author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0019 0.00013 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0086 0.00091 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.32314 0.00354 8.3e-161 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.14014 0.00817509 3.097073e-65 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.119715 0.00819719 5.718067e-48 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.108243 0.00820806 1.740543e-39 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0961854 0.00821829 1.6820530000000001e-31 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0844272 0.00822709 1.264765e-24 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0066 0.00067 6.2e-23 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3619229 (gene symbol: BMF) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3619229 (gene symbol: BMF) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg09587957 chr15:40399101 15 40399101 BMF North shore None None 5.2e-16 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3619229__gene_symbol__bmf__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0654213 0.00823888 0.000000000000002158013 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0627242 0.00824031 0.00000000000002865777 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.061952 0.00824071 0.00000000000005892642 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0615547 0.00824091 0.00000000000008509774 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0604928 0.00824145 0.0000000000002247021 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.048 0.00713 0.000000000014 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0551274 0.00824402 0.00000000002360962 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Imgenberg-Kreuz J - 26857698 2016-11-01 Primary Sjogrens syndrome EFO_0000699 Whole blood Table S1 DNA methylation Primary Sjogrens syndrome Age, sex and cell counts Beta values - Illumina HumanMethylation450 Whole blood - 500 1 - Both European cg09587957 chr15:40399101 15 40399101 BMF North shore - - 0.0000000000653 - 26857698_primary_sjogrens_syndrome_whole_blood Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0538283 0.0082446 0.00000000006842671 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.052438 0.00824521 0.0000000002079888 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0500785 0.00824621 0.000000001287136 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0498962 0.00824629 0.000000001476854 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0494659 0.00824646 0.000000002039124 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0491614 0.00824659 0.000000002557853 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Dugue PA Melbourne Collaborative Cohort Study 31552803 2019-09-25 Smoking EFO_0006527, EFO_0004318 Current vs never smoking Supplementary table 1 DNA methylation Smoking Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects M Values None Illumina HumanMethylation450 Whole blood None 1851 1 Adults Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.06 0.0102 0.0000000036 None 31552803_Dugue-PA_smoking_current_vs_never_smoking Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0483479 0.00824692 0.000000004656077 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0477405 0.00824716 0.000000007237364 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0600808 0.0111311 0.00000006859692 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0444672 0.0082484 0.00000007114928 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0442384 0.00824849 0.00000008299326 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9BXR6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q9BXR6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0422584 0.0082492 0.0000003049617 Q9BXR6 41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0568529 0.0111346 0.0000003332634 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0418035 0.00824935 0.0000004080036 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.041327 0.00824952 0.0000005517123 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0408551 0.00824968 0.0000007414668 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0408148 0.00824969 0.0000007602953 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.040771 0.00824971 0.0000007812996 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0862592 0.0174573 0.0000007851624 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0405245 0.00824979 0.0000009103754 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH34 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH34 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0835617 0.0174696 0.000001741426 A0A0C4DH34 41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0514053 0.0111111 0.000003751172 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0379249 0.00825063 0.000004330007 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Colicino E CHARGE 32697766 07-22-2020 All cause mortality EFO_0004352 basic model Table S2 All cause mortality DNA methylation Age, Sex, Cell composition (reference based), Batch effects None M values Illumina HumanMethylation450 Whole blood Effect estimates represent hazard ratio per 10% increase in DNA methylation. 12300 12 Adults Both European, African cg09587957 chr15:40399101 15 40399101 BMF North shore 0.82 None 0.0000048 None 32697766_Colicino-E_all_cause_mortality_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0366009 0.00825104 0.000009234938 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Sikdar S PACE 31536415 2019-09-19 Prenatal smoke exposure EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318 Inverse varience-weighted fixed-effects meta-analysis Table S1 DNA methylation Prenatal smoke exposure Maternal age, socioeconomic position, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Cord blood, whole blood None 5648 9 Infants Both European, African, Unclear cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0034 0.0008 0.0000095 None 31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0491337 0.0111211 0.0000100308 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Joehanes R - 27651444 2016-10-01 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S2 DNA methylation Current versus never smoking Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood, CD4+ T cells or monocytes - 9389 16 60.3 Both European,African cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0057 0.0013 0.000015 - 27651444_smoking_current_vs_never_smoking Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.047521 0.0111262 0.00001957461 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0744862 0.0174991 0.00002088706 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0349395 0.00825153 0.00002306545 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0728526 0.017436 0.00002954029 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0460626 0.0110751 0.00003212998 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0340719 0.00825178 0.0000366304 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0714782 0.0173491 0.00003809706 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0458809 0.011139 0.00003827069 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0713083 0.0174986 0.00004623894 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0449447 0.0111258 0.00005379706 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0445503 0.0111302 0.00006294529 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3 Priyanka Choudhary PACE 38052982 Dec 5, 2023 Maternal education at the time of pregnancy None Model1_Cord_European None DNA methylation Maternal education at the time of pregnancy Sex, Cell composition (reference based), Batch effects Beta values years of schooling Illumina HumanMethylation450 Cord blood Illumina HumanMethylationEPIC was also used for some cohorts 9501 None Infants Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0003 0.000076 0.000066 None 38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_european Priyanka Choudhary PACE 38052982 Dec 5, 2023 Maternal education at the time of pregnancy None Model1_Cord_All None DNA methylation Maternal education at the time of pregnancy Sex, Cell composition (reference based), Batch effects Beta values years of schooling Illumina HumanMethylation450 Cord blood Illumina HumanMethylationEPIC was also used for some cohorts 9881 None Infants Both Admixed cg09587957 chr15:40399101 15 40399101 BMF North shore 0.00029 0.000073 0.000068 None 38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_all Sharp GC - 28603561 2017-06-08 Cleft palate vs cleft lip EFO_0003959, HP_0000175 - Additional file 5 DNA methylation Cleft palate vs cleft lip Sex and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 98 1 0 Both European,Other cg09587957 chr15:40399101 15 40399101 BMF North shore 0.02414522 0.00576727 0.0000694 - 28603561_cleft_palate_vs_cleft_lip Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0325679 0.00825219 0.00007964483 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore -0.0433115 0.0110639 0.0000909403 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH34 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH34 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0435336 0.0111266 0.00009173466 A0A0C4DH34 41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0678991 0.0173744 0.00009348139 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_4 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg09587957 chr15:40399101 15 40399101 BMF North shore None None 0.000097 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg09587957 chr15:40399101 15 40399101 BMF North shore 0.0433388 0.0111227 0.00009805914 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2