author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.24144 0.01327 1e-43 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.107315 0.00820889 7.74645e-39 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.101801 0.00821368 4.219511e-35 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 3.7 0.349 3.6e-26 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.480802 0.0471427 2.333287e-24 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0834022 0.00822781 4.560839e-24 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.452574 0.0447047 5.023638e-24 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0732406 0.0082344 6.54541e-19 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.131027 0.0151956 7.204908e-18 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 2906333 (gene symbol: DAAM2) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 2906333 (gene symbol: DAAM2) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea None None 9.4e-17 None 33752734_Yao-C_gene_expression_of_affymetrix_id__2906333__gene_symbol__daam2__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0680372 0.00823744 1.586784e-16 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0665874 0.00823825 6.82562e-16 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0651984 0.008239 0.000000000000002683069 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.104423 0.0133545 0.000000000000005670885 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.104547 0.0133869 0.000000000000006119055 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0628612 0.00824024 0.00000000000002519471 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.101428 0.0133358 0.00000000000003006059 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.34632 0.0461622 0.00000000000006577347 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.114898 0.0154785 0.0000000000001207757 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.114161 0.0155697 0.0000000000002380942 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.095866 0.0133809 0.0000000000008185067 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.107485 0.0154197 0.000000000003290756 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0573822 0.00824297 0.00000000000351323 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0569161 0.00824319 0.000000000005240497 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.108007 0.0156479 0.000000000005327487 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_4 Petersen A-K KORA F4 24014485 2013-09-06 M32388_dodecanedioate EFO_0004727, EFO_0004725 no snps model Table S2 M32388_dodecanedioate DNA methylation Age, sex, body mass index, cell composition (reference based) None Beta Values Illumina HumanMethylation450 Whole blood None 1760 1 Adults Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.79 0.1 0.000000000011 None 24014485_Petersen-A-K_m32388_dodecanedioate_no_snps_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.102502 0.0155912 0.00000000005053469 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.317275 0.0484721 0.00000000006095848 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.101376 0.0155358 0.00000000007009151 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_4 Dugue P-A LOLIPOP, KORA 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Replication Supplementary Table 5 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5704 2 Adults Both Unclear cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea None None 0.00000000013 None 31789449_Dugue-P-A_alcohol_consumption_replication Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea None None 0.00000000015 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Petersen A-K KORA F4 24014485 2013-09-06 M32388_dodecanedioate EFO_0004727, EFO_0004725 snps as covariates model Table S4 M32388_dodecanedioate DNA methylation Age, sex, body mass index, cell composition (reference based), genotype None Beta Values Illumina HumanMethylation450 Whole blood used three nearby snps as covariates 1760 1 Adults Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.78 0.101 0.00000000018 None 24014485_Petersen-A-K_m32388_dodecanedioate_snps_as_covariates_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0834727 0.0132959 0.0000000003524623 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0939828 0.0153099 0.0000000008534178 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.089411 0.0148271 0.000000001676462 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0496593 0.00824638 0.000000001764463 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0491608 0.00824659 0.000000002559066 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P25311 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P25311 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.048757 0.00824675 0.000000003449334 P25311 41361833_Josephine_Robertson_P25311_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.078995 0.0134181 0.00000000401397 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.00088 0.00015 0.0000000053 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0779372 0.0133708 0.000000005695569 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0780528 0.0133944 0.000000005752098 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0884774 0.0154768 0.00000001106711 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0880412 0.0156794 0.00000002000301 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00734 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00734 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0876196 0.0156062 0.00000002008237 P00734 41361833_Josephine_Robertson_P00734_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0734591 0.0133849 0.00000004127956 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0827161 0.0150961 0.0000000434051 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_4 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Fully-adjusted model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 14040 1 Adults Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 1.9 0.355 0.000000059 Fully_Adjusted_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0713204 0.0133276 0.0000000886234 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0715273 0.0133716 0.00000008967697 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.252911 0.0473863 0.00000009551226 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04196 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04196 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0831993 0.0156295 0.0000001034454 P04196 41361833_Josephine_Robertson_P04196_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.071066 0.0134017 0.0000001157086 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O95445 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O95445 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0709447 0.013403 0.0000001219328 O95445 41361833_Josephine_Robertson_O95445_OSCA_model_2 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age*sex PATO_0000047,EFO_0000246 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation age*sex sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.00087 0.00017 0.00000015 None 33450751_Mulder-RH_age_sex_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O95445 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O95445 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.081552 0.0155551 0.0000001603607 O95445 41361833_Josephine_Robertson_O95445_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0678862 0.0131511 0.0000002474917 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.238165 0.0463077 0.000000273205 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0686963 0.0133645 0.0000002779725 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0650592 0.0127853 0.0000003652128 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0417201 0.00824938 0.0000004302334 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05543 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P05543 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0789953 0.0156701 0.0000004682751 P05543 41361833_Josephine_Robertson_P05543_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0785432 0.0156238 0.0000005036618 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_4 Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.00018658 3.78e-05 0.000000804 - 27843151_alcohol_consumption_per_day_european_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q96PD5 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q96PD5 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0661777 0.0134273 0.0000008372749 Q96PD5 41361833_Josephine_Robertson_Q96PD5_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0768053 0.0156229 0.0000008919616 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0646242 0.0131654 0.0000009269987 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01008 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01008 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0633968 0.0129482 0.0000009875998 P01008 41361833_Josephine_Robertson_P01008_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.217244 0.0446194 0.000001132011 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0758711 0.01565 0.000001260041 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0396034 0.00825009 0.000001599437 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea None None 0.0000019 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.039203 0.00825022 0.000002035766 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0739411 0.0155621 0.000002039674 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0387254 0.00825038 0.000002706329 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0621059 0.0134077 0.000003650648 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0616972 0.0133691 0.000003966214 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0611813 0.013394 0.000004968579 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0374666 0.00825077 0.000005644031 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0600398 0.0132528 0.000005934973 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0603764 0.0133345 0.000006005641 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.218708 0.0488185 0.000007511331 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.059177 0.0133444 0.000009292326 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0588619 0.0133934 0.00001116299 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0683305 0.0156027 0.00001198238 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_4 Li S - 28811542 2017-08-15 Age EFO_0000246 - Table S1 DNA methylation Age Cell counts M values years Illumina HumanMethylation450 Whole blood - 1366 2 73 Missing European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.00554 0.00131155 0.000012 - 28811542_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0360752 0.0082512 0.00001238969 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P10643 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P10643 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0360377 0.00825121 0.00001265015 P10643 41361833_Josephine_Robertson_P10643_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0576759 0.0133801 0.00001638974 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0651296 0.0151247 0.00001671772 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0576472 0.0134235 0.00001762228 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_3 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea None None 0.000024 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Gadd DA Generation Scotland 35945220 31/07/2022 CD68 protein levels (SeqId = 18922-27) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CD68 protein levels (SeqId = 18922-27) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Macrosialin 774 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.884 0.21 0.000026 None Gadd-DA_cd68_protein_levels__seqid___18922-27__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O95445 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O95445 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0561045 0.0133453 0.00002637049 O95445 41361833_Josephine_Robertson_O95445_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 LOXL3 protein levels (SeqId = 15427-35) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 LOXL3 protein levels (SeqId = 15427-35) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Lysyl oxidase homolog 3 774 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.89 0.211 0.000027 None Gadd-DA_loxl3_protein_levels__seqid___15427-35__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0560209 0.0133861 0.00002868125 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.034364 0.0082517 0.00003138549 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20851 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P20851 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0648053 0.015566 0.00003155382 P20851 41361833_Josephine_Robertson_P20851_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0650231 0.0156621 0.00003319999 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0553976 0.0134122 0.00003641643 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 ST3GAL6 protein levels (SeqId = 6947-4) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ST3GAL6 protein levels (SeqId = 6947-4) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Type 2 lactosamine alpha-2,3-sialyltransferase 774 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.87 0.211 0.000038 None Gadd-DA_st3gal6_protein_levels__seqid___6947-4__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GRID2 protein levels (SeqId = 12758-47) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GRID2 protein levels (SeqId = 12758-47) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glutamate receptor ionotropic, delta-2 774 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.869 0.211 0.000038 None Gadd-DA_grid2_protein_levels__seqid___12758-47__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01602 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01602 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0643258 0.015645 0.00003950747 P01602 41361833_Josephine_Robertson_P01602_OSCA_model_4 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0045 0.0011 0.000041 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0641163 0.01563 0.00004115786 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0641688 0.0156611 0.00004201901 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0543388 0.0134012 0.00005044331 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_2 Sikdar S PACE 31536415 2019-09-19 Prenatal smoke exposure EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318 Inverse varience-weighted fixed-effects meta-analysis Table S1 DNA methylation Prenatal smoke exposure Maternal age, socioeconomic position, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Cord blood, whole blood None 5648 9 Infants Both European, African, Unclear cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0061 0.0015 0.000051 None 31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0333553 0.00825198 0.00005324467 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0537859 0.0133445 0.00005592194 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 CAMP protein levels (SeqId = 15481-45) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CAMP protein levels (SeqId = 15481-45) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Cathelicidin antimicrobial peptide 774 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.83 0.206 0.000058 None Gadd-DA_camp_protein_levels__seqid___15481-45__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SFRP4 protein levels (SeqId = 17447-52) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SFRP4 protein levels (SeqId = 17447-52) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Secreted frizzled-related protein 4 774 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.84 0.211 0.000063 None Gadd-DA_sfrp4_protein_levels__seqid___17447-52__somascan_protein_measurement Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.038 0.00952 0.000067 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0325142 0.00825221 0.00008183608 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea - - 0.0000847 - 26500701_sex_kora_f4 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18005 1 Adults (18-65y) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.083 0.0211 0.000089 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.180847 0.0461807 0.00009034687 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea 0.0611976 0.01563 0.00009066942 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.0608467 0.0155854 0.00009500963 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_4 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg14438453 chr6:39786566 6 39786566 DAAM2 Open sea -0.00061927 0.00015835 0.0000978 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age