author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0029	0.00011	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	3187	2	65.7	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.038	0.004	0	-	28173150_serum_triglycerides_discovery_and_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for surrogate variables	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	3187	2	65.7	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.062	0.005	0	-	28173150_serum_triglycerides_discovery_and_replication_adjusted_for_surrogate_variables
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication adjusted for surrogate variables	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	3187	2	65.7	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-3.431	0.337	0	-	28173150_serum_highdensity_lipoprotein_cholesterol_discovery_and_replication_adjusted_for_surrogate_variables
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.23471	0.047298	2.265018e-147	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.26608	0.054535	1.958871e-117	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.31923	0.00635	7.5e-113	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.06596	0.0476467	2.605117e-109	None	39706196_Hannah-M.-Smith_body_fat_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.03279	0.0475389	2.847969e-103	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.12203	0.0550806	3.579438e-91	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.00621	0.0550055	4.710761e-74	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	5.8	0.331	9.1e-68	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.145657	0.00891595	1.811702e-59	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.14326	0.00889747	7.834636e-58	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.749214	0.0466214	1.029871e-57	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.15	0.00993	2.8e-48	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	Discovery and replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	Weighted Z-test meta-analysis	10238	13	54.5	Both	European,South Asian	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-	-	9.3e-47	-	28002404_body_mass_index_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.116983	0.00819988	7.175967e-46	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.122379	0.00891178	1.194968e-42	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.109727	0.00820672	1.555003e-40	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.108981	0.00820739	5.252965e-40	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.108714	0.00820764	8.118137e-40	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.707423	0.053825	2.817792e-39	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.115489	0.00893436	5.154217e-38	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.111397	0.00891932	1.294982e-35	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0982865	0.00821659	7.990965000000001e-33	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.106889	0.00895004	1.0038300000000001e-32	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.105653	0.00895782	5.807652e-32	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.105338	0.00893896	6.562814e-32	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.096087	0.00821837	1.936812e-31	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.102357	0.00885803	9.438977e-31	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Sayols-Baixeras S	REGICOR, Framingham Offspring Study	29099282	2017-11-27	Waist circumference	EFO_0004342	Meta-analysis model 1	Supplementary table 4	Waist circumference	DNA methylation	Age, sex, smoking, cell composition (reference based)	cm	M Values	Illumina HumanMethylation450	Whole blood	Removed individuals with BMI < 18.5	3156	2	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	2.3	0.2	1.3000000000000001e-30	None	29099282_Sayols-Baixeras-S_waist_circumference_meta-analysis_model_1
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-	-	1.72e-30	-	28056824_age_4_vs_age_0
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.102794	0.00895784	2.3664159999999998e-30	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.121361	0.0106662	7.176304e-30	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.093231	0.00822061	1.091051e-29	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.24	0.022	3.7e-27	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4261	5	65	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0101959	0.0009457	4.22e-27	-	28213390_serum_triglycerides_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0884386	0.00822422	7.190743e-27	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0957866	0.00894537	1.17191e-26	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Sayols-Baixeras S	REGICOR, Framingham Offspring Study	29099282	2017-11-27	Waist circumference	EFO_0004342	Meta-analysis model 2	Supplementary table 4	Waist circumference	DNA methylation	Age, sex, smoking, cell composition (reference based), batch effects	cm	M Values	Illumina HumanMethylation450	Whole blood	Removed individuals with BMI < 18.5	3156	2	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	3.2	0.3	1.5e-26	None	29099282_Sayols-Baixeras-S_waist_circumference_meta-analysis_model_2
Sayols-Baixeras S	REGICOR, Framingham Offspring Study	29099282	2017-11-27	Body mass index	EFO_0004340	Meta-analysis model 2	Supplementary table 3	Body mass index	DNA methylation	Age, sex, smoking, cell composition (reference based), batch effects	Kg/m2	M Values	Illumina HumanMethylation450	Whole blood	Removed individuals with BMI < 18.5	3156	2	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.16	0.11	5.3e-26	None	29099282_Sayols-Baixeras-S_body_mass_index_meta-analysis_model_2
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication adjusted for surrogate variables	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	2542	1	66.3	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.061	0.006	9.8e-26	-	28173150_serum_triglycerides_replication_adjusted_for_surrogate_variables
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0863259	0.00822575	1.127837e-25	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	4851	9	54.5	Both	European,South Asian	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	22.7	2.2	3e-25	-	28002404_body_mass_index_all_ancestry_replication
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Meta-analysis	Table 2	DNA methylation	Body mass index	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Leukocytes, whole blood and CD4+ T cells	Regression coefficient per 1 SD of body mass index	5464	4	59.6	Both	European,African	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-	-	2.76e-24	-	25935004_body_mass_index_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.106832	0.0104939	2.9216500000000004e-24	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0900496	0.00896572	1.167153e-23	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry discovery	Table S3	Body mass index	DNA mehtylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	5387	4	54.5	Both	European,South Asian	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	32.5	3	1.9e-23	-	28002404_body_mass_index_all_ancestry_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0818331	0.00822888	3.1527810000000003e-23	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0808563	0.00822954	1.0313160000000001e-22	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0806896	0.00822965	1.260633e-22	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0870434	0.00896228	3.121125e-22	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Meta-analysis	Table S1	DNA methylation	Body mass index	Age, sex, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood	Weighted Z-test meta-analysis	3743	4	69.2	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-	-	4.82e-22	-	28095459_body_mass_index_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0771925	0.00823194	7.747711e-21	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0839574	0.00897497	9.584188e-21	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.100869	0.0109137	2.736042e-20	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication	Table S1	DNA methylation	Triglycerides	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.015	0.0016	2.85e-20	-	28194238_triglycerides_discovery_and_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Replication adjusted for surrogate variables	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	2542	1	66.3	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-3.762	0.408	3.1e-20	-	28173150_serum_highdensity_lipoprotein_cholesterol_replication_adjusted_for_surrogate_variables
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0811732	0.00883459	4.5251139999999995e-20	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0821951	0.00897042	5.710814e-20	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	European ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2707	3	57.9	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	28	3.07	7.1e-20	-	28002404_body_mass_index_european_ancestry_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0748992	0.00823338	1.045928e-19	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-HDL-TG	None	Meta-analysis	Table S2	DNA methylation	S-HDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in small HDL	5414	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.7	0.19	2.5e-19	None	33413638_Gomez-Alonso-MDC_s-hdl-tg_meta-analysis
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for lipid-lowering medication use	Table 3	DNA methylation	Triglycerides	Age, sex, smoking, lipid-lowering medication use, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0147	0.0016	3e-19	-	28194238_triglycerides_discovery_and_replication_lipidlowering_medication_use_adjusted
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0820714	0.00914083	3.0722939999999996e-19	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	sensitivity	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.496454	0.0555465	4.355575e-19	None	39706196_Hannah-M.-Smith_glucose_sensitivity
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	13971	1	Adults (18-65y)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.096	0.01078	4.6e-19	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0799333	0.00897299	5.78719e-19	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Sayols-Baixeras S	REGICOR, Framingham Offspring Study	29099282	2017-11-27	Body mass index	EFO_0004340	Meta-analysis model 1	Supplementary table 3	Body mass index	DNA methylation	Age, sex, smoking, cell composition (reference based)	Kg/m2	M Values	Illumina HumanMethylation450	Whole blood	Removed individuals with BMI < 18.5	3156	2	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.8	0.09	6.2e-19	None	29099282_Sayols-Baixeras-S_body_mass_index_meta-analysis_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0801817	0.00902657	7.263442999999999e-19	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	European ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	4195	8	54.6	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	17.16	1.94	9.1e-19	-	28002404_body_mass_index_european_ancestry_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0714591	0.00823546	4.485768e-18	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0950712	0.0109715	4.970624e-18	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	discovery	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.412301	0.0477654	6.538513e-18	None	39706196_Hannah-M.-Smith_glucose_discovery
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Replication	Table 2	DNA methylation	Body mass index	Age, sex, smoking, study centre and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood and CD4+ T cells	Regression coefficient per 1 SD of body mass index	3368	3	61.7	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-	-	3.63e-17	-	25935004_body_mass_index_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.075137	0.00896525	5.724695e-17	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0684075	0.00823723	1.087739e-16	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0823071	0.00994073	1.339809e-16	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0902646	0.0109542	1.86387e-16	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Demerath EW	-	25935004	2015-08-01	Waist circumference	EFO_0004342	Meta-analysis	Table 3	DNA methylation	Waist circumference	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	cm	Illumina HumanMethylation450	Leukocytes and CD4+ T cells	Regression coefficient per 1 SD of waist circumference	3088	2	53.9	Both	European,African	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-	-	2.37e-16	-	25935004_waist_circumference_metaanalysis
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	2542	1	66.3	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.039	0.005	3.2e-16	-	28173150_serum_triglycerides_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0672874	0.00823786	3.38755e-16	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0671682	0.00823793	3.818706e-16	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0864662	0.0107566	9.791293e-16	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0720404	0.00898167	0.000000000000001129318	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-HDL-TG	None	Meta-analysis	Table S2	DNA methylation	M-HDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in medium HDL	5414	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.8	0.22	0.0000000000000013	None	33413638_Gomez-Alonso-MDC_m-hdl-tg_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0653707	0.00823891	0.000000000000002267509	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	3187	2	65.7	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-2.072	0.262	0.0000000000000024	-	28173150_serum_highdensity_lipoprotein_cholesterol_discovery_and_replication
Dhana K	Rotterdam study	29762635	2018-05-14	Waist Circumference	EFO_0004342	Discovery	Table 3	DNA methylation	Waist Circumference	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Leukocytes	None	1450	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0005	0.000063	0.0000000000000029	None	29762635_Dhana-K_waist_circumference_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0699941	0.00886212	0.000000000000003031558	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0710277	0.00901325	0.000000000000003492797	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Dhana K	Rotterdam study	29762635	2018-05-14	Body mass index	EFO_0004340	Discovery	Table 2	DNA methylation	Body mass index	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Leukocytes	None	1450	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0013	0.00017	0.0000000000000066	None	29762635_Dhana-K_body_mass_index_discovery
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Framingham Heart Study Batch 2	Table S1	DNA methylation	Body mass index	Age, sex and technical covariates	-	kg/m2	Illumina HumanMethylation450	Whole blood	DNA methylation was inverse normally rank transformed	1935	1	67	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0319	0.00405	0.00000000000000687	-	28095459_body_mass_index_framingham_heart_study_batch_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0698388	0.00897921	0.00000000000000786721	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0640858	0.0082396	0.000000000000007870762	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.068885	0.00898303	0.00000000000001851429	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	1955	3	61	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0102837	0.001345	0.0000000000000207	-	28213390_serum_triglycerides_replication
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	South Asian ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2680	1	51.0	Both	South Asian	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	60.27	6.92	0.000000000000025	-	28002404_body_mass_index_south_asian_ancestry_discovery
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0101074	0.0013269	0.0000000000000259	-	28213390_serum_triglycerides_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.082156	0.0108548	0.00000000000003996783	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Pfeiffer L	-	25583993	2015-01-12	Triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table 2	Triglycerides	DNA methylation	Age, sex, smoking, body mass index, alcohol consumption, physical activity, hypertension, history of MI, hemoglobin A1c, C-reactive protein, lipid-lowering drugs intake and cell counts	mg/dl	Beta values	Illumina HumanMethylation450	Whole blood	-	1776	1	61	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.059	0.008	0.0000000000000554	-	25583993_triglycerides_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0673272	0.00896791	0.00000000000006369949	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0616143	0.00824088	0.00000000000008054361	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0683313	0.00919324	0.0000000000001122145	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0796102	0.010721	0.0000000000001184155	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0650747	0.00881895	0.0000000000001680768	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0660526	0.00898814	0.0000000000002104576	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0655885	0.00897176	0.0000000000002798011	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0647023	0.00889321	0.000000000000362719	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Ligthart S	CHARGE	27955697	2016-12-12	C-reactive protein	EFO_0004458	Discovery	Table S3	DNA methylation	C-reactive protein	Age, sex, smoking, body mass index, cell counts and technical covariates	Beta values	mg/l	Illumina HumanMethylation450	Whole blood	C-reactive protein levels were log-transformed	8863	9	65	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.003	0.000415	0.000000000000504	-	27955697_creactive_protein_discovery
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Replication	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	2542	1	66.3	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-2.382	0.331	0.00000000000065	-	28173150_serum_highdensity_lipoprotein_cholesterol_replication
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for waist circumference	Table 3	DNA methylation	Triglycerides	Age, sex, smoking, waist circumference, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0124	0.0017	0.00000000000084	-	28194238_triglycerides_discovery_and_replication_waist_circumference_adjusted
Shah S	-	26119815	2015-07-02	Body mass index	EFO_0004340	Discovery	Table S1	DNA methylation	Body mass index	Age, sex and technical covariates	M values	kg/m2	Illumina HumanMethylation450	Whole blood	Residuals from the regression of DNA methylation on covariates were inverse normally rank transformed prior to analysis	1366	2	74.3	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.192	0.027	0.000000000000956	-	26119815_body_mass_index_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0782699	0.0109614	0.0000000000009736845	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_4
Braun KVE	-	28194238	2016-06-16	High-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication	Table S1	DNA methylation	High-density lipoprotein cholesterol	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0137	0.0019	0.0000000000011	-	28194238_highdensity_lipoprotein_cholesterol_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0586393	0.00824236	0.000000000001176208	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0584345	0.00824246	0.000000000001407962	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Hedman AK	-	28213390	2017-02-17	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication	Table S4	DNA methylation	Serum high-density lipoprotein cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	3889	4	63	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0002176	3.08e-05	0.00000000000166	-	28213390_serum_highdensity_lipoprotein_cholesterol_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0633992	0.00897188	0.000000000001661384	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0633872	0.0089732	0.000000000001689877	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0634757	0.00898946	0.000000000001725806	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Shah S	-	26119815	2015-07-02	Body mass index	EFO_0004340	Replication	Table S1	DNA methylation	Body mass index	Age, sex and technical covariates	M values	kg/m2	Illumina HumanMethylation450	Whole blood	Residuals from the regression of DNA methylation on covariates were inverse normally rank transformed prior to analysis	752	1	45.5	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.253	0.035	0.00000000000179	-	26119815_body_mass_index_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0758425	0.0108519	0.000000000002890961	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0583204	0.00836586	0.000000000003275834	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Dhana K	Atherosclerosis Risk in Communities	29762635	2018-05-14	Waist Circumference	EFO_0004342	Replication	Table 3	DNA methylation	Waist Circumference	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Leukocytes	None	2097	1	Adults	Both	Admixed	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.008	0.00115	0.0000000000035	None	29762635_Dhana-K_waist_circumference_replication
Demerath EW	-	25935004	2015-08-01	Waist circumference	EFO_0004342	Discovery	Table S5	DNA methylation	Waist circumference	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	cm	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of waist circumference	2097	1	56.2	Both	African	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.008	0.0012	0.00000000000352	-	25935004_waist_circumference_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0629788	0.00910108	0.000000000004706177	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0565524	0.00824336	0.000000000007143529	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_1
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for other lipids	Table 3	DNA methylation	Triglycerides	Age, sex, smoking, other lipids, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0138	0.002	0.00000000001	-	28194238_triglycerides_discovery_and_replication_other_lipids_adjusted
Petersen A-K	KORA F4	24014485	2013-09-06	M35718_dihomo-linolenate_20:3n3_or_n6	EFO_0004727, EFO_0004725	no snps model	Table S2	M35718_dihomo-linolenate_20:3n3_or_n6	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.88	0.135	0.00000000001	None	24014485_Petersen-A-K_m35718_dihomo-linolenate_20_3n3_or_n6_no_snps_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0553846	0.0082439	0.0000000000190682	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.054964	0.00824409	0.00000000002702596	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.00063	0.000093	0.000000000029	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Replication	Table 2	DNA methylation	Triglycerides	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	760	1	68	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0172	0.0026	0.0000000000327	-	28194238_triglycerides_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.060042	0.00906027	0.00000000003546285	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.358619	0.0542331	0.0000000000388254	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0575294	0.00877723	0.00000000005773286	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0537355	0.00824464	0.00000000007376012	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.069741	0.0107507	0.00000000009029325	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Ma J	FHS, RS, CARDIA, MESA	30936141	2020-05-22	Hepatic Fat	EFO_0006506, EFO_0008421	Meta-analysis model 1	Table 1	DNA methylation	Hepatic Fat	Age, sex	Beta Values	Hounsfield units	Illumina HumanMethylation450	Whole blood	Model 1 = adjusted for sex + age	3400	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	None	None	0.00000000011	None	30936141_Ma-J_hepatic_fat_meta-analysis_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0574193	0.00893955	0.0000000001376705	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.299159	0.0467578	0.00000000016119	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Ma J	FHS, RS, CARDIA, MESA	30936141	2020-05-22	Hepatic Fat	EFO_0006506, EFO_0008421	Meta-analysis model 2	Table 1	DNA methylation	Hepatic Fat	Age, sex	Beta Values	Hounsfield units	Illumina HumanMethylation450	Whole blood	Model 2 = model 1 + smoking + physical activity + alcohol consumption	3400	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	None	None	0.00000000017	None	30936141_Ma-J_hepatic_fat_meta-analysis_model_2
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting insulin	EFO_0004466	Base	Supplementary Data 1	DNA methylation	fasting insulin	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	log pmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	2.07	0.33	0.00000000019	4740	31197173_Liu-J_fasting_insulin_base
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.87	0.29	0.00000000019	4808	31197173_Liu-J_fasting_glucose_base
Kriebel J	-	27019061	2016-03-28	Fasting glucose	EFO_0004465	-	Table 3	Fasting glucose	DNA methylation	Age, sex, smoking, cell counts and technical covariates	SD	Beta values	Illumina HumanMethylation450	Whole blood	Regression coefficients are per 1% increase in DNA methylation	1448	1	59	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.056	0.0089	0.00000000025	-	27019061_fasting_glucose
Chambers JC	-	26095709	2015-07-01	Type II diabetes	EFO_0001360	Meta-analysis	Table 3	Type II diabetes	DNA methylation	Age, sex, cell counts and technical covariates	-	Beta values	Illumina HumanMethylation450	Peripheral blood	Regression coeffcient per 1 pecent increase in methylation	3805	4	53	Both	European,South Asian	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0677	0.0107	0.0000000003	-	26095709_type_ii_diabetes_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0564915	0.00896363	0.0000000003016415	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0575403	0.00913304	0.0000000003056872	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table 2	DNA methylation	Triglycerides	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	725	1	60	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0135	0.0021	0.00000000034	-	28194238_triglycerides_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14350	1	Adults (18-65y)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.15	0.0236	0.00000000036	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0662585	0.0106475	0.0000000005013232	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_4
Cardona A	EPIC-Norfolk	31506343	2019-09-10	Type II diabetes	EFO_0001360	Discovery	Table 2	Type II diabetes	DNA methylation	Age, sex, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1264	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.44	None	0.0000000006	None	31506343_Cardona-A_type_ii_diabetes_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0555482	0.00898758	0.0000000006557156	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0545231	0.00884006	0.0000000007109913	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0562687	0.00912624	0.0000000007205872	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0656425	0.0106496	0.0000000007285572	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.05484	0.00891891	0.0000000008013011	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0669114	0.0109305	0.0000000009503649	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Cardona A	LOLIPOP	31506343	2019-09-10	Type II diabetes	EFO_0001360	Replication in Indians	Table 3	Type II diabetes	DNA methylation	Cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	2664	1	Adults	Both	South Asian	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.336	None	0.0000000022	None	31506343_Cardona-A_type_ii_diabetes_replication_in_indians
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0549982	0.00920536	0.000000002360189	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0534791	0.0089693	0.000000002541658	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0490703	0.00824663	0.000000002736716	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Lothian Birth Cohort 1936	Table S1	DNA methylation	Body mass index	Age, sex and cell counts	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood	-	920	1	70	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0063	0.00105	0.00000000276	-	28095459_body_mass_index_lothian_birth_cohort_1936
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.054479	0.0091837	0.000000003057358	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Hedman AK	-	28213390	2017-02-17	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery	Table S4	DNA methylation	Serum high-density lipoprotein cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0002133	3.63e-05	0.00000000419	-	28213390_serum_highdensity_lipoprotein_cholesterol_discovery
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery adjusted for surrogate variables	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	645	1	63.2	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.065	0.011	0.0000000056	-	28173150_serum_triglycerides_discovery_adjusted_for_surrogate_variables
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0524374	0.00899737	0.000000005724807	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0476278	0.0082472	0.000000007849689	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_1
Chambers JC	-	26095709	2015-07-01	Type II diabetes	EFO_0001360	Discovery	Table 3	Type II diabetes	DNA methylation	Age, sex, cell counts and technical covariates	-	Beta values	Illumina HumanMethylation450	Peripheral blood	Regression coeffcient per 1 pecent increase in methylation	2664	1	50	Both	South Asian	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.05826891	0.0101	0.0000000084	-	26095709_type_ii_diabetes_discovery
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Discovery	Table S4	DNA methylation	Body mass index	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of body mass index	2096	1	56.2	Both	African	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0068	0.0012	0.00000000958	-	25935004_body_mass_index_discovery
Dhana K	Atherosclerosis Risk in Communities	29762635	2018-05-14	Body mass index	EFO_0004340	Replication	Table 2	DNA methylation	Body mass index	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Leukocytes	None	2097	1	Adults	Both	Admixed	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0068	0.00119	0.0000000096	None	29762635_Dhana-K_body_mass_index_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0506507	0.00893482	0.00000001464175	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_3
Lai CQ	-	27777315	2016-12-01	Postprandial lipemia	EFO_0007632	Discovery and replication	Table S2	Postprandial lipemia	DNA methylation	Age, sex, study centre and technical covariates	-	Beta values	Illumina HumanMethylation450	CD4+ T-cells	Postprandial lipemia measured using the area under the curve	979	1	48.3	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	20.64	3.63	0.0000000168	-	27777315_postprandial_lipemia_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0607069	0.0108692	0.00000002375343	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0511938	0.00919348	0.00000002614701	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_3
Cardona A	FHS	31506343	2019-09-10	Type II diabetes	EFO_0001360	Replication in Europeans	Table 3	DNA methylation	Type II diabetes	Age, sex, cell composition (reference based), batch effects, body mass index	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2607	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0086	0.0016	0.000000054	None	31506343_Cardona-A_type_ii_diabetes_replication_in_europeans
Nano J	-	28624579	2017-06-15	Gamma-glutamyl transferase	EFO_0004532	Discovery	Table 2	DNA methylation	Gamma-glutamyl transferase	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	731	1	59.6	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.009	0.001	0.000000057	-	28624579_gammaglutamyl_transferase_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0496372	0.00915457	0.00000005982667	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_3
Lai CQ	-	27777315	2016-12-01	Postprandial lipemia	EFO_0007632	Discovery	Table S2	Postprandial lipemia	DNA methylation	Age, sex, study centre and technical covariates	-	Beta values	Illumina HumanMethylation450	CD4+ T-cells	Postprandial lipemia measured using the area under the curve	653	1	48	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	25.41	4.64	0.000000061	-	27777315_postprandial_lipemia_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0587649	0.0108549	0.00000006272094	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0484555	0.00896615	0.00000006608861	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0443833	0.00824844	0.00000007529018	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0478644	0.00895797	0.00000009267577	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18059	1	Adults (18-65y)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.13	0.0237	0.00000011	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Basic_model
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.8	0.35	0.00000013	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0571777	0.010931	0.0000001711232	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0553507	0.0106194	0.0000001891362	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0477369	0.00917458	0.0000001985603	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0428146	0.008249	0.000000212788	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.047376	0.00920435	0.0000002679192	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Jiantao Ma	RS, MESA, CARDIA	30796027	Feb 22, 2019	hepatic fat	EFO_0010821	Replication	Table 1	DNA methylation	hepatic fat	Age, Sex, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylation450	whole blood	None	1904	3	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	None	None	0.00000027	None	30796027_Jiantao-Ma_hepatic_fat_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0460697	0.00895857	0.0000002745573	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Phospholipids to total lipids ratio in large HDL	EFO_0004639	None	None	DNA methylation	Phospholipids to total lipids ratio in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	682	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.047	0.0093	0.00000046	None	Battram-T_phospholipids_to_total_lipids_ratio_in_large_hdl
Jiantao Ma	FHS	30796027	Feb 22, 2019	hepatic fat	EFO_0010821	Discovery	Table 1	DNA methylation	hepatic fat	Age, Sex, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylation450	whole blood	None	1496	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	None	None	0.00000066	None	30796027_Jiantao-Ma_hepatic_fat_discovery
Battram T	ARIES	None	2020-08-20	Free cholesterol to total lipids ratio in large HDL	EFO_0008591	None	None	DNA methylation	Free cholesterol to total lipids ratio in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.144	0.029	0.00000084	None	Battram-T_free_cholesterol_to_total_lipids_ratio_in_large_hdl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P19652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0442219	0.00898609	0.0000008697158	P19652	41361833_Josephine_Robertson_P19652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0437554	0.00896427	0.000001066112	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_2
Juvinao-Quintero DL	ALSPAC, LBC1936, RSIII-1, RS-Bios	33622391	2021-02-23	Type 2 diabetes	EFO_0001360	meta-analysis	Table 2	DNA methylation	Type 2 diabetes	age, sex, batch effects, cell composition (reference based), smoking	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	3428	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.008	0.00159	0.0000013	None	33622391_Juvinao-Quintero-DL_type_2_diabetes_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0507834	0.010509	0.000001362756	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0526092	0.0109581	0.000001594885	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	SHBG protein levels (SeqId = 4929-55)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SHBG protein levels (SeqId = 4929-55)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sex hormone-binding globulin	774	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-1.19	0.249	0.0000017	None	Gadd-DA_shbg_protein_levels__seqid___4929-55__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	18413	1	Adults (18-65y)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.24	0.0503	0.0000019	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model
Kriebel J	-	27019061	2016-03-28	Fasting glucose	EFO_0004465	Adjusted for BMI	Table 3	Fasting glucose	DNA methylation	Age, sex, smoking, body mass index, cell counts and technical covariates	SD	Beta values	Illumina HumanMethylation450	Whole blood	Regression coefficients are per 1% increase in DNA methylation	1448	1	59	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.041	0.0086	0.000002	-	27019061_fasting_glucose_adjusted_for_bmi
Chen Y	None	34670603	Oct 20, 2021	Waist Circumference	EFO_0004342	Multi-ethnic Asian meta-analysis	None	Waist Circumference	DNA methylation	Age, Sex, Smoking, Cell composition (reference free), control probe PCs	cm	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	409	None	Adults (18-65 years)	Both	East Asian, South Asian, Admixed	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	94	19.9	0.0000022	None	34670603_Chen-Y_waist_circumference_multi-ethnic_asian_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0421791	0.00897691	0.000002643019	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0420354	0.0089575	0.00000271982	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Concentration of small HDL particles	EFO_0004612	None	None	DNA methylation	Concentration of small HDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	None	None	0.0000029	None	Battram-T_concentration_of_small_hdl_particles
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0487867	0.0104321	0.000002942805	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	ADIPOQ protein levels (SeqId = 3554-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADIPOQ protein levels (SeqId = 3554-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Adiponectin	774	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-1.16	0.249	0.000003	None	Gadd-DA_adipoq_protein_levels__seqid___3554-24__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0426161	0.00913391	0.000003102795	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0384115	0.00825048	0.000003257687	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	645	1	63.2	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.036	0.008	0.0000033	-	28173150_serum_triglycerides_discovery
Battram T	ARIES	None	2020-08-20	Triglycerides in medium HDL	EFO_0004530	None	None	DNA methylation	Triglycerides in medium HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	10	2.1	0.0000036	None	Battram-T_triglycerides_in_medium_hdl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0425983	0.0091906	0.000003600336	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	TLL1 protein levels (SeqId = 6383-90)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TLL1 protein levels (SeqId = 6383-90)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tolloid-like protein 1	774	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.15	0.249	0.0000037	None	Gadd-DA_tll1_protein_levels__seqid___6383-90__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Cholesterol esters to total lipids ratio in large HDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters to total lipids ratio in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	677	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.055	0.012	0.0000048	None	Battram-T_cholesterol_esters_to_total_lipids_ratio_in_large_hdl
Battram T	ARIES	None	2020-08-20	Total cholesterol to total lipids ratio in large HDL	EFO_0004574	None	None	DNA methylation	Total cholesterol to total lipids ratio in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.039	0.0085	0.0000051	None	Battram-T_total_cholesterol_to_total_lipids_ratio_in_large_hdl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0406796	0.0089503	0.000005536003	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0408685	0.00899453	0.000005571627	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_2
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-2.718	0.6	0.0000058	-	28173150_serum_highdensity_lipoprotein_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0496103	0.0109408	0.000005821749	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	PSAT1 protein levels (SeqId = 18342-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PSAT1 protein levels (SeqId = 18342-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphoserine aminotransferase	774	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.13	0.249	0.0000062	None	Gadd-DA_psat1_protein_levels__seqid___18342-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0483289	0.0107357	0.000006793115	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43251	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43251	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0370201	0.00825091	0.000007285399	P43251	41361833_Josephine_Robertson_P43251_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0491621	0.0109584	0.000007304274	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.040219	0.0089887	0.000007720471	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	D6RF35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	D6RF35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0402448	0.00900091	0.000007836878	D6RF35	41361833_Josephine_Robertson_D6RF35_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Conjugated linoleic acid	EFO_0006807	None	None	DNA methylation	Conjugated linoleic acid	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	666	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	8.6	1.91	0.0000079	None	Battram-T_conjugated_linoleic_acid
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0482184	0.010945	0.00001062863	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Total lipids in small HDL	EFO_0004529	None	None	DNA methylation	Total lipids in small HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.1	0.25	0.000011	None	Battram-T_total_lipids_in_small_hdl
Gadd DA	Generation Scotland	35945220	31/07/2022	CRELD1 protein levels (SeqId = 7628-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CRELD1 protein levels (SeqId = 7628-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cysteine-rich with EGF-like domain protein 1	774	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.09	0.249	0.000011	None	Gadd-DA_creld1_protein_levels__seqid___7628-40__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Triglycerides in small HDL	EFO_0004530	None	None	DNA methylation	Triglycerides in small HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	682	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	9.6	2.2	0.000013	None	Battram-T_triglycerides_in_small_hdl
Demerath EW	-	25935004	2015-08-01	Waist circumference	EFO_0004342	Replication	Table 3	DNA methylation	Waist circumference	Age, sex, smoking, study centre and technical covariates	Beta values	cm	Illumina HumanMethylation450	CD4+ T-cells	Regression coefficient per 1 SD of waist circumference	991	1	49	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0039	9e-04	0.0000133	-	25935004_waist_circumference_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0476807	0.0109476	0.00001337583	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_4
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base plus BMI	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects, body mass index	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.26	0.29	0.000014	4808	31197173_Liu-J_fasting_glucose_base_plus_bmi
Gadd DA	Generation Scotland	35945220	31/07/2022	ACY1 protein levels (SeqId = 3343-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACY1 protein levels (SeqId = 3343-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aminoacylase-1	774	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.08	0.249	0.000014	None	Gadd-DA_acy1_protein_levels__seqid___3343-1__somascan_protein_measurement
Chen Y	None	34670603	Oct 20, 2021	Body mass index	EFO_0004340	Multi-ethnic Asian meta-analysis	None	Body mass index	DNA methylation	Age, Sex, Smoking, Cell composition (reference free), control probe PCs	kg/m2	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	409	None	Adults (18-65 years)	Both	East Asian, South Asian, Admixed	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	35.2	8.1	0.000015	None	34670603_Chen-Y_body_mass_index_multi-ethnic_asian_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0388982	0.00899814	0.00001549964	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	D6RF35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	D6RF35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0353219	0.00825142	0.00001874879	D6RF35	41361833_Josephine_Robertson_D6RF35_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Ratio of 18:2 linoleic acid to total fatty acids	EFO_0006807, EFO_0005110	None	None	DNA methylation	Ratio of 18:2 linoleic acid to total fatty acids	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	671	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.047	0.0109	0.000019	None	Battram-T_ratio_of_18_2_linoleic_acid_to_total_fatty_acids
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.039279	0.00918933	0.00001928474	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_3
Nuotio ML	FINRISK, NFBC1966	33239708	2020-12-14	Metabolic Sydnrome	EFO_0000195	Discovery	Supplmentary table 1	DNA methylation	Metabolic Sydnrome	age, sex, smoking, alcohol consumption, cell composition (reference based), batch effects, ancestry (genomic PCs)	M Values	None	Illumina HumanMethylation450	Whole blood	No CpGs replicated	517	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.06689	0.016	0.000021	None	33239708_Nuotio-ML_metabolic_sydnrome_discovery
Battram T	ARIES	None	2020-08-20	Phospholipids in small HDL	EFO_0004639	None	None	DNA methylation	Phospholipids in small HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	684	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.71	0.4	0.000021	None	Battram-T_phospholipids_in_small_hdl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0382047	0.00899944	0.00002197107	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_2
Mamtani M	-	26798409	2016-01-20	Hypertriglyceridemic waist	EFO_0004342, EFO_0004530	-	Table S2	Liability function of hypertriglyceridemic waist	DNA methylation	Age, sex, use of statin, use of anti-hypertensive, use of diabetic medications, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	850	1	46.8	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.27235672	0.06429	0.0000227	-	26798409_hypertriglyceridemic_waist
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Osteoarthritis	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Osteoarthritis	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	16114	1	Adults (18-65y)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.071	0.01685	0.000023	None	Robert-F-Hillary_Incident_Osteoarthritis_Basic_model
Battram T	ARIES	None	2020-08-20	Free cholesterol to total lipids ratio in large LDL	EFO_0008591	None	None	DNA methylation	Free cholesterol to total lipids ratio in large LDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.123	0.029	0.000023	None	Battram-T_free_cholesterol_to_total_lipids_ratio_in_large_ldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01009	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01009	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0347461	0.00825159	0.00002559417	P01009	41361833_Josephine_Robertson_P01009_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.034453	0.00825167	0.00002993469	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	FBP1 protein levels (SeqId = 7206-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FBP1 protein levels (SeqId = 7206-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fructose-1,6-bisphosphatase 1	774	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	1.04	0.249	0.00003	None	Gadd-DA_fbp1_protein_levels__seqid___7206-20__somascan_protein_measurement
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-	-	0.0000304	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0341575	0.00825175	0.00003501245	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Triglycerides to total lipids ratio in medium HDL	EFO_0004530	None	None	DNA methylation	Triglycerides to total lipids ratio in medium HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.097	0.023	0.000036	None	Battram-T_triglycerides_to_total_lipids_ratio_in_medium_hdl
Li S	-	28811542	2017-08-15	Age	EFO_0000246	-	Table S1	DNA methylation	Age	Cell counts	M values	years	Illumina HumanMethylation450	Whole blood	-	1366	2	73	Missing	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.00464	0.00117742	0.0000406	-	28811542_age
Battram T	ARIES	None	2020-08-20	Ratio of omega 6 fatty acids to total fatty acids	EFO_0005110	None	None	DNA methylation	Ratio of omega 6 fatty acids to total fatty acids	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	671	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.047	0.0115	0.000047	None	Battram-T_ratio_of_omega_6_fatty_acids_to_total_fatty_acids
Battram T	ARIES	None	2020-08-20	Ratio of triglycerides to phosphoglycerides	EFO_0004530, FMA_85433	None	None	DNA methylation	Ratio of triglycerides to phosphoglycerides	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	663	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.72	0.177	0.000057	None	Battram-T_ratio_of_triglycerides_to_phosphoglycerides
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0441374	0.0109927	0.00005969968	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_4
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	VLDL-TG	None	Meta-analysis	Table S2	DNA methylation	VLDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in VLDL	5414	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	2.9	0.71	0.00006	None	33413638_Gomez-Alonso-MDC_vldl-tg_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P23142	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P23142	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0359429	0.00899527	0.0000648028	P23142	41361833_Josephine_Robertson_P23142_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	DEFB1 protein levels (SeqId = 6629-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DEFB1 protein levels (SeqId = 6629-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-defensin 1	774	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.995	0.25	0.000067	None	Gadd-DA_defb1_protein_levels__seqid___6629-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0328354	0.00825212	0.00006953097	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Battram T	GEO	25424692	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Never vs former smokers	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	442	1	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0103	0.00257	0.000074	None	25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__never_vs_former_smokers
Hedman AK	-	28213390	2017-02-17	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Replication	Table S4	DNA methylation	Serum high-density lipoprotein cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	1583	2	57	Both	None	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0002286	5.83e-05	0.0000872	-	28213390_serum_highdensity_lipoprotein_cholesterol_replication
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	L-LDL-FC_pct	None	Meta-analysis	Table S2	DNA methylation	L-LDL-FC_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Free cholesterol to total lipids ratio in large LDL	5414	4	Adults	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.28	0.072	0.000088	None	33413638_Gomez-Alonso-MDC_l-ldl-fc_pct_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0360165	0.0091953	0.00009012374	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	-0.0431261	0.0110163	0.00009091005	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0426849	0.0109105	0.00009183767	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.0424998	0.0108666	0.00009231786	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Glucose	EFO_0004468	None	None	DNA methylation	Glucose	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	675	1	Adults	Females	European	cg11024682	chr17:17730094	17	17730094	SREBF1	South shelf	0.28	0.071	0.000094	None	Battram-T_glucose