author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08274637 chr13:51417923 13 51417923 DLEU7 Island 0.009 0.00033 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08274637 chr13:51417923 13 51417923 DLEU7 Island -0.042 0.0016 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08274637 chr13:51417923 13 51417923 DLEU7 Island -0.034 0.0034 0 None 33450751_Mulder-RH_sex_discovery Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg08274637 chr13:51417923 13 51417923 DLEU7 Island 0.53653 0.00725 1.2e-143 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg08274637 chr13:51417923 13 51417923 DLEU7 Island - - 1.7099999999999998e-34 - 23526956_clear_cell_renal_carcinoma Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg08274637 chr13:51417923 13 51417923 DLEU7 Island -1.57926 0.11799 7.769999999999999e-23 - 25282492_fetal_vs_adult_liver Kazmi N PACE 31230546 2019-06-24 Preeclampsia EFO_0000668 Meta analysis unadjusted model Table S5 DNA methylation Preeclampsia Cell composition (reference based), batch effects, age, smoking, parity, diabetes, body mass index, sex Beta Values None Illumina HumanMethylation450 Cord blood None 3460 6 Infants Both Unclear cg08274637 chr13:51417923 13 51417923 DLEU7 Island -0.0537 0.0071 0.000000000000028 None 31230546_Kazmi-N_preeclampsia_meta_analysis_unadjusted_model Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg08274637 chr13:51417923 13 51417923 DLEU7 Island 0.013 0.0017 0.0000000000083 None 33564054_Kashima-K_gestational_age Kazmi N PACE 31230546 2019-06-24 Hypertensive disorders of pregnancy MONDO_0024664, EFO_0000537, EFO_0000668 Meta analysis unadjusted model Table S3 DNA methylation Hypertensive disorders of pregnancy None Beta Values None Illumina HumanMethylation450 Cord blood None 5242 10 Infants Both Unclear cg08274637 chr13:51417923 13 51417923 DLEU7 Island -0.0157 0.0025 0.0000000005 None 31230546_Kazmi-N_hypertensive_disorders_of_pregnancy_meta_analysis_unadjusted_model Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Ultrasound-estimated gestational age Table S1 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg08274637 chr13:51417923 13 51417923 DLEU7 Island 0.00084088 0.0001593 0.000000158 - 27717397_gestational_age_ultrasoundestimated_gestational_age Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg08274637 chr13:51417923 13 51417923 DLEU7 Island -0.00752 0.00144 0.00000018 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age*sex PATO_0000047,EFO_0000246 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation age*sex sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg08274637 chr13:51417923 13 51417923 DLEU7 Island 0.0017 0.00035 0.00000096 None 33450751_Mulder-RH_age_sex_discovery Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg08274637 chr13:51417923 13 51417923 DLEU7 Island 0.00070581 0.00015078 0.00000322 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg08274637 chr13:51417923 13 51417923 DLEU7 Island None None 0.0000038 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg08274637 chr13:51417923 13 51417923 DLEU7 Island - - 0.0000112 - 26500701_sex_kora_f4 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg08274637 chr13:51417923 13 51417923 DLEU7 Island None None 0.000031 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg08274637 chr13:51417923 13 51417923 DLEU7 Island 0.031 0.008 0.000064 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg08274637 chr13:51417923 13 51417923 DLEU7 Island None None 0.000067 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery