author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14716686	chr21:30452862	21	30452862	C21orf7	Open sea	-0.0084	0.00034	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14716686	chr21:30452862	21	30452862	C21orf7	Open sea	0.028	0.002	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3917204 (gene symbol: C21orf7)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3917204 (gene symbol: C21orf7)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg14716686	chr21:30452862	21	30452862	C21orf7	Open sea	None	None	1e-19	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3917204__gene_symbol__c21orf7__meta-analysis
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg14716686	chr21:30452862	21	30452862	C21orf7	Open sea	1.55396	0.13478	3.29e-19	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14716686	chr21:30452862	21	30452862	C21orf7	Open sea	-0.0602984	0.00824155	0.0000000000002679136	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14716686	chr21:30452862	21	30452862	C21orf7	Open sea	-0.0576649	0.00824283	0.000000000002752445	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14716686	chr21:30452862	21	30452862	C21orf7	Open sea	-0.0553586	0.00824391	0.00000000001948545	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg14716686	chr21:30452862	21	30452862	C21orf7	Open sea	-0.00113375	0.00019439	0.00000000724	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14716686	chr21:30452862	21	30452862	C21orf7	Open sea	-0.0475379	0.00824724	0.000000008374691	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg14716686	chr21:30452862	21	30452862	C21orf7	Open sea	0.00983	0.00171	0.0000000095	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14716686	chr21:30452862	21	30452862	C21orf7	Open sea	0.0465251	0.00824763	0.00000001721608	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg14716686	chr21:30452862	21	30452862	C21orf7	Open sea	0.0372213	0.00825085	0.000006496059	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age*sex	PATO_0000047,EFO_0000246	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	age*sex	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg14716686	chr21:30452862	21	30452862	C21orf7	Open sea	-0.0015	0.00037	0.000073	None	33450751_Mulder-RH_age_sex_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	CRISP2 protein levels (SeqId = 9282-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CRISP2 protein levels (SeqId = 9282-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cysteine-rich secretory protein 2	774	1	Adults (18-65 years)	Both	European	cg14716686	chr21:30452862	21	30452862	C21orf7	Open sea	-0.39	0.1	0.000089	None	Gadd-DA_crisp2_protein_levels__seqid___9282-12__somascan_protein_measurement