author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.0013	0.00014	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-	-	1.5599999999999999e-52	-	23526956_clear_cell_renal_carcinoma
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg12307200	chr3:188664632	3	188664632	-	North shore	2.20382	0.10276	1.72e-36	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.07829	0.00823123	2.169434e-21	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
De Jager PL	-	25129075	2014-08-17	Burden of neuritic amyloid plaques	EFO_0000249, EFO_0006801	Discovery model 3	Table S2	DNA methylation	Burden of neuritic amyloid plaques	Age, sex, study, cell counts, technical covariates	Beta values	-	Illumina HumanMethylation450	Cerebral cortex	Model additionally adjusted for estimated cell counts and surrogate variables	708	2	88	Both	None	cg12307200	chr3:188664632	3	188664632	-	North shore	-5.56	0.6382	2.97e-18	-	25129075_burden_of_neuritic_amyloid_plaques_discovery_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	0.0708649	0.00823581	8.435132e-18	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	3.4	0.399	8.9e-18	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
De Jager PL	-	25129075	2014-08-17	Burden of neuritic amyloid plaques	EFO_0000249, EFO_0006801	Discovery model 1	Table S2	DNA methylation	Burden of neuritic amyloid plaques	Age, sex, study and technical covariates	Beta values	-	Illumina HumanMethylation450	Cerebral cortex	-	708	2	88	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-4.98	0.5898	3.06e-17	-	25129075_burden_of_neuritic_amyloid_plaques_discovery_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.0680847	0.00823741	1.511893e-16	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Smith R	London 1, London 2, Mount Sinai, Arizona 1, Arizona 2, ROS/MAP	34112773	06-10-2021	Braak stage	EFO_0000249	Discovery	Table 2	DNA methylation	Braak stage	Age, Sex, Batch effects, neuron/glia proportion, surrogate variables	Beta values	None	Illumina HumanMethylation450	Cortex	None	1408	6	Geriatrics	Both	European, African	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.0152	0.0019	4.5e-16	None	34112773_Smith-R_braak_stage_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.0640332	0.00823963	0.000000000000008277288	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Zhang L	ROSMAP,Mt Sinai,London,Gasparoni	33257653	2020-11-30	alzheimers disease braak stage	EFO_0000249	Meta-analysis	Supplementary Data 1	DNA methylation	alzheimers disease braak stage	age, sex, cell composition (reference based), batch effects	Beta Values	Braak stage	Illumina HumanMethylation450	Prefrontal cortex	age 73-86	1030	4	Adults	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.057	0.008	0.00000000000013	None	33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis
De Jager PL	-	25129075	2014-08-17	Alzheimers disease	EFO_0000249, EFO_0006801	Discovery	Table S2	Alzheimers disease	DNA methylation	Age, sex, study and technical covariates	-	Beta values	Illumina HumanMethylation450	Cerebral cortex	-	708	2	88	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-23.5	3.4325	0.00000000000758	-	25129075_alzheimers_disease_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.0562023	0.00824352	0.00000000000960902	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	0.356561	0.0564225	0.0000000002688578	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.0513311	0.00824569	0.0000000004940256	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.0497866	0.00824633	0.000000001603676	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	0.0588029	0.0100113	0.00000000435485	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Zhang L	ROSMAP, Mt. Sinai, London, Gasparoni	33902726	04-26-2021	Braak stage	EFO_0000249	Females	Table S3	DNA methylation	Braak stage	Age, Cell composition (reference based), Batch effects,	M values	None	Illumina HumanMethylation450	Prefrontal cortex	None	642	4	Geriatrics	Females	Unclear	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.147	0.027	0.000000061	None	33902726_Zhang-L_braak_stage_females
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.0510687	0.0100632	0.0000003926236	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Lunnon K	-	25129077	2014-08-17	Alzheimers disease Braak stage	EFO_0000249, EFO_0006801	Cross-cortex model	Table S9	DNA methylation	Alzheimers disease Braak stage	Age, sex and technical covariates	Beta values	-	Illumina HumanMethylation450	Cross-cortex	-	104	1	-	Missing	None	cg12307200	chr3:188664632	3	188664632	-	North shore	-	-	0.000000399	-	25129077_alzheimers_disease_braak_stage_crosscortex_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	0.284693	0.0565756	0.0000004900255	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.0488308	0.0100337	0.000001146803	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.046342	0.0100515	0.000004052003	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.0372255	0.00825085	0.000006480246	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	0.254348	0.0564105	0.000006560177	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	0.044	0.00973	0.0000072	None	Robert-F-Hillary_Incident_COPD_Basic_model
Zhang L	ROSMAP, Mt. Sinai, London, Gasparoni	33902726	04-26-2021	Braak stage	EFO_0000249	Males	Table S3	DNA methylation	Braak stage	Age, Cell composition (reference based), Batch effects,	M values	None	Illumina HumanMethylation450	Prefrontal cortex	None	388	4	Geriatrics	Males	Unclear	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.15	0.034	0.0000076	None	33902726_Zhang-L_braak_stage_males
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.0450799	0.0100786	0.000007776358	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	0.0364557	0.00825108	0.00001001968	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Liver Cirrhosis	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Liver Cirrhosis	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18325	1	Adults (18-65y)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	0.017	0.00381	0.000011	None	Robert-F-Hillary_Incident_Liver_Cirrhosis_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.0425298	0.0100708	0.00002424576	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_2
Battram T	GEO	27886173	2020-09-15	Crohn's disease	EFO_0000384	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Crohn's disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	161	1	Adults	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.0136	0.00312	0.000026	None	27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	0.0424494	0.0101083	0.00002691112	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	0.0414777	0.0098912	0.00002764308	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	0.041658	0.0100747	0.00003570934	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	-0.0336646	0.00825189	0.00004534801	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	1.7	0.414	0.000049	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg12307200	chr3:188664632	3	188664632	-	North shore	0.00211	0.00052	0.000058	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	0.0403346	0.0100529	0.00006044034	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg12307200	chr3:188664632	3	188664632	-	North shore	0.0398452	0.0100514	0.00007400928	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3