author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.0021	0.00023	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	0.014	0.0013	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.19861	0.00913	8.2e-54	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2899333 (gene symbol: BTN3A2)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2899333 (gene symbol: BTN3A2)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	None	None	3e-27	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2899333__gene_symbol__btn3a2__meta-analysis
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2899298 (gene symbol: BTN3A2)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2899298 (gene symbol: BTN3A2)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	None	None	1.0999999999999999e-25	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2899298__gene_symbol__btn3a2__meta-analysis
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-	-	1.45e-20	-	28056824_age_4_vs_age_0
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	0.0027	None	1.9e-19	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Xueyi Shen	Generation Scotland, ALSPAC, Lothian Birth Cohorts	35354486	Mar 31, 2022	Polygenic risk scores for major depressive disorder	None	discovery	None	DNA methylation	Polygenic risk scores for major depressive disorder	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), methylation PCs	M values	None	Illumina HumanMethylationEPIC	Whole blood	Illumina HumanMethylation450K array was used for repliation analysis	8898	1	Adults	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.0176	0.0021	9.5e-17	None	35354486_Xueyi-Shen_polygenic_risk_scores_for_major_depressive_disorder_discovery
Mandaviya PR	RS, LLS, LL, NTR, CODAM, MARTHA, EGCUT, F5L, FHS, KORA, LBC1921, LBC1936	29084233	2017-10-30	homocysteine GRS	CHEBI_17230, EFO_0004578	Meta-analysis	Table S4	DNA methylation	homocysteine GRS	age, sex, cell composition (reference free), batch effects	Beta Values	GRS SD	Illumina HumanMethylation450	Whole blood	None	9894	12	Adults	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	0.039	0.005	0.0000000000000083	None	29084233_Mandaviya-PR_homocysteine_grs_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	0.0530675	0.00842755	0.0000000003123009	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.0519506	0.00842061	0.0000000007032516	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	0.049118	0.00824661	0.000000002641538	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	0.0485335	0.0083857	0.000000007283653	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	0.0499498	0.00871904	0.00000001031245	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Spiers H	-	25650246	2015-02-03	Gestational age	EFO_0005112, EFO_0000246	-	Additional file 1	DNA methylation	Gestational age	Sex and technical covariates	Beta values	days	Illumina HumanMethylation450	Fetal brain	-	179	1	-	Both	None	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.04597	0.0082	0.0000000177	-	25650246_gestational_age
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.0724984	0.0131358	0.00000003455469	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	0.0454838	0.00824803	0.00000003556789	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.0697595	0.013222	0.0000001336034	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.0421353	0.00824924	0.0000003300503	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.064791	0.0128307	0.0000004470855	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.0401513	0.00795421	0.0000004522837	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.0644491	0.0128603	0.0000005454219	None	39706196_Hannah-M.-Smith_body_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	0.040285	0.00842434	0.000001752639	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	BTN3A3 protein levels (SeqId = 17692-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	BTN3A3 protein levels (SeqId = 17692-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Butyrophilin subfamily 3 member A3	774	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.31	0.068	0.0000036	None	Gadd-DA_btn3a3_protein_levels__seqid___17692-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.035374	0.00765256	0.00000382366	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.51	0.111	0.000004	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Battram T	GEO	27886173	2020-09-15	Ulcerative colitis	EFO_0000729	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Ulcerative colitis	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	163	1	Adults	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	0.0569	0.012	0.0000051	None	27886173_Battram-T_ulcerative_colitis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.038351	0.00876456	0.0000121888	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.0364053	0.00841344	0.00001521286	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.011	0.00264	0.000017	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	0.0353332	0.00825142	0.00001863353	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	0.0349458	0.00834619	0.00002842655	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	0.0343995	0.00825168	0.0000307989	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.034908	0.00841852	0.0000339397	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	0.0354231	0.00868493	0.000045531	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	0.035422	0.00878236	0.00005527423	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14345882	chr6:26364793	6	26364793	BTN3A2	Open sea	-0.0331665	0.00825203	0.0000586887	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1