author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	3187	2	65.7	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.057	0.004	0	-	28173150_serum_triglycerides_discovery_and_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for surrogate variables	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	3187	2	65.7	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.088	0.005	0	-	28173150_serum_triglycerides_discovery_and_replication_adjusted_for_surrogate_variables
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	3187	2	65.7	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-3.199	0.255	0	-	28173150_serum_highdensity_lipoprotein_cholesterol_discovery_and_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication adjusted for surrogate variables	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	3187	2	65.7	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-5.369	0.341	0	-	28173150_serum_highdensity_lipoprotein_cholesterol_discovery_and_replication_adjusted_for_surrogate_variables
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.61452	0.0457802	1.295018e-263	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.6387	0.0477137	1.601438e-250	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.47603	0.047627	2.78526e-205	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.25258	0.00820962	1.75284e-201	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.49633	0.0493214	5.108805e-197	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.231625	0.00803204	6.38775e-178	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.233071	0.00826917	2.925449e-170	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.30928	0.0480225	2.7430370000000003e-160	None	39706196_Hannah-M.-Smith_body_fat_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.29869	0.0478858	1.152781e-158	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.31938	0.0499477	8.935784e-151	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.210765	0.0080711	5.712207e-147	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.26245	0.0498443	5.359217e-139	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	7.3	0.298	1.4e-130	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.199447	0.00822521	2.190269e-127	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.197465	0.00856116	1.179983e-115	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.190439	0.00831657	4.736417e-114	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.16716	0.0081404	2.096727e-92	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.160014	0.00839009	4.0305399999999996e-80	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.157292	0.00837919	1.044872e-77	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.41	0.0221	3.8e-75	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.146529	0.00816745	3.274928e-71	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.150505	0.00839924	4.797675e-71	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	Discovery and replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	Weighted Z-test meta-analysis	10238	13	54.5	Both	European,South Asian	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-	-	1.1e-68	-	28002404_body_mass_index_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.138024	0.00785149	1.787169e-68	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.145905	0.00832089	3.8462920000000005e-68	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication adjusted for surrogate variables	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	2542	1	66.3	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.09	0.005	2.3e-67	-	28173150_serum_triglycerides_replication_adjusted_for_surrogate_variables
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.138397	0.00817712	1.183422e-63	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.138001	0.00817757	2.6916429999999997e-63	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.136351	0.00817946	8.031662000000001e-62	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.138836	0.00841364	1.26441e-60	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4261	5	65	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0169437	0.0010462	5.42e-59	-	28213390_serum_triglycerides_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.130321	0.00817543	9.946907e-57	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.126312	0.00819044	3.051085e-53	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Replication adjusted for surrogate variables	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	2542	1	66.3	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-6.159	0.405	4e-52	-	28173150_serum_highdensity_lipoprotein_cholesterol_replication_adjusted_for_surrogate_variables
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.125096	0.00825796	1.896923e-51	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0198543	0.0013586	2.2899999999999998e-48	-	28213390_serum_triglycerides_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.15	0.01004	3.4e-48	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	discovery	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.700519	0.0479055	3.801631e-48	None	39706196_Hannah-M.-Smith_glucose_discovery
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Meta-analysis	Table 2	DNA methylation	Body mass index	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Leukocytes, whole blood and CD4+ T cells	Regression coefficient per 1 SD of body mass index	5464	4	59.6	Both	European,African	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-	-	1.0099999999999999e-46	-	25935004_body_mass_index_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.123444	0.00857949	1.275715e-46	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry discovery	Table S3	Body mass index	DNA mehtylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	5387	4	54.5	Both	European,South Asian	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	34.8	2.3	6e-46	-	28002404_body_mass_index_all_ancestry_discovery
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	2542	1	66.3	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.06	0.004	4.6e-43	-	28173150_serum_triglycerides_replication
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Meta-analysis	Table S1	DNA methylation	Body mass index	Age, sex, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood	Weighted Z-test meta-analysis	3743	4	69.2	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-	-	7.55e-43	-	28095459_body_mass_index_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.115933	0.00843069	9.218188e-43	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-	-	6.489999999999999e-42	-	28056824_age_4_vs_age_0
Sayols-Baixeras S	REGICOR, Framingham Offspring Study	29099282	2017-11-27	Waist circumference	EFO_0004342	Meta-analysis model 1	Supplementary table 4	Waist circumference	DNA methylation	Age, sex, smoking, cell composition (reference based)	cm	M Values	Illumina HumanMethylation450	Whole blood	Removed individuals with BMI < 18.5	3156	2	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2.7	0.2	1.5999999999999998e-41	None	29099282_Sayols-Baixeras-S_waist_circumference_meta-analysis_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	sensitivity	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.674971	0.0501835	4.87025e-41	None	39706196_Hannah-M.-Smith_glucose_sensitivity
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	European ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2707	3	57.9	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	38.86	2.9	6.2e-41	-	28002404_body_mass_index_european_ancestry_discovery
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for BMI	Table S9	DNA methylation	Serum triglycerides	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4261	5	65	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0145	0.0011	9.42e-41	-	28213390_serum_triglycerides_discovery_and_replication_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.111872	0.00844741	8.339117e-40	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Sayols-Baixeras S	REGICOR, Framingham Offspring Study	29099282	2017-11-27	Waist circumference	EFO_0004342	Meta-analysis model 2	Supplementary table 4	Waist circumference	DNA methylation	Age, sex, smoking, cell composition (reference based), batch effects	cm	M Values	Illumina HumanMethylation450	Whole blood	Removed individuals with BMI < 18.5	3156	2	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	3.9	0.3	1.2e-38	None	29099282_Sayols-Baixeras-S_waist_circumference_meta-analysis_model_2
Hedman AK	-	28213390	2017-02-17	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication	Table S4	DNA methylation	Serum high-density lipoprotein cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	3889	4	63	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0004296	3.32e-05	2.27e-38	-	28213390_serum_highdensity_lipoprotein_cholesterol_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.106031	0.00821003	5.978289e-38	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.10454	0.00821133	6.2222419999999995e-37	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.106998	0.0084485	1.4407449999999999e-36	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Sayols-Baixeras S	REGICOR, Framingham Offspring Study	29099282	2017-11-27	Body mass index	EFO_0004340	Meta-analysis model 2	Supplementary table 3	Body mass index	DNA methylation	Age, sex, smoking, cell composition (reference based), batch effects	Kg/m2	M Values	Illumina HumanMethylation450	Whole blood	Removed individuals with BMI < 18.5	3156	2	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.38	0.11	4.2000000000000005e-36	None	29099282_Sayols-Baixeras-S_body_mass_index_meta-analysis_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.105563	0.00844635	1.162861e-35	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Replication	Table 2	DNA methylation	Body mass index	Age, sex, smoking, study centre and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood and CD4+ T cells	Regression coefficient per 1 SD of body mass index	3368	3	61.7	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-	-	1.29e-35	-	25935004_body_mass_index_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.104872	0.00842423	2.141265e-35	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_3
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Replication	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	2542	1	66.3	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-4.048	0.329	8.199999999999999e-35	-	28173150_serum_highdensity_lipoprotein_cholesterol_replication
Hedman AK	-	28213390	2017-02-17	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery	Table S4	DNA methylation	Serum high-density lipoprotein cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0004589	3.74e-05	1.2e-34	-	28213390_serum_highdensity_lipoprotein_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.103944	0.00845721	1.506181e-34	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.102862	0.00843662	4.9937769999999996e-34	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18059	1	Adults (18-65y)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.29	0.0238	9.1e-34	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Basic_model
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery adjusted for BMI	Table S9	DNA methylation	Serum triglycerides	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0168726	0.0013963	1.29e-33	-	28213390_serum_triglycerides_discovery_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.10145	0.00842025	2.840686e-33	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.10173	0.00844793	3.0658650000000002e-33	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14350	1	Adults (18-65y)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.29	0.0238	4.2000000000000005e-33	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.07437	0.00515	1.6e-32	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.100231	0.00845385	2.804062e-32	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0972261	0.00821745	3.7500150000000003e-32	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.096674	0.0082179	8.330775000000001e-32	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0959775	0.00821846	2.2656060000000003e-31	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_1
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Framingham Heart Study Batch 2	Table S1	DNA methylation	Body mass index	Age, sex and technical covariates	-	kg/m2	Illumina HumanMethylation450	Whole blood	DNA methylation was inverse normally rank transformed	1935	1	67	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0475	0.00397	2.76e-31	-	28095459_body_mass_index_framingham_heart_study_batch_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0980218	0.00845627	6.199889e-31	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0947371	0.00821944	1.3219269999999999e-30	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0999995	0.00878611	6.901237e-30	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.532887	0.0470711	1.297956e-29	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0925807	0.00822111	2.685773e-29	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	3.6	0.319	3.8e-29	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0921895	0.00822141	4.604011e-29	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.100201	0.00901957	1.470424e-28	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.54229	0.0493025	4.721357000000001e-28	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0965048	0.00877181	4.828957e-28	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0945196	0.00862349	7.570907000000001e-28	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0920609	0.00841385	9.334765e-28	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.095738	0.00875912	1.058907e-27	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0898793	0.00822315	1.059214e-27	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Pfeiffer L	-	25583993	2015-01-12	Triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table 2	Triglycerides	DNA methylation	Age, sex, smoking, body mass index, alcohol consumption, physical activity, hypertension, history of MI, hemoglobin A1c, C-reactive protein, lipid-lowering drugs intake and cell counts	mg/dl	Beta values	Illumina HumanMethylation450	Whole blood	-	1776	1	61	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.07	0.006	1.21e-27	-	25583993_triglycerides_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0920926	0.00844051	1.3070480000000001e-27	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0977355	0.00903992	3.8433140000000006e-27	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0956238	0.00885405	4.353475e-27	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Sayols-Baixeras S	REGICOR, Framingham Offspring Study	29099282	2017-11-27	Body mass index	EFO_0004340	Meta-analysis model 1	Supplementary table 3	Body mass index	DNA methylation	Age, sex, smoking, cell composition (reference based)	Kg/m2	M Values	Illumina HumanMethylation450	Whole blood	Removed individuals with BMI < 18.5	3156	2	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.97	0.09	4.4000000000000005e-27	None	29099282_Sayols-Baixeras-S_body_mass_index_meta-analysis_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0903052	0.00839475	6.894843e-27	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.096079	0.00895727	9.622019999999999e-27	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0902638	0.00844272	1.4003579999999998e-26	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0879003	0.00822461	1.459155e-26	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0923923	0.00867706	2.22704e-26	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0894208	0.00846586	5.511578e-26	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_2
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	4851	9	54.5	Both	European,South Asian	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	19.9	1.9	1.0999999999999999e-25	-	28002404_body_mass_index_all_ancestry_replication
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication	Table S1	DNA methylation	Triglycerides	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0173	0.0017	1.4199999999999999e-25	-	28194238_triglycerides_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0887128	0.00848885	1.7908610000000001e-25	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0874985	0.00845633	5.258805e-25	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0929321	0.00902574	8.891517e-25	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for lipid-lowering medication use	Table 3	DNA methylation	Triglycerides	Age, sex, smoking, lipid-lowering medication use, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0167	0.0016	1.3999999999999999e-24	-	28194238_triglycerides_discovery_and_replication_lipidlowering_medication_use_adjusted
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0926523	0.00907089	2.067243e-24	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14391	1	Adults (18-65y)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.26	0.0257	2.5e-24	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Fully-adjusted_model
Braun KVE	-	28194238	2016-06-16	High-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication	Table S1	DNA methylation	High-density lipoprotein cholesterol	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0195	0.0019	4.16e-24	-	28194238_highdensity_lipoprotein_cholesterol_discovery_and_replication
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting insulin	EFO_0004466	Base	Supplementary Data 1	DNA methylation	fasting insulin	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	log pmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	3.15	0.31	4.8e-24	4740	31197173_Liu-J_fasting_insulin_base
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0826786	0.0082283	1.1174910000000002e-23	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Ochoa-Rosales C	ESTHER, KORA-F4 , LOLIPOP, SHIP-Trend	32033992	2020-04-01	Statin use	GO_0036273	Discovery	Table 1	Statin use	DNA methylation	sex, age, smoking, body mass index, systolic blood pressure, antihypertensive medication, coronary heart disease, type 2 diabetes, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	Some cohorts used the Illumina HumanMethylationEPIC, but results were restricted to sites measured by the HM450	6820	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0103	0.001	2.7e-23	None	32033992_Ochoa-Rosales-C_statin_use_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0859163	0.00866539	4.240316e-23	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_3
Braun KVE	-	28194238	2016-06-16	High-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication adjusted for lipid-lowering medication use	Table 3	DNA methylation	High-density lipoprotein cholesterol	Age, sex, smoking, lipid-lowering medication use, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0187	0.0019	9.5e-23	-	28194238_highdensity_lipoprotein_cholesterol_discovery_and_replication_lipidlowering_medication_use_adjusted
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0853943	0.00869387	1.060001e-22	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0881098	0.00905808	2.696672e-22	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0796523	0.00823034	4.358601e-22	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0838324	0.0086929	6.0680460000000005e-22	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.083475	0.00868616	8.401966000000001e-22	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_3
Demerath EW	-	25935004	2015-08-01	Waist circumference	EFO_0004342	Meta-analysis	Table 3	DNA methylation	Waist circumference	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	cm	Illumina HumanMethylation450	Leukocytes and CD4+ T cells	Regression coefficient per 1 SD of waist circumference	3088	2	53.9	Both	European,African	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-	-	1.0900000000000001e-21	-	25935004_waist_circumference_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0808351	0.00846373	1.487504e-21	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Hedman AK	-	28213390	2017-02-17	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication adjusted for BMI	Table S8	DNA methylation	Serum high-density lipoprotein cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	3889	4	65	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0003315	3.48e-05	1.5300000000000002e-21	-	28213390_serum_highdensity_lipoprotein_cholesterol_discovery_and_replication_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0800888	0.00862822	1.888913e-20	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_3
Hedman AK	-	28213390	2017-02-17	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery adjusted for BMI	Table S7	DNA methylation	Serum high-density lipoprotein cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0003628	3.93e-05	2.48e-20	-	28213390_serum_highdensity_lipoprotein_cholesterol_discovery_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0837624	0.00906014	2.6674909999999998e-20	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0760271	0.00823267	2.9361959999999997e-20	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0757946	0.00823282	3.821162e-20	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	L-VLDL-L	None	Meta-analysis	Table S2	DNA methylation	L-VLDL-L	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Total lipids in large VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	7.7	0.84	4e-20	None	33413638_Gomez-Alonso-MDC_l-vldl-l_meta-analysis
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	L-VLDL-P	None	Meta-analysis	Table S2	DNA methylation	L-VLDL-P	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mol/L	Illumina HumanMethylation450	Whole blood	Concentration of large VLDL particles	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	7.8	0.85	4.2e-20	None	33413638_Gomez-Alonso-MDC_l-vldl-p_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0795004	0.00870139	7.280802999999999e-20	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0750588	0.00823328	8.747797999999999e-20	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	South Asian ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2680	1	51.0	Both	South Asian	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	30.48	2.93	1e-19	-	28002404_body_mass_index_south_asian_ancestry_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	13971	1	Adults (18-65y)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.098	0.01089	1.8e-19	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0742625	0.00823377	2.1248559999999998e-19	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery adjusted for surrogate variables	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	645	1	63.2	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.083	0.009	3.3e-19	-	28173150_serum_triglycerides_discovery_adjusted_for_surrogate_variables
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	European ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	4195	8	54.6	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	14.02	1.57	3.6e-19	-	28002404_body_mass_index_european_ancestry_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0775887	0.00867385	4.1534789999999996e-19	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Dhana K	Atherosclerosis Risk in Communities	29762635	2018-05-14	Waist Circumference	EFO_0004342	Replication	Table 3	DNA methylation	Waist Circumference	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Leukocytes	None	2097	1	Adults	Both	Admixed	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0096	0.00108	4.4e-19	None	29762635_Dhana-K_waist_circumference_replication
Demerath EW	-	25935004	2015-08-01	Waist circumference	EFO_0004342	Discovery	Table S5	DNA methylation	Waist circumference	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	cm	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of waist circumference	2097	1	56.2	Both	African	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0096	0.0011	4.41e-19	-	25935004_waist_circumference_discovery
Sun D	Bogalusa Heart Study, Georgia Stress and Heart Study	31510868	2019-09-12	body mass index	EFO_0004340	meta-analysis in Europeans	Online Table I	DNA methylation	body mass index	age, sex, smoking, cell composition (reference based), batch effects	Beta Values	kg/m2	Illumina HumanMethylation450	Whole blood	None	1247	2	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0011	None	4.8e-19	None	31510868_Sun-D_body_mass_index_meta-analysis_in_europeans
Sun D	Bogalusa Heart Study	31510868	2019-09-12	body mass index	EFO_0004340	Discovery in Europeans	Online Table I	DNA methylation	body mass index	age, sex, smoking, cell composition (reference based), batch effects	Beta Values	kg/m2	Illumina HumanMethylation450	Whole blood	None	995	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0015	None	5.1e-19	None	31510868_Sun-D_body_mass_index_discovery_in_europeans
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0752466	0.00845831	6.446906e-19	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-P	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-P	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mol/L	Illumina HumanMethylation450	Whole blood	Concentration of small VLDL particles	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2.2	0.24	7.2e-19	None	33413638_Gomez-Alonso-MDC_s-vldl-p_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0792924	0.00897699	1.134825e-18	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0745782	0.00845218	1.232449e-18	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	L-VLDL-TG	None	Meta-analysis	Table S2	DNA methylation	L-VLDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in large VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	8.7	1	3.1e-18	None	33413638_Gomez-Alonso-MDC_l-vldl-tg_meta-analysis
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-HDL-TG_pct	None	Meta-analysis	Table S2	DNA methylation	M-HDL-TG_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Triglycerides to total lipids ratio in medium HDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2.1	0.24	3.4e-18	None	33413638_Gomez-Alonso-MDC_m-hdl-tg_pct_meta-analysis
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for waist circumference	Table 3	DNA methylation	Triglycerides	Age, sex, smoking, waist circumference, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0153	0.0018	3.9e-18	-	28194238_triglycerides_discovery_and_replication_waist_circumference_adjusted
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0733885	0.00847553	5.25571e-18	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_2
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-PL	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-PL	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Phospholipids in small VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2	0.23	5.8e-18	None	33413638_Gomez-Alonso-MDC_s-vldl-pl_meta-analysis
Chambers JC	-	26095709	2015-07-01	Type II diabetes	EFO_0001360	Meta-analysis	Table 3	Type II diabetes	DNA methylation	Age, sex, cell counts and technical covariates	-	Beta values	Illumina HumanMethylation450	Peripheral blood	Regression coeffcient per 1 pecent increase in methylation	3805	4	53	Both	European,South Asian	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0862	0.0101	1.1e-17	-	26095709_type_ii_diabetes_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0720084	0.00847328	2.1074880000000002e-17	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0774352	0.00911263	2.120871e-17	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0696699	0.00823651	2.957299e-17	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0762007	0.00901211	3.0420910000000006e-17	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0712029	0.00842685	3.1971470000000005e-17	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0695251	0.00823659	3.4379280000000004e-17	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-L	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-L	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Total lipids in small VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2	0.24	6.5e-17	None	33413638_Gomez-Alonso-MDC_s-vldl-l_meta-analysis
Cardona A	FHS	31506343	2019-09-10	Type II diabetes	EFO_0001360	Replication in Europeans	Table 3	DNA methylation	Type II diabetes	Age, sex, cell composition (reference based), batch effects, body mass index	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2607	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.015	0.0018	7.1e-17	None	31506343_Cardona-A_type_ii_diabetes_replication_in_europeans
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0728007	0.00872461	7.797559e-17	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Pfeiffer L	-	25583993	2015-01-12	High-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery	Table 2	High-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, body mass index, alcohol consumption, physical activity, hypertension, history of MI, hemoglobin A1c, C-reactive protein, lipid-lowering drugs intake and cell counts	mg/dl	Beta values	Illumina HumanMethylation450	Whole blood	-	1776	1	61	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.049	0.006	8.26e-17	-	25583993_highdensity_lipoprotein_cholesterol_discovery
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	L-VLDL-PL	None	Meta-analysis	Table S2	DNA methylation	L-VLDL-PL	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Phospholipids in large VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	7.9	0.95	9.5e-17	None	33413638_Gomez-Alonso-MDC_l-vldl-pl_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0685282	0.00823716	9.613417000000001e-17	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	L-VLDL-FC	None	Meta-analysis	Table S2	DNA methylation	L-VLDL-FC	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Free cholesterol in large VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	9.4	1.13	1.2e-16	None	33413638_Gomez-Alonso-MDC_l-vldl-fc_meta-analysis
Jiantao Ma	FHS	30796027	Feb 22, 2019	hepatic fat	EFO_0010821	Discovery	Table 1	DNA methylation	hepatic fat	Age, Sex, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylation450	whole blood	None	1496	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	None	None	2e-16	None	30796027_Jiantao-Ma_hepatic_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0710178	0.0086319	2.073567e-16	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0703719	0.00860556	3.134354e-16	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_3
Ma J	FHS, RS, CARDIA, MESA	30936141	2020-05-22	Hepatic Fat	EFO_0006506, EFO_0008421	Meta-analysis model 1	Table 1	DNA methylation	Hepatic Fat	Age, sex	Beta Values	Hounsfield units	Illumina HumanMethylation450	Whole blood	Model 1 = adjusted for sex + age	3400	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	None	None	3.4e-16	None	30936141_Ma-J_hepatic_fat_meta-analysis_model_1
Ma J	FHS, RS, CARDIA, MESA	30936141	2020-05-22	Hepatic Fat	EFO_0006506, EFO_0008421	Meta-analysis model 2	Table 1	DNA methylation	Hepatic Fat	Age, sex	Beta Values	Hounsfield units	Illumina HumanMethylation450	Whole blood	Model 2 = model 1 + smoking + physical activity + alcohol consumption	3400	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	None	None	7.3e-16	None	30936141_Ma-J_hepatic_fat_meta-analysis_model_2
Braun KVE	-	28194238	2016-06-16	High-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication adjusted for waist circumference	Table 3	DNA methylation	High-density lipoprotein cholesterol	Age, sex, smoking, waist circumference, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0166	0.0021	9.5e-16	-	28194238_highdensity_lipoprotein_cholesterol_discovery_and_replication_waist_circumference_adjusted
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0643732	0.00800636	9.646229e-16	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3922444 (gene symbol: ABCG1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3922444 (gene symbol: ABCG1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	None	None	0.0000000000000012	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3922444__gene_symbol__abcg1__meta-analysis
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	L-VLDL-C	None	Meta-analysis	Table S2	DNA methylation	L-VLDL-C	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Total cholesterol in large VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	8.3	1.04	0.0000000000000013	None	33413638_Gomez-Alonso-MDC_l-vldl-c_meta-analysis
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Replication	Table 2	DNA methylation	Triglycerides	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	760	1	68	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0201	0.0025	0.00000000000000146	-	28194238_triglycerides_replication
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-HDL-TG	None	Meta-analysis	Table S2	DNA methylation	M-HDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in medium HDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.8	0.22	0.0000000000000018	None	33413638_Gomez-Alonso-MDC_m-hdl-tg_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.067203	0.0084749	0.000000000000002355528	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0711557	0.00897857	0.000000000000002443859	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0659087	0.00846766	0.000000000000007519578	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_2
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	1955	3	61	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.012731	0.0016374	0.00000000000000755	-	28213390_serum_triglycerides_replication
Petersen A-K	KORA F4	24014485	2013-09-06	M32322_glutamate	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M32322_glutamate	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.82	0.095	0.00000000000001	None	24014485_Petersen-A-K_m32322_glutamate_snps_as_covariates_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0704339	0.00910317	0.0000000000000108162	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_4
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-C	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-C	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Total cholesterol in medium VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2.7	0.36	0.000000000000011	None	33413638_Gomez-Alonso-MDC_m-vldl-c_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0665099	0.00866078	0.00000000000001698573	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Petersen A-K	KORA F4	24014485	2013-09-06	M32322_glutamate	EFO_0004727, EFO_0004725	no snps model	Table S2	M32322_glutamate	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.81	0.093	0.00000000000002	None	24014485_Petersen-A-K_m32322_glutamate_no_snps_model
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0093	0.0012	0.000000000000023	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Cardona A	LOLIPOP	31506343	2019-09-10	Type II diabetes	EFO_0001360	Replication in Indians	Table 3	Type II diabetes	DNA methylation	Cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	2664	1	Adults	Both	South Asian	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.365	None	0.000000000000026	None	31506343_Cardona-A_type_ii_diabetes_replication_in_indians
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-PL_pct	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-PL_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Phospholipids to total lipids ratio in medium VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.25	0.033	0.000000000000028	None	33413638_Gomez-Alonso-MDC_m-vldl-pl_pct_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0654164	0.00861392	0.0000000000000328205	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0660162	0.00872271	0.00000000000004005546	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0658408	0.00872061	0.00000000000004608195	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0656261	0.00873044	0.00000000000005932226	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_3
Cardona A	EPIC-Norfolk	31506343	2019-09-10	Type II diabetes	EFO_0001360	Discovery	Table 2	Type II diabetes	DNA methylation	Age, sex, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1264	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.5	None	0.000000000000064	None	31506343_Cardona-A_type_ii_diabetes_discovery
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for other lipids	Table 3	DNA methylation	Triglycerides	Age, sex, smoking, other lipids, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0151	0.002	0.00000000000007	-	28194238_triglycerides_discovery_and_replication_other_lipids_adjusted
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0678183	0.00905095	0.00000000000007119484	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.067074	0.00897878	0.00000000000008453795	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0631997	0.0084838	0.00000000000009894977	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_2
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	L-VLDL-CE	None	Meta-analysis	Table S2	DNA methylation	L-VLDL-CE	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Cholesterol esters in large VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	7.6	1	0.0000000000001	None	33413638_Gomez-Alonso-MDC_l-vldl-ce_meta-analysis
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-FC	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-FC	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Free cholesterol in small VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.8	0.24	0.00000000000012	None	33413638_Gomez-Alonso-MDC_s-vldl-fc_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0610539	0.00824117	0.0000000000001347909	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-FC	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-FC	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Free cholesterol in medium VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	3.9	0.53	0.00000000000014	None	33413638_Gomez-Alonso-MDC_m-vldl-fc_meta-analysis
Dhana K	Atherosclerosis Risk in Communities	29762635	2018-05-14	Body mass index	EFO_0004340	Replication	Table 2	DNA methylation	Body mass index	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Leukocytes	None	2097	1	Adults	Both	Admixed	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0081	0.0011	0.00000000000015	None	29762635_Dhana-K_body_mass_index_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0624827	0.00845073	0.0000000000001504475	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_2
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Discovery	Table S4	DNA methylation	Body mass index	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of body mass index	2096	1	56.2	Both	African	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0081	0.0011	0.000000000000152	-	25935004_body_mass_index_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0607992	0.0082413	0.0000000000001700879	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_1
Chambers JC	-	26095709	2015-07-01	Type II diabetes	EFO_0001360	Discovery	Table 3	Type II diabetes	DNA methylation	Age, sex, cell counts and technical covariates	-	Beta values	Illumina HumanMethylation450	Peripheral blood	Regression coeffcient per 1 pecent increase in methylation	2664	1	50	Both	South Asian	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.07696104	0.0105	0.00000000000022	-	26095709_type_ii_diabetes_discovery
Shah S	-	26119815	2015-07-02	Body mass index	EFO_0004340	Discovery	Table S1	DNA methylation	Body mass index	Age, sex and technical covariates	M values	kg/m2	Illumina HumanMethylation450	Whole blood	Residuals from the regression of DNA methylation on covariates were inverse normally rank transformed prior to analysis	1366	2	74.3	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.196	0.027	0.000000000000285	-	26119815_body_mass_index_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0626991	0.00866893	0.0000000000004972007	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0612453	0.00847231	0.0000000000005110355	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Justice AE	ARIC study	32901515	09-09-2020	waist circumference-to-hip ratio	None	discovery	Table 1	waist circumference-to-hip ratio	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Body mass index, Education	cm	Beta values	Illumina HumanMethylation450	Whole blood	None	2684	1	Adults	Both	African, Other	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.23	0.032	0.00000000000056	None	32901515_Justice-AE_waist_circumference-to-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0606644	0.00847223	0.0000000000008427659	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0589822	0.0082422	0.0000000000008692199	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Braun KVE	-	28194238	2016-06-16	High-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery	Table 2	DNA methylation	High-density lipoprotein cholesterol	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	725	1	60	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0202	0.0029	0.00000000000184	-	28194238_highdensity_lipoprotein_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0602465	0.00854493	0.000000000001861815	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0632636	0.00898957	0.000000000002045008	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0593823	0.00843812	0.000000000002045773	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Free cholesterol to total lipids ratio in large HDL	EFO_0008591	None	None	DNA methylation	Free cholesterol to total lipids ratio in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.24	0.034	0.0000000000024	None	Battram-T_free_cholesterol_to_total_lipids_ratio_in_large_hdl
Dhana K	Rotterdam study	29762635	2018-05-14	Waist Circumference	EFO_0004342	Discovery	Table 3	DNA methylation	Waist Circumference	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Leukocytes	None	1450	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0005	0.000071	0.0000000000024	None	29762635_Dhana-K_waist_circumference_discovery
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-TG	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in small VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	3.3	0.47	0.000000000003	None	33413638_Gomez-Alonso-MDC_s-vldl-tg_meta-analysis
Braun KVE	-	28194238	2016-06-16	High-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Replication	Table 2	DNA methylation	High-density lipoprotein cholesterol	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	760	1	68	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0189	0.0027	0.00000000000329	-	28194238_highdensity_lipoprotein_cholesterol_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0573098	0.008243	0.000000000003739331	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0571963	0.00824306	0.000000000004122429	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0582591	0.00845677	0.000000000005845518	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Trunk total mass	EFO_0004338	None	None	DNA methylation	Trunk total mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	699	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00003	0.0000043	0.0000000000067	None	Battram-T_trunk_total_mass
Battram T	ARIES	None	2020-08-20	Trunk tissue mass	None	None	None	DNA methylation	Trunk tissue mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	699	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00003	0.0000044	0.0000000000073	None	Battram-T_trunk_tissue_mass
Battram T	ARIES	None	2020-08-20	Glycoprotein acetyls	EFO_0004555	None	None	DNA methylation	Glycoprotein acetyls	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.54	0.22	0.0000000000081	None	Battram-T_glycoprotein_acetyls
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0605345	0.00885202	0.00000000000831973	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0616811	0.00902684	0.000000000008639034	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0570734	0.0084487	0.00000000001479242	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Waist circumference	EFO_0004342	None	None	DNA methylation	Waist circumference	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	cm	Illumina HumanMethylation450	Whole blood	None	717	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0187	0.0027	0.000000000015	None	Battram-T_waist_circumference
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0559284	0.0083374	0.00000000002043695	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Total body mass	EFO_0004338	None	None	DNA methylation	Total body mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	704	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.000017	0.0000024	0.000000000021	None	Battram-T_total_body_mass
Battram T	ARIES	None	2020-08-20	Total tissue mass	None	None	None	DNA methylation	Total tissue mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	704	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.000017	0.0000025	0.000000000022	None	Battram-T_total_tissue_mass
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0608343	0.00908683	0.00000000002238612	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_4
Juvinao-Quintero DL	ALSPAC, LBC1936, RSIII-1, RS-Bios	33622391	2021-02-23	Type 2 diabetes	EFO_0001360	meta-analysis	Table 2	DNA methylation	Type 2 diabetes	age, sex, batch effects, cell composition (reference based), smoking	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	3428	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.013	0.00192	0.000000000023	None	33622391_Juvinao-Quintero-DL_type_2_diabetes_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0565104	0.00848382	0.00000000002817375	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_2
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting insulin	EFO_0004466	Base plus BMI	Supplementary Data 1	DNA methylation	fasting insulin	Age, sex, smoking, cell composition (reference based), batch effects, body mass index	Beta Values	log pmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.87	0.28	0.000000000035	4740	31197173_Liu-J_fasting_insulin_base_plus_bmi
Battram T	ARIES	None	2020-08-20	Android total mass	EFO_0004338	None	None	DNA methylation	Android total mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	704	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00015	0.000023	0.000000000035	None	Battram-T_android_total_mass
Battram T	ARIES	None	2020-08-20	Android tissue mass	None	None	None	DNA methylation	Android tissue mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	704	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00015	0.000023	0.000000000036	None	Battram-T_android_tissue_mass
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0601721	0.00911414	0.00000000004194333	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0558478	0.00846572	0.00000000004341239	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Phospholipids to total lipids ratio in large HDL	EFO_0004639	None	None	DNA methylation	Phospholipids to total lipids ratio in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	682	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.073	0.0109	0.000000000044	None	Battram-T_phospholipids_to_total_lipids_ratio_in_large_hdl
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	645	1	63.2	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.049	0.007	0.00000000005	-	28173150_serum_triglycerides_discovery
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table 2	DNA methylation	Triglycerides	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	725	1	60	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0149	0.0023	0.0000000000502	-	28194238_triglycerides_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0572222	0.00872189	0.00000000005533273	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0566786	0.00870677	0.00000000007773918	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_3
Pfeiffer L	-	25583993	2015-01-12	High-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Replication	Table 2	High-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, body mass index, alcohol consumption, physical activity, hypertension, history of MI, hemoglobin A1c, C-reactive protein, lipid-lowering drugs intake and cell counts	mg/dl	Beta values	Illumina HumanMethylation450	Whole blood	-	971	2	62	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-	-	0.00000000009	-	25583993_highdensity_lipoprotein_cholesterol_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0530523	0.00824494	0.0000000001277046	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Android fat mass	EFO_0005409	None	None	DNA methylation	Android fat mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00019	0.000028	0.00000000013	None	Battram-T_android_fat_mass
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.052795	0.00824506	0.0000000001567507	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0074	0.0012	0.00000000016	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0563013	0.00881113	0.0000000001711404	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0576791	0.00904885	0.000000000189443	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_4
Sun D	Bogalusa Heart Study Follow up	31510868	2019-09-12	body mass index	EFO_0004340	follow up in Europeans	Online Table III	DNA methylation	body mass index	age, sex, smoking, cell composition (reference based), batch effects	Beta Values	kg/m2	Illumina HumanMethylation450	Whole blood	None	439	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0016	None	0.00000000019	None	31510868_Sun-D_body_mass_index_follow_up_in_europeans
Battram T	ARIES	None	2020-08-20	Total cholesterol to total lipids ratio in large HDL	EFO_0004574	None	None	DNA methylation	Total cholesterol to total lipids ratio in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.064	0.0099	0.00000000023	None	Battram-T_total_cholesterol_to_total_lipids_ratio_in_large_hdl
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication adjusted for BMI	Table S9	DNA methylation	Serum triglycerides	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	1955	3	61	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0108413	0.0017117	0.000000000239	-	28213390_serum_triglycerides_replication_adjusted_for_bmi
Battram T	ARIES	None	2020-08-20	Trunk fat mass	EFO_0005409	None	None	DNA methylation	Trunk fat mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	705	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.000034	0.0000053	0.00000000024	None	Battram-T_trunk_fat_mass
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	XL-VLDL-TG	None	Meta-analysis	Table S2	DNA methylation	XL-VLDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in very large VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	11	1.7	0.00000000024	None	33413638_Gomez-Alonso-MDC_xl-vldl-tg_meta-analysis
Battram T	ARIES	None	2020-08-20	Weight	EFO_0004338	None	None	DNA methylation	Weight	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	kg	Illumina HumanMethylation450	Whole blood	None	714	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0151	0.00237	0.00000000031	None	Battram-T_weight
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0531949	0.00846722	0.0000000003426743	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0535774	0.00853204	0.0000000003491156	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_3
Mamtani M	-	26798409	2016-01-20	Hypertriglyceridemic waist	EFO_0004342, EFO_0004530	-	Table S2	Liability function of hypertriglyceridemic waist	DNA methylation	Age, sex, use of statin, use of anti-hypertensive, use of diabetic medications, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	850	1	46.8	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.35737672	0.05701	0.000000000365	-	26798409_hypertriglyceridemic_waist
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-TG_pct	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-TG_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Triglycerides to total lipids ratio in medium VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.84	0.13	0.00000000038	None	33413638_Gomez-Alonso-MDC_m-vldl-tg_pct_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0569419	0.00909023	0.0000000003855129	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_4
Kriebel J	-	27019061	2016-03-28	HOMA-IR	EFO_0004501	-	Table 3	HOMA-IR	DNA methylation	Age, sex, smoking, cell counts and technical covariates	SD	Beta values	Illumina HumanMethylation450	Whole blood	Regression coefficients are per 1% increase in DNA methylation	1440	1	59	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.047	0.0075	0.00000000039	-	27019061_homair
Kriebel J	-	27019061	2016-03-28	Fasting glucose	EFO_0004465	-	Table 3	Fasting glucose	DNA methylation	Age, sex, smoking, cell counts and technical covariates	SD	Beta values	Illumina HumanMethylation450	Whole blood	Regression coefficients are per 1% increase in DNA methylation	1448	1	59	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.044	0.007	0.00000000042	-	27019061_fasting_glucose
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.051537	0.0082456	0.0000000004211501	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0541018	0.00865772	0.0000000004245886	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Pfeiffer L	-	25583993	2015-01-12	Triglycerides	EFO_0004530, CHEBI_17855	Replication	Table 2	Triglycerides	DNA methylation	Age, sex, smoking, body mass index, alcohol consumption, physical activity, hypertension, history of MI, hemoglobin A1c, C-reactive protein, lipid-lowering drugs intake and cell counts	mg/dl	Beta values	Illumina HumanMethylation450	Whole blood	-	971	2	62	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-	-	0.000000000556	-	25583993_triglycerides_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0538668	0.0087109	0.000000000642188	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Insulin	None	fasting	None	DNA methylation	Insulin	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	pmol/l	Illumina HumanMethylation450	Whole blood	None	674	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0121	0.0019	0.00000000071	None	Battram-T_insulin_fasting
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	Serum-TG	EFO_0004530	Meta-analysis	Table S2	DNA methylation	Serum-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Serum total triglycerides	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2.7	0.45	0.00000000072	None	33413638_Gomez-Alonso-MDC_serum-tg_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0507672	0.00824592	0.0000000007623865	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_1
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Lothian Birth Cohort 1936	Table S1	DNA methylation	Body mass index	Age, sex and cell counts	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood	-	920	1	70	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.009	0.00145	0.000000000778	-	28095459_body_mass_index_lothian_birth_cohort_1936
Gadd DA	Generation Scotland	35945220	31/07/2022	HMGCS1 protein levels (SeqId = 13496-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HMGCS1 protein levels (SeqId = 13496-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hydroxymethylglutaryl-CoA synthase, cytoplasmic	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.48	0.241	0.00000000079	None	Gadd-DA_hmgcs1_protein_levels__seqid___13496-19__somascan_protein_measurement
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	VLDL-TG	None	Meta-analysis	Table S2	DNA methylation	VLDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	3.8	0.61	0.000000001	None	33413638_Gomez-Alonso-MDC_vldl-tg_meta-analysis
Hidalgo B	-	24170695	2014-02-01	HOMA-IR	EFO_0004501	Discovery	Table 3	DNA methylation	HOMA-IR	Age, sex, study centre and technical covariates	Beta values	-	Illumina HumanMethylation450	CD4+ T-cells	-	544	1	48	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.03564	0.005812	0.00000000122	-	24170695_homair_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.055226	0.00909356	0.000000001285757	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Cholesterol esters to total lipids ratio in large HDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters to total lipids ratio in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	677	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.086	0.014	0.0000000013	None	Battram-T_cholesterol_esters_to_total_lipids_ratio_in_large_hdl
Justice AE	ARIC study	32901515	09-09-2020	waist circumference	None	discovery	Table 1	waist circumference	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Body mass index, Education	None	Beta values	Illumina HumanMethylation450	Whole blood	None	2684	1	Adults	Both	African, Other	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.096	0.016	0.0000000014	None	32901515_Justice-AE_waist_circumference_discovery
Dhana K	Rotterdam study	29762635	2018-05-14	Body mass index	EFO_0004340	Discovery	Table 2	DNA methylation	Body mass index	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Leukocytes	None	1450	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0011	0.00018	0.0000000017	None	29762635_Dhana-K_body_mass_index_discovery
Battram T	ARIES	None	2020-08-20	HDL cholesterol	EFO_0004612	fasting	None	DNA methylation	HDL cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	691	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.55	0.091	0.0000000022	None	Battram-T_hdl_cholesterol_fasting
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0507589	0.00848321	0.000000002235431	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_2
Ma J	CARDSYA, FHS, MESA, RS	30936141	2019-02-21	Nonalcoholic fatty liver disease	EFO_0003095, EFO_1001248	discovery and replication	Table 1	Nonalcoholic fatty liver disease	DNA methylation	Age, sex, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole Blood, Monocytes	None	4525	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	None	None	0.0000000025	None	30936141_Ma-J_nonalcoholic_fatty_liver_disease_discovery_and_replication
Ma J	FHS, RS, CARDIA, MESA	30936141	2020-05-22	Hepatic Fat	EFO_0006506, EFO_0008421	Meta-analysis model 3	Table 1	DNA methylation	Hepatic Fat	Age, sex	Beta Values	Hounsfield units	Illumina HumanMethylation450	Whole blood	Model 3 = model 2 + BMI	3400	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	None	None	0.0000000025	None	30936141_Ma-J_hepatic_fat_meta-analysis_model_3
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	XS-VLDL-TG	None	Meta-analysis	Table S2	DNA methylation	XS-VLDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in very small VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2.2	0.37	0.0000000026	None	33413638_Gomez-Alonso-MDC_xs-vldl-tg_meta-analysis
Walker R	Generation Scotland	33397400	2021-01-04	APOE e2 vs e4	EFO_0007659	Meta-analysis	Table 1	DNA methylation	APOE e2 vs e4	age, sex, smoking, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylationEPIC	Whole blood	None	3587	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.025	0.0042	0.0000000027	Effect direction is relative to carriers of the e2 allele	33397400_Walker-R_apoe_e2_vs_e4_meta-analysis
Battram T	ARIES	None	2020-08-20	Triglycerides in VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides in VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	677	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.55	0.092	0.0000000028	None	Battram-T_triglycerides_in_vldl
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-CE	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-CE	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Cholesterol esters in medium VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2.2	0.37	0.0000000031	None	33413638_Gomez-Alonso-MDC_m-vldl-ce_meta-analysis
Jiantao Ma	RS, MESA, CARDIA	30796027	Feb 22, 2019	hepatic fat	EFO_0010821	Replication	Table 1	DNA methylation	hepatic fat	Age, Sex, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylation450	whole blood	None	1904	3	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	None	None	0.0000000033	None	30796027_Jiantao-Ma_hepatic_fat_replication
Battram T	ARIES	None	2020-08-20	Ratio of triglycerides to phosphoglycerides	EFO_0004530, FMA_85433	None	None	DNA methylation	Ratio of triglycerides to phosphoglycerides	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	663	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.23	0.204	0.0000000034	None	Battram-T_ratio_of_triglycerides_to_phosphoglycerides
Battram T	ARIES	None	2020-08-20	Total fat mass	EFO_0005409	None	None	DNA methylation	Total fat mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.000019	0.0000031	0.0000000034	None	Battram-T_total_fat_mass
Battram T	ARIES	None	2020-08-20	Mean diameter for HDL particles	EFO_0008592	None	None	DNA methylation	Mean diameter for HDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	nm	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.88	0.147	0.0000000036	None	Battram-T_mean_diameter_for_hdl_particles
Lai CQ	-	27777315	2016-12-01	Postprandial lipemia	EFO_0007632	Discovery and replication	Table S2	Postprandial lipemia	DNA methylation	Age, sex, study centre and technical covariates	-	Beta values	Illumina HumanMethylation450	CD4+ T-cells	Postprandial lipemia measured using the area under the curve	979	1	48.3	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	16.59	2.8	0.00000000425	-	27777315_postprandial_lipemia_discovery_and_replication
Battram T	ARIES	None	2020-08-20	Triglycerides	EFO_0004530	fasting	None	DNA methylation	Triglycerides	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.5	0.083	0.0000000043	None	Battram-T_triglycerides_fasting
Koh I-U	The Korea Epigenome Study (KES)	32788176	07-02-2020	Obesity	EFO_0001073	Discovery	Supplementary table S7	DNA methylation	Obesity	Cell composition (reference based), Batch effects	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	450	1	Adults	Males	Unclear	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0116	0.00194	0.0000000044	None	32788176_Koh-I-U_obesity_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0497421	0.00848121	0.000000004588642	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_2
Kriebel J	-	27019061	2016-03-28	2-hour glucose	EFO_0004468	-	Table 3	2-hour glucose	DNA methylation	Age, sex, smoking, cell counts and technical covariates	SD	Beta values	Illumina HumanMethylation450	Whole blood	Regression coefficients are per 1% increase in DNA methylation	1448	1	59	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.042	0.0072	0.0000000046	-	27019061_2hour_glucose
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.048329	0.00824692	0.000000004720804	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Battram T	ARIES	None	2020-08-20	VLDL cholesterol	EFO_0008317	fasting	None	DNA methylation	VLDL cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.08	0.183	0.0000000049	None	Battram-T_vldl_cholesterol_fasting
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	MUFA	EFO_0006823	Meta-analysis	Table S2	DNA methylation	MUFA	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Monounsaturated fatty acids 16:1, 18:1	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.11	0.19	0.000000005	None	33413638_Gomez-Alonso-MDC_mufa_meta-analysis
Gadd DA	Generation Scotland	35945220	31/07/2022	ADIPOQ protein levels (SeqId = 3554-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADIPOQ protein levels (SeqId = 3554-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Adiponectin	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.4	0.241	0.0000000058	None	Gadd-DA_adipoq_protein_levels__seqid___3554-24__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0504993	0.00869403	0.000000006434242	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Arm circumference	EFO_0004589	None	None	DNA methylation	Arm circumference	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	cm	Illumina HumanMethylation450	Whole blood	DXA scan measurement	717	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.056	0.0096	0.0000000066	None	Battram-T_arm_circumference
Kriebel J	-	27019061	2016-03-28	Fasting insulin	EFO_0004466	-	Table 3	Fasting insulin	DNA methylation	Age, sex, smoking, cell counts and technical covariates	SD	Beta values	Illumina HumanMethylation450	Whole blood	Regression coefficients are per 1% increase in DNA methylation	1440	1	59	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.043	0.0074	0.0000000069	-	27019061_fasting_insulin
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0491746	0.00848739	0.000000007020463	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0520297	0.00899875	0.00000000753751	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Triglycerides in large VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	670	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2.38	0.41	0.0000000086	None	Battram-T_triglycerides_in_large_vldl
Battram T	ARIES	None	2020-08-20	Concentration of medium VLDL particles	EFO_0008317	None	None	DNA methylation	Concentration of medium VLDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	676	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	29000000	None	0.0000000088	None	Battram-T_concentration_of_medium_vldl_particles
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.048753	0.00847163	0.000000008844815	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_2
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-TG	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in medium VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	4.3	0.74	0.0000000093	None	33413638_Gomez-Alonso-MDC_m-vldl-tg_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0473103	0.00824733	0.00000000985914	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Phospholipids in medium VLDL	EFO_0004639	None	None	DNA methylation	Phospholipids in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	676	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	4.3	0.74	0.000000012	None	Battram-T_phospholipids_in_medium_vldl
Battram T	ARIES	None	2020-08-20	Concentration of large VLDL particles	EFO_0008317	None	None	DNA methylation	Concentration of large VLDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	670	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	85000000	15000000	0.000000012	None	Battram-T_concentration_of_large_vldl_particles
Battram T	ARIES	None	2020-08-20	Free cholesterol in large HDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-4.5	0.78	0.000000013	None	Battram-T_free_cholesterol_in_large_hdl
Battram T	ARIES	None	2020-08-20	Serum total triglycerides	EFO_0004530	None	None	DNA methylation	Serum total triglycerides	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	676	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.44	0.077	0.000000014	None	Battram-T_serum_total_triglycerides
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0468135	0.00824752	0.00000001404335	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0467483	0.00824754	0.00000001470704	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Free cholesterol in very large VLDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in very large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	633	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	55	9.5	0.000000015	None	Battram-T_free_cholesterol_in_very_large_vldl
Battram T	ARIES	None	2020-08-20	Triglycerides to total lipids ratio in medium HDL	EFO_0004530	None	None	DNA methylation	Triglycerides to total lipids ratio in medium HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.156	0.027	0.000000015	None	Battram-T_triglycerides_to_total_lipids_ratio_in_medium_hdl
Battram T	ARIES	None	2020-08-20	Insulin	None	None	None	DNA methylation	Insulin	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	uU/ml	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.037	0.0064	0.000000015	None	Battram-T_insulin
Battram T	ARIES	None	2020-08-20	Total lipids in large VLDL	EFO_0004529	None	None	DNA methylation	Total lipids in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	671	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.4	0.245	0.000000015	None	Battram-T_total_lipids_in_large_vldl
Battram T	ARIES	None	2020-08-20	Total lipids in medium VLDL	EFO_0004529	None	None	DNA methylation	Total lipids in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	676	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.82	0.143	0.000000016	None	Battram-T_total_lipids_in_medium_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0511198	0.00905412	0.00000001672462	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Cholesterol esters in large VLDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	661	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	12.3	2.16	0.000000017	None	Battram-T_cholesterol_esters_in_large_vldl
Battram T	ARIES	None	2020-08-20	Triglycerides in small VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2.18	0.38	0.000000017	None	Battram-T_triglycerides_in_small_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0476216	0.00845041	0.00000001778414	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Cholesterol esters in very large VLDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in very large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	635	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	51	8.8	0.000000018	None	Battram-T_cholesterol_esters_in_very_large_vldl
Battram T	ARIES	None	2020-08-20	Total cholesterol in large VLDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	664	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	6.3	1.1	0.000000019	None	Battram-T_total_cholesterol_in_large_vldl
Gadd DA	Generation Scotland	35945220	31/07/2022	MXRA8 protein levels (SeqId = 10521-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MXRA8 protein levels (SeqId = 10521-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Matrix remodeling-associated protein 8	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.35	0.242	0.000000021	None	Gadd-DA_mxra8_protein_levels__seqid___10521-10__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Body mass index	EFO_0004340	None	None	DNA methylation	Body mass index	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	714	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.039	0.0069	0.000000021	None	Battram-T_body_mass_index
Battram T	ARIES	None	2020-08-20	Triglycerides in small HDL	EFO_0004530	None	None	DNA methylation	Triglycerides in small HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	682	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	14.5	2.6	0.000000023	None	Battram-T_triglycerides_in_small_hdl
Battram T	ARIES	None	2020-08-20	Free cholesterol in medium VLDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	675	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	6.4	1.14	0.000000023	None	Battram-T_free_cholesterol_in_medium_vldl
Battram T	ARIES	None	2020-08-20	Total cholesterol in large HDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.03	0.183	0.000000023	None	Battram-T_total_cholesterol_in_large_hdl
Battram T	ARIES	None	2020-08-20	Total cholesterol in very large VLDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in very large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	646	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	26.4	4.7	0.000000023	None	Battram-T_total_cholesterol_in_very_large_vldl
Battram T	ARIES	None	2020-08-20	Android region fat	EFO_0005409	None	None	DNA methylation	Android region fat	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.81	0.32	0.000000025	None	Battram-T_android_region_fat
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	XL-VLDL-P	None	Meta-analysis	Table S2	DNA methylation	XL-VLDL-P	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mol/L	Illumina HumanMethylation450	Whole blood	Concentration of very large VLDL particles	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	9.3	1.7	0.000000025	None	33413638_Gomez-Alonso-MDC_xl-vldl-p_meta-analysis
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.54	0.28	0.000000026	4808	31197173_Liu-J_fasting_glucose_base
Battram T	ARIES	None	2020-08-20	Hip circumference	EFO_0005093	None	None	DNA methylation	Hip circumference	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	cm	Illumina HumanMethylation450	Whole blood	DXA scan measurement	715	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0192	0.0034	0.000000026	None	Battram-T_hip_circumference
Battram T	ARIES	None	2020-08-20	Android tissue fat	EFO_0005409	None	None	DNA methylation	Android tissue fat	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.8	0.32	0.000000027	None	Battram-T_android_tissue_fat
Battram T	ARIES	None	2020-08-20	Triglycerides in medium VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	673	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.5	0.266	0.000000027	None	Battram-T_triglycerides_in_medium_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0495341	0.00890624	0.00000002717945	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0470405	0.00848534	0.000000030119	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_2
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-3.475	0.628	0.000000031	-	28173150_serum_highdensity_lipoprotein_cholesterol_discovery
Battram T	ARIES	None	2020-08-20	Phospholipids in large VLDL	EFO_0004639	None	None	DNA methylation	Phospholipids in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	669	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	7.6	1.36	0.000000032	None	Battram-T_phospholipids_in_large_vldl
Battram T	ARIES	None	2020-08-20	Total lipids in very large VLDL	EFO_0004529	None	None	DNA methylation	Total lipids in very large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	651	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	5.6	1	0.000000034	None	Battram-T_total_lipids_in_very_large_vldl
Braun KVE	-	28194238	2016-06-16	Total cholesterol	EFO_0004574	Discovery and replication	Table S1	DNA methylation	Total cholesterol	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0043	8e-04	0.0000000366	-	28194238_total_cholesterol_discovery_and_replication
Gadd DA	Generation Scotland	35945220	31/07/2022	VOPP1 protein levels (SeqId = 14618-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VOPP1 protein levels (SeqId = 14618-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Vesicular, overexpressed in cancer, prosurvival protein 1	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.32	0.24	0.000000038	None	Gadd-DA_vopp1_protein_levels__seqid___14618-26__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Cholesterol esters in large HDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.33	0.24	0.000000041	None	Battram-T_cholesterol_esters_in_large_hdl
Battram T	ARIES	None	2020-08-20	Mean diameter for VLDL particles	EFO_0008594	None	None	DNA methylation	Mean diameter for VLDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	nm	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.147	0.026	0.000000042	None	Battram-T_mean_diameter_for_vldl_particles
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0452016	0.00824813	0.00000004317976	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0450157	0.0082482	0.00000004903475	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Concentration of small VLDL particles	EFO_0008317	None	None	DNA methylation	Concentration of small VLDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	681	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	20000000	None	0.00000005	None	Battram-T_concentration_of_small_vldl_particles
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.046291	0.00848908	0.00000005032683	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0462455	0.00850429	0.00000005477555	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0448314	0.00824827	0.0000000555954	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Pyruvate	EFO_0010117	None	None	DNA methylation	Pyruvate	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	7	1.28	0.000000056	None	Battram-T_pyruvate
Battram T	ARIES	None	2020-08-20	Free cholesterol in large VLDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	659	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	11.9	2.17	0.000000059	None	Battram-T_free_cholesterol_in_large_vldl
Battram T	ARIES	None	2020-08-20	Trunk region fat	EFO_0005409	None	None	DNA methylation	Trunk region fat	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.98	0.36	0.000000062	None	Battram-T_trunk_region_fat
Koh I-U	The Korea Epigenome Study (KES)	32788176	07-02-2020	Obesity	EFO_0001073	Replication 1	Supplementary table S7	DNA methylation	Obesity	Cell composition (reference based), Batch effects	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	373	1	Adults	Males	Unclear	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0122	0.00222	0.000000065	None	32788176_Koh-I-U_obesity_replication_1
Shah S	-	26119815	2015-07-02	Body mass index	EFO_0004340	Replication	Table S1	DNA methylation	Body mass index	Age, sex and technical covariates	M values	kg/m2	Illumina HumanMethylation450	Whole blood	Residuals from the regression of DNA methylation on covariates were inverse normally rank transformed prior to analysis	752	1	45.5	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.195	0.036	0.0000000675	-	26119815_body_mass_index_replication
Battram T	ARIES	None	2020-08-20	Trunk tissue fat	EFO_0005409	None	None	DNA methylation	Trunk tissue fat	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.93	0.35	0.000000074	None	Battram-T_trunk_tissue_fat
Battram T	ARIES	None	2020-08-20	Concentration of very large HDL particles	EFO_0004612	None	None	DNA methylation	Concentration of very large HDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	None	None	0.000000075	None	Battram-T_concentration_of_very_large_hdl_particles
Battram T	ARIES	None	2020-08-20	Total lipids in small VLDL	EFO_0004529	None	None	DNA methylation	Total lipids in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	681	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.94	0.173	0.000000081	None	Battram-T_total_lipids_in_small_vldl
Battram T	ARIES	None	2020-08-20	Arm region fat	EFO_0005409	None	None	DNA methylation	Arm region fat	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2.29	0.42	0.000000085	None	Battram-T_arm_region_fat
Battram T	ARIES	None	2020-08-20	Total cholesterol in very large HDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in very large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.71	0.32	0.000000087	None	Battram-T_total_cholesterol_in_very_large_hdl
Battram T	ARIES	None	2020-08-20	Concentration of very large VLDL particles	EFO_0004611	None	None	DNA methylation	Concentration of very large VLDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	616	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	570000000	100000000	0.000000093	None	Battram-T_concentration_of_very_large_vldl_particles
Sun D	Bogalusa Heart Study	31510868	2019-09-12	body mass index	EFO_0004340	Discovery in Africans	Online Table II	DNA methylation	body mass index	age, sex, smoking, cell composition (reference based), batch effects	Beta Values	kg/m2	Illumina HumanMethylation450	Whole blood	None	490	1	Adults	Both	African	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0011	None	0.000000094	None	31510868_Sun-D_body_mass_index_discovery_in_africans
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-LDL-TG_pct	None	Meta-analysis	Table S2	DNA methylation	S-LDL-TG_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Triglycerides to total lipids ratio in small LDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.82	0.34	0.000000098	None	33413638_Gomez-Alonso-MDC_s-ldl-tg_pct_meta-analysis
Battram T	ARIES	None	2020-08-20	Triglycerides in very small VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides in very small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	5.4	1	0.0000001	None	Battram-T_triglycerides_in_very_small_vldl
Battram T	ARIES	None	2020-08-20	Arm tissue fat	EFO_0005409	None	None	DNA methylation	Arm tissue fat	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2.24	0.42	0.0000001	None	Battram-T_arm_tissue_fat
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.043922	0.0082486	0.0000001025638	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Stroke (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Stroke (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18056	1	Adults (18-65y)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.088	0.01649	0.00000011	None	Robert-F-Hillary_Prevalent_Stroke_(Self-report)_Basic_model
Battram T	ARIES	None	2020-08-20	Arm fat mass	EFO_0005409	None	None	DNA methylation	Arm fat mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	696	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00019	0.000036	0.00000012	None	Battram-T_arm_fat_mass
Battram T	ARIES	None	2020-08-20	Hip shaft bone mineral content	EFO_0007621	None	None	DNA methylation	Hip shaft bone mineral content	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	701	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.075	0.0141	0.00000012	None	Battram-T_hip_shaft_bone_mineral_content
Battram T	ARIES	None	2020-08-20	Phospholipids in very large HDL	EFO_0004639	None	None	DNA methylation	Phospholipids in very large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.56	0.29	0.00000013	None	Battram-T_phospholipids_in_very_large_hdl
Battram T	ARIES	None	2020-08-20	Triglycerides in chylomicrons and extremely large VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides in chylomicrons and extremely large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	654	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	20.2	3.8	0.00000013	None	Battram-T_triglycerides_in_chylomicrons_and_extremely_large_vldl
Gadd DA	Generation Scotland	35945220	31/07/2022	S100A13 protein levels (SeqId = 7223-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	S100A13 protein levels (SeqId = 7223-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein S100-A13	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.28	0.242	0.00000013	None	Gadd-DA_s100a13_protein_levels__seqid___7223-60__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	WNT5A protein levels (SeqId = 13268-45)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	WNT5A protein levels (SeqId = 13268-45)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein Wnt-5a	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.28	0.242	0.00000013	None	Gadd-DA_wnt5a_protein_levels__seqid___13268-45__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0445792	0.00846179	0.0000001396396	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Total lipids in large HDL	EFO_0004529	None	None	DNA methylation	Total lipids in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.53	0.1	0.00000014	None	Battram-T_total_lipids_in_large_hdl
Battram T	ARIES	None	2020-08-20	Total lipids in very large HDL	EFO_0004529	None	None	DNA methylation	Total lipids in very large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.8	0.15	0.00000014	None	Battram-T_total_lipids_in_very_large_hdl
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.001	0.00019	0.00000015	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	ARIES	None	2020-08-20	Cholesterol esters in very large HDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in very large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	682	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-2.28	0.43	0.00000015	None	Battram-T_cholesterol_esters_in_very_large_hdl
Battram T	ARIES	None	2020-08-20	Free cholesterol in very large HDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in very large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-6.2	1.17	0.00000016	None	Battram-T_free_cholesterol_in_very_large_hdl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0431113	0.0082489	0.0000001752906	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SHBG protein levels (SeqId = 4929-55)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SHBG protein levels (SeqId = 4929-55)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sex hormone-binding globulin	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.26	0.242	0.00000018	None	Gadd-DA_shbg_protein_levels__seqid___4929-55__somascan_protein_measurement
Hidalgo B	-	24170695	2014-02-01	Fasting insulin	EFO_0004466	Discovery	Table 2	DNA methylation	Fasting insulin	Age, sex, study centre and technical covariates	Beta values	-	Illumina HumanMethylation450	CD4+ T-cells	-	544	1	48	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.03488	0.006598	0.000000183	-	24170695_fasting_insulin_discovery
Battram T	ARIES	None	2020-08-20	Phospholipids in chylomicrons and extremely large VLDL	EFO_0004639	None	None	DNA methylation	Phospholipids in chylomicrons and extremely large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	657	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	108	20.6	0.00000019	None	Battram-T_phospholipids_in_chylomicrons_and_extremely_large_vldl
Battram T	ARIES	None	2020-08-20	Triglycerides in medium HDL	EFO_0004530	None	None	DNA methylation	Triglycerides in medium HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	13.2	2.5	0.00000019	None	Battram-T_triglycerides_in_medium_hdl
Battram T	ARIES	None	2020-08-20	Triglycerides in very large VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides in very large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	636	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	8.1	1.55	0.00000019	None	Battram-T_triglycerides_in_very_large_vldl
Battram T	ARIES	None	2020-08-20	Alanine	EFO_0009765	None	None	DNA methylation	Alanine	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2.9	0.55	0.00000019	None	Battram-T_alanine
Battram T	ARIES	None	2020-08-20	Gynoid fat free mass	None	None	None	DNA methylation	Gynoid fat free mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00022	0.000041	0.00000019	None	Battram-T_gynoid_fat_free_mass
Gadd DA	Generation Scotland	35945220	31/07/2022	LGALS3BP protein levels (SeqId = 5000-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LGALS3BP protein levels (SeqId = 5000-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Galectin-3-binding protein	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.26	0.242	0.0000002	None	Gadd-DA_lgals3bp_protein_levels__seqid___5000-52__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Free cholesterol in chylomicrons and extremely large VLDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in chylomicrons and extremely large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	645	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	154	29	0.0000002	None	Battram-T_free_cholesterol_in_chylomicrons_and_extremely_large_vldl
Battram T	ARIES	None	2020-08-20	Total cholesterol in chylomicrons and extremely large VLDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in chylomicrons and extremely large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	661	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	74	14.1	0.00000021	None	Battram-T_total_cholesterol_in_chylomicrons_and_extremely_large_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0428295	0.008249	0.000000210728	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Gynoid total mass	EFO_0004338	None	None	DNA methylation	Gynoid total mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	705	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.000083	0.000016	0.00000022	None	Battram-T_gynoid_total_mass
Battram T	ARIES	None	2020-08-20	Phospholipids in small VLDL	EFO_0004639	None	None	DNA methylation	Phospholipids in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	4.2	0.8	0.00000024	None	Battram-T_phospholipids_in_small_vldl
Battram T	ARIES	None	2020-08-20	Phospholipids in very large VLDL	EFO_0004639	None	None	DNA methylation	Phospholipids in very large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	622	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	31.5	6	0.00000024	None	Battram-T_phospholipids_in_very_large_vldl
Battram T	ARIES	None	2020-08-20	Concentration of large HDL particles	EFO_0004612	None	None	DNA methylation	Concentration of large HDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	None	None	0.00000024	None	Battram-T_concentration_of_large_hdl_particles
Braun KVE	-	28194238	2016-06-16	High-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication adjusted for other lipids	Table 3	DNA methylation	High-density lipoprotein cholesterol	Age, sex, smoking, other lipids, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0116	0.0022	0.00000025	-	28194238_highdensity_lipoprotein_cholesterol_discovery_and_replication_other_lipids_adjusted
Battram T	ARIES	None	2020-08-20	Trunk bone mineral density	EFO_0007591	None	None	DNA methylation	Trunk bone mineral density	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g/cm2	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2.03	0.39	0.00000025	None	Battram-T_trunk_bone_mineral_density
Battram T	ARIES	None	2020-08-20	Ratio of apolipoprotein B to apolipoprotein A I	EFO_0004615, EFO_0004614	None	None	DNA methylation	Ratio of apolipoprotein B to apolipoprotein A I	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.37	0.26	0.00000026	None	Battram-T_ratio_of_apolipoprotein_b_to_apolipoprotein_a_i
Battram T	ARIES	None	2020-08-20	Gynoid tissue mass	None	None	None	DNA methylation	Gynoid tissue mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	705	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.000084	0.000016	0.00000026	None	Battram-T_gynoid_tissue_mass
Battram T	ARIES	None	2020-08-20	Arms tissue mass	None	None	None	DNA methylation	Arms tissue mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	696	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00013	0.000025	0.00000026	None	Battram-T_arms_tissue_mass
Battram T	ARIES	None	2020-08-20	Concentration of chylomicrons and extremely large VLDL particles	EFO_0008596	None	None	DNA methylation	Concentration of chylomicrons and extremely large VLDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	623	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	3100000000	600000000	0.00000027	None	Battram-T_concentration_of_chylomicrons_and_extremely_large_vldl_particles
Kriebel J	-	27019061	2016-03-28	2-hour insulin	EFO_0004467	-	Table 3	2-hour insulin	DNA methylation	Age, sex, smoking, cell counts and technical covariates	SD	Beta values	Illumina HumanMethylation450	Whole blood	Regression coefficients are per 1% increase in DNA methylation	617	1	68	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.058	0.0113	0.00000029	-	27019061_2hour_insulin
Gadd DA	Generation Scotland	35945220	31/07/2022	EHMT2 protein levels (SeqId = 5843-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EHMT2 protein levels (SeqId = 5843-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Histone-lysine N-methyltransferase EHMT2	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.24	0.242	0.0000003	None	Gadd-DA_ehmt2_protein_levels__seqid___5843-60__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Gynoid lean mass	EFO_0004995	None	None	DNA methylation	Gynoid lean mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00022	0.000043	0.0000003	None	Battram-T_gynoid_lean_mass
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	VLDL-C	EFO_0008317	Meta-analysis	Table S2	DNA methylation	VLDL-C	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Total cholesterol in VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.3	0.25	0.0000003	None	33413638_Gomez-Alonso-MDC_vldl-c_meta-analysis
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-L	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-L	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Total lipids in medium VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	3.3	0.65	0.0000003	None	33413638_Gomez-Alonso-MDC_m-vldl-l_meta-analysis
Battram T	ARIES	None	2020-08-20	Arm total mass	EFO_0004338	None	None	DNA methylation	Arm total mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	696	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00013	0.000025	0.00000031	None	Battram-T_arm_total_mass
Battram T	ARIES	None	2020-08-20	Total fat free mass	None	None	None	DNA methylation	Total fat free mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	704	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.000033	0.0000064	0.00000033	None	Battram-T_total_fat_free_mass
Battram T	ARIES	None	2020-08-20	Total cholesterol in medium VLDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	675	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2.77	0.54	0.00000035	None	Battram-T_total_cholesterol_in_medium_vldl
Ochoa-Rosales C	Rotterdam Study	32033992	2020-04-01	Statin use	GO_0036273	Replication	Table 1	Statin use	DNA methylation	sex, age, smoking, body mass index, systolic blood pressure, antihypertensive medication, coronary heart disease, type 2 diabetes, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1450	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0115	0.0023	0.00000038	None	32033992_Ochoa-Rosales-C_statin_use_replication
Gadd DA	Generation Scotland	35945220	31/07/2022	RTN4R protein levels (SeqId = 5105-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RTN4R protein levels (SeqId = 5105-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Reticulon-4 receptor	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.23	0.242	0.00000039	None	Gadd-DA_rtn4r_protein_levels__seqid___5105-2__somascan_protein_measurement
Anna Ulrich	None	38184627	Dec 5, 2023	Idiopathic/heritable pulmonary arterial hypertension	None	Discovery	None	DNA methylation	Idiopathic/heritable pulmonary arterial hypertension	Age, Sex, Smoking, Cell composition (reference based), Ancestry (other), first ten principal components computed from control probes	Beta values	None	Illumina HumanMethylationEPIC	whole blood	None	1655	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	26	5.2	0.00000042	None	38184627_Anna-Ulrich_idiopathic_heritable_pulmonary_arterial_hypertension_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0428076	0.00846456	0.0000004304175	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Total lipids in chylomicrons and extremely large VLDL	EFO_0004529	None	None	DNA methylation	Total lipids in chylomicrons and extremely large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	662	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	13.3	2.6	0.00000045	None	Battram-T_total_lipids_in_chylomicrons_and_extremely_large_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0441786	0.00878907	0.0000005053051	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0435797	0.00867598	0.0000005146152	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Total cholesterol to total lipids ratio in very small VLDL	EFO_0004574	None	None	DNA methylation	Total cholesterol to total lipids ratio in very small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.047	0.0093	0.00000052	None	Battram-T_total_cholesterol_to_total_lipids_ratio_in_very_small_vldl
Battram T	ARIES	None	2020-08-20	Free cholesterol to total lipids ratio in large LDL	EFO_0008591	None	None	DNA methylation	Free cholesterol to total lipids ratio in large LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.172	0.034	0.00000053	None	Battram-T_free_cholesterol_to_total_lipids_ratio_in_large_ldl
Battram T	ARIES	None	2020-08-20	Total lean mass	EFO_0004995	None	None	DNA methylation	Total lean mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	704	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.000034	0.0000067	0.00000062	None	Battram-T_total_lean_mass
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0420855	0.00847529	0.0000006923489	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Leg total mass	EFO_0004338	None	None	DNA methylation	Leg total mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	704	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.000039	0.0000078	0.0000007	None	Battram-T_leg_total_mass
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0431099	0.00868678	0.000000702987	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0409183	0.00824966	0.0000007128221	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Leg tissue mass	None	None	None	DNA methylation	Leg tissue mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	704	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00004	0.000008	0.00000079	None	Battram-T_leg_tissue_mass
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-P	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-P	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mol/L	Illumina HumanMethylation450	Whole blood	Concentration of medium VLDL particles	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	3.4	0.68	0.00000081	None	33413638_Gomez-Alonso-MDC_m-vldl-p_meta-analysis
Battram T	ARIES	None	2020-08-20	Free cholesterol in small VLDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	5.9	1.19	0.00000083	None	Battram-T_free_cholesterol_in_small_vldl
Battram T	ARIES	None	2020-08-20	Cholesterol esters in chylomicrons and extremely large VLDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in chylomicrons and extremely large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	651	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	125	25	0.00000083	None	Battram-T_cholesterol_esters_in_chylomicrons_and_extremely_large_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0430646	0.00873692	0.0000008353659	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	TFRC protein levels (SeqId = 6895-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TFRC protein levels (SeqId = 6895-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transferrin receptor protein 1	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.17	0.242	0.0000013	None	Gadd-DA_tfrc_protein_levels__seqid___6895-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0437299	0.00905362	0.000001378432	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Total cholesterol in HDL2	EFO_0004574	None	None	DNA methylation	Total cholesterol in HDL2	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.58	0.119	0.0000014	None	Battram-T_total_cholesterol_in_hdl2
Battram T	ARIES	None	2020-08-20	Hip total bone mineral content	EFO_0007621	None	None	DNA methylation	Hip total bone mineral content	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	702	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.031	0.0064	0.0000015	None	Battram-T_hip_total_bone_mineral_content
Battram T	ARIES	None	2020-08-20	Total region fat	EFO_0005409	None	None	DNA methylation	Total region fat	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2.06	0.43	0.0000016	None	Battram-T_total_region_fat
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.039571	0.0082501	0.000001631144	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Total cholesterol in VLDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	681	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.73	0.151	0.0000017	None	Battram-T_total_cholesterol_in_vldl
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery adjusted for surrogate variables	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.925	0.403	0.0000017	-	28173150_serum_highdensity_lipoprotein_cholesterol_discovery_adjusted_for_surrogate_variables
Battram T	ARIES	None	2020-08-20	Phospholipids in large HDL	EFO_0004639	None	None	DNA methylation	Phospholipids in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.14	0.24	0.0000017	None	Battram-T_phospholipids_in_large_hdl
Battram T	ARIES	None	2020-08-20	Total tissue fat	EFO_0005409	None	None	DNA methylation	Total tissue fat	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.99	0.41	0.0000019	None	Battram-T_total_tissue_fat
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0414815	0.00871246	0.000001943118	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Pelvis bone mineral density	EFO_0007591	None	None	DNA methylation	Pelvis bone mineral density	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g/cm2	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.46	0.31	0.000002	None	Battram-T_pelvis_bone_mineral_density
Battram T	ARIES	None	2020-08-20	Total cholesterol in HDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.52	0.108	0.0000021	None	Battram-T_total_cholesterol_in_hdl
Gadd DA	Generation Scotland	35945220	31/07/2022	APOC3 protein levels (SeqId = 6461-54)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APOC3 protein levels (SeqId = 6461-54)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Apolipoprotein C-III	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.15	0.242	0.0000021	None	Gadd-DA_apoc3_protein_levels__seqid___6461-54__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Gynoid bone mass	EFO_0004512	None	None	DNA methylation	Gynoid bone mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0032	0.00066	0.0000023	None	Battram-T_gynoid_bone_mass
Battram T	ARIES	None	2020-08-20	Cholesterol esters in medium VLDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	677	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	4.6	0.96	0.0000023	None	Battram-T_cholesterol_esters_in_medium_vldl
Battram T	ARIES	None	2020-08-20	Triglycerides to total lipids ratio in small HDL	EFO_0004530	None	None	DNA methylation	Triglycerides to total lipids ratio in small HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.169	0.035	0.0000023	None	Battram-T_triglycerides_to_total_lipids_ratio_in_small_hdl
Battram T	ARIES	None	2020-08-20	Total cholesterol in small VLDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2.22	0.47	0.0000024	None	Battram-T_total_cholesterol_in_small_vldl
Battram T	ARIES	None	2020-08-20	C-Reactive Protein	EFO_0004458	None	None	DNA methylation	C-Reactive Protein	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mg/l	Illumina HumanMethylation450	Whole blood	None	649	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.123	0.026	0.0000025	None	Battram-T_c-reactive_protein
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	South Asian ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	656	1	53.8	Both	South Asian	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	35.07	7.37	0.0000025	-	28002404_body_mass_index_south_asian_ancestry_replication
Gadd DA	Generation Scotland	35945220	31/07/2022	COL3A1 protein levels (SeqId = 18880-81)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COL3A1 protein levels (SeqId = 18880-81)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Collagen alpha-1(III) chain	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.12	0.24	0.0000027	None	Gadd-DA_col3a1_protein_levels__seqid___18880-81__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Android fat free mass	None	None	None	DNA methylation	Android fat free mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	701	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00036	0.000077	0.0000029	None	Battram-T_android_fat_free_mass
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0385776	0.00825043	0.000002953733	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	DEFB1 protein levels (SeqId = 6629-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DEFB1 protein levels (SeqId = 6629-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-defensin 1	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.128	0.242	0.0000031	None	Gadd-DA_defb1_protein_levels__seqid___6629-3__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Free cholesterol to total lipids ratio in small HDL	EFO_0008591	None	None	DNA methylation	Free cholesterol to total lipids ratio in small HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.284	0.06	0.0000031	None	Battram-T_free_cholesterol_to_total_lipids_ratio_in_small_hdl
Battram T	ARIES	None	2020-08-20	Triglycerides to total lipids ratio in small VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides to total lipids ratio in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	681	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.035	0.0074	0.0000033	None	Battram-T_triglycerides_to_total_lipids_ratio_in_small_vldl
Battram T	ARIES	None	2020-08-20	Android lean mass	EFO_0004995	None	None	DNA methylation	Android lean mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	701	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00036	0.000078	0.0000035	None	Battram-T_android_lean_mass
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-PL	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-PL	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Phospholipids in medium VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	3	0.65	0.0000036	None	33413638_Gomez-Alonso-MDC_m-vldl-pl_meta-analysis
Battram T	ARIES	None	2020-08-20	Ribs bone mineral density	EFO_0007591	None	None	DNA methylation	Ribs bone mineral density	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g/cm2	Illumina HumanMethylation450	Whole blood	DXA scan measurement	702	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2.26	0.48	0.0000036	None	Battram-T_ribs_bone_mineral_density
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0398626	0.00860603	0.00000365368	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Lai CQ	-	27777315	2016-12-01	Postprandial lipemia	EFO_0007632	Discovery	Table S2	Postprandial lipemia	DNA methylation	Age, sex, study centre and technical covariates	-	Beta values	Illumina HumanMethylation450	CD4+ T-cells	Postprandial lipemia measured using the area under the curve	653	1	48	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	16.47	3.53	0.00000383	-	27777315_postprandial_lipemia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.041853	0.00908014	0.000004074628	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Triglycerides to total lipids ratio in very small VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides to total lipids ratio in very small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.041	0.0089	0.0000042	None	Battram-T_triglycerides_to_total_lipids_ratio_in_very_small_vldl
Battram T	ARIES	None	2020-08-20	Spine bone mineral content	EFO_0007621	None	None	DNA methylation	Spine bone mineral content	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	705	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0029	0.00062	0.0000042	None	Battram-T_spine_bone_mineral_content
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0379216	0.00825063	0.000004338558	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0389136	0.00848045	0.000004498746	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	NFASC protein levels (SeqId = 7179-69)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NFASC protein levels (SeqId = 7179-69)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neurofascin	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.09	0.24	0.0000054	None	Gadd-DA_nfasc_protein_levels__seqid___7179-69__somascan_protein_measurement
Huang D	BHS, GSH, DILGOM, ETS, EGCUT (Asthma), EGCUT (Young_O), FTC, HBCS,JHS, NTR, PREVEND, YFS, EpiGO, LACHY	32520614	2020-11-12	Systolic Blood Pressure	EFO_0006335	Discovery	Table 2, table 3	DNA methylation	Systolic Blood Pressure	age, sex, ancestry, body mass index, cell composition (reference based)	Beta Values	mmHg	Illumina HumanMethylation450	Whole blood	Includes some twins	4820	15	Adults	Both	European, Admixed	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	None	None	0.0000057	None	32520614_Huang-D_systolic_blood_pressure_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	ST6GALNAC6 protein levels (SeqId = 7228-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ST6GALNAC6 protein levels (SeqId = 7228-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.08	0.24	0.0000061	None	Gadd-DA_st6galnac6_protein_levels__seqid___7228-2__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Total lipids in small HDL	EFO_0004529	None	None	DNA methylation	Total lipids in small HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.34	0.29	0.0000065	None	Battram-T_total_lipids_in_small_hdl
Gadd DA	Generation Scotland	35945220	31/07/2022	RET protein levels (SeqId = 3220-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RET protein levels (SeqId = 3220-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proto-oncogene tyrosine-protein kinase receptor Ret	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.08	0.241	0.0000071	None	Gadd-DA_ret_protein_levels__seqid___3220-40__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.039062	0.00869623	0.000007115262	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0396812	0.0088476	0.00000734815	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_4
Hedman AK	-	28213390	2017-02-17	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Replication	Table S4	DNA methylation	Serum high-density lipoprotein cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	1583	2	57	Both	None	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0003218	7.18e-05	0.00000743	-	28213390_serum_highdensity_lipoprotein_cholesterol_replication
Battram T	ARIES	None	2020-08-20	Lactate	EFO_0007745	None	None	DNA methylation	Lactate	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	662	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.71	0.157	0.000008	None	Battram-T_lactate
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q16610	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q16610	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0377547	0.00849325	0.000008842846	Q16610	41361833_Josephine_Robertson_Q16610_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	ADAMTSL2 protein levels (SeqId = 6379-62)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADAMTSL2 protein levels (SeqId = 6379-62)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: ADAMTS-like protein 2	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.07	0.242	0.000009	None	Gadd-DA_adamtsl2_protein_levels__seqid___6379-62__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0403409	0.00908633	0.000009072675	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	APOM protein levels (SeqId = 10445-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APOM protein levels (SeqId = 10445-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Apolipoprotein M	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.07	0.24	0.0000092	None	Gadd-DA_apom_protein_levels__seqid___10445-20__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0375241	0.00847449	0.000009584465	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Inflammatory Bowel Disease	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Inflammatory Bowel Disease	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17959	1	Adults (18-65y)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.03	0.00676	0.0000097	None	Robert-F-Hillary_Incident_Inflammatory_Bowel_Disease_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0365083	0.00825107	0.000009728294	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0373849	0.00845625	0.000009895892	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	CRELD1 protein levels (SeqId = 7628-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CRELD1 protein levels (SeqId = 7628-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cysteine-rich with EGF-like domain protein 1	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.07	0.242	0.00001	None	Gadd-DA_creld1_protein_levels__seqid___7628-40__somascan_protein_measurement
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-HDL-TG	None	Meta-analysis	Table S2	DNA methylation	S-HDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in small HDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	2	0.45	0.000011	None	33413638_Gomez-Alonso-MDC_s-hdl-tg_meta-analysis
Gadd DA	Generation Scotland	35945220	31/07/2022	DSG2 protein levels (SeqId = 9484-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DSG2 protein levels (SeqId = 9484-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Desmoglein-2	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.07	0.242	0.000011	None	Gadd-DA_dsg2_protein_levels__seqid___9484-75__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0362464	0.00825115	0.00001126335	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0365729	0.00837506	0.00001269008	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CTSO protein levels (SeqId = 9264-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CTSO protein levels (SeqId = 9264-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cathepsin O	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.047	0.24	0.000013	None	Gadd-DA_ctso_protein_levels__seqid___9264-11__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IL1RAP protein levels (SeqId = 14048-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL1RAP protein levels (SeqId = 14048-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-1 receptor accessory protein	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.049	0.24	0.000013	None	Gadd-DA_il1rap_protein_levels__seqid___14048-7__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Total body bone mass	None	None	None	DNA methylation	Total body bone mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00037	0.000084	0.000014	None	Battram-T_total_body_bone_mass
Battram T	ARIES	None	2020-08-20	Total body bone mineral content	EFO_0007621	None	None	DNA methylation	Total body bone mineral content	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00037	0.000084	0.000014	None	Battram-T_total_body_bone_mineral_content
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0368464	0.00848646	0.00001422716	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	LAMC2 protein levels (SeqId = 9580-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LAMC2 protein levels (SeqId = 9580-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Laminin subunit gamma-2	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.05	0.242	0.000015	None	Gadd-DA_lamc2_protein_levels__seqid___9580-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CPM protein levels (SeqId = 9416-77)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CPM protein levels (SeqId = 9416-77)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Carboxypeptidase M	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.04	0.242	0.000016	None	Gadd-DA_cpm_protein_levels__seqid___9416-77__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Leg fat free mass	None	None	None	DNA methylation	Leg fat free mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	704	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.000079	0.000018	0.000016	None	Battram-T_leg_fat_free_mass
Battram T	ARIES	None	2020-08-20	Spine area	None	None	None	DNA methylation	Spine area	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	cm2	Illumina HumanMethylation450	Whole blood	DXA scan measurement	699	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0058	0.00134	0.000016	None	Battram-T_spine_area
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07357	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07357	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0355991	0.00825134	0.00001611251	P07357	41361833_Josephine_Robertson_P07357_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07357	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07357	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0376896	0.00874742	0.00001653213	P07357	41361833_Josephine_Robertson_P07357_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04180	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04180	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0365485	0.00849373	0.00001695893	P04180	41361833_Josephine_Robertson_P04180_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Trunk bone mineral content	EFO_0007621	None	None	DNA methylation	Trunk bone mineral content	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00072	0.00017	0.000018	None	Battram-T_trunk_bone_mineral_content
Battram T	ARIES	None	2020-08-20	Trunk bone mass	EFO_0004512	None	None	DNA methylation	Trunk bone mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00072	0.00017	0.000018	None	Battram-T_trunk_bone_mass
Battram T	ARIES	None	2020-08-20	Apolipoprotein B	EFO_0004615	None	None	DNA methylation	Apolipoprotein B	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.75	0.174	0.000018	None	Battram-T_apolipoprotein_b
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Inflammatory Bowel Disease	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Inflammatory Bowel Disease	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14084	1	Adults (18-65y)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.034	0.00793	0.000019	None	Robert-F-Hillary_Incident_Inflammatory_Bowel_Disease_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0362013	0.00846654	0.00001916499	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	IGFBP4 protein levels (SeqId = 2950-57)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IGFBP4 protein levels (SeqId = 2950-57)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Insulin-like growth factor-binding protein 4	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.03	0.24	0.00002	None	Gadd-DA_igfbp4_protein_levels__seqid___2950-57__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Hip lower neck bone mineral content	EFO_0007621	None	None	DNA methylation	Hip lower neck bone mineral content	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	704	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.36	0.084	0.00002	None	Battram-T_hip_lower_neck_bone_mineral_content
Gadd DA	Generation Scotland	35945220	31/07/2022	ACY1 protein levels (SeqId = 3343-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACY1 protein levels (SeqId = 3343-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aminoacylase-1	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.02	0.241	0.000021	None	Gadd-DA_acy1_protein_levels__seqid___3343-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07357	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07357	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0361052	0.00849559	0.00002152075	P07357	41361833_Josephine_Robertson_P07357_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0360075	0.00847688	0.00002172787	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0359511	0.00848419	0.00002274844	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Concentration of very small VLDL particles	EFO_0008317	None	None	DNA methylation	Concentration of very small VLDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	17000000	None	0.000023	None	Battram-T_concentration_of_very_small_vldl_particles
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-TG_pct	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-TG_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Triglycerides to total lipids ratio in small VLDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.2	0.29	0.000024	None	33413638_Gomez-Alonso-MDC_s-vldl-tg_pct_meta-analysis
Battram T	ARIES	None	2020-08-20	Total cholesterol to total lipids ratio in medium HDL	EFO_0004574	None	None	DNA methylation	Total cholesterol to total lipids ratio in medium HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	682	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.076	0.0178	0.000024	None	Battram-T_total_cholesterol_to_total_lipids_ratio_in_medium_hdl
Battram T	ARIES	None	2020-08-20	Leg bone mineral content	EFO_0007621	None	None	DNA methylation	Leg bone mineral content	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	705	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00094	0.00022	0.000025	None	Battram-T_leg_bone_mineral_content
Battram T	ARIES	None	2020-08-20	Leg lean mass	EFO_0004995	None	None	DNA methylation	Leg lean mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	704	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.000082	0.000019	0.000025	None	Battram-T_leg_lean_mass
Battram T	ARIES	None	2020-08-20	Leg bone mass	EFO_0004512	None	None	DNA methylation	Leg bone mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	705	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00094	0.00022	0.000025	None	Battram-T_leg_bone_mass
Battram T	ARIES	None	2020-08-20	Trunk fat free mass	None	None	None	DNA methylation	Trunk fat free mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	695	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.000055	0.000013	0.000027	None	Battram-T_trunk_fat_free_mass
Gadd DA	Generation Scotland	35945220	31/07/2022	CXCL12 protein levels (SeqId = 3516-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXCL12 protein levels (SeqId = 3516-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Stromal cell-derived factor 1	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1.01	0.242	0.000027	None	Gadd-DA_cxcl12_protein_levels__seqid___3516-60__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Gynoid fat mass	EFO_0005409	None	None	DNA methylation	Gynoid fat mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	705	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.000087	0.000021	0.000029	None	Battram-T_gynoid_fat_mass
Battram T	ARIES	None	2020-08-20	Cholesterol esters to total lipids ratio in very small VLDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters to total lipids ratio in very small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.045	0.0106	0.000029	None	Battram-T_cholesterol_esters_to_total_lipids_ratio_in_very_small_vldl
Battram T	ARIES	None	2020-08-20	Pelvis bone mineral content	EFO_0007621	None	None	DNA methylation	Pelvis bone mineral content	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0017	0.0004	0.000029	None	Battram-T_pelvis_bone_mineral_content
Gadd DA	Generation Scotland	35945220	31/07/2022	PSAT1 protein levels (SeqId = 18342-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PSAT1 protein levels (SeqId = 18342-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphoserine aminotransferase	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1	0.24	0.000033	None	Gadd-DA_psat1_protein_levels__seqid___18342-2__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Saturated fatty acids	EFO_0005110	None	None	DNA methylation	Saturated fatty acids	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	669	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.194	0.046	0.000033	None	Battram-T_saturated_fatty_acids
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0358563	0.00868291	0.00003655269	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	ANTXR1 protein levels (SeqId = 10464-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ANTXR1 protein levels (SeqId = 10464-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Anthrax toxin receptor 1	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-1	0.242	0.000037	None	Gadd-DA_antxr1_protein_levels__seqid___10464-6__somascan_protein_measurement
Vehmeijer FOL	PACE	33239103	25/11/2020	Body mass index	EFO_0004340	adolescent BMI and methylation	Table S2D	DNA methylation	Body mass index	maternal age, maternal educational level, maternal smoking during pregnancy, maternal pre-pregnancy BMI, parity, gestational age at birth, cell composition (reference based)	Beta Values	kg/m2	Illumina HumanMethylation450	Whole blood	None	2842	23	Children	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0181	0.0044	0.000039	None	33239103_Vehmeijer-FOL_body_mass_index_adolescent_bmi_and_methylation
Battram T	ARIES	None	2020-08-20	Total fatty acids	EFO_0005110	None	None	DNA methylation	Total fatty acids	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	672	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.07	0.0169	0.000039	None	Battram-T_total_fatty_acids
Battram T	ARIES	None	2020-08-20	Cholesterol esters in small VLDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	3.1	0.74	0.00004	None	Battram-T_cholesterol_esters_in_small_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0374113	0.00911604	0.00004084452	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Total cholesterol to total lipids ratio in small VLDL	EFO_0004574	None	None	DNA methylation	Total cholesterol to total lipids ratio in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	681	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.033	0.0079	0.000042	None	Battram-T_total_cholesterol_to_total_lipids_ratio_in_small_vldl
Gadd DA	Generation Scotland	35945220	31/07/2022	SDCBP protein levels (SeqId = 17806-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SDCBP protein levels (SeqId = 17806-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Syntenin-1	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.988	0.242	0.000043	None	Gadd-DA_sdcbp_protein_levels__seqid___17806-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IGFBP2 protein levels (SeqId = 8469-41)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IGFBP2 protein levels (SeqId = 8469-41)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Insulin-like growth factor-binding protein 2	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.99	0.242	0.000044	None	Gadd-DA_igfbp2_protein_levels__seqid___8469-41__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P69905	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P69905	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0346831	0.00849147	0.00004441279	P69905	41361833_Josephine_Robertson_P69905_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Monounsaturated fatty acids 16:1 18:1	EFO_0005110	None	None	DNA methylation	Monounsaturated fatty acids 16:1 18:1	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	667	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.205	0.05	0.000046	None	Battram-T_monounsaturated_fatty_acids_16_1_18_1
Gadd DA	Generation Scotland	35945220	31/07/2022	NEU1 protein levels (SeqId = 15426-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NEU1 protein levels (SeqId = 15426-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sialidase-1	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.984	0.242	0.000046	None	Gadd-DA_neu1_protein_levels__seqid___15426-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	INHBA protein levels (SeqId = 19622-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	INHBA protein levels (SeqId = 19622-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Inhibin beta A chain	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.98	0.242	0.000047	None	Gadd-DA_inhba_protein_levels__seqid___19622-7__somascan_protein_measurement
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-HDL-TG_pct	None	Meta-analysis	Table S2	DNA methylation	S-HDL-TG_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Triglycerides to total lipids ratio in small HDL	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.8	0.43	0.000048	None	33413638_Gomez-Alonso-MDC_s-hdl-tg_pct_meta-analysis
Gadd DA	Generation Scotland	35945220	31/07/2022	KAZALD1 protein levels (SeqId = 7144-234)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KAZALD1 protein levels (SeqId = 7144-234)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Kazal-type serine protease inhibitor domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.98	0.242	0.000048	None	Gadd-DA_kazald1_protein_levels__seqid___7144-234__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Hip lower neck bone mineral density	EFO_0007702	None	None	DNA methylation	Hip lower neck bone mineral density	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g/cm2	Illumina HumanMethylation450	Whole blood	DXA scan measurement	704	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.02	0.25	0.000048	None	Battram-T_hip_lower_neck_bone_mineral_density
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0347951	0.00856439	0.00004874724	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Huang D	BHS, GSH, DILGOM, ETS, EGCUT (Asthma), EGCUT (Young_O), FTC, HBCS,JHS, NTR, PREVEND, YFS, EpiGO, LACHY	32520614	2020-11-12	Diastolic Blood Pressure	EFO_0006336	Discovery	Table 2, table 3	DNA methylation	Diastolic Blood Pressure	age, sex, ancestry, body mass index, cell composition (reference based)	Beta Values	mmHg	Illumina HumanMethylation450	Whole blood	Includes some twins	4820	15	Adults	Both	European, Admixed	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	None	None	0.000051	None	32520614_Huang-D_diastolic_blood_pressure_discovery
Battram T	ARIES	None	2020-08-20	Ratio of omega 6 fatty acids to total fatty acids	EFO_0005110	None	None	DNA methylation	Ratio of omega 6 fatty acids to total fatty acids	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	671	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.055	0.0136	0.000052	None	Battram-T_ratio_of_omega_6_fatty_acids_to_total_fatty_acids
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.035147	0.0087216	0.00005608717	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	ASAH2 protein levels (SeqId = 3212-30)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ASAH2 protein levels (SeqId = 3212-30)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neutral ceramidase	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.97	0.241	0.000057	None	Gadd-DA_asah2_protein_levels__seqid___3212-30__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Trunk lean mass	EFO_0004995	None	None	DNA methylation	Trunk lean mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	693	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.000055	0.000014	0.000058	None	Battram-T_trunk_lean_mass
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-	-	0.0000586	-	26500701_sex_kora_f4
Battram T	ARIES	None	2020-08-20	Hip total bone mineral density	EFO_0007702	None	None	DNA methylation	Hip total bone mineral density	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g/cm2	Illumina HumanMethylation450	Whole blood	DXA scan measurement	702	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.01	0.25	0.000059	None	Battram-T_hip_total_bone_mineral_density
Battram T	ARIES	None	2020-08-20	Isoleucine	EFO_0009793	None	None	DNA methylation	Isoleucine	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	679	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	13.1	3.2	0.000064	None	Battram-T_isoleucine
Battram T	ARIES	None	2020-08-20	Hip total T score	EFO_0007702	None	None	DNA methylation	Hip total T score	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	DXA scan measurement	702	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.121	0.03	0.000066	None	Battram-T_hip_total_t_score
Gadd DA	Generation Scotland	35945220	31/07/2022	ANTXR2 protein levels (SeqId = 15559-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ANTXR2 protein levels (SeqId = 15559-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Anthrax toxin receptor 2	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.96	0.24	0.000067	None	Gadd-DA_antxr2_protein_levels__seqid___15559-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	OLFML3 protein levels (SeqId = 8660-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	OLFML3 protein levels (SeqId = 8660-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Olfactomedin-like protein 3	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.96	0.24	0.000067	None	Gadd-DA_olfml3_protein_levels__seqid___8660-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HEXB protein levels (SeqId = 15470-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HEXB protein levels (SeqId = 15470-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-hexosaminidase subunit beta	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.96	0.242	0.000068	None	Gadd-DA_hexb_protein_levels__seqid___15470-11__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0345822	0.00869213	0.00006966459	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0337679	0.00848829	0.00006978237	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q16610	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q16610	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0328015	0.00825213	0.0000707432	Q16610	41361833_Josephine_Robertson_Q16610_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Hip neck bone mineral content	EFO_0007621	None	None	DNA methylation	Hip neck bone mineral content	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g/cm2	Illumina HumanMethylation450	Whole blood	DXA scan measurement	704	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.188	0.047	0.000071	None	Battram-T_hip_neck_bone_mineral_content
Battram T	ARIES	None	2020-08-20	Hip shaft bone mineral density	EFO_0007591	None	None	DNA methylation	Hip shaft bone mineral density	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g/cm2	Illumina HumanMethylation450	Whole blood	DXA scan measurement	701	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.81	0.204	0.000074	None	Battram-T_hip_shaft_bone_mineral_density
Nuotio ML	FINRISK, NFBC1966	33239708	2020-12-14	Metabolic Sydnrome	EFO_0000195	Discovery	Supplmentary table 1	DNA methylation	Metabolic Sydnrome	age, sex, smoking, alcohol consumption, cell composition (reference based), batch effects, ancestry (genomic PCs)	M Values	None	Illumina HumanMethylation450	Whole blood	No CpGs replicated	517	1	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.07662	0.019	0.000074	None	33239708_Nuotio-ML_metabolic_sydnrome_discovery
Battram T	ARIES	None	2020-08-20	Leg fat mass	EFO_0005409	None	None	DNA methylation	Leg fat mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	706	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.00004	0.00001	0.000076	None	Battram-T_leg_fat_mass
Gadd DA	Generation Scotland	35945220	31/07/2022	LARGE protein levels (SeqId = 7935-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LARGE protein levels (SeqId = 7935-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: LARGE xylosyl- and glucuronyltransferase 1	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.95	0.24	0.000078	None	Gadd-DA_large_protein_levels__seqid___7935-26__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0342758	0.00867835	0.00007865589	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Hip Trochanter bone mineral density	EFO_0007702	None	None	DNA methylation	Hip Trochanter bone mineral density	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g/cm2	Illumina HumanMethylation450	Whole blood	DXA scan measurement	705	1	Adults	Females	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	1.06	0.27	0.000084	None	Battram-T_hip_trochanter_bone_mineral_density
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	MUFAtoFA	None	Meta-analysis	Table S2	DNA methylation	MUFAtoFA	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Ratio of monounsaturated fatty acids to total fatty acids	5414	4	Adults	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.39	0.098	0.000085	None	33413638_Gomez-Alonso-MDC_mufatofa_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0324071	0.00825223	0.00008638013	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	FAM177A1 protein levels (SeqId = 8039-41)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FAM177A1 protein levels (SeqId = 8039-41)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein FAM177A1	774	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.94	0.24	0.000088	None	Gadd-DA_fam177a1_protein_levels__seqid___8039-41__somascan_protein_measurement
Demerath EW	-	25935004	2015-08-01	Waist circumference	EFO_0004342	Replication	Table 3	DNA methylation	Waist circumference	Age, sex, smoking, study centre and technical covariates	Beta values	cm	Illumina HumanMethylation450	CD4+ T-cells	Regression coefficient per 1 SD of waist circumference	991	1	49	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	0.0043	0.0011	0.0000939	-	25935004_waist_circumference_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07357	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P07357	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg06500161	chr21:43656587	21	43656587	ABCG1	South shore	-0.0356308	0.00913589	0.00009658734	P07357	41361833_Josephine_Robertson_P07357_OSCA_model_4