author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.0022	0.00013	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0645	0.00361	9.8e-43	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.0874	0.00822498	2.805717e-26	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.0831316	0.00822799	6.382661e-24	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-	-	8.97e-19	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0800106	0.00960117	8.544566e-17	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Petersen A-K	KORA F4	24014485	2013-09-06	M32388_dodecanedioate	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M32388_dodecanedioate	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.96	0.173	0.0000000000000019	None	24014485_Petersen-A-K_m32388_dodecanedioate_snps_as_covariates_model
Petersen A-K	KORA F4	24014485	2013-09-06	M32388_dodecanedioate	EFO_0004727, EFO_0004725	no snps model	Table S2	M32388_dodecanedioate	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.95	0.171	0.0000000000000086	None	24014485_Petersen-A-K_m32388_dodecanedioate_no_snps_model
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	1.9	0.252	0.000000000000015	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0672091	0.00959543	0.000000000002590527	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0564035	0.00824343	0.000000000008105349	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.0556874	0.00824376	0.00000000001481075	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.0533655	0.00824481	0.00000000009937767	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.244979	0.0379946	0.0000000001165357	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.0527771	0.00824506	0.0000000001589988	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0526919	0.0082451	0.0000000001701285	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0522188	0.00824531	0.0000000002471879	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Cardona A	EPIC-Norfolk	31506343	2019-09-10	Type II diabetes	EFO_0001360	Discovery	Table 2	Type II diabetes	DNA methylation	Age, sex, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1264	1	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.49	None	0.00000000033	None	31506343_Cardona-A_type_ii_diabetes_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	discovery	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.226945	0.0375932	0.000000001602498	None	39706196_Hannah-M.-Smith_glucose_discovery
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	Discovery and replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	Weighted Z-test meta-analysis	10238	13	54.5	Both	European,South Asian	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-	-	0.0000000019	-	28002404_body_mass_index_discovery_and_replication
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.047	0.00783	0.0000000027	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.225151	0.037972	0.000000003098233	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0514834	0.00873821	0.000000003904891	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.0082	0.0014	0.0000000046	None	33450751_Mulder-RH_sex_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.1	0.0175	0.0000000081	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0471167	0.0082474	0.00000001132133	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.214903	0.0380923	0.0000000171065	None	39706196_Hannah-M.-Smith_body_fat_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	13971	1	Adults (18-65y)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.048	0.00857	0.000000019	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0463242	0.00824771	0.00000001982763	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0458691	0.00824788	0.00000002724275	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry discovery	Table S3	Body mass index	DNA mehtylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	5387	4	54.5	Both	European,South Asian	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	17.5	3	0.000000046	-	28002404_body_mass_index_all_ancestry_discovery
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.00051	0.000095	0.00000014	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Ma J	FHS, RS, CARDIA, MESA	30936141	2020-05-22	Hepatic Fat	EFO_0006506, EFO_0008421	Meta-analysis model 1	Table 1	DNA methylation	Hepatic Fat	Age, sex	Beta Values	Hounsfield units	Illumina HumanMethylation450	Whole blood	Model 1 = adjusted for sex + age	3400	4	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	None	None	0.0000002	None	30936141_Ma-J_hepatic_fat_meta-analysis_model_1
Ma J	FHS, RS, CARDIA, MESA	30936141	2020-05-22	Hepatic Fat	EFO_0006506, EFO_0008421	Meta-analysis model 2	Table 1	DNA methylation	Hepatic Fat	Age, sex	Beta Values	Hounsfield units	Illumina HumanMethylation450	Whole blood	Model 2 = model 1 + smoking + physical activity + alcohol consumption	3400	4	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	None	None	0.00000027	None	30936141_Ma-J_hepatic_fat_meta-analysis_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.0423377	0.00824917	0.0000002897781	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.0421779	0.00824922	0.0000003211526	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0421069	0.00824925	0.0000003361253	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0046	0.00091	0.0000005	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.00035719	7.34e-05	0.00000131	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Jiantao Ma	FHS	30796027	Feb 22, 2019	hepatic fat	EFO_0010821	Discovery	Table 1	DNA methylation	hepatic fat	Age, Sex, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylation450	whole blood	None	1496	1	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	None	None	0.0000024	None	30796027_Jiantao-Ma_hepatic_fat_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	sensitivity	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.187262	0.0402528	0.000003308448	None	39706196_Hannah-M.-Smith_glucose_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.185387	0.0401176	0.000003845207	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.0442984	0.00961344	0.000004100536	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.0380069	0.00825061	0.000004128314	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.0439313	0.00958725	0.000004637645	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0404542	0.00884168	0.000004792095	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0440496	0.00962884	0.000004806874	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.0373859	0.0082508	0.000005911569	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	South Asian ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2680	1	51.0	Both	South Asian	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	22.5	4.38	0.0000061	-	28002404_body_mass_index_south_asian_ancestry_discovery
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	1.2	0.261	0.0000076	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0365228	0.00825106	0.000009649226	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	European ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2707	3	57.9	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	15.03	3.46	0.000014	-	28002404_body_mass_index_european_ancestry_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.160984	0.0370661	0.00001411996	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.172928	0.0403812	0.00001859075	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.041173	0.00962087	0.00001884618	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0407675	0.00961932	0.00002268118	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0403384	0.00960413	0.00002683664	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Breeze C	TOPMed	33931109	04-30-2021	estimated glomerular filtration rate (eGFR)	EFO_0005208	Summary results from LMMs were meta-analyzed within and across ethnicities	None	estimated glomerular filtration rate (eGFR)	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Study-specific variables	mL/min/1.73 m2	Beta values	Illumina HumanMethylationEPIC	Whole blood	Ethnicity-stratified analyses were performed using linear mixed models adjusting for age, sex, smoking, and study-specific and technical variables.	13537	6	Adults	Both	European, African, Other	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	26	6.14	0.000027	None	33931109_Breeze-C_estimated_glomerular_filtration_rate__egfr__summary_results_from_lmms_were_meta-analyzed_within_and_across_ethnicities
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.0399474	0.00961928	0.00003302195	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_2
Ma J	CARDSYA, FHS, MESA, RS	30936141	2019-02-21	Nonalcoholic fatty liver disease	EFO_0003095, EFO_1001248	discovery and replication	Table 1	Nonalcoholic fatty liver disease	DNA methylation	Age, sex, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole Blood, Monocytes	None	4525	4	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	None	None	0.000034	None	30936141_Ma-J_nonalcoholic_fatty_liver_disease_discovery_and_replication
Ma J	FHS, RS, CARDIA, MESA	30936141	2020-05-22	Hepatic Fat	EFO_0006506, EFO_0008421	Meta-analysis model 3	Table 1	DNA methylation	Hepatic Fat	Age, sex	Beta Values	Hounsfield units	Illumina HumanMethylation450	Whole blood	Model 3 = model 2 + BMI	3400	4	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	None	None	0.000034	None	30936141_Ma-J_hepatic_fat_meta-analysis_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0390393	0.00948708	0.00003893023	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.0023	0.00053	0.000039	None	33564054_Kashima-K_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0386077	0.00957085	0.00005513966	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.0332118	0.00825202	0.00005733759	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	0.038659	0.00960934	0.00005773412	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting insulin	EFO_0004466	Base	Supplementary Data 1	DNA methylation	fasting insulin	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	log pmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	1.25	0.32	0.000081	4738	31197173_Liu-J_fasting_insulin_base
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14020176	chr17:72764985	17	72764985	SLC9A3R1	Open sea	-0.0376128	0.00956432	0.0000844145	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3