author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11860434 chr7:102067440 7 102067440 - Open sea -0.004 0.00022 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg11860434 chr7:102067440 7 102067440 - Open sea 0.027 0.0011 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg11860434 chr7:102067440 7 102067440 - Open sea -0.61565 0.00739 3.2e-153 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea 0.0892329 0.00822363 2.510763e-27 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg11860434 chr7:102067440 7 102067440 - Open sea - - 5.03e-27 - 23526956_clear_cell_renal_carcinoma Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Ultrasound-estimated gestational age Table S1 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg11860434 chr7:102067440 7 102067440 - Open sea -0.00095125 9.87e-05 3.9200000000000006e-21 - 27717397_gestational_age_ultrasoundestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea 0.0704698 0.00823604 1.2801460000000002e-17 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3065015 (gene symbol: POLR2J) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3065015 (gene symbol: POLR2J) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg11860434 chr7:102067440 7 102067440 - Open sea None None 2.1e-17 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3065015__gene_symbol__polr2j__meta-analysis Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg11860434 chr7:102067440 7 102067440 - Open sea -0.0073 0.00078 0.0000000000000018 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea 0.0580651 0.00824264 0.000000000001944459 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea -0.0510637 0.0082458 0.0000000006072439 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea -0.0490538 0.00824663 0.00000000277031 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea 0.0478753 0.0082471 0.000000006565677 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea 0.0470455 0.00824743 0.00000001191025 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea 0.0447615 0.0082483 0.00000005829928 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg11860434 chr7:102067440 7 102067440 - Open sea -0.00052566 9.95e-05 0.000000156 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea 0.041673 0.0082494 0.000000443304 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea 0.0399885 0.00824997 0.000001265577 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea 0.0373473 0.00825081 0.000006044078 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 SIGLEC14 protein levels (SeqId = 8248-222) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SIGLEC14 protein levels (SeqId = 8248-222) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sialic acid-binding Ig-like lectin 14 774 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea 0.63 0.138 0.0000062 None Gadd-DA_siglec14_protein_levels__seqid___8248-222__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea -0.037184 0.00825086 0.000006636047 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea 0.0366431 0.00825103 0.000009018138 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11860434 chr7:102067440 7 102067440 - Open sea None None 0.00001 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11860434 chr7:102067440 7 102067440 - Open sea None None 0.000016 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea -0.0389656 0.00911501 0.00001924459 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Kazmi N PACE 31230546 2019-06-24 Preeclampsia EFO_0000668 Meta analysis unadjusted model Table S5 DNA methylation Preeclampsia Cell composition (reference based), batch effects, age, smoking, parity, diabetes, body mass index, sex Beta Values None Illumina HumanMethylation450 Cord blood None 3460 6 Infants Both Unclear cg11860434 chr7:102067440 7 102067440 - Open sea 0.0193 0.0045 0.00002 None 31230546_Kazmi-N_preeclampsia_meta_analysis_unadjusted_model Gadd DA Generation Scotland 35945220 31/07/2022 BST1 protein levels (SeqId = 4535-50) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 BST1 protein levels (SeqId = 4535-50) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 774 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea 0.58 0.139 0.000026 None Gadd-DA_bst1_protein_levels__seqid___4535-50__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea -0.0369851 0.00889696 0.00003242211 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 ART3 protein levels (SeqId = 7970-315) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ART3 protein levels (SeqId = 7970-315) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Ecto-ADP-ribosyltransferase 3 774 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea 0.57 0.139 0.000037 None Gadd-DA_art3_protein_levels__seqid___7970-315__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 RPN1 protein levels (SeqId = 6458-6) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RPN1 protein levels (SeqId = 6458-6) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 774 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea 0.56 0.139 0.000051 None Gadd-DA_rpn1_protein_levels__seqid___6458-6__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea 0.0335896 0.00829203 0.00005129984 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg11860434 chr7:102067440 7 102067440 - Open sea -0.102084 0.0252286 0.00005223901 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea -0.0332224 0.00825201 0.00005702445 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea -0.0330279 0.00825207 0.00006301699 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg11860434 chr7:102067440 7 102067440 - Open sea None None 0.000068 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg11860434 chr7:102067440 7 102067440 - Open sea 0.0362263 0.00913269 0.0000732313 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg11860434 chr7:102067440 7 102067440 - Open sea - - 0.000075 - 26500701_sex_kora_f4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg11860434 chr7:102067440 7 102067440 - Open sea -0.0924526 0.0233529 0.00007557316 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery