author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.0036	0.00011	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.08558	0.00159	0	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.78	0.0233	7.900000000000001e-246	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	0.64322	0.00817	1.0999999999999999e-148	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Former vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	156	1	Adults	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.33	0.0161	6.8e-93	None	31552803_Dugue-PA_smoking_former_vs_never_smoking
Zeilinger S	-	23691101	2013-05-17	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking discovery	Table S1	DNA methylation	Smoking	Age, sex, body mass index, alcohol consumption and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	1011	1	60.8	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-	-	1.72e-75	-	23691101_smoking_current_vs_never_smoking_discovery
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.76	0.0463	2.0000000000000002e-60	-	25556184_smoking_current_vs_never_smoking
Ambatipudi S	-	26864933	2016-05-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Age, breast cancer status, menopausal status, use of contraceptive pill, use of hormone replacement therapy and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	721	1	52.6	Females	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-	-	5.900000000000001e-59	-	26864933_smoking_current_vs_never_smoking
Dogan MV	-	28686328	2017-07-07	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S1	DNA methylation	Smoking	Age, sex and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	1597	1	67	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-1.30923041	0.0865	8.509999999999999e-52	-	28686328_smoking
Shah S	-	25249537	2014-09-23	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking discovery	Table S2	DNA methylation	Smoking	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	535	1	70	Both	None	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.11226658	0.0075	9.999999999999999e-51	-	25249537_smoking_current_vs_never_smoking_discovery
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-	-	2.85e-49	-	28056824_age_4_vs_age_0
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	0.0015	None	5.5e-48	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Chatziioannou A	EnviroGenomarkers project consortium	28225026	2017-02-22	Tobacco smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S2	DNA methylation	Current vs never smoking	Age, sex, body mass index, study centre and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	454	2	52	Both	None	cg06126421	chr6:30720080	6	30720080	-	Open sea	-	-	7.27e-43	-	28225026_tobacco_smoking
Sayols-Baixeras S	-	26829059	2015-01-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Age, sex, physical activity and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	449	1	63.1	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-	-	6.69e-38	-	26829059_smoking_current_vs_never_smoking
Sayols-Baixeras S	-	26829059	2015-01-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking adjusted for cell counts	Table S1	DNA methylation	Smoking	Age, sex, physical activity, cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	449	1	63.1	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-	-	1.54e-36	-	26829059_smoking_current_vs_never_smoking_adjusted_for_cell_counts
Sayols-Baixeras S	-	26829059	2015-01-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Smoking status	Table S1	DNA methylation	Smoking	Age, sex, physical activity and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	645	1	63.2	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-	-	1.65e-36	-	26829059_smoking_smoking_status
Zeilinger S	-	23691101	2013-05-17	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking replication	Table S2	DNA methylation	Smoking	Age, sex, body mass index, alcohol consumption and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	468	1	53	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-	-	3.73e-36	-	23691101_smoking_current_vs_never_smoking_replication
Nones K	-	24500968	2014-05-09	Pancreatic ductal adenocarcinoma	EFO_0002517	-	Table S4	DNA methylation	Pancreatic ductal adenocarcinoma	-	Beta values	-	Illumina HumanMethylation450	Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata	-	196	1	-	Missing	None	cg06126421	chr6:30720080	6	30720080	-	Open sea	-	-	3.9900000000000003e-35	-	24500968_pancreatic_ductal_adenocarcinoma
Besingi W	-	24334605	2014-05-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table 2	DNA methylation	Smoking	Age, sex, exposure to snuff, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole Blood	-	421	1	43.8	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.049	0.0042	5.51e-32	-	24334605_smoking
Ambatipudi S	-	26864933	2016-05-01	Smoking	EFO_0005671, EFO_0004318	Former vs never smoking	Table S2	DNA methylation	Smoking	Age, breast cancer status, menopausal status, use of contraceptive pill, use of hormone replacement therapy and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	717	1	53.4	Females	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-	-	1.32e-26	-	26864933_smoking_former_vs_never_smoking
Battram T	GEO	25424692	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Never vs current smokers	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	201	1	Adults	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	0.1356	0.0109	5.8e-26	None	25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__never_vs_current_smokers
Petersen A-K	KORA F4	24014485	2013-09-06	M36098_4-vinylphenol_sulfate	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M36098_4-vinylphenol_sulfate	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.95	0.126	4.1e-25	None	24014485_Petersen-A-K_m36098_4-vinylphenol_sulfate_snps_as_covariates_model
Tsaprouni LG	CARDIOGENICS	25424692	2014-10-31	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S2	DNA methylation	Smoking	Age, sex, disease status, centre and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	464	1	55.4	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-	-	1.8199999999999997e-23	-	25424692_smoking
Zeilinger S	-	23691101	2013-05-17	Smoking	EFO_0005671, EFO_0004318	Former vs never smoking	Table S1	DNA methylation	Smoking	Age, sex, body mass index, alcohol consumption and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	1531	1	61.5	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-	-	1.5000000000000002e-22	-	23691101_smoking_former_vs_never_smoking
Petersen A-K	KORA F4	24014485	2013-09-06	M36098_4-vinylphenol_sulfate	EFO_0004727, EFO_0004725	no snps model	Table S2	M36098_4-vinylphenol_sulfate	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.93	0.118	2.2e-22	None	24014485_Petersen-A-K_m36098_4-vinylphenol_sulfate_no_snps_model
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.0973	0.0105	1.7e-20	-	27651444_smoking_current_vs_never_smoking
Battram T	GEO	25424692	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Never vs former smokers	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	442	1	Adults	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	0.0541	0.00574	3e-19	None	25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__never_vs_former_smokers
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0005671, EFO_0004318	Former vs never smoking	Table S5	DNA methylation	Former versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	13474	16	62.9	Both	European,African	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.0365	0.0042	3e-18	-	27651444_smoking_former_vs_never_smoking
Zhang Y	-	26826776	2016-04-01	Serum cotinine	EFO_0007813	Replication	Table 2	DNA methylation	Serum cotinine	Age, sex, body mass index, physical activity, total cholesterol, systolic blood pressure, prevalence of cardiovascular disease, diabetes, cancer, leukocyte, cell counts and technical covariates	Beta values	ng/ml	Illumina HumanMethylation450	Whole blood	-	500	1	62	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.0012	0.000142	2.85e-17	-	26826776_serum_cotinine_replication
Zhu X	-	26756918	2016-07-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S1	DNA methylation	Smoking	Age, sex, alcohol consumption, body mass index and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	Regression coefficients are for inverse normally transformed DNA methylation	596	4	53.9	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.359	0.043139	8.65e-17	-	26756918_smoking
Karlsson Linner R	-	29086770	2017-10-31	Educational attainment	EFO_0004784	Basic model	Table S1.6b	DNA methylation	Educational attainment	Age, sex, cell counts and technical covariates	Beta values	years of schooling	Illumina HumanMethylation450	Whole blood	-	10767	27	57	Both	None	cg06126421	chr6:30720080	6	30720080	-	Open sea	-	-	9.6e-17	-	29086770_educational_attainment_basic_model
van Dongen J	BIOS	30631468	2018-03-23	Educational attainment	EFO_0004784	model 1	Table S2	DNA methylation	Educational attainment	Sex, age, batch effects, cell composition (reference based)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4152	4	Adults	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	0.03	0.004	2.5e-16	None	30631468_van-Dongen-J_educational_attainment_model_1
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.34855	0.0448	0.00000000000000711	-	25650246_gestational_age
Li S	-	28811542	2017-08-15	Age	EFO_0000246	-	Table S1	DNA methylation	Age	Cell counts	M values	years	Illumina HumanMethylation450	Whole blood	-	1366	2	73	Missing	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.0211	0.00276444	0.0000000000000115	-	28811542_age
Colicino E	CHARGE	32697766	07-22-2020	All cause mortality	EFO_0004352	basic model	Table S2	All cause mortality	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	None	M values	Illumina HumanMethylation450	Whole blood	Effect estimates represent hazard ratio per 10% increase in DNA methylation.	12300	12	Adults	Both	European, African	cg06126421	chr6:30720080	6	30720080	-	Open sea	0.89	None	0.00000000000018	None	32697766_Colicino-E_all_cause_mortality_basic_model
Wahl A	Leiden Longevity Study, KORA F4	29055820	2017-10-18	IgG glycosylation measure - LC_IGP45	EFO_0005193	None	Table S4	IgG glycosylation measure - LC_IGP45	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using LC/MS - 76 glycan traits assessed in total	2249	2	Adults	Both	Unclear	cg06126421	chr6:30720080	6	30720080	-	Open sea	-1.8	0.25	0.00000000000088	None	29055820_Wahl-A_igg_glycosylation_measure_-_lc_igp45
Wahl A	Leiden Longevity Study, KORA F4	29055820	2017-10-18	IgG glycosylation measure - LC_IGP43	EFO_0005193	None	Table S4	IgG glycosylation measure - LC_IGP43	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using LC/MS - 76 glycan traits assessed in total	2249	2	Adults	Both	Unclear	cg06126421	chr6:30720080	6	30720080	-	Open sea	-1.7	0.24	0.000000000001	None	29055820_Wahl-A_igg_glycosylation_measure_-_lc_igp43
van Dongen J	ALSPAC, Dunedin, E-risk, FinnTwin12, GS:SFHS, GLAKU, HELIX, LLD, NFBC1996, NFBC1986, NTR, SATSA, YFS	33420481	2021-01-08	Aggressive behaviour	EFO_0003015	Meta-analysis in whole blood	eTable 6	DNA methylation	Aggressive behaviour	age, sex, cell compostion (reference based), cell composition (reference free), batch effects	Beta Values	None	Illumina HumanMethylation450, Illumina HumanMethylationEPIC	Whole blood	Age range from 7 - 70	14434	13	Adults	Both	Unclear	cg06126421	chr6:30720080	6	30720080	-	Open sea	None	None	0.0000000000099	None	33420481_van-Dongen-J_aggressive_behaviour_meta-analysis_in_whole_blood
Marzi SJ	E-Risk	29325449	2018-01-12	Smoking	EFO_0006526	None	S2	DNA methylation	Smoking	sex, cell composition (reference based), batch effects	Beta Values	Pack years	Illumina HumanMethylation450	Whole blood	Analysis of twins	1658	1	Adults	Both	Unclear	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.01	None	0.000000000016	None	29325449_Marzi-SJ_smoking
Shah S	-	25249537	2014-09-23	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking replication	Table S2	DNA methylation	Smoking	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	232	1	79	Both	None	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.09756882	0.0146	0.0000000000231	-	25249537_smoking_current_vs_never_smoking_replication
Shenker NS	-	23175441	2013-03-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Breast cancer cohort	Table S3	DNA methylation	Smoking	Age, case-control status and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	184	1	50.5	Females	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-	-	0.0000000000709	-	23175441_smoking_breast_cancer_cohort
Dogan MV	-	24559495	2014-02-22	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table 2	DNA methylation	Smoking	Cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral Blood	-	111	1	48.4	Females	African	cg06126421	chr6:30720080	6	30720080	-	Open sea	-	-	0.000000000291	-	24559495_smoking
Fasanelli F	-	26667048	2015-12-15	Lung cancer	EFO_0001071	-	Table 1	Lung cancer	DNA methylation	Cell counts and technical covariates	-	Beta values	Illumina HumanMethylation450	Whole blood	Regression coefficients are per 1-SD of DNA methylation	250	1	47	Females	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.8916	0.1476	0.00000000152	-	26667048_lung_cancer
Ligthart S	CHARGE	27955697	2016-12-12	C-reactive protein	EFO_0004458	Discovery	Table S3	DNA methylation	C-reactive protein	Age, sex, smoking, body mass index, cell counts and technical covariates	Beta values	mg/l	Illumina HumanMethylation450	Whole blood	C-reactive protein levels were log-transformed	8863	9	65	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.0052	0.000865	0.0000000018	-	27955697_creactive_protein_discovery
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Discovery	Table S4	DNA methylation	Body mass index	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of body mass index	2096	1	56.2	Both	African	cg06126421	chr6:30720080	6	30720080	-	Open sea	0.0099	0.0017	0.00000000834	-	25935004_body_mass_index_discovery
Carmona JJ	Normative Aging Study	30343628	2018-10-21	Lung function	EFO_0004314, EFO_0003892	Discovery. FEV1	Table S1	Lung function	DNA methylation	Season, follow up time, batch effects, weight, weight squared, log(height), age, vitamin C intake, years of education, taking corticosteroids or beta-2-adrenergic agonists or AHFS or LAMA, smoking	L/s	Beta Values	Illumina HumanMethylation450	Whole blood	None	633	1	Adults	Males	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	1.26	0.22	0.0000000098	None	30343628_Carmona-JJ_lung_function_discovery__fev1
Zhang Y	-	26826776	2016-04-01	Serum cotinine	EFO_0007813	Discovery	Table 2	DNA methylation	Serum cotinine	Age, sex and technical covariates	Beta values	ng/ml	Illumina HumanMethylation450	Whole blood	-	500	1	62	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.001	0.00018	0.0000000156	-	26826776_serum_cotinine_discovery
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-	-	0.0000000387	-	26500701_sex_kora_f4
van Dongen J	BIOS	30631468	2018-03-23	Educational attainment	EFO_0004784	model 3	Table S2	DNA methylation	Educational attainment	Sex, age, batch effects, cell composition (reference based), smoking, body mass index	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4152	4	Adults	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	0.017	0.003	0.000000044	None	30631468_van-Dongen-J_educational_attainment_model_3
Karabegovic I	Airwave, ALSPAC, ESTHER, FHS, KORA, Rotterdam Study, Twins UK, ARIC, CHS, EPIC	33990564	05-14-2021	Coffee and tea consumption	None	Meta-analysis	Table 2	DNA methylation	Coffee and tea consumption	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Alcohol consumption	Beta values	None	Illumina HumanMethylation450	Whole blood	None	15789	15	Adults	Both	European, African	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.0011	0.0002	0.000000045	None	33990564_Karabegovic-I_coffee_and_tea_consumption_meta-analysis
van Dongen J	BIOS	30631468	2018-03-23	Educational attainment	EFO_0004784	model 2	Table S2	DNA methylation	Educational attainment	Sex, age, batch effects, cell composition (reference based), smoking	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4152	4	Adults	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	0.017	0.003	0.000000047	None	30631468_van-Dongen-J_educational_attainment_model_2
Karlsson Linner R	-	29086770	2017-10-31	Educational attainment	EFO_0004784	Adjusted model	Table S1.7b	DNA methylation	Educational attainment	Age, sex, smoking, body mass index, cell counts and technical covariates	Beta values	years of schooling	Illumina HumanMethylation450	Whole blood	-	10767	27	57	Both	None	cg06126421	chr6:30720080	6	30720080	-	Open sea	-	-	0.0000000663	-	29086770_educational_attainment_adjusted_model
Liu C	CHARGE+	27843151	2016-12-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	European ancestry	Table S5	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g der day	Illumina HumanMethylation450	Whole blood	-	9643	10	64.2	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.00028606	5.31e-05	0.0000000699	-	27843151_alcohol_consumption_per_day_european_ancestry
Liu C	CHARGE+	27843151	2016-11-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	African ancestry	Table S6	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g per day	Illumina HumanMethylation450	Whole blood	-	2423	3	56	Both	African	cg06126421	chr6:30720080	6	30720080	-	Open sea	-9.62e-05	1.81e-05	0.000000113	-	27843151_alcohol_consumption_per_day_african_ancestry
Battram T	GEO	24559495	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE53045	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Peripheral blood mononuclear cells	None	111	1	Adults	Females	African	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.0858	0.0149	0.00000012	None	24559495_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse53045
Carmona JJ	Normative Aging Study	30343628	2018-10-21	Lung function	EFO_0004312, EFO_0003892	Discovery. FVC measurements used to measure lung function	Table S1	Lung function	DNA methylation	Season, follow up time, batch effects, weight, weight squared, log(height), age, vitamin C intake, years of education, taking corticosteroids or beta-2-adrenergic agonists or AHFS or LAMA, smoking	L	Beta Values	Illumina HumanMethylation450	Whole blood	None	633	1	Adults	Males	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	1.2	0.24	0.00000018	None	30343628_Carmona-JJ_lung_function_discovery__fvc_measurements_used_to_measure_lung_function
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	0.0039	0.00077	0.00000035	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Battram T	GEO	25424692	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Former vs current smokers	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	285	1	Adults	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	0.0656	0.01341	0.0000018	None	25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__former_vs_current_smokers
Shenker NS	-	23175441	2013-03-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Colon cancer cohort	Table S3	DNA methylation	Smoking	Age, case-control status and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	190	1	55	Both	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-	-	0.00000266	-	23175441_smoking_colon_cancer_cohort
Smith AK	Psychiatric Genomics Consortium (PGC) PTSD Epigenetics Workgroup	33235198	2020-11-24	post-traumatic stress disorder	EFO_0001358	Meta-analysis	Supplementary data 2	DNA methylation	post-traumatic stress disorder	Age, sex, smoking, cell composition (reference based), batch effects, ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	Controls had been exposed to trauma but did not have a current diagnosis of PTSD or a prior history of PTSD	1896	10	Adults	Both	European, African	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.11	0.0236	0.0000032	None	33235198_Smith-AK_post-traumatic_stress_disorder_meta-analysis
Carmona JJ	Normative Aging Study	30343628	2018-10-21	Lung function	EFO_0004313, EFO_0003892	Discovery. FEF25%-75% measurements used to measure lung function	Table S1	Lung function	DNA methylation	Season, follow up time, batch effects, weight, weight squared, log(height), age, vitamin C intake, years of education, taking corticosteroids or beta-2-adrenergic agonists or AHFS or LAMA, smoking	L/min	Beta Values	Illumina HumanMethylation450	Whole blood	None	633	1	Adults	Males	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	0.68	0.15	0.0000039	None	30343628_Carmona-JJ_lung_function_discovery__fef25_-75__measurements_used_to_measure_lung_function
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.545835	0.1206	0.000006	-	27105112_hiv_infection_neutrophils
Karabegovic I	ARIC, CHS, EPIC	33990564	05-14-2021	Coffee and tea consumption	None	Replication	Table 2	DNA methylation	Coffee and tea consumption	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Body mass index, Alcohol consumption	Beta values	None	Illumina HumanMethylation450	Whole blood	None	6177	3	Adults	Both	European, African	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.0021	0.0005	0.0000079	None	33990564_Karabegovic-I_coffee_and_tea_consumption_replication
Sharp G	PACE	33517419	2021-01-29	Maternal body mass index	EFO_0004340	Adjusted for paternal BMI using whole blood in childhood in females only	https://osf.io/ebtw7/	DNA methylation	Maternal body mass index	paternal bmi, cell composition (reference based), batch effects, maternal age, paternal age, maternal smoking during pregnancy, paternal smoking during or prior to pregnancy, socio-economic position and maternal parity	Beta Values	kg/m2	Illumina HumanMethylation450, Illumina HumanMethylationEPIC	Whole blood	Probes that were common to both arrays were included in the meta-analysis	960	6	Children	Females	European, Admixed	cg06126421	chr6:30720080	6	30720080	-	Open sea	-0.00337	0.00084	0.000058	None	33517419_Sharp-G_maternal_body_mass_index_adjusted_for_paternal_bmi_using_whole_blood_in_childhood_in_females_only