author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0029	0.00029	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-4.9	0.194	1.8999999999999998e-138	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.37933	0.00694	2.4e-119	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.159853	0.0081504	1.450612e-84	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.155653	0.00815594	3.173887e-80	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.142034	0.00841948	2.9665659999999997e-63	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.16335	0.00976496	3.090346e-62	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-3.3	0.201	3.5000000000000003e-60	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.127401	0.00818929	3.860281e-54	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.150267	0.00971412	1.490925e-53	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.297767	0.0195103	2.8841870000000007e-52	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.123814	0.00819304	3.273065e-51	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.125633	0.00836615	1.3553949999999998e-50	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.121713	0.00819519	1.552135e-49	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.296039	0.0201491	1.4147409999999998e-48	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.121318	0.00843646	1.427759e-46	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.120927	0.00849924	1.235343e-45	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.139052	0.00985276	6.223391e-45	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.117335	0.00836247	1.948293e-44	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.117915	0.0085234	2.9590260000000002e-43	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.11499	0.00848874	1.483002e-41	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.300342	0.0223487	5.611983e-41	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.110039	0.00820643	9.318559e-41	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.267455	0.0202188	9.431256e-40	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.10467	0.00821122	5.075818e-37	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.101382	0.00821403	7.957507e-35	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.101294	0.00854277	2.7698750000000003e-32	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.100145	0.00847708	4.641728e-32	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.10075	0.00854409	6.000194e-32	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.237134	0.0201782	9.110246e-32	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0963133	0.00821819	1.399975e-31	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0958576	0.00821855	2.689432e-31	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0995915	0.00854526	2.985827e-31	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0977165	0.00853512	3.206113e-30	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0967347	0.00851817	9.189784999999999e-30	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0893533	0.00822355	2.138982e-27	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.10644	0.0098046	2.371081e-27	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_4
Ligthart S	CHARGE	27955697	2016-12-12	C-reactive protein	EFO_0004458	Discovery	Table S3	DNA methylation	C-reactive protein	Age, sex, smoking, body mass index, cell counts and technical covariates	Beta values	mg/l	Illumina HumanMethylation450	Whole blood	C-reactive protein levels were log-transformed	8863	9	65	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0069	0.000637	2.53e-27	-	27955697_creactive_protein_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0924526	0.00853017	2.8751870000000002e-27	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0914301	0.00845236	3.617643e-27	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0889439	0.00822385	3.685926e-27	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0909145	0.00844047	5.934935e-27	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0918462	0.0085358	6.692123000000001e-27	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0874002	0.00822498	2.804989e-26	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0871414	0.00822516	3.928214e-26	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0869539	0.0082253	5.010339e-26	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.100364	0.00957044	1.223622e-25	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0857638	0.00822615	2.319647e-25	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.239505	0.0231714	5.713796e-25	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0881436	0.00855334	8.1149280000000005e-25	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.103451	0.0100541	9.543752000000001e-25	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.23458	0.0230242	2.6169969999999998e-24	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0838062	0.00822753	2.756154e-24	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0832195	0.00822231	5.335863e-24	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0864059	0.00854789	6.071963e-24	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0861495	0.00853466	7.022734e-24	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0826819	0.0082283	1.1129140000000001e-23	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0821932	0.00822863	2.029494e-23	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0970892	0.00996596	2.331848e-22	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0793347	0.00823055	6.351641e-22	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.081955	0.00854503	1.010784e-21	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0807233	0.00854621	4.061053e-21	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0794223	0.00854806	1.735552e-20	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0924503	0.0100945	5.951703e-20	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0028	None	7.3e-20	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-	-	7.58e-20	-	26857698_primary_sjogrens_syndrome_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.074809	0.00854022	2.171147e-18	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0717807	0.00823527	3.1800430000000002e-18	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0736729	0.0085339	6.585941e-18	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.070614	0.00823596	1.099666e-17	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0725473	0.00857093	2.817556e-17	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0716563	0.00856167	6.308432e-17	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.083679	0.0100021	6.486867e-17	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Marttila S	-	25888029	2015-03-14	Ageing	GO_0007568	-	Additional file 1	DNA methylation	Age group	Sex and cell counts	Beta values	-	Illumina HumanMethylation450	Peripheral blood mononuclear cells	Variable dispersion beta regression model	143	1	58.5	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.71400911	0.086	1.05e-16	-	25888029_ageing
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.034	0.00412	1.2e-16	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0805634	0.0097558	1.60715e-16	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.190772	0.023113	1.642838e-16	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0703516	0.00856437	2.307986e-16	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0694705	0.00856182	5.284985e-16	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0696384	0.00861409	6.740814e-16	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0815078	0.0101196	8.598342e-16	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0666547	0.00833741	0.000000000000001395918	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0650771	0.00823907	0.000000000000003019722	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0648272	0.0082392	0.000000000000003849855	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0675846	0.00859187	0.000000000000003912522	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0785501	0.0100037	0.000000000000004374315	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0783872	0.00998665	0.000000000000004476013	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.064157	0.00823956	0.000000000000007350893	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0666696	0.00857362	0.000000000000007973641	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0634809	0.0082921	0.00000000000002044162	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0658365	0.00860237	0.00000000000002080691	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0658222	0.00864272	0.00000000000002777944	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_3
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	Discovery and replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	Weighted Z-test meta-analysis	10238	13	54.5	Both	European,South Asian	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-	-	0.000000000000035	-	28002404_body_mass_index_discovery_and_replication
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.069	0.0092	0.000000000000035	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0756574	0.0100034	0.00000000000004168107	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0650604	0.00861406	0.00000000000004510595	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0647615	0.00857514	0.00000000000004530347	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0756882	0.0100584	0.00000000000005582784	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0643995	0.00856487	0.00000000000005837703	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0756289	0.0100993	0.00000000000007363663	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0622763	0.00836691	0.0000000000001037661	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0612722	0.00824106	0.0000000000001103556	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0636723	0.00857256	0.0000000000001168003	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0672494	0.00915154	0.0000000000002111645	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0628713	0.00856567	0.0000000000002249606	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.062835	0.00857194	0.0000000000002416032	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.06337	0.00864898	0.0000000000002478802	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0628708	0.00864707	0.0000000000003755255	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0657458	0.00926828	0.000000000001366202	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0606757	0.0085944	0.000000000001740936	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0598348	0.00857767	0.000000000003175003	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0702074	0.0100928	0.000000000003643971	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0572437	0.00824303	0.000000000003957735	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0569417	0.00824318	0.000000000005126848	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	GBP1 protein levels (SeqId = 15326-64)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GBP1 protein levels (SeqId = 15326-64)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Guanylate-binding protein 1	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.67	0.097	0.0000000000065	None	Gadd-DA_gbp1_protein_levels__seqid___15326-64__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0584718	0.00853758	0.000000000007746032	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0586314	0.00856268	0.000000000007823737	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0591223	0.00865862	0.000000000008940011	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_3
Fernandez-Sanles A	REGICOR	33883000	04-21-2021	Acute myocardial infarction	EFO_0008583	Meta-analysis model1	Additional Table 2	Acute myocardial infarction	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	None	Beta values	Illumina HumanMethylationEPIC	Whole blood	Cases and controls matched by age and sex. Blood samples were drawn within the first 24 hours post-AMI for cases and at follow-up for controls.	595	2	Adults	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.96	0.14	0.00000000001	None	33883000_Fernandez-Sanles-A_acute_myocardial_infarction_meta-analysis_model1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0685121	0.0100584	0.00000000001003873	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.15086	0.022496	0.00000000002057801	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0552107	0.00824398	0.0000000000220329	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0548526	0.00824414	0.00000000002962862	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0548739	0.00830425	0.00000000004031712	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0665253	0.0101396	0.00000000005526184	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0539096	0.00824456	0.00000000006406483	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0651216	0.00998974	0.00000000007316633	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_4
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.00139389	0.0002123	0.0000000000807	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0536186	0.00824469	0.00000000008106393	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0653708	0.0101343	0.0000000001150328	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0547254	0.00857646	0.0000000001813567	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0615737	0.00967677	0.0000000002036769	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0534858	0.00858135	0.0000000004707096	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_2
Fernandez-Sanles A	REGICOR	33883000	04-21-2021	Acute myocardial infarction	EFO_0008583	Meta-analysis model2	Additional Table 2	Acute myocardial infarction	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects	None	Beta values	Illumina HumanMethylationEPIC	Whole blood	Cases and controls matched by age and sex. Blood samples were drawn within the first 24 hours post-AMI for cases and at follow-up for controls.	582	2	Adults	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.98	0.16	0.00000000052	None	33883000_Fernandez-Sanles-A_acute_myocardial_infarction_meta-analysis_model2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0507367	0.00824594	0.0000000007804	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0500921	0.00824621	0.000000001273989	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0499969	0.00824625	0.000000001368952	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.060088	0.0100323	0.000000002154604	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0474795	0.00794553	0.000000002345144	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0593402	0.0100475	0.000000003583199	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0507972	0.00861271	0.000000003761911	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Mendelson MM	FHS	29740313	2018-04-24	Soluble tumor necrosis factor receptor 2	EFO_0008384, NCIT_C117749	None	Table S1	DNA methylation	Soluble tumor necrosis factor receptor 2	Age, sex, body mass index, smoking, batch effects	Beta Values	pg/ml	Illumina HumanMethylation450	Whole blood	None	2468	1	Adults	Both	Unclear	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0162	0.00276	0.0000000052	None	29740313_Mendelson-MM_soluble_tumor_necrosis_factor_receptor_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0498589	0.00855586	0.000000005746108	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0497444	0.00855037	0.000000006086678	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_2
Ligthart S	CHARGE	27955697	2016-12-12	C-reactive protein	EFO_0004458	Replication	Table S3	DNA methylation	C-reactive protein	Age, sex, smoking, body mass index, cell counts and technical covariates	Beta values	mg/l	Illumina HumanMethylation450	Whole blood	C-reactive protein levels were log-transformed	4111	4	59.7	Missing	African	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0081	0.001395	0.00000000631	-	27955697_creactive_protein_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.047648	0.00824719	0.000000007736741	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	PACAP protein levels (SeqId = 16322-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PACAP protein levels (SeqId = 16322-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Marginal zone B- and B1-cell-specific protein	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.57	0.098	0.0000000083	None	Gadd-DA_pacap_protein_levels__seqid___16322-10__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0492255	0.00857633	0.000000009672581	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0473101	0.00824733	0.000000009860791	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0472587	0.00824735	0.00000001023001	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0490152	0.00861034	0.00000001275143	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0577188	0.0101456	0.0000000130213	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0483453	0.00855926	0.00000001650478	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0462783	0.00824773	0.000000020476	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry discovery	Table S3	Body mass index	DNA mehtylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	5387	4	54.5	Both	European,South Asian	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-12.7	2.1	0.000000021	-	28002404_body_mass_index_all_ancestry_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0479124	0.00858196	0.00000002407003	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0460444	0.00824781	0.00000002411259	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Chronic Pain	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Chronic Pain	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	11591	1	Adults (18-65y)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.056	0.01	0.000000026	None	Robert-F-Hillary_Incident_Chronic_Pain_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0550672	0.00998406	0.00000003536599	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.019	0.00349	0.000000037	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0467983	0.00858343	0.00000005056309	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0466213	0.0085941	0.0000000589374	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.046785	0.00863581	0.00000006137165	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0457853	0.00857925	0.00000009603568	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0460017	0.00865806	0.0000001093123	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0456117	0.00865356	0.0000001377088	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0448695	0.0085772	0.0000001706815	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_2
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	European ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2707	3	57.9	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-10.74	2.07	0.00000021	-	28002404_body_mass_index_european_ancestry_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	GZMA protein levels (SeqId = 3440-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GZMA protein levels (SeqId = 3440-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granzyme A	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.51	0.099	0.00000025	None	Gadd-DA_gzma_protein_levels__seqid___3440-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0446297	0.00866249	0.000000260983	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0439522	0.00857347	0.0000002988721	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0438625	0.00857947	0.0000003219311	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	4851	9	54.5	Both	European,South Asian	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-6.5	1.3	0.00000034	-	28002404_body_mass_index_all_ancestry_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0420184	0.00824928	0.0000003557075	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Fernandez-Sanles A	REGICOR	33883000	04-21-2021	Acute myocardial infarction	EFO_0008583	Meta-analysis model3	Additional Table 2	Acute myocardial infarction	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, diabetes, hypertension, hypercholesterolemia	None	Beta values	Illumina HumanMethylationEPIC	Whole blood	Cases and controls matched by age and sex. Blood samples were drawn within the first 24 hours post-AMI for cases and at follow-up for controls.	506	2	Adults	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.86	0.17	0.00000037	None	33883000_Fernandez-Sanles-A_acute_myocardial_infarction_meta-analysis_model3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0437911	0.0086312	0.0000003951646	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0415654	0.00824944	0.0000004745993	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CRP protein levels (SeqId = 4337-49)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CRP protein levels (SeqId = 4337-49)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-reactive protein	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.5	0.099	0.00000049	None	Gadd-DA_crp_protein_levels__seqid___4337-49__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0428737	0.00854376	0.000000527868	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	C5 protein levels (SeqId = 2381-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C5 protein levels (SeqId = 2381-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement C5	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.5	0.099	0.00000054	None	Gadd-DA_c5_protein_levels__seqid___2381-52__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0411226	0.00824959	0.0000006273028	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CHAD protein levels (SeqId = 13460-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CHAD protein levels (SeqId = 13460-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Chondroadherin	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.49	0.099	0.00000066	None	Gadd-DA_chad_protein_levels__seqid___13460-4__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0408919	0.00824967	0.0000007246533	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0497457	0.0100441	0.0000007399353	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0404137	0.00824983	0.0000009748316	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0420535	0.00858957	0.0000009890969	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	C3 protein levels (SeqId = 2754-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C3 protein levels (SeqId = 2754-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement C3	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.48	0.099	0.0000011	None	Gadd-DA_c3_protein_levels__seqid___2754-50__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.04105	0.00843638	0.00000115161	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CXCL9 protein levels (SeqId = 9188-119)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXCL9 protein levels (SeqId = 9188-119)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-X-C motif chemokine 9	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.48	0.099	0.0000012	None	Gadd-DA_cxcl9_protein_levels__seqid___9188-119__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14350	1	Adults (18-65y)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.047	0.0097	0.0000012	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0416086	0.00857467	0.000001231686	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0399486	0.00824998	0.000001296782	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.04885	0.0101233	0.000001410694	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0485662	0.0100669	0.000001418889	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0397654	0.00825004	0.000001449751	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TP53 protein levels (SeqId = 6123-69)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TP53 protein levels (SeqId = 6123-69)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cellular tumor antigen p53	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.47	0.099	0.0000016	None	Gadd-DA_tp53_protein_levels__seqid___6123-69__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LRRC15 protein levels (SeqId = 6557-50)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LRRC15 protein levels (SeqId = 6557-50)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leucine-rich repeat-containing protein 15	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.47	0.099	0.0000017	None	Gadd-DA_lrrc15_protein_levels__seqid___6557-50__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0482193	0.0101346	0.000001974833	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_4
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	South Asian ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2680	1	51.0	Both	South Asian	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-30.81	5.7	0.000002	-	28002404_body_mass_index_south_asian_ancestry_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0390877	0.00825026	0.000002181238	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0406142	0.00857279	0.000002183182	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0407983	0.0086583	0.00000247495	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0402984	0.00857731	0.000002647737	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	CXCL10 protein levels (SeqId = 4141-79)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXCL10 protein levels (SeqId = 4141-79)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-X-C motif chemokine 10	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.46	0.099	0.0000027	None	Gadd-DA_cxcl10_protein_levels__seqid___4141-79__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0367151	0.00785994	0.000003021613	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	COL11A2 protein levels (SeqId = 11278-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COL11A2 protein levels (SeqId = 11278-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Collagen alpha-2(XI) chain	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.46	0.099	0.0000032	None	Gadd-DA_col11a2_protein_levels__seqid___11278-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SAA1 protein levels (SeqId = 15515-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SAA1 protein levels (SeqId = 15515-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serum amyloid A-1 protein	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.46	0.099	0.0000039	None	Gadd-DA_saa1_protein_levels__seqid___15515-2__somascan_protein_measurement
Darina Czamara	BET, ITU, PREDO	38600394	Apr 10, 2024	sex	EFO:0000001	meta-analysis of robust linear regression results per cohort	None	DNA methylation	sex	Smoking,Cell composition (reference based),Gestational age	M values	None	Illumina HumanMethylationEPIC	placenta	None	746	3	Infants (< 4 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.1637553	0.0355827	0.000004182	None	38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.037913	0.00825064	0.000004360296	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	NTM protein levels (SeqId = 10907-116)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NTM protein levels (SeqId = 10907-116)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neurotrimin	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.45	0.099	0.0000045	None	Gadd-DA_ntm_protein_levels__seqid___10907-116__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0392762	0.00856855	0.000004604649	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	European ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	4195	8	54.6	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-5.65	1.24	0.0000048	-	28002404_body_mass_index_european_ancestry_replication
Gadd DA	Generation Scotland	35945220	31/07/2022	ITIH4 protein levels (SeqId = 4811-33)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ITIH4 protein levels (SeqId = 4811-33)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Inter-alpha-trypsin inhibitor heavy chain H4	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.45	0.099	0.0000051	None	Gadd-DA_itih4_protein_levels__seqid___4811-33__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0394326	0.00865237	0.000005220054	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	C5 protein levels (SeqId = 4482-66)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C5 protein levels (SeqId = 4482-66)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement C5|Complement component C6	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.45	0.099	0.0000053	None	Gadd-DA_c5_protein_levels__seqid___4482-66__somascan_protein_measurement
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-	-	0.00000564	-	26500701_sex_kora_f4
Gadd DA	Generation Scotland	35945220	31/07/2022	CHST12 protein levels (SeqId = 6626-81)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CHST12 protein levels (SeqId = 6626-81)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Carbohydrate sulfotransferase 12	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.45	0.099	0.0000057	None	Gadd-DA_chst12_protein_levels__seqid___6626-81__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0386221	0.00858033	0.000006807917	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P19652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0370486	0.0082509	0.000007168103	P19652	41361833_Josephine_Robertson_P19652_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	STAT1 protein levels (SeqId = 10370-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STAT1 protein levels (SeqId = 10370-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Signal transducer and activator of transcription 1-alpha/beta	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.44	0.099	0.0000073	None	Gadd-DA_stat1_protein_levels__seqid___10370-21__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0369585	0.00825093	0.00000754497	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0871045	0.0195435	0.000008362352	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	MRC1 protein levels (SeqId = 2637-77)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MRC1 protein levels (SeqId = 2637-77)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Macrophage mannose receptor 1	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.44	0.099	0.0000084	None	Gadd-DA_mrc1_protein_levels__seqid___2637-77__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	C9 protein levels (SeqId = 3060-43)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C9 protein levels (SeqId = 3060-43)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement component C9	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.43	0.097	0.0000086	None	Gadd-DA_c9_protein_levels__seqid___3060-43__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TPP1 protein levels (SeqId = 17691-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TPP1 protein levels (SeqId = 17691-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tripeptidyl-peptidase 1	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.44	0.099	0.0000091	None	Gadd-DA_tpp1_protein_levels__seqid___17691-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SOD3 protein levels (SeqId = 5660-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SOD3 protein levels (SeqId = 5660-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Extracellular superoxide dismutase [Cu-Zn]	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.44	0.098	0.0000092	None	Gadd-DA_sod3_protein_levels__seqid___5660-51__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	13971	1	Adults (18-65y)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.02	0.00443	0.0000093	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model
Gadd DA	Generation Scotland	35945220	31/07/2022	SAA2 protein levels (SeqId = 18832-65)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SAA2 protein levels (SeqId = 18832-65)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serum amyloid A-2 protein	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.44	0.099	0.0000094	None	Gadd-DA_saa2_protein_levels__seqid___18832-65__somascan_protein_measurement
Liu C	CHARGE+	27843151	2016-11-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	African ancestry	Table S6	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g per day	Illumina HumanMethylation450	Whole blood	-	2423	3	56	Both	African	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-6.81e-05	1.55e-05	0.0000109	-	27843151_alcohol_consumption_per_day_african_ancestry
Gadd DA	Generation Scotland	35945220	31/07/2022	CFB protein levels (SeqId = 4129-72)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CFB protein levels (SeqId = 4129-72)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement factor B	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.43	0.099	0.000011	None	Gadd-DA_cfb_protein_levels__seqid___4129-72__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0361415	0.00825118	0.00001194128	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	IMPDH1 protein levels (SeqId = 5229-90)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IMPDH1 protein levels (SeqId = 5229-90)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Inosine-5'-monophosphate dehydrogenase 1	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.43	0.098	0.000012	None	Gadd-DA_impdh1_protein_levels__seqid___5229-90__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0432723	0.00990003	0.00001245713	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.036901	0.00846478	0.00001313304	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0372774	0.00856941	0.0000137028	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	SLAMF6 protein levels (SeqId = 5128-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SLAMF6 protein levels (SeqId = 5128-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: SLAM family member 6	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.43	0.099	0.000014	None	Gadd-DA_slamf6_protein_levels__seqid___5128-53__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	C5 protein levels (SeqId = 2851-63)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C5 protein levels (SeqId = 2851-63)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement C5	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.43	0.098	0.000014	None	Gadd-DA_c5_protein_levels__seqid___2851-63__somascan_protein_measurement
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting insulin	EFO_0004466	Base	Supplementary Data 1	DNA methylation	fasting insulin	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	log pmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.8	0.18	0.000015	4732	31197173_Liu-J_fasting_insulin_base
Gadd DA	Generation Scotland	35945220	31/07/2022	NPTN protein levels (SeqId = 7194-36)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NPTN protein levels (SeqId = 7194-36)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neuroplastin	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.43	0.099	0.000015	None	Gadd-DA_nptn_protein_levels__seqid___7194-36__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0423062	0.00977432	0.00001512603	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	ADM2 protein levels (SeqId = 8100-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADM2 protein levels (SeqId = 8100-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein ADM2	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.43	0.099	0.000016	None	Gadd-DA_adm2_protein_levels__seqid___8100-15__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0434443	0.0100853	0.0000166053	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CFI protein levels (SeqId = 2567-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CFI protein levels (SeqId = 2567-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement factor I	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.43	0.099	0.000017	None	Gadd-DA_cfi_protein_levels__seqid___2567-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0368631	0.00856971	0.00001706984	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	IMPDH2 protein levels (SeqId = 5250-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IMPDH2 protein levels (SeqId = 5250-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Inosine-5'-monophosphate dehydrogenase 2	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.42	0.099	0.000019	None	Gadd-DA_impdh2_protein_levels__seqid___5250-53__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0084	0.002	0.00002	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	CST6 protein levels (SeqId = 14711-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CST6 protein levels (SeqId = 14711-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cystatin-M	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.42	0.099	0.000021	None	Gadd-DA_cst6_protein_levels__seqid___14711-27__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0429869	0.0101288	0.00002209159	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.03668	0.00866335	0.00002310479	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	FOXJ2 protein levels (SeqId = 14204-55)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FOXJ2 protein levels (SeqId = 14204-55)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Forkhead box protein J2	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.417	0.099	0.000024	None	Gadd-DA_foxj2_protein_levels__seqid___14204-55__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NTM protein levels (SeqId = 8428-102)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NTM protein levels (SeqId = 8428-102)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neurotrimin	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.42	0.099	0.000025	None	Gadd-DA_ntm_protein_levels__seqid___8428-102__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MXRA8 protein levels (SeqId = 10521-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MXRA8 protein levels (SeqId = 10521-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Matrix remodeling-associated protein 8	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.42	0.099	0.000025	None	Gadd-DA_mxra8_protein_levels__seqid___10521-10__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0346627	0.00825161	0.00002676395	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_1
Inkster A	Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827	34044884	03-08-2021	Sex	PATO_0001894	Discovery	Supplementary Table 1	DNA methylation	Sex	Ancestry (genomic PCs), Gestational age, Dataset	M values	None	Illumina HumanMethylation450	Placenta	None	585	4	Infants	Both	European, East Asian, African, Admixed	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	2.1	None	0.000029	None	34044884_Inkster-A_sex_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	SLAMF7 protein levels (SeqId = 5487-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SLAMF7 protein levels (SeqId = 5487-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: SLAM family member 7	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.41	0.099	0.000029	None	Gadd-DA_slamf7_protein_levels__seqid___5487-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MSR1 protein levels (SeqId = 15533-97)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MSR1 protein levels (SeqId = 15533-97)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Macrophage scavenger receptor types I and II	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.412	0.099	0.000031	None	Gadd-DA_msr1_protein_levels__seqid___15533-97__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	OPCML protein levels (SeqId = 15622-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	OPCML protein levels (SeqId = 15622-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Opioid-binding protein/cell adhesion molecule	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.411	0.099	0.000031	None	Gadd-DA_opcml_protein_levels__seqid___15622-13__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	UROD protein levels (SeqId = 19289-29)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UROD protein levels (SeqId = 19289-29)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Uroporphyrinogen decarboxylase	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.41	0.099	0.000032	None	Gadd-DA_urod_protein_levels__seqid___19289-29__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0356518	0.00858126	0.00003276941	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0409019	0.00987956	0.0000349175	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	TTN protein levels (SeqId = 11352-42)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TTN protein levels (SeqId = 11352-42)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Titin	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.41	0.099	0.000036	None	Gadd-DA_ttn_protein_levels__seqid___11352-42__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0418184	0.0101468	0.0000378748	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	DSG2 protein levels (SeqId = 9484-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DSG2 protein levels (SeqId = 9484-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Desmoglein-2	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.41	0.099	0.000038	None	Gadd-DA_dsg2_protein_levels__seqid___9484-75__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GOLM1 protein levels (SeqId = 17456-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GOLM1 protein levels (SeqId = 17456-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Golgi membrane protein 1	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.41	0.099	0.000039	None	Gadd-DA_golm1_protein_levels__seqid___17456-53__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0414355	0.0100979	0.00004093813	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0351247	0.00856348	0.00004123557	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	CXCL11 protein levels (SeqId = 3038-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXCL11 protein levels (SeqId = 3038-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-X-C motif chemokine 11	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.4	0.099	0.000042	None	Gadd-DA_cxcl11_protein_levels__seqid___3038-9__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0352936	0.0086232	0.00004283538	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0334498	0.00825195	0.00005070264	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0347868	0.00863045	0.00005589055	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	TMEM132C protein levels (SeqId = 7173-141)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TMEM132C protein levels (SeqId = 7173-141)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transmembrane protein 132C	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.4	0.099	0.000062	None	Gadd-DA_tmem132c_protein_levels__seqid___7173-141__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CD163 protein levels (SeqId = 5028-59)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD163 protein levels (SeqId = 5028-59)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Scavenger receptor cysteine-rich type 1 protein M130	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.39	0.099	0.000063	None	Gadd-DA_cd163_protein_levels__seqid___5028-59__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0404454	0.0101138	0.0000639096	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CREBBP protein levels (SeqId = 13614-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CREBBP protein levels (SeqId = 13614-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CREB-binding protein	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.39	0.099	0.000065	None	Gadd-DA_crebbp_protein_levels__seqid___13614-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	VEGFA protein levels (SeqId = 2597-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VEGFA protein levels (SeqId = 2597-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Vascular endothelial growth factor A	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.39	0.099	0.000066	None	Gadd-DA_vegfa_protein_levels__seqid___2597-8__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.0384941	0.00967237	0.00006930436	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Osteoarthritis	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Osteoarthritis	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	16114	1	Adults (18-65y)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.028	0.00706	0.000072	None	Robert-F-Hillary_Incident_Osteoarthritis_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	0.03403	0.00857881	0.00007320623	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	C6 protein levels (SeqId = 4127-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C6 protein levels (SeqId = 4127-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement component C6	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.39	0.098	0.000077	None	Gadd-DA_c6_protein_levels__seqid___4127-75__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LY9 protein levels (SeqId = 3324-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LY9 protein levels (SeqId = 3324-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-lymphocyte surface antigen Ly-9	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.39	0.099	0.000078	None	Gadd-DA_ly9_protein_levels__seqid___3324-51__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	F9 protein levels (SeqId = 4876-32)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	F9 protein levels (SeqId = 4876-32)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Coagulation factor IX	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.39	0.099	0.00008	None	Gadd-DA_f9_protein_levels__seqid___4876-32__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.0398608	0.0101055	0.00008034749	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CLPSL1 protein levels (SeqId = 9526-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CLPSL1 protein levels (SeqId = 9526-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Colipase-like protein 1	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.39	0.099	0.000086	None	Gadd-DA_clpsl1_protein_levels__seqid___9526-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SERPINA7 protein levels (SeqId = 2706-69)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SERPINA7 protein levels (SeqId = 2706-69)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thyroxine-binding globulin	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.39	0.099	0.000089	None	Gadd-DA_serpina7_protein_levels__seqid___2706-69__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DNAJB9 protein levels (SeqId = 11214-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DNAJB9 protein levels (SeqId = 11214-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: DnaJ homolog subfamily B member 9	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.39	0.099	0.000089	None	Gadd-DA_dnajb9_protein_levels__seqid___11214-40__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	C4A protein levels (SeqId = 18821-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C4A protein levels (SeqId = 18821-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement C4-A|Complement C4-B	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.39	0.099	0.000089	None	Gadd-DA_c4a_protein_levels__seqid___18821-9__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TXNDC5 protein levels (SeqId = 11212-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TXNDC5 protein levels (SeqId = 11212-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thioredoxin domain-containing protein 5	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.387	0.099	0.000092	None	Gadd-DA_txndc5_protein_levels__seqid___11212-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DHX58 protein levels (SeqId = 14012-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DHX58 protein levels (SeqId = 14012-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Probable ATP-dependent RNA helicase DHX58	774	1	Adults (18-65 years)	Both	European	cg10636246	chr1:159046973	1	159046973	AIM2	Open sea	-0.39	0.099	0.000093	None	Gadd-DA_dhx58_protein_levels__seqid___14012-17__somascan_protein_measurement