author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.004 0.00025 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore 0.52408 0.00752 9.099999999999999e-139 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.0721639 0.00823504 2.106436e-18 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3818732 (gene symbol: ARHGEF18) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3818732 (gene symbol: ARHGEF18) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore None None 9.3e-18 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3818732__gene_symbol__arhgef18__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.0646793 0.00823928 0.000000000000004442954 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.063677 0.00823982 0.0000000000000116341 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.0542403 0.00824442 0.00000000004895747 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.0507962 0.00824591 0.000000000745662 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore 0.0499536 0.00824626 0.000000001414347 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -1.1 0.19 0.0000000026 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.0499316 0.00854202 0.00000000516069 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore 0.0472409 0.00824735 0.00000001036121 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.0465311 0.00824763 0.00000001714356 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.0480763 0.00854063 0.00000001844411 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore 0.0461682 0.00824777 0.00000002211554 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore 0.162616 0.0292951 0.00000002880583 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.029 0.00525 0.000000044 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.0439658 0.00852666 0.0000002551829 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Tan Q Middleaged Danish Twins (MADT) 34427971 Aug 24, 2021 Age EFO_0000246 Discovery Table S1 DNA methylation Age Cell composition (reference based) M values years Illumina HumanMethylation450 Whole blood None 492 1 Geriatrics Males European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore 0.0093 0.00175 0.00000048 None 34427971_Tan-Q_age_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.0428412 0.00853025 0.000000516645 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore 0.0086 0.0017 0.00000059 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.0393745 0.00849931 0.000003640863 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Knijnenburg None 30833390 Mar 19, 2019 early preterm birth (<28 weeks) EFO_0003917 discovery Supplementary dataset 10 DNA methylation early preterm birth (<28 weeks) Age, Ancestry (genomic PCs), time since birth M values None Illumina HumanMethylation450 whole blood None 784 1 Adults Females Admixed cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore 0.16 0.034 0.0000037 None 30833390_Knijnenburg_early_preterm_birth___28_weeks__discovery Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.09933 0.0224679 0.000009826 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore 0.0365432 0.00852094 0.00001809261 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore 0.0359692 0.00851638 0.00002419519 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.0346004 0.00825163 0.00002767125 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore 0.0353853 0.00853087 0.00003374109 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore 0.0343165 0.00853782 0.00005865146 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore 0.0330528 0.00825206 0.0000622191 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.0336721 0.00846023 0.00006923479 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.0328344 0.00825212 0.00006956542 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.0327461 0.00837186 0.00009215766 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11734329 chr19:7460671 19 7460671 ARHGEF18 South shore -0.0321316 0.00825231 0.00009918444 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1