author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island 0.0039 0.00038 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island 0.61773 0.01015 6.4e-128 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island - - 1.14e-49 - 28056824_age_4_vs_age_0 Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island - - 1.66e-28 - 23526956_clear_cell_renal_carcinoma Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3042919 (gene symbol: MIR196B) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg11532431 chr7:27169674 7 27169674 HOXA4 Island None None 7.7e-20 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3042919__gene_symbol__mir196b__meta-analysis Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg11532431 chr7:27169674 7 27169674 HOXA4 Island - - 0.000000000000158 - 24500968_pancreatic_ductal_adenocarcinoma Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island -0.019 0.0026 0.00000000000026 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island 0.07 0.011 0.00000000062 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Zhang L ROSMAP, Mt. Sinai, London, Gasparoni 33902726 04-26-2021 Braak stage EFO_0000249 Males Table S3 DNA methylation Braak stage Age, Cell composition (reference based), Batch effects, M values None Illumina HumanMethylation450 Prefrontal cortex None 388 4 Geriatrics Males Unclear cg11532431 chr7:27169674 7 27169674 HOXA4 Island 0.17 0.033 0.00000017 None 33902726_Zhang-L_braak_stage_males Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island -0.0413463 0.00824951 0.000000545033 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island 0.0410193 0.00824962 0.0000006692135 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island 0.0400004 0.00816087 0.0000009613016 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island -0.0390254 0.00825028 0.000002263961 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island -0.0380612 0.0082243 0.000003725659 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age*sex PATO_0000047,EFO_0000246 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation age*sex sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island 0.0019 0.00041 0.0000071 None 33450751_Mulder-RH_age_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island -0.0366067 0.00823811 0.000008912555 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island -0.0473214 0.0107046 0.000009896271 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island 0.0098 0.00226 0.000016 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11532431 chr7:27169674 7 27169674 HOXA4 Island None None 0.000019 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11532431 chr7:27169674 7 27169674 HOXA4 Island 0.0342337 0.00807992 0.00002280229 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_3 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11532431 chr7:27169674 7 27169674 HOXA4 Island None None 0.00008 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11532431 chr7:27169674 7 27169674 HOXA4 Island None None 0.000086 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery