author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0046	0.00024	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.02	0.0013	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	sex	PATO_0000047	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	sex	gestational age,cohort,cell composition (reference based),batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.022	0.0027	0	None	33450751_Mulder-RH_sex_discovery
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.44203	0.00927	1.1e-108	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.554676	0.0268131	6.256589e-94	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.54811	0.026999	1.428645e-90	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.52676	0.0269232	2.498112e-84	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-	-	4.62e-83	-	28056824_age_4_vs_age_0
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.463194	0.0261278	1.054113e-69	None	39706196_Hannah-M.-Smith_body_fat_discovery
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-2.9	0.163	4.999999999999999e-69	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.458263	0.0260721	1.463549e-68	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.435793	0.0260737	3.194903e-62	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.127151	0.00818956	6.21255e-54	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.124426	0.0084186	4.455788e-49	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.112887	0.00842099	9.760275e-41	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.109534	0.00820689	2.134546e-40	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.10848	0.00820785	1.1861070000000001e-39	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	None	None	2.2e-39	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.110107	0.0084521	1.403158e-38	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.109899	0.00843751	1.4437089999999998e-38	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Richard MA	CHARGE	29198723	2019-11-25	Systolic Blood Pressure	EFO_0006335	Meta-analysis	Table S4	DNA methylation	Systolic Blood Pressure	Age, sex, smoking, batch effects, ancestry, body mass index, blood cell counts	Beta Values	mmHg	Illumina HumanMethylation450	Whole blood, CD4+ T cells	Overall meta-analysis of discovery and replication cohorts	17010	14	Adults	Both	African, Admixed, European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0003	None	2.7e-34	None	29198723_Richard-MA_systolic_blood_pressure_meta-analysis
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous decade consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	None	None	6.2000000000000004e-34	None	31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0996981	0.00821544	9.9412e-34	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0984298	0.00821648	6.476375e-33	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0990577	0.00853531	5.271044e-31	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0974682	0.00844695	1.139909e-30	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Lifetime consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	None	None	2.2e-29	None	31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	Discovery and replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	Weighted Z-test meta-analysis	10238	13	54.5	Both	European,South Asian	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-	-	1.5000000000000002e-28	-	28002404_body_mass_index_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.093634	0.00846542	2.5164050000000003e-28	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0891746	0.00822368	2.7131820000000003e-27	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0875572	0.00822486	2.285595e-26	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0870513	0.00822523	4.415665e-26	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0945761	0.00902302	1.2925960000000001e-25	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0856084	0.00821232	2.353096e-25	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0909584	0.0088051	6.266729999999999e-25	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0861493	0.0083881	1.160929e-24	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0831542	0.00822798	6.205871e-24	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0872762	0.00873815	2.04512e-23	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Petersen A-K	KORA F4	24014485	2013-09-06	M32197_3-4-hydroxyphenyllactate	EFO_0004727, EFO_0004725	no snps model	Table S2	M32197_3-4-hydroxyphenyllactate	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	3.8	0.067	2.6e-23	None	24014485_Petersen-A-K_m32197_3-4-hydroxyphenyllactate_no_snps_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0854072	0.00865807	6.995233e-23	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0827476	0.00847384	1.861572e-22	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0830239	0.00853161	2.589916e-22	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0799262	0.00823016	3.1457499999999997e-22	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0816874	0.00847813	6.60149e-22	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0830737	0.00864834	8.766792e-22	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.080627	0.00846938	2.000355e-21	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Richard MA	CHARGE	29198723	2019-11-25	Diastolic Blood Pressure	EFO_0006336	Meta-analysis	Table S4	DNA methylation	Diastolic Blood Pressure	Age, sex, smoking, batch effects, ancestry, body mass index, blood cell counts	Beta Values	mmHg	Illumina HumanMethylation450	Whole blood, CD4+ T cells	Overall meta-analysis of discovery and replication cohorts	17010	14	Adults	Both	African, Admixed, European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0004	None	2.1e-21	None	29198723_Richard-MA_diastolic_blood_pressure_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0790087	0.00839492	5.60593e-21	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Petersen A-K	KORA F4	24014485	2013-09-06	M37202_4-androsten-3betacomma17beta-diol_disulfate_1*	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M37202_4-androsten-3betacomma17beta-diol_disulfate_1*	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.93	0.12	6.5e-21	None	24014485_Petersen-A-K_m37202_4-androsten-3betacomma17beta-diol_disulfate_1__snps_as_covariates_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0771774	0.00828372	1.367218e-20	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0766939	0.00823225	1.373391e-20	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0762274	0.00821072	1.859174e-20	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	sensitivity	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.250214	0.0271151	3.0625279999999997e-20	None	39706196_Hannah-M.-Smith_glucose_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0752499	0.00823316	7.060383e-20	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0773245	0.00847622	8.279356e-20	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0778616	0.00854664	9.269453999999999e-20	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0769336	0.00846793	1.164449e-19	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4261	5	65	Both	None	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0165689	0.0018504	3.43e-19	-	28213390_serum_triglycerides_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0758755	0.00847892	4.0210929999999994e-19	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0729004	0.0082346	9.486747999999998e-19	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.231309	0.0264181	2.2029060000000002e-18	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	discovery	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.227237	0.0260117	2.625556e-18	None	39706196_Hannah-M.-Smith_glucose_discovery
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	European ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2707	3	57.9	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-13.48	1.56	4.5e-18	-	28002404_body_mass_index_european_ancestry_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0716041	0.00832737	8.873808e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.1	0.012	9.2e-18	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0703055	0.00819851	1.0853760000000001e-17	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0700696	0.00823628	1.9484e-17	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry discovery	Table S3	Body mass index	DNA mehtylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	5387	4	54.5	Both	European,South Asian	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-14.5	1.6	2.1e-17	-	28002404_body_mass_index_all_ancestry_discovery
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.046	0.00543	2.1e-17	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0702707	0.00847005	1.166072e-16	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0701416	0.00847012	1.325477e-16	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0703808	0.00854225	1.880057e-16	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0698325	0.00848886	2.090755e-16	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0675035	0.00823774	2.724554e-16	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.215438	0.0265238	4.858584e-16	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Ligthart S	CHARGE	27955697	2016-12-12	C-reactive protein	EFO_0004458	Discovery	Table S3	DNA methylation	C-reactive protein	Age, sex, smoking, body mass index, cell counts and technical covariates	Beta values	mg/l	Illumina HumanMethylation450	Whole blood	C-reactive protein levels were log-transformed	8863	9	65	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0068	0.000839	5.29e-16	-	27955697_creactive_protein_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0664891	0.0082383	7.526894e-16	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0679397	0.00847723	0.000000000000001189986	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0675287	0.00848727	0.000000000000001899171	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.065278	0.00823896	0.000000000000002482543	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-1.4	0.173	0.0000000000000026	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0671381	0.00848668	0.000000000000002735054	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0668153	0.00847345	0.000000000000003359312	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0647377	0.00823925	0.000000000000004198614	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0694573	0.00884317	0.000000000000004296554	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_4
Aslibekyan S	-	26110892	2015-07-01	Body mass index	EFO_0004340	Meta-analysis	Table 2	DNA methylation	Body mass index	Age, sex, smoking, study centre and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	CD4+ T-cells, leukocytes and whole blood	-	5474	4	59.1	Both	European,African	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-	-	0.0000000000000047	-	26110892_body_mass_index_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0656134	0.00848688	0.00000000000001134803	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0695691	0.00901039	0.00000000000001228779	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0215042	0.0027886	0.0000000000000125	-	28213390_serum_triglycerides_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0678349	0.0090402	0.00000000000006560995	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0671659	0.00901078	0.00000000000009565936	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0622144	0.00835236	0.00000000000009950645	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0629579	0.00849232	0.0000000000001297283	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Nano J	-	28624579	2017-06-15	Gamma-glutamyl transferase	EFO_0004532	Meta-analysis	Table S2	DNA methylation	Gamma-glutamyl transferase	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	1450	2	63.5	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.017	0.002	0.00000000000018	-	28624579_gammaglutamyl_transferase_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0666971	0.0090566	0.0000000000001873239	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0657434	0.00895495	0.0000000000002222276	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0603862	0.0082415	0.0000000000002474799	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0610896	0.00834964	0.0000000000002678565	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0599624	0.00824171	0.0000000000003626759	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0599482	0.00824172	0.0000000000003673535	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0616273	0.00847325	0.0000000000003689467	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0591043	0.00824214	0.0000000000007801638	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_1
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	4851	9	54.5	Both	European,South Asian	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-8.9	1.2	0.00000000000094	-	28002404_body_mass_index_all_ancestry_replication
Xu K	National Health and Resilience in Veterans Study	31386212	2019-08-06	Alcohol Consumption	EFO_0004329, EFO_0007878	adjusted for bmi	Table 2	DNA methylation	Alcohol Consumption	Age, smoking, cell composition (reference based), body mass index	Beta Values	AUDIT-C score	Illumina HumanMethylationEPIC	Saliva	None	1135	1	Adults	Males	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	None	None	0.0000000000014	None	31386212_Xu-K_alcohol_consumption_adjusted_for_bmi
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0024	None	0.0000000000016	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0587579	0.00832949	0.000000000001813594	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for BMI	Table S9	DNA methylation	Serum triglycerides	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4261	5	65	Both	None	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0135	0.0019	0.00000000000205	-	28213390_serum_triglycerides_discovery_and_replication_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0579494	0.0082427	0.000000000002150482	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0596482	0.00848711	0.000000000002186265	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0594354	0.00847112	0.000000000002378989	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0617159	0.00887782	0.000000000003761648	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0614285	0.0090109	0.00000000000965048	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0530179	0.00778358	0.00000000001003385	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0576331	0.0084797	0.00000000001112569	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0552763	0.00824395	0.00000000002086564	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0565651	0.00849478	0.00000000002858826	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0569362	0.00855591	0.00000000002941404	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_3
Xu K	National Health and Resilience in Veterans Study	31386212	2019-08-06	Alcohol Consumption	EFO_0004329, EFO_0007878	not adjusted for bmi	Table 2	DNA methylation	Alcohol Consumption	Age, smoking, cell composition (reference based)	Beta Values	AUDIT-C score	Illumina HumanMethylationEPIC	Saliva	None	1135	1	Adults	Males	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	None	None	0.000000000032	None	31386212_Xu-K_alcohol_consumption_not_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0564518	0.00855507	0.00000000004291917	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_3
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Meta-analysis	Table S1	DNA methylation	Body mass index	Age, sex, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood	Weighted Z-test meta-analysis	3743	4	69.2	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-	-	0.0000000000503	-	28095459_body_mass_index_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0541216	0.00824447	0.00000000005392562	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Wilson LE	Sister Study	30938765	2019-02-14	Alcohol Consumption	EFO_0004329, EFO_0007878	replication	Web Table 1	DNA methylation	Alcohol Consumption	Age,  breast cancer status, smoking, body mass index, menopausal status, ancestry (other), batch effects, cell composition (reference based)	M Values	drinks per week	Illumina HumanMethylation450	Whole blood	Discovery P-value not reported	187	1	Adults	Females	Unclear	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	None	None	0.000000000055	None	30938765_Wilson-LE_alcohol_consumption_replication
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	European ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	4195	8	54.6	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-7.08	1.08	0.000000000057	-	28002404_body_mass_index_european_ancestry_replication
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery adjusted for BMI	Table S9	DNA methylation	Serum triglycerides	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0187794	0.0028965	0.0000000000896	-	28213390_serum_triglycerides_discovery_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0548145	0.00849318	0.000000000112403	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.160885	0.0254341	0.0000000002581903	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Cardona A	EPIC-Norfolk	31506343	2019-09-10	Type II diabetes	EFO_0001360	Discovery	Table 2	Type II diabetes	DNA methylation	Age, sex, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1264	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.4	None	0.00000000028	None	31506343_Cardona-A_type_ii_diabetes_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0517251	0.00824552	0.0000000003638324	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Liu C	CHARGE+	27843151	2016-12-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	European ancestry	Table S5	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g der day	Illumina HumanMethylation450	Whole blood	-	9643	10	64.2	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.00094059	0.0001501	0.000000000369	-	27843151_alcohol_consumption_per_day_european_ancestry
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0516522	0.00824555	0.0000000003850687	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0545536	0.0087544	0.0000000004744617	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0563869	0.00906063	0.0000000005001044	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0519707	0.00838049	0.0000000005746837	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Ma J	FHS, RS, CARDIA, MESA	30936141	2020-05-22	Hepatic Fat	EFO_0006506, EFO_0008421	Meta-analysis model 1	Table 1	DNA methylation	Hepatic Fat	Age, sex	Beta Values	Hounsfield units	Illumina HumanMethylation450	Whole blood	Model 1 = adjusted for sex + age	3400	4	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	None	None	0.00000000067	None	30936141_Ma-J_hepatic_fat_meta-analysis_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0504124	0.00824607	0.0000000009993944	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14350	1	Adults (18-65y)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.078	0.0128	0.0000000011	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0545761	0.00895161	0.00000000110934	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	PSAT1 protein levels (SeqId = 18342-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PSAT1 protein levels (SeqId = 18342-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphoserine aminotransferase	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.78	0.13	0.0000000018	None	Gadd-DA_psat1_protein_levels__seqid___18342-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0512073	0.00851479	0.000000001853854	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_3
Ma J	FHS, RS, CARDIA, MESA	30936141	2020-05-22	Hepatic Fat	EFO_0006506, EFO_0008421	Meta-analysis model 2	Table 1	DNA methylation	Hepatic Fat	Age, sex	Beta Values	Hounsfield units	Illumina HumanMethylation450	Whole blood	Model 2 = model 1 + smoking + physical activity + alcohol consumption	3400	4	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	None	None	0.0000000021	None	30936141_Ma-J_hepatic_fat_meta-analysis_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.053871	0.0089935	0.000000002147769	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	SCUBE1 protein levels (SeqId = 8989-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SCUBE1 protein levels (SeqId = 8989-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Signal peptide, CUB and EGF-like domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.78	0.131	0.0000000024	None	Gadd-DA_scube1_protein_levels__seqid___8989-40__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0504989	0.00848742	0.000000002744933	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.050471	0.00848756	0.000000002802197	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0524417	0.00884955	0.000000003175261	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0502957	0.00849819	0.000000003323368	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0499228	0.0085607	0.000000005604779	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0510849	0.00876901	0.000000005809525	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_4
Liu C	CHARGE+	27843151	2016-11-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	CD14+ monocytes	Table S7	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g per day	Illumina HumanMethylation450	CD14+ monocytes	-	1251	1	60	Both	European,African,Admixed	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.000714	0.000122	0.00000000662	-	27843151_alcohol_consumption_per_day_cd14_monocytes
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0489861	0.00844904	0.000000006855808	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0478143	0.00824713	0.000000006861885	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0492043	0.00849338	0.000000007045515	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0477639	0.00824715	0.000000007115927	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Nano J	-	28624579	2017-06-15	Gamma-glutamyl transferase	EFO_0004532	Discovery	Table 2	DNA methylation	Gamma-glutamyl transferase	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	731	1	59.6	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.017	0.003	0.000000011	-	28624579_gammaglutamyl_transferase_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0480198	0.00846594	0.0000000143709	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0466916	0.00824757	0.00000001530808	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Aslibekyan S	-	26110892	2015-07-01	Waist circumference	EFO_0004342	Discovery GOLDN	Table 3	DNA methylation	Waist circumference	Age, sex, smoking, study centre and technical covariates	Beta values	cm	Illumina HumanMethylation450	CD4+ T-cells	-	991	1	49	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-6e-04	1e-04	0.000000017	-	26110892_waist_circumference_discovery_goldn
Aslibekyan S	-	26110892	2015-07-01	Body mass index	EFO_0004340	FHS 1	Table 2	DNA methylation	Body mass index	Age, sex and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood	-	1935	1	65	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.02	0.004	0.000000017	-	26110892_body_mass_index_fhs_1
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Framingham Heart Study Batch 2	Table S1	DNA methylation	Body mass index	Age, sex and technical covariates	-	kg/m2	Illumina HumanMethylation450	Whole blood	DNA methylation was inverse normally rank transformed	1935	1	67	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0232	0.0041	0.000000019	-	28095459_body_mass_index_framingham_heart_study_batch_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0476424	0.00850139	0.00000002131481	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0462157	0.00824775	0.00000002139332	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Aslibekyan S	-	26110892	2015-07-01	Waist circumference	EFO_0004342	Meta-analysis	Table 3	DNA methylation	Waist circumference	Age, sex, smoking, study centre and technical covariates	Beta values	cm	Illumina HumanMethylation450	CD4+ T-cells and leukocytes	-	3097	2	53.8	Both	European,African	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-	-	0.000000022	-	26110892_waist_circumference_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0474042	0.00850231	0.00000002512475	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0459834	0.00827259	0.00000002768074	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0469764	0.00846356	0.00000002899067	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0456408	0.00824797	0.00000003191331	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Ratio of omega 6 fatty acids to total fatty acids	EFO_0005110	None	None	DNA methylation	Ratio of omega 6 fatty acids to total fatty acids	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	671	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.072	0.013	0.000000033	None	Battram-T_ratio_of_omega_6_fatty_acids_to_total_fatty_acids
Karabegovic I	Airwave, ALSPAC, ESTHER, FHS, KORA, Rotterdam Study, Twins UK, ARIC, CHS, EPIC	33990564	05-14-2021	Coffee and tea consumption	None	Meta-analysis	Table 2	DNA methylation	Coffee and tea consumption	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Alcohol consumption	Beta values	None	Illumina HumanMethylation450	Whole blood	None	15789	15	Adults	Both	European, African	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0011	0.0002	0.000000047	None	33990564_Karabegovic-I_coffee_and_tea_consumption_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0462627	0.00846596	0.00000004716257	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.04663	0.0085742	0.00000005462036	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Ratio of 18:2 linoleic acid to total fatty acids	EFO_0006807, EFO_0005110	None	None	DNA methylation	Ratio of 18:2 linoleic acid to total fatty acids	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	671	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.067	0.0123	0.000000057	None	Battram-T_ratio_of_18_2_linoleic_acid_to_total_fatty_acids
Aslibekyan S	-	26110892	2015-07-01	Body mass index	EFO_0004340	Discovery GOLDN	Table 2	DNA methylation	Body mass index	Age, sex, smoking, study centre and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	CD4+ T-cells	-	991	1	49	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0015	3e-04	0.000000066	-	26110892_body_mass_index_discovery_goldn
Jiantao Ma	FHS	30796027	Feb 22, 2019	hepatic fat	EFO_0010821	Discovery	Table 1	DNA methylation	hepatic fat	Age, Sex, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylation450	whole blood	None	1496	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	None	None	0.000000075	None	30796027_Jiantao-Ma_hepatic_fat_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0449005	0.00836407	0.00000008071309	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0478712	0.00896657	0.00000009493153	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.136242	0.0255246	0.00000009526625	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0437374	0.00824867	0.0000001159768	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Mean diameter for VLDL particles	EFO_0008594	None	None	DNA methylation	Mean diameter for VLDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	nm	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.133	0.026	0.00000023	None	Battram-T_mean_diameter_for_vldl_particles
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0435139	0.00843399	0.0000002510449	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Ratio of polyunsaturated fatty acids to total fatty acids	EFO_0010733, EFO_0005110	None	None	DNA methylation	Ratio of polyunsaturated fatty acids to total fatty acids	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	671	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.063	0.0122	0.00000027	None	Battram-T_ratio_of_polyunsaturated_fatty_acids_to_total_fatty_acids
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	1955	3	61	Both	None	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0126963	0.0024725	0.000000282	-	28213390_serum_triglycerides_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0435085	0.00849662	0.0000003082788	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0433274	0.00849757	0.0000003460733	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	13971	1	Adults (18-65y)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.03	0.00587	0.00000037	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0433182	0.00855101	0.0000004115128	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0452229	0.00896057	0.0000004544722	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_4
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	South Asian ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2680	1	51.0	Both	South Asian	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-28.59	4.99	0.00000047	-	28002404_body_mass_index_south_asian_ancestry_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0451514	0.0089774	0.00000049772	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0412709	0.00824954	0.0000005715442	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0412566	0.00824954	0.0000005766881	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CFHR1 protein levels (SeqId = 15468-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CFHR1 protein levels (SeqId = 15468-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement factor H-related protein 1	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.64	0.129	0.00000061	None	Gadd-DA_cfhr1_protein_levels__seqid___15468-14__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PRSS2 protein levels (SeqId = 5034-79)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PRSS2 protein levels (SeqId = 5034-79)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Trypsin-2	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.64	0.131	0.00000096	None	Gadd-DA_prss2_protein_levels__seqid___5034-79__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0439934	0.00906793	0.000001237716	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0411887	0.00850037	0.000001275706	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0409524	0.00851347	0.000001521992	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Free cholesterol in large VLDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	659	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-9.9	2.07	0.0000019	None	Battram-T_free_cholesterol_in_large_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0430116	0.00903162	0.000001932009	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0418389	0.00878773	0.000001944277	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	DEFB1 protein levels (SeqId = 6629-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DEFB1 protein levels (SeqId = 6629-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-defensin 1	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.619	0.131	0.0000022	None	Gadd-DA_defb1_protein_levels__seqid___6629-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0427469	0.00903933	0.000002277518	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Ratio of monounsaturated fatty acids to total fatty acids	EFO_0005110	None	None	DNA methylation	Ratio of monounsaturated fatty acids to total fatty acids	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	669	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.057	0.0121	0.0000027	None	Battram-T_ratio_of_monounsaturated_fatty_acids_to_total_fatty_acids
Cardona A	LOLIPOP	31506343	2019-09-10	Type II diabetes	EFO_0001360	Replication in Indians	Table 3	Type II diabetes	DNA methylation	Cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	2664	1	Adults	Both	South Asian	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.211	None	0.000003	None	31506343_Cardona-A_type_ii_diabetes_replication_in_indians
Gadd DA	Generation Scotland	35945220	31/07/2022	CBLN1 protein levels (SeqId = 9313-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CBLN1 protein levels (SeqId = 9313-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cerebellin-1	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.61	0.131	0.0000031	None	Gadd-DA_cbln1_protein_levels__seqid___9313-27__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Triglycerides	EFO_0004530	fasting	None	DNA methylation	Triglycerides	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.37	0.08	0.0000037	None	Battram-T_triglycerides_fasting
Battram T	ARIES	None	2020-08-20	VLDL cholesterol	EFO_0008317	fasting	None	DNA methylation	VLDL cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.82	0.176	0.0000038	None	Battram-T_vldl_cholesterol_fasting
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0390508	0.00847467	0.000004101025	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Cholesterol esters in large VLDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	661	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-9.5	2.06	0.0000043	None	Battram-T_cholesterol_esters_in_large_vldl
Battram T	ARIES	None	2020-08-20	Total cholesterol to total lipids ratio in medium HDL	EFO_0004574	None	None	DNA methylation	Total cholesterol to total lipids ratio in medium HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	682	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.079	0.0171	0.0000043	None	Battram-T_total_cholesterol_to_total_lipids_ratio_in_medium_hdl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0392536	0.00853709	0.000004301124	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_3
Karabegovic I	Airwave, ALSPAC, ESTHER, FHS, KORA, Rotterdam Study, Twins UK	33990564	05-14-2021	Coffee and tea consumption	None	Discovery	Table 2	DNA methylation	Coffee and tea consumption	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Body mass index, Alcohol consumption	Beta values	None	Illumina HumanMethylation450	Whole blood	None	9612	7	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0011	0.0002	0.0000044	None	33990564_Karabegovic-I_coffee_and_tea_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0389335	0.00849395	0.00000460631	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	ADIPOQ protein levels (SeqId = 3554-24)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADIPOQ protein levels (SeqId = 3554-24)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Adiponectin	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.6	0.131	0.000005	None	Gadd-DA_adipoq_protein_levels__seqid___3554-24__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ADSSL1 protein levels (SeqId = 13998-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADSSL1 protein levels (SeqId = 13998-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Adenylosuccinate synthetase isozyme 1	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.592	0.131	0.000006	None	Gadd-DA_adssl1_protein_levels__seqid___13998-26__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0372567	0.00825084	0.000006365916	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_1
Nano J	-	28624579	2017-06-15	Gamma-glutamyl transferase	EFO_0004532	Replication	Table 2	DNA methylation	Gamma-glutamyl transferase	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	719	1	67.5	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.017	0.003	0.0000067	-	28624579_gammaglutamyl_transferase_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0403042	0.00896024	0.000006908783	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0385752	0.00858037	0.00000698568	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0406902	0.0090577	0.000007098799	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0380416	0.00847794	0.000007273884	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.037579	0.00840211	0.000007786466	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Liu C	CHARGE+	27843151	2016-11-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	African ancestry	Table S6	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g per day	Illumina HumanMethylation450	Whole blood	-	2423	3	56	Both	African	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-7.87e-05	1.76e-05	0.00000811	-	27843151_alcohol_consumption_per_day_african_ancestry
Battram T	ARIES	None	2020-08-20	Serum total triglycerides	EFO_0004530	None	None	DNA methylation	Serum total triglycerides	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	676	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.33	0.074	0.0000084	None	Battram-T_serum_total_triglycerides
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0379404	0.00853719	0.000008889244	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_3
Juvinao-Quintero DL	ALSPAC, LBC1936, RSIII-1, RS-Bios	33622391	2021-02-23	Type 2 diabetes	EFO_0001360	meta-analysis	Table 2	DNA methylation	Type 2 diabetes	age, sex, batch effects, cell composition (reference based), smoking	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	3428	4	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.015	0.00336	0.0000095	None	33622391_Juvinao-Quintero-DL_type_2_diabetes_meta-analysis
Battram T	ARIES	None	2020-08-20	Free cholesterol to total lipids ratio in IDL	EFO_0008591	None	None	DNA methylation	Free cholesterol to total lipids ratio in IDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	674	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.196	0.044	0.0000096	None	Battram-T_free_cholesterol_to_total_lipids_ratio_in_idl
Battram T	ARIES	None	2020-08-20	Triglycerides in large VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	670	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-1.76	0.39	0.0000098	None	Battram-T_triglycerides_in_large_vldl
Battram T	ARIES	None	2020-08-20	Free cholesterol in medium VLDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	675	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-4.9	1.09	0.00001	None	Battram-T_free_cholesterol_in_medium_vldl
Battram T	ARIES	None	2020-08-20	Total cholesterol in large VLDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	664	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-4.7	1.06	0.00001	None	Battram-T_total_cholesterol_in_large_vldl
Jiantao Ma	RS, MESA, CARDIA	30796027	Feb 22, 2019	hepatic fat	EFO_0010821	Replication	Table 1	DNA methylation	hepatic fat	Age, Sex, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylation450	whole blood	None	1904	3	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	None	None	0.000011	None	30796027_Jiantao-Ma_hepatic_fat_replication
Battram T	ARIES	None	2020-08-20	Phospholipids in small VLDL	EFO_0004639	None	None	DNA methylation	Phospholipids in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-3.4	0.78	0.000011	None	Battram-T_phospholipids_in_small_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0394965	0.00898983	0.00001123405	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Cholesterol esters to total lipids ratio in medium HDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters to total lipids ratio in medium HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.075	0.017	0.000012	None	Battram-T_cholesterol_esters_to_total_lipids_ratio_in_medium_hdl
Battram T	ARIES	None	2020-08-20	Glycoprotein acetyls	EFO_0004555	None	None	DNA methylation	Glycoprotein acetyls	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.96	0.22	0.000012	None	Battram-T_glycoprotein_acetyls
Battram T	ARIES	None	2020-08-20	Triglycerides in VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides in VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	677	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.39	0.088	0.000013	None	Battram-T_triglycerides_in_vldl
Gadd DA	Generation Scotland	35945220	31/07/2022	ACY1 protein levels (SeqId = 3343-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACY1 protein levels (SeqId = 3343-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aminoacylase-1	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.57	0.131	0.000013	None	Gadd-DA_acy1_protein_levels__seqid___3343-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EFS protein levels (SeqId = 12572-236)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EFS protein levels (SeqId = 12572-236)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Embryonal Fyn-associated substrate	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.57	0.131	0.000013	None	Gadd-DA_efs_protein_levels__seqid___12572-236__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Triglycerides in medium VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	673	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-1.12	0.256	0.000013	None	Battram-T_triglycerides_in_medium_vldl
Battram T	ARIES	None	2020-08-20	Triglycerides in small HDL	EFO_0004530	None	None	DNA methylation	Triglycerides in small HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	682	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-10.8	2.5	0.000014	None	Battram-T_triglycerides_in_small_hdl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.038166	0.00879036	0.00001422673	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	OXT protein levels (SeqId = 8356-88)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	OXT protein levels (SeqId = 8356-88)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Oxytocin-neurophysin 1	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.56	0.131	0.000015	None	Gadd-DA_oxt_protein_levels__seqid___8356-88__somascan_protein_measurement
Cardona A	FHS	31506343	2019-09-10	Type II diabetes	EFO_0001360	Replication in Europeans	Table 3	DNA methylation	Type II diabetes	Age, sex, cell composition (reference based), batch effects, body mass index	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	2607	1	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.016	0.0036	0.000015	None	31506343_Cardona-A_type_ii_diabetes_replication_in_europeans
Battram T	ARIES	None	2020-08-20	Triglycerides to total lipids ratio in medium HDL	EFO_0004530	None	None	DNA methylation	Triglycerides to total lipids ratio in medium HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.115	0.026	0.000016	None	Battram-T_triglycerides_to_total_lipids_ratio_in_medium_hdl
Battram T	ARIES	None	2020-08-20	Concentration of large VLDL particles	EFO_0008317	None	None	DNA methylation	Concentration of large VLDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	670	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-62000000	14000000	0.000016	None	Battram-T_concentration_of_large_vldl_particles
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-	-	0.0000167	-	26500701_sex_kora_f4
Battram T	ARIES	None	2020-08-20	Free cholesterol in small VLDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-5	1.15	0.000017	None	Battram-T_free_cholesterol_in_small_vldl
Colicino E	CHARGE	32697766	07-22-2020	All cause mortality	EFO_0004352	basic model	Table S2	All cause mortality	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	None	M values	Illumina HumanMethylation450	Whole blood	Effect estimates represent hazard ratio per 10% increase in DNA methylation.	12300	12	Adults	Both	European, African	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.93	None	0.000017	None	32697766_Colicino-E_all_cause_mortality_basic_model
Battram T	ARIES	None	2020-08-20	Phospholipids in large VLDL	EFO_0004639	None	None	DNA methylation	Phospholipids in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	669	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-5.7	1.31	0.000019	None	Battram-T_phospholipids_in_large_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0383345	0.00899733	0.00002051031	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	ALDOB protein levels (SeqId = 18185-118)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ALDOB protein levels (SeqId = 18185-118)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fructose-bisphosphate aldolase B	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.55	0.13	0.000021	None	Gadd-DA_aldob_protein_levels__seqid___18185-118__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FTL protein levels (SeqId = 15324-58)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FTL protein levels (SeqId = 15324-58)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ferritin light chain	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.55	0.131	0.000022	None	Gadd-DA_ftl_protein_levels__seqid___15324-58__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FTH1 protein levels (SeqId = 5934-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FTH1 protein levels (SeqId = 5934-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ferritin heavy chain|Ferritin light chain	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.55	0.131	0.000022	None	Gadd-DA_fth1_protein_levels__seqid___5934-1__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Concentration of medium VLDL particles	EFO_0008317	None	None	DNA methylation	Concentration of medium VLDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	676	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-20000000	None	0.000023	None	Battram-T_concentration_of_medium_vldl_particles
Battram T	ARIES	None	2020-08-20	Phospholipids in medium VLDL	EFO_0004639	None	None	DNA methylation	Phospholipids in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	676	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-3	0.71	0.000024	None	Battram-T_phospholipids_in_medium_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0347924	0.00825157	0.00002496595	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Triglycerides in medium HDL	EFO_0004530	None	None	DNA methylation	Triglycerides in medium HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-10.3	2.4	0.000025	None	Battram-T_triglycerides_in_medium_hdl
Battram T	ARIES	None	2020-08-20	Total lipids in large VLDL	EFO_0004529	None	None	DNA methylation	Total lipids in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	671	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-1.01	0.237	0.000025	None	Battram-T_total_lipids_in_large_vldl
Battram T	ARIES	None	2020-08-20	Total lipids in medium VLDL	EFO_0004529	None	None	DNA methylation	Total lipids in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	676	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.58	0.138	0.000026	None	Battram-T_total_lipids_in_medium_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0381771	0.00909076	0.00002690301	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	RBP5 protein levels (SeqId = 19241-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RBP5 protein levels (SeqId = 19241-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Retinol-binding protein 5	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.55	0.13	0.000027	None	Gadd-DA_rbp5_protein_levels__seqid___19241-31__somascan_protein_measurement
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting glucose	EFO_0004465	Base	Supplementary Data 1	DNA methylation	fasting glucose	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	mmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.69	0.17	0.000029	4806	31197173_Liu-J_fasting_glucose_base
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.034192	0.00825174	0.00003437939	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	GSTA1 protein levels (SeqId = 17138-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GSTA1 protein levels (SeqId = 17138-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glutathione S-transferase A1	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.54	0.13	0.000037	None	Gadd-DA_gsta1_protein_levels__seqid___17138-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RBP4 protein levels (SeqId = 15633-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RBP4 protein levels (SeqId = 15633-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Retinol-binding protein 4	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.54	0.131	0.000037	None	Gadd-DA_rbp4_protein_levels__seqid___15633-6__somascan_protein_measurement
Huang D	BHS, GSH, DILGOM, ETS, EGCUT (Asthma), EGCUT (Young_O), FTC, HBCS,JHS, NTR, PREVEND, YFS, EpiGO, LACHY	32520614	2020-11-12	Systolic Blood Pressure	EFO_0006335	Discovery	Table 2, table 3	DNA methylation	Systolic Blood Pressure	age, sex, ancestry, body mass index, cell composition (reference based)	Beta Values	mmHg	Illumina HumanMethylation450	Whole blood	Includes some twins	4820	15	Adults	Both	European, Admixed	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	None	None	0.000043	None	32520614_Huang-D_systolic_blood_pressure_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0349059	0.00854143	0.00004399626	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Triglycerides in small VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-1.52	0.37	0.000044	None	Battram-T_triglycerides_in_small_vldl
Gadd DA	Generation Scotland	35945220	31/07/2022	FBP1 protein levels (SeqId = 7206-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FBP1 protein levels (SeqId = 7206-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fructose-1,6-bisphosphatase 1	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.53	0.13	0.000047	None	Gadd-DA_fbp1_protein_levels__seqid___7206-20__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0344273	0.00845818	0.00004719849	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Monounsaturated fatty acids 16:1 18:1	EFO_0005110	None	None	DNA methylation	Monounsaturated fatty acids 16:1 18:1	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	667	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.195	0.048	0.000048	None	Battram-T_monounsaturated_fatty_acids_16_1_18_1
Battram T	ARIES	None	2020-08-20	Triglycerides to total lipids ratio in small VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides to total lipids ratio in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	681	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.029	0.0071	0.000049	None	Battram-T_triglycerides_to_total_lipids_ratio_in_small_vldl
Battram T	ARIES	None	2020-08-20	Concentration of small VLDL particles	EFO_0008317	None	None	DNA methylation	Concentration of small VLDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	681	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-14000000	None	0.000053	None	Battram-T_concentration_of_small_vldl_particles
Battram T	ARIES	None	2020-08-20	Free cholesterol to total lipids ratio in large VLDL	EFO_0008591	None	None	DNA methylation	Free cholesterol to total lipids ratio in large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	676	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.036	0.0089	0.000056	None	Battram-T_free_cholesterol_to_total_lipids_ratio_in_large_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0361324	0.00900669	0.00006057572	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	S100A13 protein levels (SeqId = 7223-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	S100A13 protein levels (SeqId = 7223-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein S100-A13	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.52	0.131	0.000062	None	Gadd-DA_s100a13_protein_levels__seqid___7223-60__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Total cholesterol in medium VLDL	EFO_0004574	None	None	DNA methylation	Total cholesterol in medium VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	675	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-2.07	0.51	0.000063	None	Battram-T_total_cholesterol_in_medium_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0340593	0.00852268	0.0000646512	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.0338711	0.00848808	0.00006627214	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	POTEG protein levels (SeqId = 7960-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	POTEG protein levels (SeqId = 7960-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: POTE ankyrin domain family member G	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.52	0.131	0.000073	None	Gadd-DA_poteg_protein_levels__seqid___7960-53__somascan_protein_measurement
Nicolas Fragoso-Bargas	EPIPREG	36534481	Dec 19, 2022	HOMA-IR	EFO:0000001	discovery	Supplementary Table 2	DNA methylation	HOMA-IR	Smoking,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	analysis in pregnancy (cross ancestry)	456	1	Adults (18-65 years)	Females	European,South Asian	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.087628351	0.022063527	0.0000832	None	36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	SPACA1 protein levels (SeqId = 6228-58)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SPACA1 protein levels (SeqId = 6228-58)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sperm acrosome membrane-associated protein 1	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.51	0.131	0.000084	None	Gadd-DA_spaca1_protein_levels__seqid___6228-58__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	0.03341	0.00850335	0.00008567544	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	IGFBP4 protein levels (SeqId = 2950-57)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IGFBP4 protein levels (SeqId = 2950-57)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Insulin-like growth factor-binding protein 4	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.51	0.13	0.000086	None	Gadd-DA_igfbp4_protein_levels__seqid___2950-57__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Triglycerides in HDL	EFO_0004530	None	None	DNA methylation	Triglycerides in HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	682	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-3.9	1	0.000086	None	Battram-T_triglycerides_in_hdl
Gadd DA	Generation Scotland	35945220	31/07/2022	KLB protein levels (SeqId = 19557-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	KLB protein levels (SeqId = 19557-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-klotho	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.511	0.13	0.000086	None	Gadd-DA_klb_protein_levels__seqid___19557-3__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Cholesterol esters in chylomicrons and extremely large VLDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters in chylomicrons and extremely large VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	651	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-94	24	0.000087	None	Battram-T_cholesterol_esters_in_chylomicrons_and_extremely_large_vldl
Anna Ulrich	None	38184627	Dec 5, 2023	Idiopathic/heritable pulmonary arterial hypertension	None	Discovery	None	DNA methylation	Idiopathic/heritable pulmonary arterial hypertension	Age, Sex, Smoking, Cell composition (reference based), Ancestry (other), first ten principal components computed from control probes	Beta values	None	Illumina HumanMethylationEPIC	whole blood	None	1655	4	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-11	2.8	0.000088	None	38184627_Anna-Ulrich_idiopathic_heritable_pulmonary_arterial_hypertension_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	APOC3 protein levels (SeqId = 6461-54)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APOC3 protein levels (SeqId = 6461-54)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Apolipoprotein C-III	774	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.51	0.131	0.000088	None	Gadd-DA_apoc3_protein_levels__seqid___6461-54__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P19652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.0322723	0.00825227	0.00009243581	P19652	41361833_Josephine_Robertson_P19652_OSCA_model_1
Ma J	CARDSYA, FHS, MESA, RS	30936141	2019-02-21	Nonalcoholic fatty liver disease	EFO_0003095, EFO_1001248	discovery and replication	Table 1	Nonalcoholic fatty liver disease	DNA methylation	Age, sex, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole Blood, Monocytes	None	4525	4	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	None	None	0.000098	None	30936141_Ma-J_nonalcoholic_fatty_liver_disease_discovery_and_replication
Battram T	ARIES	None	2020-08-20	Total lipids in small VLDL	EFO_0004529	None	None	DNA methylation	Total lipids in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	681	1	Adults	Females	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	-0.66	0.167	0.000098	None	Battram-T_total_lipids_in_small_vldl
Ma J	FHS, RS, CARDIA, MESA	30936141	2020-05-22	Hepatic Fat	EFO_0006506, EFO_0008421	Meta-analysis model 3	Table 1	DNA methylation	Hepatic Fat	Age, sex	Beta Values	Hounsfield units	Illumina HumanMethylation450	Whole blood	Model 3 = model 2 + BMI	3400	4	Adults	Both	European	cg14476101	chr1:120255992	1	120255992	PHGDH	South shore	None	None	0.000098	None	30936141_Ma-J_hepatic_fat_meta-analysis_model_3