author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Dugue PA Melbourne Collaborative Cohort Study 31552803 2019-09-25 Smoking EFO_0006527, EFO_0004318 Current vs never smoking Supplementary table 1 DNA methylation Smoking Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects M Values None Illumina HumanMethylation450 Whole blood None 1851 1 Adults Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.21 0.0224 8e-21 None 31552803_Dugue-PA_smoking_current_vs_never_smoking Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.031 0.0035 3.6e-19 None Robert-F-Hillary_Incident_COPD_Basic_model Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 2902736 (gene symbol: C6orf48) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 2902736 (gene symbol: C6orf48) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore None None 4.9e-16 None 33752734_Yao-C_gene_expression_of_affymetrix_id__2902736__gene_symbol__c6orf48__meta-analysis Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore 0.08151 0.00965 0.0000000000000071 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore 0.0091 0.0012 0.00000000000016 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.99 0.139 0.00000000000084 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.0518492 0.00824547 0.0000000003302487 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.0517165 0.00832181 0.000000000528557 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Zeilinger S - 23691101 2013-05-17 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking discovery Table S1 DNA methylation Smoking Age, sex, body mass index, alcohol consumption and cell counts M values - Illumina HumanMethylation450 Whole blood - 1011 1 60.8 Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore - - 0.000000000991 - 23691101_smoking_current_vs_never_smoking_discovery Joehanes R - 27651444 2016-10-01 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S2 DNA methylation Current versus never smoking Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood, CD4+ T cells or monocytes - 9389 16 60.3 Both European,African cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.024 0.004 0.0000000013 - 27651444_smoking_current_vs_never_smoking Battram T GEO 27886173 2020-09-15 Crohn's disease EFO_0000384 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Crohn's disease Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 161 1 Adults Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore 0.0441 0.00684 0.0000000018 None 27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.00596 0.001 0.0000000026 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Bozack PRISM 34569420 Oct 22, 2021 Infant sex PATO_0001894 Umbilical artery Supplementary table 10 DNA methylation Infant sex Cell composition (reference free), Batch effects, Ancestry (other) M values None Illumina HumanMethylation450 Umbilical artery None 229 1 Infants Both European, African, Other cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore None None 0.0000000093 None 34569420_Bozack_infant_sex_umbilical_artery Guida F - 25556184 2015-04-15 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S1 DNA methylation Smoking Cell counts and technical covariates M values - Illumina HumanMethylation450 Whole blood - 582 2 54 Females European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.23 0.0406 0.0000000148 - 25556184_smoking_current_vs_never_smoking Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent COPD (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent COPD (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18078 1 Adults (18-65y) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.032 0.00613 0.00000014 None Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.0432786 0.0083031 0.0000001889988 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_2 Dugue PA Melbourne Collaborative Cohort Study 31552803 2019-09-25 Smoking EFO_0006527, EFO_0004318 Former vs never smoking Supplementary table 1 DNA methylation Smoking Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects M Values None Illumina HumanMethylation450 Whole blood None 156 1 Adults Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.08 0.0154 0.00000019 None 31552803_Dugue-PA_smoking_former_vs_never_smoking Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.0427167 0.00824904 0.0000002267699 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JMB2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JMB2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.0412607 0.00835264 0.0000007905086 A0A0G2JMB2 41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore 0.0407065 0.00834017 0.000001067788 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.011 0.002 0.00000146 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns Sikdar S PACE 31536415 2019-09-19 Prenatal smoke exposure EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318 Inverse varience-weighted fixed-effects meta-analysis Table S1 DNA methylation Prenatal smoke exposure Maternal age, socioeconomic position, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Cord blood, whole blood None 5648 9 Infants Both European, African, Unclear cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.0108 0.0023 0.0000016 None 31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity, white blood cell counts and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.011 0.002 0.00000163 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.0394115 0.00825016 0.000001795967 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Christiansen C TwinsUK, NSHD, NCDS1, NCDS2, BCS70 33593402 2021-02-16 Smoking EFO_0004318, EFO_0006527 Current vs never smoking meta-analysis in European samples Table S1 DNA methylation Smoking Sex, cell composition (reference based), body mass index, batch effects, relatedness Beta Values None Illumina HumanMethylationEPIC Whole blood None 912 5 Adults Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore None None 0.0000018 None 33593402_Christiansen-C_smoking_current_vs_never_smoking_meta-analysis_in_european_samples Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Lung Cancer None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Lung Cancer Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18364 1 Adults (18-65y) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.0089 0.00187 0.000002 None Robert-F-Hillary_Incident_Lung_Cancer_Basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore 0.10186 0.02202 0.000003757165 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore 0.037907 0.00825064 0.000004375413 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Any maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 6685 13 0 Missing European,East Asian,African,Admixed,Other cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.009 0.002 0.0000045 - 27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.0375721 0.00825074 0.000005311219 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_1 Battram T GEO 27886173 2020-09-15 Inflammatory bowel disease EFO_0003767 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Inflammatory bowel disease Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 240 1 Adults Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.0337 0.00725 0.0000057 None 27886173_Battram-T_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore 0.0373867 0.0082508 0.000005909086 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.0363441 0.00806683 0.000006676805 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore 0.0374151 0.00832665 0.000007062723 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore 0.0372421 0.00832973 0.000007844236 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore 0.0367117 0.0083287 0.00001051387 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.0352623 0.00826587 0.00002002427 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.0353754 0.00833812 0.00002222848 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.0352641 0.00835097 0.00002427943 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.0348433 0.00825156 0.00002429246 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore None None 0.000026 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore 0.0346619 0.00825161 0.00002677534 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore 0.0344739 0.00825166 0.00002960353 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore 0.0343151 0.00825171 0.00003221049 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.00078 0.00019 0.000042 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore 0.0338404 0.00831026 0.00004682983 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore 0.0334332 0.00825196 0.00005114165 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.0365312 0.00901979 0.00005145693 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore 0.0332616 0.008252 0.00005588425 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore -0.017 0.00412 0.000058 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore 0.0335074 0.00833586 0.00005857012 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg13541527 chr6:31804078 6 31804078 C6orf48;SNORD52 South shore 0.0331003 0.00838617 0.00007950442 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_3