author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.27939 0.00576 5e-110 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 5 0.371 8.8e-42 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0956904 0.00821868 3.4149990000000002e-31 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0912856 0.0082221 1.5853070000000002e-28 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3695107 (gene symbol: TK2) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3695107 (gene symbol: TK2) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg07512993 chr16:66582592 16 66582592 TK2 North shore None None 1e-27 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3695107__gene_symbol__tk2__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0996308 0.0118983 6.093029000000001e-17 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.393244 0.0493022 0.000000000000001602635 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0654896 0.00823885 0.000000000000002018454 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.093094 0.0119173 0.000000000000006026174 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0919417 0.0118809 0.0000000000000107057 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0636805 0.00823981 0.0000000000000115953 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0635883 0.00823986 0.00000000000001266032 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0616845 0.00824085 0.00000000000007548814 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0848666 0.0118622 0.0000000000008804096 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Fully-adjusted model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 14040 1 Adults Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 2.6 0.372 0.0000000000015 Fully_Adjusted_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.344025 0.0494367 0.000000000003552389 None 39706196_Hannah-M.-Smith_body_fat_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.405923 0.058985 0.000000000006112992 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0818114 0.0119186 0.000000000006957167 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0073 0.0011 0.00000000007 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0068 0.0011 0.00000000013 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0527787 0.00824506 0.0000000001587969 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0699012 0.0119003 0.00000000434883 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.28523 0.0493066 0.00000000738394 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.277244 0.0479749 0.000000007640409 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0461108 0.00824779 0.00000002302143 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0660518 0.0119078 0.0000000295738 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0651632 0.0119027 0.0000000445596 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0448895 0.00824825 0.0000000534396 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Battram T GEO 27886173 2020-09-15 Crohn's disease EFO_0000384 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Crohn's disease Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 161 1 Adults Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0265 0.00465 0.000000068 None 27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.316097 0.0594 0.0000001042015 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0429718 0.00824894 0.0000001920462 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0606598 0.0117171 0.0000002284452 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0826937 0.0160831 0.0000002758425 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.292616 0.0575979 0.000000380526 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0594781 0.0117415 0.000000412035 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_3 Knijnenburg None 30833390 Mar 19, 2019 early preterm birth (<28 weeks) EFO_0003917 discovery Supplementary dataset 10 DNA methylation early preterm birth (<28 weeks) Age, Ancestry (genomic PCs), time since birth M values None Illumina HumanMethylation450 whole blood None 784 1 Adults Females Admixed cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.18 0.035 0.0000006 None 30833390_Knijnenburg_early_preterm_birth___28_weeks__discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0410735 0.0082496 0.0000006469106 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0409147 0.00824966 0.0000007144163 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0406708 0.00824974 0.0000008314992 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0804163 0.0165179 0.000001136667 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 discovery None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.236863 0.0487109 0.000001168202 None 39706196_Hannah-M.-Smith_glucose_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0579563 0.0119371 0.000001215505 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0552781 0.0114172 0.000001300782 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0398244 0.00825002 0.000001398742 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0573303 0.0119334 0.000001569136 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0521196 0.0110083 0.000002215646 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0390322 0.00825028 0.00000225482 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0390308 0.00825028 0.000002256702 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.048 0.01015 0.0000026 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0550242 0.0118173 0.000003248362 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.00466 0.00102 0.0000045 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0537114 0.0117569 0.000004952404 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0374821 0.00825077 0.000005593691 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.053961 0.0119326 0.000006169531 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O95445 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O95445 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0538327 0.0119448 0.000006632144 O95445 41361833_Josephine_Robertson_O95445_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0720589 0.0160639 0.000007321008 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0367934 0.00825098 0.000008284908 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0527047 0.0119063 0.000009641572 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.071425 0.0161876 0.00001029989 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_4 Battram T GEO 27886173 2020-09-15 Inflammatory bowel disease EFO_0003767 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Inflammatory bowel disease Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 240 1 Adults Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0196 0.00434 0.000011 None 27886173_Battram-T_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.259522 0.0591998 0.00001172939 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0695751 0.0159817 0.00001349337 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_4 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg07512993 chr16:66582592 16 66582592 TK2 North shore None None 0.000015 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0357256 0.0082513 0.0000150307 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0515558 0.0119177 0.00001528556 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0498942 0.0119497 0.000029924 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0453766 0.0108864 0.00003088026 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0343876 0.00825169 0.00003099394 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04275 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04275 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0342789 0.00825172 0.00003283425 P04275 41361833_Josephine_Robertson_P04275_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.0341004 0.00825177 0.00003608471 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02760 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02760 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0490648 0.0119399 0.00003990138 P02760 41361833_Josephine_Robertson_P02760_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0642641 0.0156779 0.00004171322 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_4 Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.016 0.004 0.000045 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.00062 0.00016 0.000065 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore -0.0475033 0.0118925 0.00006517686 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_2 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 13971 1 Adults (18-65y) Both European cg07512993 chr16:66582592 16 66582592 TK2 North shore 0.042 0.01074 0.000085 None Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model