author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0041 0.00027 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.42122 0.00641 5e-134 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.104649 0.00821124 5.245603e-37 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.102271 0.00821328 2.0601919999999999e-35 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea - - 5.28e-30 - 23526956_clear_cell_renal_carcinoma Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0899032 0.00822314 1.025851e-27 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.083946 0.00822743 2.314102e-24 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 2439554 (gene symbol: AIM2) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 2439554 (gene symbol: AIM2) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg07195224 chr1:159047034 1 159047034 AIM2 Open sea None None 3.6000000000000003e-22 None 33752734_Yao-C_gene_expression_of_affymetrix_id__2439554__gene_symbol__aim2__meta-analysis Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 2362351 (gene symbol: PYHIN1) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 2362351 (gene symbol: PYHIN1) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg07195224 chr1:159047034 1 159047034 AIM2 Open sea None None 3.9e-21 None 33752734_Yao-C_gene_expression_of_affymetrix_id__2362351__gene_symbol__pyhin1__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0775329 0.00823172 5.230418e-21 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Marttila S - 25888029 2015-03-14 Ageing GO_0007568 - Additional file 1 DNA methylation Age group Sex and cell counts Beta values - Illumina HumanMethylation450 Peripheral blood mononuclear cells Variable dispersion beta regression model 143 1 58.5 Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.77471868 0.0838 2.25e-20 - 25888029_ageing Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.087004 0.00981737 8.731027e-19 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.231913 0.0274897 3.5288420000000003e-17 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.230725 0.0275118 5.3934920000000004e-17 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.080394 0.00980629 2.640659e-16 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0763958 0.00980562 0.000000000000007090831 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0635954 0.00823986 0.00000000000001257514 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0750648 0.00984372 0.00000000000002576722 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0615965 0.00824089 0.00000000000008187851 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0611404 0.00824112 0.0000000000001245389 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0586576 0.00824236 0.000000000001157481 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0578959 0.00824272 0.000000000002252722 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -2.4 0.342 0.0000000000031 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.033 0.00474 0.0000000000032 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0558124 0.0082437 0.00000000001333907 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0633401 0.00979637 0.0000000001040381 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.00122711 0.00018982 0.000000000154 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.052745 0.00824508 0.0000000001631091 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0616238 0.00981093 0.0000000003455934 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.17191 0.0275998 0.0000000004812517 None 39706196_Hannah-M.-Smith_body_fat_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.16351 0.0268426 0.000000001141446 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0485998 0.00824681 0.000000003871819 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18005 1 Adults (18-65y) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.073 0.0124 0.0000000055 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0564775 0.00977505 0.00000000772575 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Hannon E - 27572077 2016-08-30 Schizophrenia EFO_0000692 Phase 2 Table S3 DNA methylation Schizophrenia Age, sex, smoking, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 847 1 - Missing European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.010283 0.00181 0.0000000134 - 27572077_schizophrenia_phase_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.046676 0.00824757 0.00000001547835 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0459931 0.00824783 0.00000002499114 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.054577 0.00980168 0.00000002620113 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0533223 0.00983013 0.00000005908162 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0530394 0.00979225 0.00000006174532 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0444813 0.0082484 0.00000007047563 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0437824 0.00824865 0.0000001125611 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0515735 0.00979526 0.0000001420503 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0508866 0.00973024 0.0000001720837 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0480691 0.00981423 0.0000009790155 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0646332 0.0132464 0.000001075806 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_4 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent COPD (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent COPD (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18078 1 Adults (18-65y) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.041 0.00832 0.0000011 None Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0400684 0.00824994 0.000001205227 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0472755 0.00981289 0.000001466827 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I1 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I1 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0385768 0.00825043 0.000002955146 A0A075B6I1 41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1 Hannon E - 27572077 2016-08-30 Schizophrenia EFO_0000692 Phase 1 Table S3 DNA methylation Schizophrenia Age, sex, smoking, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 675 1 - Missing European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.014707 0.003173 0.00000357 - 27572077_schizophrenia_phase_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0378893 0.00825064 0.000004420618 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0452333 0.00989154 0.000004848999 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0447186 0.009811 0.00000520601 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0372321 0.00825085 0.000006456116 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 GZMK protein levels (SeqId = 9545-156) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GZMK protein levels (SeqId = 9545-156) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Granzyme K 774 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.69 0.155 0.0000083 None Gadd-DA_gzmk_protein_levels__seqid___9545-156__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0366475 0.00825103 0.000008995695 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0364109 0.0082511 0.00001027445 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0362623 0.00825114 0.00001116425 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0426752 0.00972717 0.00001156109 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0359208 0.00825124 0.00001349625 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0352296 0.00825145 0.00001971365 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 GZMA protein levels (SeqId = 3440-7) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GZMA protein levels (SeqId = 3440-7) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Granzyme A 774 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.66 0.155 0.00002 None Gadd-DA_gzma_protein_levels__seqid___3440-7__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0349844 0.00825152 0.00002251319 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0416414 0.0098447 0.00002352898 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.040913 0.0097025 0.00002493419 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0406967 0.00965263 0.00002500235 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0346113 0.00825162 0.00002750979 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0405321 0.00982614 0.00003728953 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0332229 0.00825201 0.00005701108 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 HMGCS2 protein levels (SeqId = 13704-5) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HMGCS2 protein levels (SeqId = 13704-5) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Hydroxymethylglutaryl-CoA synthase, mitochondrial 774 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.62 0.156 0.000065 None Gadd-DA_hmgcs2_protein_levels__seqid___13704-5__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0328258 0.00825212 0.00006987315 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q15848 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q15848 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea 0.0327629 0.00825214 0.00007214481 Q15848 41361833_Josephine_Robertson_Q15848_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0324997 0.00825221 0.00008244081 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg07195224 chr1:159047034 1 159047034 AIM2 Open sea None None 0.000084 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Liver Cirrhosis None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Liver Cirrhosis Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18325 1 Adults (18-65y) Both European cg07195224 chr1:159047034 1 159047034 AIM2 Open sea -0.0073 0.00186 0.000093 None Robert-F-Hillary_Incident_Liver_Cirrhosis_Basic_model