author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.34188 0.00689 9.1e-112 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -1.92974 0.09821 9.62e-34 - 25282492_fetal_vs_adult_liver Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea 0.0027 None 2.6999999999999997e-25 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 2436467 (gene symbol: NUP210L) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 2436467 (gene symbol: NUP210L) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea None None 6.3e-21 None 33752734_Yao-C_gene_expression_of_affymetrix_id__2436467__gene_symbol__nup210l__meta-analysis Joehanes R - 27651444 2016-10-01 Smoking EFO_0006527, EFO_0005671, EFO_0004318 Current vs never smoking Table S2 DNA methylation Current versus never smoking Age, sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood, CD4+ T cells or monocytes - 9389 16 60.3 Both European,African cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.0152 0.0017 2.9e-19 - 27651444_smoking_current_vs_never_smoking Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.01524 0.0017 2.9e-19 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea 0.05099 0.00824583 0.0000000006426569 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea 0.0497229 0.00824636 0.000000001682218 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Bozack PRISM 34569420 Oct 22, 2021 Infant sex PATO_0001894 Placenta Supplementary table 9 DNA methylation Infant sex Cell composition (reference free), Batch effects, Ancestry (genomic PCs) M values None Illumina HumanMethylation450 Placenta None 229 1 Infants Both European, African, Other cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea None None 0.000000018 None 34569420_Bozack_infant_sex_placenta Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.046429 0.00824767 0.00000001842008 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.0449391 0.00824823 0.0000000516628 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.0431719 0.00824887 0.0000001684661 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.0431345 0.00824889 0.0000001726508 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.0412248 0.00824955 0.0000005883405 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea 0.0399214 0.00824999 0.00000131849 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea 0.0397634 0.00825004 0.000001451572 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.017 0.00356 0.0000019 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea 0.038975 0.0082503 0.00000233315 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04217 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04217 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.0383756 0.00825049 0.000003327025 P04217 41361833_Josephine_Robertson_P04217_OSCA_model_1 Christiansen C TwinsUK, NSHD, NCDS1, NCDS2, BCS70 33593402 2021-02-16 Smoking EFO_0004318, EFO_0006527 Current vs never smoking meta-analysis in European samples Table S1 DNA methylation Smoking Sex, cell composition (reference based), body mass index, batch effects, relatedness Beta Values None Illumina HumanMethylationEPIC Whole blood None 912 5 Adults Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea None None 0.0000037 None 33593402_Christiansen-C_smoking_current_vs_never_smoking_meta-analysis_in_european_samples Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.005 0.001 0.0000038 None 33564054_Kashima-K_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.03789 0.00825064 0.000004418937 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea 0.0055 None 0.0000056 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.0373365 0.00825081 0.00000608163 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea 0.0371177 0.00825088 0.000006891714 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea 0.0370111 0.00825091 0.000007322608 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea 0.0366679 0.00825102 0.000008892855 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.038163 0.00876876 0.00001357186 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.0356149 0.00825133 0.00001597385 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JRQ6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JRQ6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea 0.0346808 0.0082516 0.00002650578 A0A0G2JRQ6 41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00450 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00450 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.0368827 0.00877854 0.00002667712 P00450 41361833_Josephine_Robertson_P00450_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH36 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH36 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea 0.0346145 0.00825162 0.00002746277 A0A0C4DH36 41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_1 Cronjé HT Prospective Urban and Rural Epidemiology study 31910897 2020-01-07 Alcohol consumption EFO_0004329, NCIT_C16273 None Additional file 2a DNA methylation Alcohol consumption Age, body mass index, smoking, cell composition (reference based), batch effects Beta Values grams per day Illumina HumanMethylationEPIC Whole blood None 108 1 Adults Males African cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea 0.001 0.00024 0.000037 None 31910897_Cronjé-HT_alcohol_consumption Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea None None 0.000053 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02763 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02763 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.0330325 0.00825207 0.00006286921 P02763 41361833_Josephine_Robertson_P02763_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea 0.0329274 0.00825209 0.00006634253 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH25 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH25 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea 0.0328223 0.00825212 0.0000699962 A0A0C4DH25 41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.0347242 0.00875877 0.00007389601 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg16274678 chr1:154127952 1 154127952 TPM3;NUP210L Open sea -0.0326378 0.00825217 0.00007687523 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1