author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	5.4	0.276	2e-83	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.19428	0.00583	5.8e-82	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.121503	0.0081954	2.27429e-49	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.597016	0.0407513	2.615932e-48	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.584218	0.0404963	6.610265e-47	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.116781	0.00820008	1.021578e-45	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.115041	0.00820175	2.0804469999999998e-44	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.131965	0.0094869	1.039814e-43	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.432203	0.0322865	1.155673e-40	None	39706196_Hannah-M.-Smith_body_fat_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.41692	0.0322236	4.1092209999999996e-38	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.104021	0.00821178	1.3960049999999999e-36	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	3.5	0.283	4.0999999999999997e-35	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-1.96429	0.09601	5.32e-35	-	25282492_fetal_vs_adult_liver
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.50048	0.0406768	1.206659e-34	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.11516	0.00948943	9.920834e-34	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0957002	0.00821868	3.3672190000000003e-31	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.371255	0.0322305	1.372802e-30	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.108828	0.00948457	2.394204e-30	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.45274	0.0394893	2.516927e-30	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0913565	0.00822204	1.439426e-28	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0879841	0.00822455	1.3073179999999998e-26	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0984628	0.00951113	4.9787830000000005e-25	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0980705	0.00948524	5.70275e-25	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0845383	0.00822701	1.09956e-24	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.080985	0.00822945	8.829531e-23	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0807414	0.00822961	1.184464e-22	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0932436	0.00951873	1.37664e-22	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.091589	0.00952299	7.810952000000001e-22	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.299585	0.0313145	1.237525e-21	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.082104	0.00868711	3.845932e-21	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0873361	0.00950374	4.461233e-20	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0856875	0.00942992	1.1487609999999998e-19	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Ligthart S	CHARGE	27955697	2016-12-12	C-reactive protein	EFO_0004458	Discovery	Table S3	DNA methylation	C-reactive protein	Age, sex, smoking, body mass index, cell counts and technical covariates	Beta values	mg/l	Illumina HumanMethylation450	Whole blood	C-reactive protein levels were log-transformed	8863	9	65	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0045	5e-04	2.29e-19	-	27955697_creactive_protein_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0734155	0.00823429	5.404946e-19	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.084366	0.00949181	6.917868999999999e-19	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.083963	0.00952385	1.316922e-18	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0724804	0.00823486	1.4965820000000001e-18	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	Discovery and replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	Weighted Z-test meta-analysis	10238	13	54.5	Both	European,South Asian	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-	-	2.3e-18	-	28002404_body_mass_index_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0707046	0.00823591	9.993160000000001e-18	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.081012	0.00951979	1.90854e-17	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0780581	0.00919036	2.1963450000000002e-17	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0953977	0.0113382	4.330777e-17	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0800459	0.00953515	5.0888440000000003e-17	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_2
Sun D	Bogalusa Heart Study, Georgia Stress and Heart Study	31510868	2019-09-12	body mass index	EFO_0004340	meta-analysis in Europeans	Online Table I	DNA methylation	body mass index	age, sex, smoking, cell composition (reference based), batch effects	Beta Values	kg/m2	Illumina HumanMethylation450	Whole blood	None	1247	2	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0012	None	8e-17	None	31510868_Sun-D_body_mass_index_meta-analysis_in_europeans
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0995391	0.0119841	1.076534e-16	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0683283	0.00823727	1.179425e-16	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Demerath EW	-	25935004	2015-08-01	Waist circumference	EFO_0004342	Meta-analysis	Table 3	DNA methylation	Waist circumference	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	cm	Illumina HumanMethylation450	Leukocytes and CD4+ T cells	Regression coefficient per 1 SD of waist circumference	3088	2	53.9	Both	European,African	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-	-	2.15e-16	-	25935004_waist_circumference_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0668967	0.00823808	5.012615e-16	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.054	0.00668	6e-16	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0764777	0.00951185	9.646247e-16	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Hedman AK	-	28213390	2017-02-17	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication	Table S4	DNA methylation	Serum high-density lipoprotein cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	3889	4	63	Both	None	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0002678	3.34e-05	0.00000000000000101	-	28213390_serum_highdensity_lipoprotein_cholesterol_discovery_and_replication
Petersen A-K	KORA F4	24014485	2013-09-06	M32338_glycine	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M32338_glycine	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.66	0.058	0.0000000000000016	None	24014485_Petersen-A-K_m32338_glycine_snps_as_covariates_model
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-	-	0.00000000000000162	-	26857698_primary_sjogrens_syndrome_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0655708	0.0082388	0.000000000000001863973	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0653641	0.00823891	0.000000000000002282211	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Meta-analysis	Table 2	DNA methylation	Body mass index	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Leukocytes, whole blood and CD4+ T cells	Regression coefficient per 1 SD of body mass index	5464	4	59.6	Both	European,African	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-	-	0.00000000000000245	-	25935004_body_mass_index_metaanalysis
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting insulin	EFO_0004466	Base	Supplementary Data 1	DNA methylation	fasting insulin	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	log pmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	1.99	0.25	0.0000000000000028	4735	31197173_Liu-J_fasting_insulin_base
Petersen A-K	KORA F4	24014485	2013-09-06	M32338_glycine	EFO_0004727, EFO_0004725	no snps model	Table S2	M32338_glycine	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.65	0.058	0.0000000000000029	None	24014485_Petersen-A-K_m32338_glycine_no_snps_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0947366	0.0120965	0.000000000000005141555	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0683349	0.0087945	0.00000000000000835486	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0076	0.001	0.000000000000032	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0712003	0.00951602	0.00000000000007726641	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_2
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	South Asian ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2680	1	51.0	Both	South Asian	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	61.05	7.16	0.000000000000078	-	28002404_body_mass_index_south_asian_ancestry_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	discovery	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.236945	0.0318353	0.0000000000001030159	None	39706196_Hannah-M.-Smith_glucose_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0709097	0.0095638	0.00000000000012888	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0705376	0.00953283	0.0000000000001441739	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0609308	0.00824123	0.0000000000001508474	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.089275	0.0121176	0.0000000000001832987	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0687181	0.00949278	0.0000000000004744975	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Demerath EW	-	25935004	2015-08-01	Waist circumference	EFO_0004342	Discovery	Table S5	DNA methylation	Waist circumference	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	cm	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of waist circumference	2097	1	56.2	Both	African	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0083	0.0012	0.0000000000015	-	25935004_waist_circumference_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0577176	0.00824281	0.000000000002629612	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.066169	0.00951135	0.000000000003627167	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0663251	0.00954532	0.000000000003849241	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.063097	0.00912538	0.000000000004891184	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0658331	0.00952237	0.000000000004922829	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0854931	0.012374	0.000000000005079956	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_4
Ligthart S	CHARGE	27955697	2016-12-12	C-reactive protein	EFO_0004458	Replication	Table S3	DNA methylation	C-reactive protein	Age, sex, smoking, body mass index, cell counts and technical covariates	Beta values	mg/l	Illumina HumanMethylation450	Whole blood	C-reactive protein levels were log-transformed	4111	4	59.7	Missing	African	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0073	0.001068	0.00000000000829	-	27955697_creactive_protein_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0636269	0.00931092	0.00000000000860915	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0560501	0.00824359	0.00000000001092394	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0622006	0.00928674	0.00000000002192969	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0617227	0.00924205	0.00000000002501525	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0793288	0.0121457	0.00000000006728319	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.053697	0.00824466	0.0000000000760893	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0811394	0.0124713	0.00000000007963594	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_4
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	4851	9	54.5	Both	European,South Asian	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	9.3	1.4	0.000000000087	-	28002404_body_mass_index_all_ancestry_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0803451	0.012555	0.0000000001606569	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0524648	0.0082452	0.000000000203634	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Sun D	Bogalusa Heart Study Follow up	31510868	2019-09-12	body mass index	EFO_0004340	follow up in Europeans	Online Table III	DNA methylation	body mass index	age, sex, smoking, cell composition (reference based), batch effects	Beta Values	kg/m2	Illumina HumanMethylation450	Whole blood	None	439	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0017	None	0.00000000034	None	31510868_Sun-D_body_mass_index_follow_up_in_europeans
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	sensitivity	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.2537	0.0404506	0.0000000003649478	None	39706196_Hannah-M.-Smith_glucose_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0765868	0.0122379	0.000000000400415	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0511542	0.00824576	0.0000000005663158	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Meta-analysis	Table S1	DNA methylation	Body mass index	Age, sex, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood	Weighted Z-test meta-analysis	3743	4	69.2	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-	-	0.000000000734	-	28095459_body_mass_index_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0507774	0.00824592	0.0000000007564697	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0573645	0.00934116	0.0000000008409791	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0724374	0.0118933	0.000000001153113	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0580089	0.00953366	0.000000001196583	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0498595	0.0082463	0.000000001518204	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_1
Hedman AK	-	28213390	2017-02-17	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery	Table S4	DNA methylation	Serum high-density lipoprotein cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0002578	4.3e-05	0.00000000204	-	28213390_serum_highdensity_lipoprotein_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0685594	0.0114951	0.000000002514695	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0565418	0.00953716	0.000000003124331	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0742172	0.0125344	0.000000003270097	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_4
Sun D	Bogalusa Heart Study	31510868	2019-09-12	body mass index	EFO_0004340	Discovery in Europeans	Online Table I	DNA methylation	body mass index	age, sex, smoking, cell composition (reference based), batch effects	Beta Values	kg/m2	Illumina HumanMethylation450	Whole blood	None	995	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0011	None	0.0000000035	None	31510868_Sun-D_body_mass_index_discovery_in_europeans
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	European ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	4195	8	54.6	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	8.81	1.5	0.0000000038	-	28002404_body_mass_index_european_ancestry_replication
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry discovery	Table S3	Body mass index	DNA mehtylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	5387	4	54.5	Both	European,South Asian	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	15.8	2.5	0.0000000039	-	28002404_body_mass_index_all_ancestry_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0485125	0.00824685	0.00000000412781	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Sun D	Georgia Stress and Heart Study	31510868	2019-09-12	body mass index	EFO_0004340	Replication in Europeans	Online Table I	DNA methylation	body mass index	age, sex, smoking, cell composition (reference based), batch effects	Beta Values	kg/m2	Illumina HumanMethylation450	Unspecified	tissue type not specified for this cohort	252	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0016	None	0.0000000052	None	31510868_Sun-D_body_mass_index_replication_in_europeans
Justice AE	ARIC study	32901515	09-09-2020	waist circumference-to-hip ratio	None	discovery	Table 1	waist circumference-to-hip ratio	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Body mass index, Education	cm	Beta values	Illumina HumanMethylation450	Whole blood	None	2684	1	Adults	Both	African, Other	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.13	0.023	0.0000000067	None	32901515_Justice-AE_waist_circumference-to-hip_ratio_discovery
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Replication	Table 2	DNA methylation	Body mass index	Age, sex, smoking, study centre and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood and CD4+ T cells	Regression coefficient per 1 SD of body mass index	3368	3	61.7	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-	-	0.00000000701	-	25935004_body_mass_index_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0553564	0.00958223	0.0000000077595	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0546604	0.00949121	0.000000008628168	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Raffield LM	The Jackson Heart Study	31985870	2020-01-27	Coagulation factor VIII	EFO_0004634, EFO_0004630	None	Table 5	Coagulation factor VIII	DNA methylation	Cell composition (reference based), batch effects, age, ssex, ancestry (genomic PCs)	None	Beta Values	Illumina HumanMethylationEPIC	Whole blood	None	1670	1	Adults	Both	African	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	None	None	0.0000000099	None	31985870_Raffield-LM_coagulation_factor_viii
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0470058	0.00824744	0.00000001225119	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0543861	0.00954654	0.0000000124321	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0539798	0.00954344	0.00000001576288	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0519219	0.00919415	0.00000001660319	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.083	0.0149	0.000000027	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0528082	0.00954037	0.00000003161312	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.068477	0.012393	0.00000003342206	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0684013	0.0123861	0.00000003400425	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0518696	0.00949739	0.0000000479943	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0520216	0.00954337	0.0000000508775	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_2
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Discovery	Table S4	DNA methylation	Body mass index	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of body mass index	2096	1	56.2	Both	African	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0065	0.0012	0.0000000529	-	25935004_body_mass_index_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	13971	1	Adults (18-65y)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.039	0.00711	0.000000057	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0446996	0.00824832	0.00000006079942	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0671527	0.0124999	0.00000007894436	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_4
Hedman AK	-	28213390	2017-02-17	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Replication	Table S4	DNA methylation	Serum high-density lipoprotein cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	1583	2	57	Both	None	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0002829	5.29e-05	0.0000000895	-	28213390_serum_highdensity_lipoprotein_cholesterol_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0507761	0.00954461	0.0000001053641	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.050936	0.00958626	0.0000001091532	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0434752	0.00824876	0.0000001379762	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0492445	0.00936913	0.0000001492533	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0498504	0.00952274	0.0000001673666	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0430925	0.0082489	0.0000001774726	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Battram T	GEO	27886173	2020-09-15	Crohn's disease	EFO_0000384	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Crohn's disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	161	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0264	0.00482	0.0000002	None	27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0620489	0.0119858	0.0000002286259	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0494013	0.00958999	0.0000002619919	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0422666	0.00824919	0.0000003033653	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_1
Battram T	GEO	27886173	2020-09-15	Inflammatory bowel disease	EFO_0003767	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Inflammatory bowel disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	240	1	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.026	0.00493	0.00000031	None	27886173_Battram-T_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0619223	0.0121136	0.0000003231278	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0470696	0.00927803	0.0000003958835	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0629168	0.0124506	0.0000004394817	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0472132	0.00940331	0.0000005203191	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0479274	0.00954948	0.0000005259149	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0411967	0.00824956	0.000000598808	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0401686	0.00824991	0.000001133435	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0462877	0.00952416	0.000001185847	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0394829	0.00825013	0.000001720299	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.043834	0.00935079	0.000002787276	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Glycoprotein acetyls	EFO_0004555	None	None	DNA methylation	Glycoprotein acetyls	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.74	0.16	0.0000028	None	Battram-T_glycoprotein_acetyls
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	European ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2707	3	57.9	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	11.28	2.43	0.0000035	-	28002404_body_mass_index_european_ancestry_discovery
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting insulin	EFO_0004466	Base plus BMI	Supplementary Data 1	DNA methylation	fasting insulin	Age, sex, smoking, cell composition (reference based), batch effects, body mass index	Beta Values	log pmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	1.05	0.23	0.0000036	4735	31197173_Liu-J_fasting_insulin_base_plus_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0579758	0.0125158	0.000003649287	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0381414	0.00825056	0.000003816755	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0379871	0.00825061	0.000004176138	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	C4A protein levels (SeqId = 4481-34)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C4A protein levels (SeqId = 4481-34)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement C4-A|Complement C4-B	774	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.81	0.176	0.0000042	None	Gadd-DA_c4a_protein_levels__seqid___4481-34__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0438778	0.00956297	0.000004505667	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0559109	0.0122433	0.000004996352	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CRP protein levels (SeqId = 4337-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CRP protein levels (SeqId = 4337-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-reactive protein	774	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.81	0.177	0.0000052	None	Gadd-DA_crp_protein_levels__seqid___4337-49__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0433209	0.00955108	0.000005786506	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0368294	0.00825097	0.000008117956	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Lothian Birth Cohort 1936	Table S1	DNA methylation	Body mass index	Age, sex and cell counts	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood	-	920	1	70	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0066	0.00148	0.00000944	-	28095459_body_mass_index_lothian_birth_cohort_1936
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0421934	0.00953061	0.000009617589	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.036308	0.00825113	0.00001088296	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.00067	0.00015	0.000011	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14391	1	Adults (18-65y)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.074	0.0169	0.000012	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Fully-adjusted_model
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18059	1	Adults (18-65y)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.07	0.016	0.000013	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0414457	0.00954806	0.00001429475	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Framingham Heart Study Batch 2	Table S1	DNA methylation	Body mass index	Age, sex and technical covariates	-	kg/m2	Illumina HumanMethylation450	Whole blood	DNA methylation was inverse normally rank transformed	1935	1	67	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0176	0.00405	0.0000153	-	28095459_body_mass_index_framingham_heart_study_batch_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0404149	0.00937723	0.00001643947	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_3
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.00041823	9.72e-05	0.0000184	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0352178	0.00825145	0.00001984102	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q16610	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q16610	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0348887	0.00825154	0.00002370528	Q16610	41361833_Josephine_Robertson_Q16610_OSCA_model_1
Demerath EW	-	25935004	2015-08-01	Waist circumference	EFO_0004342	Replication	Table 3	DNA methylation	Waist circumference	Age, sex, smoking, study centre and technical covariates	Beta values	cm	Illumina HumanMethylation450	CD4+ T-cells	Regression coefficient per 1 SD of waist circumference	991	1	49	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0031	7e-04	0.0000256	-	25935004_waist_circumference_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0398007	0.00949641	0.0000279191	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0522522	0.0124776	0.00002834896	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Rheumatoid Arthritis (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Rheumatoid Arthritis (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18055	1	Adults (18-65y)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.051	0.0123	0.000031	None	Robert-F-Hillary_Prevalent_Rheumatoid_Arthritis_(Self-report)_Basic_model
Battram T	ARIES	None	2020-08-20	Android region fat	EFO_0005409	None	None	DNA methylation	Android region fat	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.94	0.23	0.000031	None	Battram-T_android_region_fat
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0522473	0.0125453	0.00003135433	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Android tissue fat	EFO_0005409	None	None	DNA methylation	Android tissue fat	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.93	0.22	0.000034	None	Battram-T_android_tissue_fat
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0341602	0.00825175	0.00003496251	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0341267	0.00825176	0.0000355874	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0339352	0.00825182	0.00003936196	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0379214	0.00939541	0.00005460755	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0503348	0.0125024	0.00005701835	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0377707	0.00953074	0.00007435066	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	SOD3 protein levels (SeqId = 5660-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SOD3 protein levels (SeqId = 5660-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Extracellular superoxide dismutase [Cu-Zn]	774	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.69	0.174	0.000077	None	Gadd-DA_sod3_protein_levels__seqid___5660-51__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Insulin	None	None	None	DNA methylation	Insulin	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	uU/ml	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.018	0.0045	0.000078	None	Battram-T_insulin
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	-0.0373867	0.00952489	0.00008706766	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06192883	chr15:52554171	15	52554171	MYO5C	Open sea	0.0321614	0.0082523	0.00009771811	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1