author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.014	0.00044	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.073	0.0021	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.12509	0.00672	6.4e-45	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.11506	0.00820174	2.0143579999999998e-44	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.114555	0.00820222	4.788e-44	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.118438	0.00874959	1.6911579999999998e-41	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.118015	0.00875147	3.3643969999999997e-41	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.12601	0.00942623	1.606589e-40	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.123654	0.00941398	3.4498830000000005e-39	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.113739	0.00875292	2.1440019999999998e-38	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.112383	0.0087575	1.708983e-37	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.102543	0.00821305	1.361588e-35	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.10211	0.00821342	2.634373e-35	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.116781	0.00941967	4.041693e-35	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.101476	0.00821395	6.902561e-35	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.108105	0.00875819	7.8791e-35	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.107421	0.00876699	2.386989e-34	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.114049	0.0093677	6.181177999999999e-34	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.104222	0.00875147	1.498952e-32	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.103873	0.00875524	2.555409e-32	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.101418	0.00875208	6.4726950000000005e-31	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.108895	0.00941225	8.006177e-31	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.100171	0.0087389	2.732778e-30	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0996841	0.00871996	3.8953169999999996e-30	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.192294	0.0168792	5.761126e-30	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.206454	0.0183463	2.78937e-29	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0917072	0.00822178	8.918030000000001e-29	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0962393	0.00869799	2.4134490000000003e-28	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_3
Mendelson MM	FHS	29740313	2018-04-24	Soluble tumor necrosis factor receptor 2	EFO_0008384, NCIT_C117749	None	Table S1	DNA methylation	Soluble tumor necrosis factor receptor 2	Age, sex, body mass index, smoking, batch effects	Beta Values	pg/ml	Illumina HumanMethylation450	Whole blood	None	2468	1	Adults	Both	Unclear	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.052	0.00469	6.7e-28	None	29740313_Mendelson-MM_soluble_tumor_necrosis_factor_receptor_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0890579	0.00822376	3.1686770000000002e-27	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.101453	0.00944123	7.813858e-27	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0939657	0.00877082	1.104836e-26	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0933461	0.0087702	2.3318479999999998e-26	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0974948	0.00944583	6.8588799999999995e-25	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0848796	0.00822678	7.145023000000001e-25	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0966244	0.00944145	1.687225e-24	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0897511	0.00877821	1.8641609999999998e-24	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0833328	0.00822785	4.972287e-24	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0885108	0.00877592	7.647744e-24	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0882787	0.00877822	1.025965e-23	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0872515	0.00878655	3.6437690000000005e-23	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0923904	0.00935866	6.479659e-23	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_4
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-3.52263	0.3606	1.5100000000000001e-22	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0858627	0.0087807	1.630538e-22	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0857348	0.00878341	1.9371190000000001e-22	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0921715	0.00945824	2.264074e-22	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0793075	0.00823056	6.559547e-22	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_1
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-	-	1.5300000000000002e-21	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0887248	0.0092984	1.6190529999999999e-21	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_4
Reynolds LM	-	25404168	2014-11-18	Age	EFO_0000246	Monocytes	Additional file 1	DNA methylation	Age	Sex, ethnicity and technical covariates	M values	years	Illumina HumanMethylation450	Monocytes	-	1264	1	60	Both	European,African,Admixed	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-	-	4.7400000000000006e-21	-	25404168_age_monocytes
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0806531	0.00866191	1.439792e-20	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0802006	0.00874545	5.321787e-20	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	LAG3 protein levels (SeqId = 9950-229)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LAG3 protein levels (SeqId = 9950-229)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lymphocyte activation gene 3 protein	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.73	0.081	1e-19	None	Gadd-DA_lag3_protein_levels__seqid___9950-229__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0743664	0.00823371	1.893468e-19	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	FCGR3B protein levels (SeqId = 3311-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FCGR3B protein levels (SeqId = 3311-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Low affinity immunoglobulin gamma Fc region receptor III-B	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.72	0.081	5.5e-19	None	Gadd-DA_fcgr3b_protein_levels__seqid___3311-27__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0779142	0.00876723	6.9995329999999995e-19	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0776537	0.00877187	9.517884999999998e-19	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0725641	0.00823481	1.3669590000000001e-18	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0722554	0.00823499	1.908559e-18	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0770212	0.00878991	2.117206e-18	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0762668	0.0087577	3.402824e-18	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0817065	0.00939156	3.668218e-18	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0763565	0.00878441	3.924404e-18	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0752777	0.00873632	7.591012e-18	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0709414	0.00823577	7.779284e-18	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0732702	0.00854392	1.082258e-17	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.080213	0.00946644	2.6081360000000002e-17	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CD48 protein levels (SeqId = 3292-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD48 protein levels (SeqId = 3292-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CD48 antigen	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.68	0.081	2.7e-17	None	Gadd-DA_cd48_protein_levels__seqid___3292-75__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0738399	0.00877025	4.1328430000000003e-17	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	CECR1 protein levels (SeqId = 6077-63)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CECR1 protein levels (SeqId = 6077-63)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Adenosine deaminase 2	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.68	0.081	6.3e-17	None	Gadd-DA_cecr1_protein_levels__seqid___6077-63__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.078446	0.0094466	1.092632e-16	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	GBP1 protein levels (SeqId = 15326-64)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GBP1 protein levels (SeqId = 15326-64)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Guanylate-binding protein 1	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.66	0.08	1.3e-16	None	Gadd-DA_gbp1_protein_levels__seqid___15326-64__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0721762	0.00878283	2.243449e-16	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0673248	0.00823784	3.26222e-16	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0698873	0.00863245	6.129377e-16	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0690217	0.00862518	0.000000000000001311595	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0657407	0.00823871	0.000000000000001577519	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0657326	0.00823871	0.00000000000000159018	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0697759	0.00879508	0.00000000000000228351	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0746475	0.00943948	0.000000000000002801277	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CD163 protein levels (SeqId = 5028-59)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD163 protein levels (SeqId = 5028-59)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Scavenger receptor cysteine-rich type 1 protein M130	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.64	0.081	0.0000000000000034	None	Gadd-DA_cd163_protein_levels__seqid___5028-59__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0691774	0.00880194	0.000000000000004129398	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.066048	0.00843603	0.000000000000005241204	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.068658	0.00877627	0.000000000000005502358	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0683068	0.00877343	0.000000000000007398017	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0681579	0.00876061	0.000000000000007732312	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0675865	0.00869548	0.000000000000008197824	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0723679	0.00934002	0.000000000000009934097	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0674268	0.00870634	0.00000000000001021665	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Rheumatoid Arthritis (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Rheumatoid Arthritis (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18055	1	Adults (18-65y)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.051	0.0066	0.000000000000011	None	Robert-F-Hillary_Prevalent_Rheumatoid_Arthritis_(Self-report)_Basic_model
Chung SA	-	26192630	2015-07-20	Autoantibody production in systemic lupus erythematosus	EFO_0004866, EFO_0002690	Combined	Table S1	DNA methylation	Autoantibody production in systemic lupus erythematosus	Age, disease duration, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	Wilcoxon rank sum test	326	2	46	Females	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-	-	0.000000000000012	-	26192630_autoantibody_production_in_systemic_lupus_erythematosus_combined
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0676003	0.00878428	0.00000000000001497913	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0633195	0.00824	0.00000000000001634212	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0725122	0.00943779	0.00000000000001650135	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0659855	0.00867933	0.00000000000003077992	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.062557	0.0082404	0.00000000000003352477	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	LY9 protein levels (SeqId = 3324-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LY9 protein levels (SeqId = 3324-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-lymphocyte surface antigen Ly-9	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.61	0.081	0.000000000000034	None	Gadd-DA_ly9_protein_levels__seqid___3324-51__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.141141	0.0188566	0.00000000000007498502	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01762	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01762	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0657888	0.00879602	0.00000000000007890673	P01762	41361833_Josephine_Robertson_P01762_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0615698	0.00824091	0.00000000000008392424	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.92	0.124	0.00000000000012	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0646388	0.0087689	0.000000000000177914	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01762	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01762	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0647719	0.0088013	0.0000000000001946218	P01762	41361833_Josephine_Robertson_P01762_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0632848	0.00861047	0.0000000000002090632	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Battram T	GEO	23334450	2020-09-15	Rheumatoid arthritis	EFO_0000685	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE42861	None	DNA methylation	Rheumatoid arthritis	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	689	1	Adults	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0564	0.00755	0.00000000000025	None	23334450_Battram-T_rheumatoid_arthritis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse42861
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0603681	0.00824151	0.0000000000002515599	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01762	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01762	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0602507	0.00824157	0.0000000000002797202	P01762	41361833_Josephine_Robertson_P01762_OSCA_model_1
Chung SA	-	26192630	2015-07-20	Autoantibody production in systemic lupus erythematosus	EFO_0004866, EFO_0002690	Linear regression model	Table 2	DNA methylation	Autoantibody production in systemic lupus erythematosus	Age, ethnicity, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	326	2	46	Females	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.12	0.0166	0.00000000000046	-	26192630_autoantibody_production_in_systemic_lupus_erythematosus_linear_regression_model
Gadd DA	Generation Scotland	35945220	31/07/2022	CSF1R protein levels (SeqId = 13682-47)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CSF1R protein levels (SeqId = 13682-47)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Macrophage colony-stimulating factor 1 receptor	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.58	0.08	0.0000000000006	None	Gadd-DA_csf1r_protein_levels__seqid___13682-47__somascan_protein_measurement
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-	-	0.000000000000605	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0593844	0.008242	0.00000000000060827	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0633315	0.00879105	0.0000000000006127901	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0592982	0.00824204	0.0000000000006567839	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.121997	0.0169684	0.0000000000006747302	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.000251	3.53e-05	0.00000000000113	-	28213390_serum_total_cholesterol_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0615772	0.00865102	0.000000000001146601	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0616801	0.00873908	0.000000000001765483	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0668113	0.00947821	0.000000000001883535	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CRTAM protein levels (SeqId = 7968-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CRTAM protein levels (SeqId = 7968-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cytotoxic and regulatory T-cell molecule	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.57	0.081	0.0000000000021	None	Gadd-DA_crtam_protein_levels__seqid___7968-15__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GZMA protein levels (SeqId = 3440-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GZMA protein levels (SeqId = 3440-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granzyme A	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.56	0.081	0.0000000000026	None	Gadd-DA_gzma_protein_levels__seqid___3440-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0615668	0.00880689	0.000000000002852242	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_3
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0002469	3.54e-05	0.00000000000309	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0608645	0.00874478	0.000000000003544826	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0658904	0.00947556	0.000000000003708332	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0591753	0.00851496	0.000000000003818817	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0610351	0.00879874	0.000000000004178824	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0652955	0.00942009	0.000000000004337693	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CD5L protein levels (SeqId = 3293-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD5L protein levels (SeqId = 3293-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CD5 antigen-like	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.56	0.08	0.0000000000048	None	Gadd-DA_cd5l_protein_levels__seqid___3293-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0605768	0.00875895	0.000000000004838356	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.065267	0.00944537	0.000000000005048481	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_4
Li S	-	28811542	2017-08-15	Age	EFO_0000246	-	Table S1	DNA methylation	Age	Cell counts	M values	years	Illumina HumanMethylation450	Whole blood	-	1366	2	73	Missing	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0245	0.00360857	0.00000000000563	-	28811542_age
Gadd DA	Generation Scotland	35945220	31/07/2022	IL18BP protein levels (SeqId = 3073-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL18BP protein levels (SeqId = 3073-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-18-binding protein	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.55	0.081	0.0000000000093	None	Gadd-DA_il18bp_protein_levels__seqid___3073-51__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0561629	0.00824354	0.000000000009933345	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0596559	0.00880206	0.00000000001269474	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0593944	0.00878565	0.00000000001428248	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	IL15RA protein levels (SeqId = 14054-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL15RA protein levels (SeqId = 14054-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-15 receptor subunit alpha	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.55	0.081	0.000000000015	None	Gadd-DA_il15ra_protein_levels__seqid___14054-17__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0638331	0.009455	0.00000000001520908	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0593238	0.00880486	0.00000000001670108	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0608818	0.00904154	0.00000000001717127	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0632685	0.00941548	0.00000000001889179	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0588349	0.00878243	0.00000000002172652	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0588853	0.00879359	0.00000000002214021	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_2
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.04987	0.0075	0.0000000000228	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0589349	0.00880878	0.00000000002305077	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0551562	0.008244	0.00000000002305214	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0584455	0.00879825	0.00000000003185148	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0547326	0.0082442	0.00000000003270659	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Colicino E	CHARGE	32697766	07-22-2020	All cause mortality	EFO_0004352	basic model	Table S2	All cause mortality	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	None	M values	Illumina HumanMethylation450	Whole blood	Effect estimates represent hazard ratio per 10% increase in DNA methylation.	12300	12	Adults	Both	European, African	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.88	None	0.000000000034	None	32697766_Colicino-E_all_cause_mortality_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0625931	0.00946366	0.00000000003869339	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	IL12B protein levels (SeqId = 13733-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL12B protein levels (SeqId = 13733-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-12 subunit beta	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.53	0.081	0.000000000039	None	Gadd-DA_il12b_protein_levels__seqid___13733-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0544281	0.00824433	0.000000000041993	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0543104	0.00824439	0.0000000000462348	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0621586	0.00946709	0.00000000005351402	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01762	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01762	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0622183	0.00947667	0.00000000005363414	P01762	41361833_Josephine_Robertson_P01762_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0540879	0.00824449	0.00000000005542793	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0575719	0.00879673	0.00000000006159926	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	VCAM1 protein levels (SeqId = 2967-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VCAM1 protein levels (SeqId = 2967-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Vascular cell adhesion protein 1	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.53	0.081	0.000000000062	None	Gadd-DA_vcam1_protein_levels__seqid___2967-8__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.057539	0.00880188	0.00000000006478617	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0613479	0.00940743	0.0000000000720278	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	B2M protein levels (SeqId = 3485-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	B2M protein levels (SeqId = 3485-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-2-microglobulin	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.53	0.081	0.000000000075	None	Gadd-DA_b2m_protein_levels__seqid___3485-28__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.061613	0.0094838	0.00000000008477433	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0571152	0.0087981	0.00000000008756878	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0570715	0.00880206	0.00000000009225365	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0564988	0.00871657	0.00000000009355296	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0607666	0.00940987	0.0000000001096258	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0528743	0.00824502	0.0000000001471754	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0602481	0.00942987	0.0000000001719376	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_4
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.037	0.00516	0.00000000018	None	32795589_Kyung-WK_eosinophilia_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	TNFRSF1B protein levels (SeqId = 3152-57)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNFRSF1B protein levels (SeqId = 3152-57)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tumor necrosis factor receptor superfamily member 1B	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.51	0.081	0.00000000021	None	Gadd-DA_tnfrsf1b_protein_levels__seqid___3152-57__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.055727	0.00877184	0.0000000002174649	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0584637	0.0092571	0.0000000002769772	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0519924	0.0082454	0.000000000295268	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0554116	0.00878832	0.0000000002961749	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0519382	0.00824543	0.0000000003080491	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.76	0.12	0.00000000031	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0553245	0.00879772	0.000000000329637	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CXCL11 protein levels (SeqId = 3038-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXCL11 protein levels (SeqId = 3038-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-X-C motif chemokine 11	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.51	0.081	0.00000000033	None	Gadd-DA_cxcl11_protein_levels__seqid___3038-9__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0518427	0.00824547	0.0000000003319328	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0552589	0.0088051	0.0000000003576581	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0515925	0.00824558	0.0000000004033813	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0549073	0.00878483	0.0000000004211519	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0586918	0.00939092	0.0000000004222263	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0571168	0.0091397	0.0000000004236789	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0546694	0.00874857	0.0000000004246385	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0579951	0.00935613	0.0000000005848552	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_4
Aslibekyan S	CHARGE	29617535	2018-04-04	Tumour necrosis factor-alpha	EFO_0003271	Meta-analysis model 3	Table 2	DNA methylation	Tumour necrosis factor-alpha	Age, sex, batch effects, cell composition (reference based), smoking, body mass index	Beta Values	pg/ml	Illumina HumanMethylation450	Whole blood	Some associations replicated - see paper	4163	5	Adults	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.02	0.003	0.00000000063	None	29617535_Aslibekyan-S_tumour_necrosis_factor-alpha_meta-analysis_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	SEMA7A protein levels (SeqId = 7019-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SEMA7A protein levels (SeqId = 7019-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Semaphorin-7A	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.5	0.081	0.00000000065	None	Gadd-DA_sema7a_protein_levels__seqid___7019-13__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0585187	0.00947812	0.0000000006830425	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0540357	0.00879126	0.0000000008125399	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	IL12B protein levels (SeqId = 10365-132)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL12B protein levels (SeqId = 10365-132)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-12 subunit beta|Interleukin-23 subunit alpha	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.496	0.081	0.00000000082	None	Gadd-DA_il12b_protein_levels__seqid___10365-132__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0581735	0.00947594	0.0000000008514453	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0564755	0.00921236	0.0000000008990652	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0533673	0.00877644	0.000000001225973	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0556516	0.00915213	0.000000001226127	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0575665	0.00947703	0.000000001275959	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0529869	0.00873299	0.000000001331657	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CXCL10 protein levels (SeqId = 4141-79)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXCL10 protein levels (SeqId = 4141-79)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-X-C motif chemokine 10	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.49	0.081	0.0000000015	None	Gadd-DA_cxcl10_protein_levels__seqid___4141-79__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TNFRSF1B protein levels (SeqId = 8368-102)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNFRSF1B protein levels (SeqId = 8368-102)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tumor necrosis factor receptor superfamily member 1B	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.49	0.081	0.0000000015	None	Gadd-DA_tnfrsf1b_protein_levels__seqid___8368-102__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.110288	0.018325	0.00000000179507	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0564763	0.00939635	0.00000000189401	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0566028	0.00943167	0.000000002002937	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_4
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.891967	0.1491	0.00000000219	-	27105112_hiv_infection_neutrophils
Colicino E	CHARGE	32697766	07-22-2020	All cause mortality	EFO_0004352	fully adjusted model	Table S3	All cause mortality	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Body mass index, Education, Physical activity, alcohol consumption, hypertension, diabetes, history of cancer, coronary heart disease	None	Beta values	Illumina HumanMethylation450	Whole blood	Effect estimates represent hazard ratio per 10% increase in DNA methylation.	12300	12	Adults	Both	European, African	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.87	None	0.0000000024	None	32697766_Colicino-E_all_cause_mortality_fully_adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0522288	0.00875211	0.000000002463803	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0523046	0.00876879	0.000000002504799	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0523726	0.00880405	0.000000002764388	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0523457	0.00880684	0.000000002848938	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0486381	0.0082468	0.000000003764524	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0516447	0.00878704	0.000000004258918	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0556136	0.00947665	0.000000004492857	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0483596	0.00824691	0.000000004616456	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_1
Zhang X	-	27672717	2016-08-12	Human immunodeficiency virus	EFO_0000764	-	Table 1	DNA methylation	Human immunodeficiency virus	Age, smoking, ethnicity, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	378	1	49.2	Both	European,African,Other	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-	-	0.00000000496	-	27672717_human_immunodeficiency_virus
Gadd DA	Generation Scotland	35945220	31/07/2022	MSR1 protein levels (SeqId = 15533-97)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MSR1 protein levels (SeqId = 15533-97)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Macrophage scavenger receptor types I and II	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.473	0.081	0.000000005	None	Gadd-DA_msr1_protein_levels__seqid___15533-97__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0513782	0.00880741	0.00000000554147	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0498889	0.00858063	0.000000006221962	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_3
Battram T	GEO	27886173	2020-09-15	Crohn's disease	EFO_0000384	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Crohn's disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	161	1	Adults	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0779	0.01262	0.0000000068	None	27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0510442	0.00880214	0.000000006805789	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0509042	0.00879311	0.000000007221024	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.011	0.002	0.0000000073	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0476073	0.00824721	0.000000007966543	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0507579	0.00879989	0.00000000818283	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0475394	0.00824724	0.000000008365241	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01705	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01705	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0544922	0.00948967	0.000000009527214	P01705	41361833_Josephine_Robertson_P01705_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0502911	0.0087684	0.000000009914755	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0503333	0.00877921	0.00000001004735	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0537286	0.0093884	0.00000001067901	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01705	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01705	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.047131	0.0082474	0.00000001120672	P01705	41361833_Josephine_Robertson_P01705_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	FOLR2 protein levels (SeqId = 15587-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FOLR2 protein levels (SeqId = 15587-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Folate receptor beta	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.46	0.081	0.000000012	None	Gadd-DA_folr2_protein_levels__seqid___15587-20__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CD97 protein levels (SeqId = 18881-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD97 protein levels (SeqId = 18881-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CD97 antigen	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.46	0.081	0.000000013	None	Gadd-DA_cd97_protein_levels__seqid___18881-7__somascan_protein_measurement
Chilunga FP	RODAM	33890479	04-23-2021	Migration	None	Discovery	Table 2	DNA methylation	Migration	Age, Sex, Cell composition (reference based), Batch effects, Body mass index, Type 2 diabetes	Beta values	None	Illumina HumanMethylation450	Whole blood	None	712	1	Adults	Both	African	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	None	None	0.000000013	None	33890479_Chilunga-FP_migration_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0468231	0.00824752	0.00000001394763	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0499212	0.00879633	0.00000001411259	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0499052	0.00880466	0.00000001471582	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0495426	0.00874753	0.0000000151004	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_3
Chung SA	-	26192630	2015-07-20	Autoantibody production in systemic lupus erythematosus	EFO_0004866, EFO_0002690	Discovery	Table 2	DNA methylation	Autoantibody production in systemic lupus erythematosus	Technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	Wilcoxon rank sum test	186	1	46	Females	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-	-	0.000000016	-	26192630_autoantibody_production_in_systemic_lupus_erythematosus_discovery
Aslibekyan S	CHARGE	29617535	2018-04-04	Tumour necrosis factor-alpha	EFO_0003271	Meta-analysis model 2	eTable 3	DNA methylation	Tumour necrosis factor-alpha	Age, sex, batch effects, cell composition (reference based)	Beta Values	pg/ml	Illumina HumanMethylation450	Whole blood	None	4163	5	Adults	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.02	0.003	0.000000018	None	29617535_Aslibekyan-S_tumour_necrosis_factor-alpha_meta-analysis_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0493877	0.00879095	0.00000001966761	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0462506	0.00824774	0.0000000208768	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Song N	St Jude Lifetime Cohort	33823916	2021-04-06	Cancer treatment: Antimetabolites and asparaginase enzymes	None	None	Table S2	DNA methylation	Cancer treatment: Antimetabolites and asparaginase enzymes	sex, age, other cancer treatment exposures, cell composition (reference based), ancestry (genomic PCs), batch effects	M Values	None	Illumina HumanMethylationEPIC	Whole blood	None	2052	1	Children	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.118	0.02	0.000000022	None	33823916_Song-N_cancer_treatment__antimetabolites_and_asparaginase_enzymes
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0528397	0.00944925	0.00000002285472	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0461006	0.00824779	0.00000002318533	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0527951	0.0094607	0.00000002441345	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0460217	0.00824782	0.00000002449652	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0515339	0.0092401	0.00000002487479	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CD8A protein levels (SeqId = 15462-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD8A protein levels (SeqId = 15462-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-cell surface glycoprotein CD8 alpha chain	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.45	0.081	0.000000025	None	Gadd-DA_cd8a_protein_levels__seqid___15462-28__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SLAMF6 protein levels (SeqId = 5128-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SLAMF6 protein levels (SeqId = 5128-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: SLAM family member 6	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.45	0.081	0.000000027	None	Gadd-DA_slamf6_protein_levels__seqid___5128-53__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MICB protein levels (SeqId = 5102-55)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MICB protein levels (SeqId = 5102-55)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: MHC class I polypeptide-related sequence B	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.45	0.081	0.00000003	None	Gadd-DA_micb_protein_levels__seqid___5102-55__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0455759	0.00824799	0.00000003337656	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0485224	0.00878155	0.00000003341598	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	FAIM3 protein levels (SeqId = 6574-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FAIM3 protein levels (SeqId = 6574-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fas apoptotic inhibitory molecule 3	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.446	0.081	0.000000037	None	Gadd-DA_faim3_protein_levels__seqid___6574-11__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0521191	0.00947738	0.000000038766	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01705	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01705	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0480276	0.00881416	0.00000005149676	P01705	41361833_Josephine_Robertson_P01705_OSCA_model_3
Aslibekyan S	CHARGE	29617535	2018-04-04	Tumour necrosis factor-alpha	EFO_0003271	Meta-analysis base model	eTable 3	DNA methylation	Tumour necrosis factor-alpha	Age, sex, batch effects	Beta Values	pg/ml	Illumina HumanMethylation450	Whole blood	None	4163	5	Adults	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.02	0.004	0.000000054	None	29617535_Aslibekyan-S_tumour_necrosis_factor-alpha_meta-analysis_base_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0477447	0.00877771	0.00000005434291	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01705	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01705	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0477059	0.00880527	0.00000006126315	P01705	41361833_Josephine_Robertson_P01705_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0476348	0.00881329	0.00000006586481	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.047418	0.00880383	0.00000007312564	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0474025	0.00880466	0.00000007405631	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_2
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0002725	5.09e-05	0.0000000874	-	28213390_serum_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0503143	0.00941814	0.00000009316248	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0469297	0.00878514	0.00000009332725	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Chung SA	-	26192630	2015-07-20	Autoantibody production in systemic lupus erythematosus	EFO_0004866, EFO_0002690	Replication	Table 2	DNA methylation	Autoantibody production in systemic lupus erythematosus	Technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	Wilcoxon rank sum test	140	1	46	Females	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-	-	0.000000094	-	26192630_autoantibody_production_in_systemic_lupus_erythematosus_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0440467	0.00824856	0.00000009436824	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_1
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0002722	5.1e-05	0.0000000962	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Kresovich JK	Sister Study	31600381	2019-10-10	parity	NCIT_C16955	None	Table 3	DNA methylation	parity	cell composition (reference based), batch effects, weight, smoking, alcohol consumption	M Values	None	Illumina HumanMethylation450	Whole blood	None	2356	1	Adults	Females	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.04	None	0.0000001	None	31600381_Kresovich-JK_parity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.101214	0.018994	0.0000001001434	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Gadd DA	Generation Scotland	35945220	31/07/2022	TLR4 protein levels (SeqId = 3647-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TLR4 protein levels (SeqId = 3647-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lymphocyte antigen 96|Toll-like receptor 4	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.43	0.081	0.00000013	None	Gadd-DA_tlr4_protein_levels__seqid___3647-49__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0434546	0.00824877	0.0000001398644	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	ICAM1 protein levels (SeqId = 4342-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ICAM1 protein levels (SeqId = 4342-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Intercellular adhesion molecule 1	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.43	0.081	0.00000014	None	Gadd-DA_icam1_protein_levels__seqid___4342-10__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0495989	0.00943287	0.0000001476057	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_4
Reynolds LM	-	25404168	2014-11-18	Age	EFO_0000246	T cells	Additional file 1	DNA methylation	Age	Sex, ethnicity and technical covariates	M values	Years	Illumina HumanMethylation450	T cells	-	227	1	-	Missing	None	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-	-	0.00000017	-	25404168_age_t_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0483888	0.00927331	0.0000001832666	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0427656	0.00824902	0.0000002196718	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0449701	0.00869824	0.0000002371361	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0488454	0.00949181	0.0000002694535	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0450321	0.00880316	0.0000003169507	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	UMOD protein levels (SeqId = 9451-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UMOD protein levels (SeqId = 9451-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Uromodulin	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.41	0.081	0.00000045	None	Gadd-DA_umod_protein_levels__seqid___9451-20__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0415789	0.00824943	0.0000004705582	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SEMA4A protein levels (SeqId = 16915-153)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SEMA4A protein levels (SeqId = 16915-153)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Semaphorin-4A	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.41	0.081	0.00000052	None	Gadd-DA_sema4a_protein_levels__seqid___16915-153__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.047649	0.00949291	0.0000005243427	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0441306	0.00879277	0.0000005256153	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	CXCL9 protein levels (SeqId = 9188-119)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXCL9 protein levels (SeqId = 9188-119)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-X-C motif chemokine 9	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.41	0.081	0.00000053	None	Gadd-DA_cxcl9_protein_levels__seqid___9188-119__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0438637	0.00875267	0.0000005464798	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.044019	0.00881034	0.0000005911889	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0439532	0.00880103	0.0000005979328	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0410658	0.00824961	0.000000650051	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0436392	0.00880881	0.0000007349573	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0435507	0.00881455	0.0000007867077	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0433673	0.00880252	0.0000008454641	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.043265	0.00878929	0.0000008638897	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CXCL13 protein levels (SeqId = 3487-32)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXCL13 protein levels (SeqId = 3487-32)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-X-C motif chemokine 13	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.4	0.081	0.00000089	None	Gadd-DA_cxcl13_protein_levels__seqid___3487-32__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0427449	0.00875467	0.000001058414	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CD300C protein levels (SeqId = 5066-134)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD300C protein levels (SeqId = 5066-134)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CMRF35-like molecule 6	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.39	0.081	0.0000011	None	Gadd-DA_cd300c_protein_levels__seqid___5066-134__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0427774	0.0088031	0.000001189833	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CDCP1 protein levels (SeqId = 16818-200)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CDCP1 protein levels (SeqId = 16818-200)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CUB domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.39	0.081	0.0000012	None	Gadd-DA_cdcp1_protein_levels__seqid___16818-200__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0455265	0.00937397	0.000001205964	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0406584	0.00838824	0.000001265845	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0416543	0.00860067	0.000001291083	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0424411	0.00879361	0.000001404531	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	SIGLEC5 protein levels (SeqId = 16792-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SIGLEC5 protein levels (SeqId = 16792-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sialic acid-binding Ig-like lectin 5	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.38	0.08	0.0000015	None	Gadd-DA_siglec5_protein_levels__seqid___16792-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LILRB2 protein levels (SeqId = 5091-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LILRB2 protein levels (SeqId = 5091-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leukocyte immunoglobulin-like receptor subfamily B member 2	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.39	0.081	0.0000015	None	Gadd-DA_lilrb2_protein_levels__seqid___5091-28__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NCR1 protein levels (SeqId = 8360-169)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NCR1 protein levels (SeqId = 8360-169)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Natural cytotoxicity triggering receptor 1	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.39	0.081	0.0000016	None	Gadd-DA_ncr1_protein_levels__seqid___8360-169__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0421342	0.00881028	0.000001749066	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.039391	0.00825016	0.000001818255	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0416445	0.00879164	0.000002191229	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	IL2RB protein levels (SeqId = 9343-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL2RB protein levels (SeqId = 9343-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-2 receptor subunit beta	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.38	0.081	0.0000022	None	Gadd-DA_il2rb_protein_levels__seqid___9343-16__somascan_protein_measurement
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2025	3	61	Both	None	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0002313	4.9e-05	0.00000232	-	28213390_serum_total_cholesterol_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0389819	0.0082503	0.000002323468	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6J9	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6J9	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0447914	0.0094854	0.000002355429	A0A075B6J9	41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0411388	0.0088152	0.00000308636	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_3
Liu C	CHARGE+	27843151	2016-11-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	African ancestry	Table S6	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g per day	Illumina HumanMethylation450	Whole blood	-	2423	3	56	Both	African	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.00011553	2.48e-05	0.00000333	-	27843151_alcohol_consumption_per_day_african_ancestry
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0438042	0.00942373	0.000003376235	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	APOL3 protein levels (SeqId = 16823-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APOL3 protein levels (SeqId = 16823-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Apolipoprotein L3	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.38	0.081	0.0000034	None	Gadd-DA_apol3_protein_levels__seqid___16823-75__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IGFLR1 protein levels (SeqId = 7244-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IGFLR1 protein levels (SeqId = 7244-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: IGF-like family receptor 1	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.38	0.081	0.0000036	None	Gadd-DA_igflr1_protein_levels__seqid___7244-16__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0381938	0.00825055	0.000003701567	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.043655	0.00944414	0.000003824863	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.038096	0.00825058	0.000003919159	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_1
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	2.212	0.482	0.0000044	-	28173150_serum_highdensity_lipoprotein_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0423971	0.00925012	0.000004612441	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.040276	0.00880264	0.00000479108	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0433983	0.00949498	0.000004901688	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.040181	0.00880466	0.000005068955	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	FCRL3 protein levels (SeqId = 4440-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FCRL3 protein levels (SeqId = 4440-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fc receptor-like protein 3	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.37	0.081	0.0000052	None	Gadd-DA_fcrl3_protein_levels__seqid___4440-15__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.014	0.00307	0.0000052	None	Robert-F-Hillary_Incident_COPD_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	SEMA4D protein levels (SeqId = 5737-61)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SEMA4D protein levels (SeqId = 5737-61)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Semaphorin-4D	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.37	0.081	0.0000053	None	Gadd-DA_sema4d_protein_levels__seqid___5737-61__somascan_protein_measurement
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2025	3	61	Both	None	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0002234	4.92e-05	0.00000554	-	28213390_serum_total_cholesterol_replication_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0397609	0.00880034	0.00000628812	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0395138	0.00880374	0.000007234047	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	IL27RA protein levels (SeqId = 5132-71)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL27RA protein levels (SeqId = 5132-71)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-27 receptor subunit alpha	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.36	0.081	0.0000073	None	Gadd-DA_il27ra_protein_levels__seqid___5132-71__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0370081	0.00825092	0.000007335104	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SIGLEC7 protein levels (SeqId = 2742-68)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SIGLEC7 protein levels (SeqId = 2742-68)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sialic acid-binding Ig-like lectin 7	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.36	0.081	0.0000078	None	Gadd-DA_siglec7_protein_levels__seqid___2742-68__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0368581	0.00825096	0.000007987007	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.039106	0.00881194	0.00000915283	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0389161	0.00879211	0.000009657688	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CD300A protein levels (SeqId = 5630-48)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD300A protein levels (SeqId = 5630-48)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CMRF35-like molecule 8	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.36	0.081	0.00001	None	Gadd-DA_cd300a_protein_levels__seqid___5630-48__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PACAP protein levels (SeqId = 16322-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PACAP protein levels (SeqId = 16322-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Marginal zone B- and B1-cell-specific protein	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.35	0.08	0.00001	None	Gadd-DA_pacap_protein_levels__seqid___16322-10__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0388302	0.00880101	0.00001031399	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0774069	0.017561	0.00001050152	None	39706196_Hannah-M.-Smith_bmi_discovery
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery	Supplementary Table 2	DNA methylation	HOMA-IR	Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (cross ancestry)	456	1	Adults (18-65 years)	Females	European,South Asian	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.158221027	0.03551012	0.0000106	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	ENTPD1 protein levels (SeqId = 7999-23)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ENTPD1 protein levels (SeqId = 7999-23)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ectonucleoside triphosphate diphosphohydrolase 1	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.35	0.081	0.000011	None	Gadd-DA_entpd1_protein_levels__seqid___7999-23__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EBI3 protein levels (SeqId = 10851-77)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EBI3 protein levels (SeqId = 10851-77)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-27 subunit beta	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.35	0.081	0.000012	None	Gadd-DA_ebi3_protein_levels__seqid___10851-77__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0384872	0.00881273	0.00001266984	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	LY75 protein levels (SeqId = 16620-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LY75 protein levels (SeqId = 16620-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lymphocyte antigen 75	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.35	0.08	0.000013	None	Gadd-DA_ly75_protein_levels__seqid___16620-26__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0359722	0.00825123	0.00001311802	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0383113	0.00881803	0.00001404325	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	LTA protein levels (SeqId = 3505-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LTA protein levels (SeqId = 3505-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lymphotoxin-alpha|Lymphotoxin-beta	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.35	0.081	0.000015	None	Gadd-DA_lta_protein_levels__seqid___3505-6__somascan_protein_measurement
Battram T	GEO	27886173	2020-09-15	Inflammatory bowel disease	EFO_0003767	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Inflammatory bowel disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	240	1	Adults	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.056	0.01266	0.000015	None	27886173_Battram-T_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0377188	0.00872875	0.00001561937	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	FCRL1 protein levels (SeqId = 5728-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FCRL1 protein levels (SeqId = 5728-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fc receptor-like protein 1	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.35	0.081	0.000016	None	Gadd-DA_fcrl1_protein_levels__seqid___5728-60__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0379919	0.00880821	0.00001619335	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0378928	0.00879579	0.00001657627	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0354717	0.00825138	0.00001727644	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0368494	0.00858937	0.00001797277	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	MRC1 protein levels (SeqId = 2637-77)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MRC1 protein levels (SeqId = 2637-77)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Macrophage mannose receptor 1	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.34	0.081	0.000022	None	Gadd-DA_mrc1_protein_levels__seqid___2637-77__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SIGLEC14 protein levels (SeqId = 8248-222)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SIGLEC14 protein levels (SeqId = 8248-222)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sialic acid-binding Ig-like lectin 14	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.34	0.081	0.000022	None	Gadd-DA_siglec14_protein_levels__seqid___8248-222__somascan_protein_measurement
Battram T	GEO	29921915	2020-09-15	Multiple sclerosis	EFO_0003885	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE106648	None	DNA methylation	Multiple sclerosis	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	279	1	Young adults	Both	Unclear	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0423	0.00983	0.000023	None	29921915_Battram-T_multiple_sclerosis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse106648
Gadd DA	Generation Scotland	35945220	31/07/2022	IGLL1 protein levels (SeqId = 6485-59)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IGLL1 protein levels (SeqId = 6485-59)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Immunoglobulin lambda-like polypeptide 1	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.34	0.081	0.000023	None	Gadd-DA_igll1_protein_levels__seqid___6485-59__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0379908	0.00898334	0.00002361317	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	DDX58 protein levels (SeqId = 12382-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DDX58 protein levels (SeqId = 12382-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Probable ATP-dependent RNA helicase DDX58	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.34	0.081	0.000026	None	Gadd-DA_ddx58_protein_levels__seqid___12382-2__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Rheumatoid Arthritis (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Rheumatoid Arthritis (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14391	1	Adults (18-65y)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.029	0.0069	0.000026	None	Robert-F-Hillary_Prevalent_Rheumatoid_Arthritis_(Self-report)_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0344341	0.00825168	0.00003023734	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0342029	0.00825174	0.0000341831	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6J9	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6J9	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0364697	0.00881352	0.00003524068	A0A075B6J9	41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.036068	0.00874776	0.00003758539	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0340069	0.0082518	0.00003790624	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0388052	0.00942664	0.00003867003	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	RNASET2 protein levels (SeqId = 16913-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RNASET2 protein levels (SeqId = 16913-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ribonuclease T2	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.333	0.081	0.000039	None	Gadd-DA_rnaset2_protein_levels__seqid___16913-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CR2 protein levels (SeqId = 15570-99)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CR2 protein levels (SeqId = 15570-99)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement receptor type 2	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.33	0.081	0.000039	None	Gadd-DA_cr2_protein_levels__seqid___15570-99__somascan_protein_measurement
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery adjusted for surrogate variables	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	1.946	0.475	0.000041	-	28173150_serum_highdensity_lipoprotein_cholesterol_discovery_adjusted_for_surrogate_variables
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6J9	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6J9	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.0361489	0.00881117	0.00004107046	A0A075B6J9	41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	IBSP protein levels (SeqId = 3415-61)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IBSP protein levels (SeqId = 3415-61)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Bone sialoprotein 2	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.33	0.081	0.000042	None	Gadd-DA_ibsp_protein_levels__seqid___3415-61__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0360358	0.0087992	0.00004238027	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.033727	0.00825187	0.0000438946	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	FJX1 protein levels (SeqId = 7921-65)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FJX1 protein levels (SeqId = 7921-65)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Four-jointed box protein 1	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.331	0.081	0.000044	None	Gadd-DA_fjx1_protein_levels__seqid___7921-65__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UST protein levels (SeqId = 8364-74)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UST protein levels (SeqId = 8364-74)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Uronyl 2-sulfotransferase	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.33	0.081	0.000044	None	Gadd-DA_ust_protein_levels__seqid___8364-74__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0376245	0.00924298	0.00004713755	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0381254	0.00936752	0.00004726972	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	LGALS3BP protein levels (SeqId = 5000-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LGALS3BP protein levels (SeqId = 5000-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Galectin-3-binding protein	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.33	0.081	0.000053	None	Gadd-DA_lgals3bp_protein_levels__seqid___5000-52__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0333457	0.00825198	0.00005351057	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	EPHB2 protein levels (SeqId = 8225-86)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EPHB2 protein levels (SeqId = 8225-86)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ephrin type-B receptor 2	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.33	0.081	0.000058	None	Gadd-DA_ephb2_protein_levels__seqid___8225-86__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SEMA6B protein levels (SeqId = 5121-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SEMA6B protein levels (SeqId = 5121-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Semaphorin-6B	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.32	0.081	0.000061	None	Gadd-DA_sema6b_protein_levels__seqid___5121-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19827	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P19827	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0380963	0.00950386	0.00006140769	P19827	41361833_Josephine_Robertson_P19827_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0351103	0.00876049	0.00006159125	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	CD86 protein levels (SeqId = 5337-64)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD86 protein levels (SeqId = 5337-64)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-lymphocyte activation antigen CD86	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.32	0.081	0.000062	None	Gadd-DA_cd86_protein_levels__seqid___5337-64__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TINAGL1 protein levels (SeqId = 11192-168)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TINAGL1 protein levels (SeqId = 11192-168)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tubulointerstitial nephritis antigen-like	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.324	0.081	0.000064	None	Gadd-DA_tinagl1_protein_levels__seqid___11192-168__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CD14 protein levels (SeqId = 8969-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD14 protein levels (SeqId = 8969-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Monocyte differentiation antigen CD14	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.32	0.081	0.000066	None	Gadd-DA_cd14_protein_levels__seqid___8969-49__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	BTN3A3 protein levels (SeqId = 17692-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BTN3A3 protein levels (SeqId = 17692-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Butyrophilin subfamily 3 member A3	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.32	0.081	0.000069	None	Gadd-DA_btn3a3_protein_levels__seqid___17692-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0349899	0.00879659	0.00006992978	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	TNFAIP6 protein levels (SeqId = 5036-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNFAIP6 protein levels (SeqId = 5036-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tumor necrosis factor-inducible gene 6 protein	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.32	0.081	0.00008	None	Gadd-DA_tnfaip6_protein_levels__seqid___5036-50__somascan_protein_measurement
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery (south asians)	Supplementary Table 4	DNA methylation	HOMA-IR	Age,Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (south asians)	162	1	Adults (18-65 years)	Females	South Asian	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.221373979	0.055229956	0.0000817	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(south_asians)
Gadd DA	Generation Scotland	35945220	31/07/2022	TNFSF13B protein levels (SeqId = 3059-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNFSF13B protein levels (SeqId = 3059-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tumor necrosis factor ligand superfamily member 13B	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.32	0.081	0.000083	None	Gadd-DA_tnfsf13b_protein_levels__seqid___3059-50__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.032389	0.00825224	0.00008717335	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PLXNB2 protein levels (SeqId = 9216-100)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PLXNB2 protein levels (SeqId = 9216-100)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Plexin-B2	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.32	0.081	0.000088	None	Gadd-DA_plxnb2_protein_levels__seqid___9216-100__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	KL protein levels (SeqId = 15384-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KL protein levels (SeqId = 15384-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Klotho	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.32	0.081	0.00009	None	Gadd-DA_kl_protein_levels__seqid___15384-15__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MENT protein levels (SeqId = 5744-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MENT protein levels (SeqId = 5744-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein MENT	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.32	0.081	0.000093	None	Gadd-DA_ment_protein_levels__seqid___5744-12__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ISG15 protein levels (SeqId = 14151-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ISG15 protein levels (SeqId = 14151-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-like protein ISG15	774	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	-0.32	0.081	0.000093	None	Gadd-DA_isg15_protein_levels__seqid___14151-4__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.036869	0.00946779	0.00009898068	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_4