author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age*sex PATO_0000047,EFO_0000246 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation age*sex sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island 0.0028 0.00033 0 None 33450751_Mulder-RH_age_sex_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island 0.0057 0.00031 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.021 0.0021 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.042 0.0032 0 None 33450751_Mulder-RH_sex_discovery Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island - - 3.2e-58 - 28056824_age_4_vs_age_0 Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg14962509 chr1:36039655 1 36039655 TFAP2E Island -2.3656 0.14009 3.3800000000000003e-29 - 25282492_fetal_vs_adult_liver Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg14962509 chr1:36039655 1 36039655 TFAP2E Island 0.018 0.0015 1.1e-21 None 33564054_Kashima-K_gestational_age Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island - - 2.16e-17 - 23526956_clear_cell_renal_carcinoma Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.0708234 0.011038 0.0000000001430552 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.0510916 0.00824579 0.0000000005943184 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.0502551 0.00824334 0.000000001111672 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Battram T GEO 27886173 2020-09-15 Inflammatory bowel disease EFO_0003767 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640 None DNA methylation Inflammatory bowel disease Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 240 1 Adults Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.0283 0.00456 0.0000000028 None 27886173_Battram-T_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.0487207 0.00825428 0.000000003659891 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.0480023 0.00824705 0.000000005988484 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.0470964 0.00824741 0.00000001148643 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.0469718 0.00824257 0.00000001230589 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.0469823 0.00824745 0.00000001245823 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.0468305 0.00825603 0.00000001435782 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island 0.00069173 0.0001236 0.0000000278 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Zhang L ROSMAP,Mt Sinai,London,Gasparoni 33257653 2020-11-30 alzheimers disease braak stage EFO_0000249 Meta-analysis Supplementary Data 1 DNA methylation alzheimers disease braak stage age, sex, cell composition (reference based), batch effects Beta Values Braak stage Illumina HumanMethylation450 Prefrontal cortex age 73-86 1030 4 Adults Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island 0.041 0.008 0.000000058 None 33257653_Zhang-L_alzheimers_disease_braak_stage_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island 0.0430442 0.00818106 0.0000001449382 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.0410266 0.00826355 0.0000006955744 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.0386607 0.00788858 0.0000009644656 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island 0.0400574 0.00824994 0.000001213329 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.038313 0.00806958 0.000002075587 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island 0.0381876 0.00810648 0.000002490803 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_3 Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Ultrasound-estimated gestational age Table S1 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island 0.00065107 0.00013816 0.00000278 - 27717397_gestational_age_ultrasoundestimated_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.03791 0.00825064 0.000004367801 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.0358114 0.00801562 0.000007965381 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.0368606 0.00825771 0.000008112502 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island -0.0351126 0.00794494 0.000009964004 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island 0.0359041 0.00826613 0.00001411605 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg14962509 chr1:36039655 1 36039655 TFAP2E Island None None 0.000033 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg14962509 chr1:36039655 1 36039655 TFAP2E Island 0.032605 0.00825218 0.00007816322 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1