levels (SeqId = 19109-32)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TCEAL8 protein levels (SeqId = 19109-32)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transcription elongation factor A protein-like 8	774	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	-0.44	0.112	0.000098	None	Gadd-DA_tceal8_protein_levels__seqid___19109-32__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg05575921	chr5:373378	5	373378	AHRR	North shore	0.0394743	0.0101358	0.00009881352	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_3