author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.01	0.00035	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.062	0.0015	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-	-	9.23e-63	-	23526956_clear_cell_renal_carcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.11158	0.00820501	7.280023999999999e-42	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.109642	0.00820679	1.7868500000000002e-40	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.109534	0.00820689	2.132685e-40	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.107834	0.00858819	5.6396619999999996e-36	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.106142	0.00859456	7.272332e-35	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.105768	0.00859085	1.162671e-34	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.104536	0.00859494	7.168501e-34	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.109765	0.00916813	7.055754e-33	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.107794	0.00911695	4.13009e-32	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.100383	0.00856951	1.494798e-31	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0962666	0.00821822	1.4968899999999998e-31	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.106844	0.00917078	3.1345899999999997e-31	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0983302	0.00855379	1.876572e-30	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.103943	0.00918703	1.4823400000000002e-29	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0927121	0.00822101	2.240023e-29	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0923501	0.00822129	3.691055e-29	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0938238	0.00858846	1.126427e-27	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0937488	0.00859985	1.450975e-27	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0931478	0.00860997	3.5598599999999996e-27	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.199535	0.0184994	4.834773e-27	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0925038	0.00859447	6.474931000000001e-27	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.09175	0.0085932	1.631283e-26	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0870651	0.00822522	4.3375459999999996e-26	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0953086	0.00916568	3.086055e-25	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0876573	0.00853757	1.199658e-24	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0843825	0.00822712	1.337982e-24	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0815903	0.00822904	4.238213e-23	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.194131	0.0197102	7.871353000000001e-23	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	1.28154	0.09592	8.63e-23	-	25282492_fetal_vs_adult_liver
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0840877	0.00861404	1.923915e-22	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0835019	0.00860974	3.565363e-22	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0826065	0.0085751	6.715597e-22	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.086935	0.00910751	1.566073e-21	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0801585	0.0084966	4.521337e-21	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0860175	0.00919145	9.249228e-21	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0838224	0.00904854	2.2458679999999998e-20	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_4
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-	-	4.01e-20	-	26857698_primary_sjogrens_syndrome_whole_blood
Mendelson MM	FHS	29740313	2018-04-24	Soluble tumor necrosis factor receptor 2	EFO_0008384, NCIT_C117749	None	Table S1	DNA methylation	Soluble tumor necrosis factor receptor 2	Age, sex, body mass index, smoking, batch effects	Beta Values	pg/ml	Illumina HumanMethylation450	Whole blood	None	2468	1	Adults	Both	Unclear	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0246	0.00273	4.3e-19	None	29740313_Mendelson-MM_soluble_tumor_necrosis_factor_receptor_2
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-2.219587	0.2501	7.06e-19	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0815328	0.00919739	8.537671999999999e-19	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0763245	0.00861308	8.792303e-19	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0728052	0.00823466	1.052172e-18	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0728029	0.00823466	1.05488e-18	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0724978	0.00823484	1.468636e-18	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0719504	0.00823517	2.650484e-18	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0747653	0.00861456	4.410078e-18	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0738778	0.00862692	1.201278e-17	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0787329	0.00920929	1.359677e-17	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0783161	0.00921026	2.0220970000000003e-17	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0697105	0.00823649	2.8348310000000003e-17	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0726799	0.00861936	3.7065930000000003e-17	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0725216	0.00862403	4.5031790000000006e-17	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0712221	0.0085259	7.208989000000001e-17	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0715132	0.00863262	1.2926e-16	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	FCGR3B protein levels (SeqId = 3311-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FCGR3B protein levels (SeqId = 3311-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Low affinity immunoglobulin gamma Fc region receptor III-B	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.792	0.096	1.5e-16	None	Gadd-DA_fcgr3b_protein_levels__seqid___3311-27__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0678089	0.00823757	2.000658e-16	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0677237	0.00823762	2.180905e-16	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0672581	0.00823788	3.488817e-16	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0751162	0.00920283	3.553019e-16	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0745786	0.00915963	4.196213e-16	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0653963	0.0082389	0.000000000000002211603	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0653257	0.00823894	0.000000000000002369681	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0718034	0.00918189	0.000000000000005636373	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_4
Battram T	GEO	23334450	2020-09-15	Rheumatoid arthritis	EFO_0000685	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE42861	None	DNA methylation	Rheumatoid arthritis	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	689	1	Adults	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0318	0.00399	0.0000000000000075	None	23334450_Battram-T_rheumatoid_arthritis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse42861
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0663106	0.00862801	0.00000000000001620425	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0662183	0.00862068	0.00000000000001673831	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.066066	0.00861321	0.00000000000001823542	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0647032	0.00844545	0.00000000000001955413	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0660623	0.00862377	0.00000000000001967793	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.063025	0.00824016	0.00000000000002159149	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0658347	0.00861596	0.00000000000002288219	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0654893	0.00858945	0.00000000000002602101	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.065196	0.00860761	0.00000000000003828105	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0695303	0.00918582	0.00000000000003975866	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CECR1 protein levels (SeqId = 6077-63)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CECR1 protein levels (SeqId = 6077-63)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Adenosine deaminase 2	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.72	0.096	0.000000000000045	None	Gadd-DA_cecr1_protein_levels__seqid___6077-63__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0649268	0.00861142	0.00000000000004989601	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0646453	0.00859999	0.00000000000005933092	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0645029	0.00860564	0.00000000000006986633	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0680119	0.00919557	0.0000000000001477872	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CD163 protein levels (SeqId = 5028-59)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD163 protein levels (SeqId = 5028-59)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Scavenger receptor cysteine-rich type 1 protein M130	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.71	0.096	0.00000000000016	None	Gadd-DA_cd163_protein_levels__seqid___5028-59__somascan_protein_measurement
Liu Y	-	23334450	2013-01-20	Rheumatoid arthritis	EFO_0000685	-	Table S3	DNA methylation	Rheumatoid arthritis	Age, sex, smoking and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	691	1	51.9	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.03024	0.0041	0.000000000000161	-	23334450_rheumatoid_arthritis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0636347	0.00862202	0.0000000000001661739	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	GBP1 protein levels (SeqId = 15326-64)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GBP1 protein levels (SeqId = 15326-64)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Guanylate-binding protein 1	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.7	0.095	0.00000000000017	None	Gadd-DA_gbp1_protein_levels__seqid___15326-64__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0605997	0.0082414	0.0000000000002039308	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1
Aslibekyan S	CHARGE	29617535	2018-04-04	Tumour necrosis factor-alpha	EFO_0003271	Meta-analysis model 3	Table 2	DNA methylation	Tumour necrosis factor-alpha	Age, sex, batch effects, cell composition (reference based), smoking, body mass index	Beta Values	pg/ml	Illumina HumanMethylation450	Whole blood	Some associations replicated - see paper	4163	5	Adults	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.01	0.002	0.00000000000021	None	29617535_Aslibekyan-S_tumour_necrosis_factor-alpha_meta-analysis_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0630868	0.00859517	0.00000000000022516	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0630732	0.00862709	0.0000000000002787231	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0667978	0.00914451	0.0000000000002922299	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.062224	0.00861335	0.0000000000005291567	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0617655	0.00856255	0.0000000000005722631	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0662278	0.00918861	0.0000000000005973098	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0593146	0.00824203	0.0000000000006472522	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	LAG3 protein levels (SeqId = 9950-229)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LAG3 protein levels (SeqId = 9950-229)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lymphocyte activation gene 3 protein	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.69	0.096	0.00000000000074	None	Gadd-DA_lag3_protein_levels__seqid___9950-229__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0616839	0.00860766	0.0000000000008080596	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0611693	0.00857706	0.000000000001037551	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0649625	0.00913335	0.000000000001191003	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_4
Chung SA	-	26192630	2015-07-20	Autoantibody production in systemic lupus erythematosus	EFO_0004866, EFO_0002690	Combined	Table S1	DNA methylation	Autoantibody production in systemic lupus erythematosus	Age, disease duration, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	Wilcoxon rank sum test	326	2	46	Females	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-	-	0.0000000000017	-	26192630_autoantibody_production_in_systemic_lupus_erythematosus_combined
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0601561	0.00857835	0.000000000002442424	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_3
Aslibekyan S	CHARGE	29617535	2018-04-04	Tumour necrosis factor-alpha	EFO_0003271	Meta-analysis model 2	eTable 3	DNA methylation	Tumour necrosis factor-alpha	Age, sex, batch effects, cell composition (reference based)	Beta Values	pg/ml	Illumina HumanMethylation450	Whole blood	None	4163	5	Adults	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.01	0.002	0.0000000000028	None	29617535_Aslibekyan-S_tumour_necrosis_factor-alpha_meta-analysis_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0576195	0.00824285	0.000000000002862766	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0567705	0.00824326	0.000000000005934102	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0619278	0.00900447	0.000000000006340268	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0590539	0.00859801	0.000000000006757669	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0565081	0.00824338	0.000000000007417531	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0560014	0.00824361	0.00000000001138097	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.055853	0.00824368	0.00000000001289187	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0582515	0.00861238	0.0000000000139608	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0579426	0.00860871	0.00000000001751136	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_2
Aslibekyan S	CHARGE	29617535	2018-04-04	Tumour necrosis factor-alpha	EFO_0003271	Meta-analysis base model	eTable 3	DNA methylation	Tumour necrosis factor-alpha	Age, sex, batch effects	Beta Values	pg/ml	Illumina HumanMethylation450	Whole blood	None	4163	5	Adults	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.01	0.002	0.00000000002	None	29617535_Aslibekyan-S_tumour_necrosis_factor-alpha_meta-analysis_base_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0613362	0.00913945	0.00000000002001966	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0570118	0.00857772	0.0000000000310746	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0573514	0.00863253	0.00000000003168174	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0565507	0.00863722	0.00000000006052378	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CSF1R protein levels (SeqId = 13682-47)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CSF1R protein levels (SeqId = 13682-47)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Macrophage colony-stimulating factor 1 receptor	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.62	0.095	0.000000000095	None	Gadd-DA_csf1r_protein_levels__seqid___13682-47__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CD48 protein levels (SeqId = 3292-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD48 protein levels (SeqId = 3292-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CD48 antigen	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.62	0.096	0.00000000014	None	Gadd-DA_cd48_protein_levels__seqid___3292-75__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.05291	0.00824501	0.0000000001430507	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.052615	0.00824514	0.0000000001808237	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Chung SA	-	26192630	2015-07-20	Autoantibody production in systemic lupus erythematosus	EFO_0004866, EFO_0002690	Linear regression model	Table 2	DNA methylation	Autoantibody production in systemic lupus erythematosus	Age, ethnicity, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	326	2	46	Females	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.045	0.0071	0.0000000002	-	26192630_autoantibody_production_in_systemic_lupus_erythematosus_linear_regression_model
Zhang X	-	27672717	2016-08-12	Human immunodeficiency virus	EFO_0000764	-	Table 1	DNA methylation	Human immunodeficiency virus	Age, smoking, ethnicity, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	378	1	49.2	Both	European,African,Other	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-	-	0.000000000201	-	27672717_human_immunodeficiency_virus
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0523475	0.00824525	0.0000000002233702	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0582437	0.00917525	0.0000000002246841	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0547031	0.00862239	0.0000000002299868	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0580273	0.00921873	0.0000000003171768	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.057585	0.00916261	0.0000000003376106	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	VCAM1 protein levels (SeqId = 2967-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	VCAM1 protein levels (SeqId = 2967-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Vascular cell adhesion protein 1	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.6	0.096	0.00000000036	None	Gadd-DA_vcam1_protein_levels__seqid___2967-8__somascan_protein_measurement
Chilunga FP	RODAM	33890479	04-23-2021	Migration	None	Discovery	Table 2	DNA methylation	Migration	Age, Sex, Cell composition (reference based), Batch effects, Body mass index, Type 2 diabetes	Beta values	None	Illumina HumanMethylation450	Whole blood	None	712	1	Adults	Both	African	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	None	None	0.00000000043	None	33890479_Chilunga-FP_migration_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.119788	0.0191983	0.0000000004491316	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0524164	0.00851855	0.0000000007790591	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0528538	0.00862306	0.0000000009049668	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0563908	0.00921283	0.0000000009542119	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0528511	0.00863984	0.0000000009769004	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0523581	0.00860051	0.000000001173386	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0501913	0.00824617	0.000000001181862	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0523824	0.00863156	0.000000001321152	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0084	0.0014	0.0000000015	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0504719	0.00839217	0.000000001851069	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CRTAM protein levels (SeqId = 7968-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CRTAM protein levels (SeqId = 7968-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cytotoxic and regulatory T-cell molecule	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.57	0.096	0.0000000021	None	Gadd-DA_crtam_protein_levels__seqid___7968-15__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0506673	0.00846935	0.000000002249474	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0547687	0.00915511	0.00000000225127	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0492429	0.00824655	0.000000002407562	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0491737	0.00824658	0.000000002534712	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	LY9 protein levels (SeqId = 3324-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LY9 protein levels (SeqId = 3324-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-lymphocyte surface antigen Ly-9	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.57	0.096	0.0000000026	None	Gadd-DA_ly9_protein_levels__seqid___3324-51__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.050345	0.0084755	0.000000002913597	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0511392	0.00863483	0.000000003243046	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0541779	0.00922364	0.000000004351382	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_4
Liu C	CHARGE+	27843151	2016-11-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	African ancestry	Table S6	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g per day	Illumina HumanMethylation450	Whole blood	-	2423	3	56	Both	African	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-8.54e-05	1.46e-05	0.00000000454	-	27843151_alcohol_consumption_per_day_african_ancestry
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	CD19+ B cells	Table S6	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	CD19+ B cells	-	71	1	-	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-	-	0.00000000541	-	26857698_primary_sjogrens_syndrome_cd19_b_cells
Gadd DA	Generation Scotland	35945220	31/07/2022	IL15RA protein levels (SeqId = 14054-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL15RA protein levels (SeqId = 14054-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-15 receptor subunit alpha	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.56	0.096	0.0000000057	None	Gadd-DA_il15ra_protein_levels__seqid___14054-17__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.11698	0.0202081	0.000000007212905	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-1.1	0.198	0.0000000073	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0498778	0.00862878	0.000000007603916	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	SEMA7A protein levels (SeqId = 7019-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SEMA7A protein levels (SeqId = 7019-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Semaphorin-7A	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.55	0.096	0.0000000082	None	Gadd-DA_sema7a_protein_levels__seqid___7019-13__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0495019	0.00858644	0.000000008323944	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	IL12B protein levels (SeqId = 13733-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL12B protein levels (SeqId = 13733-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-12 subunit beta	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.55	0.096	0.00000001	None	Gadd-DA_il12b_protein_levels__seqid___13733-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0526975	0.0092033	0.00000001048872	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0493018	0.00861077	0.00000001050894	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0469539	0.00824746	0.00000001271206	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01762	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01762	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0521229	0.00922388	0.00000001626221	P01762	41361833_Josephine_Robertson_P01762_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0484891	0.0086025	0.00000001765998	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0516893	0.00917648	0.00000001805729	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.048568	0.00863121	0.0000000186697	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0477588	0.00849208	0.0000000190074	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	GZMA protein levels (SeqId = 3440-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GZMA protein levels (SeqId = 3440-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granzyme A	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.53	0.096	0.000000024	None	Gadd-DA_gzma_protein_levels__seqid___3440-7__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0460305	0.00824782	0.00000002434719	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0513769	0.00922257	0.00000002580675	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0459135	0.00824786	0.00000002641351	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CXCL10 protein levels (SeqId = 4141-79)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXCL10 protein levels (SeqId = 4141-79)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-X-C motif chemokine 10	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.53	0.096	0.000000027	None	Gadd-DA_cxcl10_protein_levels__seqid___4141-79__somascan_protein_measurement
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.02655	0.0046	0.000000031	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Battram T	GEO	27886173	2020-09-15	Crohn's disease	EFO_0000384	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Crohn's disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	161	1	Adults	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0417	0.00711	0.000000031	None	27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Chung SA	-	26192630	2015-07-20	Autoantibody production in systemic lupus erythematosus	EFO_0004866, EFO_0002690	Discovery	Table 2	DNA methylation	Autoantibody production in systemic lupus erythematosus	Technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	Wilcoxon rank sum test	186	1	46	Females	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-	-	0.000000033	-	26192630_autoantibody_production_in_systemic_lupus_erythematosus_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0502712	0.00909654	0.00000003324471	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	IL12B protein levels (SeqId = 10365-132)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL12B protein levels (SeqId = 10365-132)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-12 subunit beta|Interleukin-23 subunit alpha	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.529	0.096	0.000000034	None	Gadd-DA_il12b_protein_levels__seqid___10365-132__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0455544	0.00828441	0.00000003887531	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0459235	0.00835825	0.000000039859	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	ICAM1 protein levels (SeqId = 4342-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ICAM1 protein levels (SeqId = 4342-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Intercellular adhesion molecule 1	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.52	0.096	0.000000052	None	Gadd-DA_icam1_protein_levels__seqid___4342-10__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0448654	0.00824826	0.00000005432164	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.044786	0.00824829	0.00000005733731	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0499096	0.00923492	0.00000006602518	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0464886	0.00863919	0.00000007516079	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0477469	0.00889562	0.00000008106993	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	TNFRSF1B protein levels (SeqId = 3152-57)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNFRSF1B protein levels (SeqId = 3152-57)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tumor necrosis factor receptor superfamily member 1B	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.51	0.096	0.000000086	None	Gadd-DA_tnfrsf1b_protein_levels__seqid___3152-57__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01762	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01762	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0460711	0.00863529	0.00000009685487	P01762	41361833_Josephine_Robertson_P01762_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01762	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01762	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0440003	0.00824858	0.00000009734264	P01762	41361833_Josephine_Robertson_P01762_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0460394	0.0086383	0.00000009983857	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0488577	0.00919465	0.0000001089884	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.045619	0.00858544	0.0000001090933	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0472907	0.00890727	0.0000001116984	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0455039	0.00857823	0.0000001145725	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0466543	0.00880218	0.0000001172848	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0457662	0.00864626	0.0000001219435	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0434932	0.00824876	0.0000001363442	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0472206	0.00896622	0.0000001410137	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0454537	0.0086398	0.0000001453189	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01705	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01705	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0430696	0.00824891	0.0000001801543	P01705	41361833_Josephine_Robertson_P01705_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0450102	0.00863281	0.00000018747	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0450354	0.00864607	0.0000001926637	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0449794	0.00863753	0.0000001940554	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0448191	0.00862359	0.000000204949	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	CD300C protein levels (SeqId = 5066-134)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD300C protein levels (SeqId = 5066-134)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CMRF35-like molecule 6	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.49	0.096	0.00000023	None	Gadd-DA_cd300c_protein_levels__seqid___5066-134__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0425771	0.00824908	0.0000002482602	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01762	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01762	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0445646	0.00864211	0.0000002546288	P01762	41361833_Josephine_Robertson_P01762_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0471638	0.00914995	0.0000002575574	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.044499	0.00864081	0.0000002640483	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0444672	0.00863691	0.0000002659746	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01705	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01705	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0475221	0.00923506	0.0000002697841	P01705	41361833_Josephine_Robertson_P01705_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0440266	0.00860927	0.000000319625	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0421532	0.00824923	0.0000003262773	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TNFRSF1B protein levels (SeqId = 8368-102)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNFRSF1B protein levels (SeqId = 8368-102)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tumor necrosis factor receptor superfamily member 1B	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.49	0.096	0.00000033	None	Gadd-DA_tnfrsf1b_protein_levels__seqid___8368-102__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MICB protein levels (SeqId = 5102-55)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MICB protein levels (SeqId = 5102-55)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: MHC class I polypeptide-related sequence B	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.49	0.096	0.00000034	None	Gadd-DA_micb_protein_levels__seqid___5102-55__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0419802	0.00824929	0.0000003645009	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0438963	0.00862765	0.0000003665896	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_3
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	2.459	0.485	0.0000004	-	28173150_serum_highdensity_lipoprotein_cholesterol_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	SIGLEC7 protein levels (SeqId = 2742-68)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SIGLEC7 protein levels (SeqId = 2742-68)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sialic acid-binding Ig-like lectin 7	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.49	0.096	0.0000004	None	Gadd-DA_siglec7_protein_levels__seqid___2742-68__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0462063	0.0091198	0.0000004099382	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0467417	0.00922942	0.000000414612	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0466499	0.0092134	0.0000004171423	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0417556	0.00824937	0.0000004206353	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0435902	0.00863416	0.000000450447	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0465501	0.00923259	0.0000004663506	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0433646	0.00864678	0.0000005362152	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0432685	0.00863976	0.0000005561785	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CD97 protein levels (SeqId = 18881-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD97 protein levels (SeqId = 18881-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CD97 antigen	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.48	0.096	0.00000056	None	Gadd-DA_cd97_protein_levels__seqid___18881-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FOLR2 protein levels (SeqId = 15587-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FOLR2 protein levels (SeqId = 15587-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Folate receptor beta	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.48	0.096	0.00000064	None	Gadd-DA_folr2_protein_levels__seqid___15587-20__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IL18BP protein levels (SeqId = 3073-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL18BP protein levels (SeqId = 3073-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-18-binding protein	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.48	0.096	0.00000071	None	Gadd-DA_il18bp_protein_levels__seqid___3073-51__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SLAMF6 protein levels (SeqId = 5128-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SLAMF6 protein levels (SeqId = 5128-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: SLAM family member 6	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.48	0.096	0.00000072	None	Gadd-DA_slamf6_protein_levels__seqid___5128-53__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0450921	0.00916478	0.0000008741909	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0402323	0.00824989	0.000001090022	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.041648	0.0085498	0.000001120637	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0419532	0.00862475	0.000001160657	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01705	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01705	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0420102	0.00864841	0.000001200695	P01705	41361833_Josephine_Robertson_P01705_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01705	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01705	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0419441	0.008638	0.000001211608	P01705	41361833_Josephine_Robertson_P01705_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0400108	0.00824996	0.000001248432	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0416829	0.00862248	0.000001350265	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CXCL11 protein levels (SeqId = 3038-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXCL11 protein levels (SeqId = 3038-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-X-C motif chemokine 11	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.46	0.096	0.0000014	None	Gadd-DA_cxcl11_protein_levels__seqid___3038-9__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0415464	0.00862249	0.000001461822	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0415372	0.00864707	0.000001573695	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0395465	0.00825011	0.000001655449	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0395206	0.00825012	0.000001681613	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	MSR1 protein levels (SeqId = 15533-97)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MSR1 protein levels (SeqId = 15533-97)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Macrophage scavenger receptor types I and II	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.46	0.096	0.0000017	None	Gadd-DA_msr1_protein_levels__seqid___15533-97__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0441462	0.00922657	0.000001729296	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0411165	0.00861218	0.00000182135	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.043757	0.0091805	0.00000189443	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0409579	0.00862193	0.000002049092	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0391919	0.00825023	0.000002049353	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-	-	0.00000217	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0406693	0.00858708	0.000002199059	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0408278	0.00862476	0.000002224219	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	CD5L protein levels (SeqId = 3293-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD5L protein levels (SeqId = 3293-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CD5 antigen-like	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.45	0.095	0.0000024	None	Gadd-DA_cd5l_protein_levels__seqid___3293-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0407218	0.0086375	0.000002444958	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0423574	0.00899294	0.000002499043	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CXCL13 protein levels (SeqId = 3487-32)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXCL13 protein levels (SeqId = 3487-32)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-X-C motif chemokine 13	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.45	0.096	0.0000025	None	Gadd-DA_cxcl13_protein_levels__seqid___3487-32__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0387449	0.00825037	0.000002675247	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0405506	0.00863563	0.000002680604	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0431516	0.00920771	0.00000280469	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	ENTPD1 protein levels (SeqId = 7999-23)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ENTPD1 protein levels (SeqId = 7999-23)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ectonucleoside triphosphate diphosphohydrolase 1	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.45	0.096	0.0000032	None	Gadd-DA_entpd1_protein_levels__seqid___7999-23__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IL2RB protein levels (SeqId = 9343-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL2RB protein levels (SeqId = 9343-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-2 receptor subunit beta	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.45	0.096	0.0000033	None	Gadd-DA_il2rb_protein_levels__seqid___9343-16__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	B2M protein levels (SeqId = 3485-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	B2M protein levels (SeqId = 3485-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-2-microglobulin	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.44	0.096	0.0000036	None	Gadd-DA_b2m_protein_levels__seqid___3485-28__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.039809	0.00863717	0.000004079555	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0424397	0.00922392	0.000004238835	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	LILRB2 protein levels (SeqId = 5091-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LILRB2 protein levels (SeqId = 5091-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Leukocyte immunoglobulin-like receptor subfamily B member 2	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.44	0.096	0.0000043	None	Gadd-DA_lilrb2_protein_levels__seqid___5091-28__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0396464	0.00863139	0.000004399683	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0413023	0.00902445	0.000004762163	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0394894	0.00863797	0.000004879504	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0414127	0.0091086	0.000005496926	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0391727	0.00861887	0.000005537635	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	SEMA4D protein levels (SeqId = 5737-61)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SEMA4D protein levels (SeqId = 5737-61)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Semaphorin-4D	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.44	0.096	0.0000057	None	Gadd-DA_sema4d_protein_levels__seqid___5737-61__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FAIM3 protein levels (SeqId = 6574-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FAIM3 protein levels (SeqId = 6574-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fas apoptotic inhibitory molecule 3	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.435	0.096	0.0000058	None	Gadd-DA_faim3_protein_levels__seqid___6574-11__somascan_protein_measurement
Chung SA	-	26192630	2015-07-20	Autoantibody production in systemic lupus erythematosus	EFO_0004866, EFO_0002690	Replication	Table 2	DNA methylation	Autoantibody production in systemic lupus erythematosus	Technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	Wilcoxon rank sum test	140	1	46	Females	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-	-	0.0000062	-	26192630_autoantibody_production_in_systemic_lupus_erythematosus_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0388558	0.00862647	0.000006712089	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0371021	0.00825089	0.000006953129	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0377906	0.00842144	0.000007263619	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0386819	0.00862521	0.000007355658	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19827	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P19827	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0387445	0.00864598	0.000007478267	P19827	41361833_Josephine_Robertson_P19827_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19827	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P19827	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0413418	0.00924559	0.000007825191	P19827	41361833_Josephine_Robertson_P19827_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19827	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P19827	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0384824	0.00865706	0.000008845479	P19827	41361833_Josephine_Robertson_P19827_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CDCP1 protein levels (SeqId = 16818-200)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CDCP1 protein levels (SeqId = 16818-200)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CUB domain-containing protein 1	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.43	0.096	0.0000092	None	Gadd-DA_cdcp1_protein_levels__seqid___16818-200__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0365103	0.00825107	0.000009717522	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0363657	0.00825111	0.00001053754	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0380072	0.00863503	0.00001082575	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Rheumatoid Arthritis (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Rheumatoid Arthritis (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18055	1	Adults (18-65y)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.032	0.0072	0.000011	None	Robert-F-Hillary_Prevalent_Rheumatoid_Arthritis_(Self-report)_Basic_model
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	None	None	0.000012	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	UMOD protein levels (SeqId = 9451-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UMOD protein levels (SeqId = 9451-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Uromodulin	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.42	0.096	0.000012	None	Gadd-DA_umod_protein_levels__seqid___9451-20__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0404123	0.00923741	0.0000122359	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0375655	0.00863786	0.00001377211	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CD300A protein levels (SeqId = 5630-48)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD300A protein levels (SeqId = 5630-48)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CMRF35-like molecule 8	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.41	0.096	0.000015	None	Gadd-DA_cd300a_protein_levels__seqid___5630-48__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ICAM2 protein levels (SeqId = 5486-73)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ICAM2 protein levels (SeqId = 5486-73)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Intercellular adhesion molecule 2	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.41	0.096	0.000018	None	Gadd-DA_icam2_protein_levels__seqid___5486-73__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NCR1 protein levels (SeqId = 8360-169)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NCR1 protein levels (SeqId = 8360-169)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Natural cytotoxicity triggering receptor 1	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.41	0.096	0.000019	None	Gadd-DA_ncr1_protein_levels__seqid___8360-169__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6J9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6J9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0351894	0.00825146	0.00002014842	A0A075B6J9	41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6J9	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6J9	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0368047	0.0086417	0.00002066595	A0A075B6J9	41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	APOL3 protein levels (SeqId = 16823-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	APOL3 protein levels (SeqId = 16823-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Apolipoprotein L3	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.41	0.096	0.000021	None	Gadd-DA_apol3_protein_levels__seqid___16823-75__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0364534	0.00863222	0.00002425875	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0347589	0.00825158	0.00002541885	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.036011	0.00856312	0.00002622091	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0387712	0.00922596	0.00002656624	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6J9	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6J9	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0363119	0.00864584	0.0000268574	A0A075B6J9	41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0360641	0.00863474	0.00002975753	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0360365	0.00863561	0.00003023327	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19827	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P19827	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0343499	0.0082517	0.00003162174	P19827	41361833_Josephine_Robertson_P19827_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0356999	0.00858245	0.00003205659	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0380086	0.00916303	0.00003372278	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CD8A protein levels (SeqId = 15462-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD8A protein levels (SeqId = 15462-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-cell surface glycoprotein CD8 alpha chain	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.4	0.096	0.000034	None	Gadd-DA_cd8a_protein_levels__seqid___15462-28__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0380628	0.00921113	0.00003612045	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_4
Sharp GC	-	28603561	2017-06-08	Cleft palate vs cleft lip	EFO_0003959, HP_0000175	-	Additional file 5	DNA methylation	Cleft palate vs cleft lip	Sex and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	98	1	0	Both	European,Other	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.04542167	0.01041092	0.0000363	-	28603561_cleft_palate_vs_cleft_lip
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0356142	0.00863607	0.00003745843	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_3
Battram T	GEO	29921915	2020-09-15	Multiple sclerosis	EFO_0003885	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE106648	None	DNA methylation	Multiple sclerosis	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	279	1	Young adults	Both	Unclear	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0241	0.00574	0.000038	None	29921915_Battram-T_multiple_sclerosis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse106648
Gadd DA	Generation Scotland	35945220	31/07/2022	LAMC2 protein levels (SeqId = 9580-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LAMC2 protein levels (SeqId = 9580-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Laminin subunit gamma-2	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.39	0.096	0.000039	None	Gadd-DA_lamc2_protein_levels__seqid___9580-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0377924	0.00919012	0.00003939038	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6J9	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6J9	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0379076	0.00923058	0.00004034569	A0A075B6J9	41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_4
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.359061	0.0877	0.000042	-	27105112_hiv_infection_neutrophils
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0353681	0.0086393	0.00004265282	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0337612	0.00825186	0.00004311812	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	NFASC protein levels (SeqId = 7179-69)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NFASC protein levels (SeqId = 7179-69)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neurofascin	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.39	0.096	0.000044	None	Gadd-DA_nfasc_protein_levels__seqid___7179-69__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0352723	0.00864947	0.0000456706	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.034411	0.00843915	0.00004575458	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0352128	0.0086421	0.00004634394	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0783261	0.0192547	0.00004764859	None	39706196_Hannah-M.-Smith_body_fat_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	IL27RA protein levels (SeqId = 5132-71)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL27RA protein levels (SeqId = 5132-71)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-27 receptor subunit alpha	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.39	0.096	0.000051	None	Gadd-DA_il27ra_protein_levels__seqid___5132-71__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FCRL1 protein levels (SeqId = 5728-60)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FCRL1 protein levels (SeqId = 5728-60)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fc receptor-like protein 1	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.39	0.096	0.000051	None	Gadd-DA_fcrl1_protein_levels__seqid___5728-60__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0333797	0.00825197	0.00005257693	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0343708	0.00853596	0.00005687553	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0342794	0.00855844	0.00006223642	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.032975	0.00825208	0.00006474747	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0344215	0.00864397	0.00006862854	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0806634	0.0203496	0.00007403774	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Gadd DA	Generation Scotland	35945220	31/07/2022	SEMA6B protein levels (SeqId = 5121-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SEMA6B protein levels (SeqId = 5121-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Semaphorin-6B	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.38	0.096	0.000075	None	Gadd-DA_sema6b_protein_levels__seqid___5121-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PLXNB2 protein levels (SeqId = 9216-100)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PLXNB2 protein levels (SeqId = 9216-100)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Plexin-B2	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.38	0.096	0.000077	None	Gadd-DA_plxnb2_protein_levels__seqid___9216-100__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0339296	0.00859067	0.00007865406	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	SIGLEC9 protein levels (SeqId = 3007-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SIGLEC9 protein levels (SeqId = 3007-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sialic acid-binding Ig-like lectin 9	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.38	0.096	0.000079	None	Gadd-DA_siglec9_protein_levels__seqid___3007-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LTA protein levels (SeqId = 3505-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LTA protein levels (SeqId = 3505-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lymphotoxin-alpha|Lymphotoxin-beta	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.38	0.096	0.000081	None	Gadd-DA_lta_protein_levels__seqid___3505-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IL3RA protein levels (SeqId = 13744-37)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL3RA protein levels (SeqId = 13744-37)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-3 receptor subunit alpha	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.38	0.096	0.000081	None	Gadd-DA_il3ra_protein_levels__seqid___13744-37__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0339706	0.00863329	0.00008363733	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery adjusted for surrogate variables	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	1.634	0.416	0.000084	-	28173150_serum_highdensity_lipoprotein_cholesterol_discovery_adjusted_for_surrogate_variables
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	0.0324207	0.00825223	0.00008578924	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SELL protein levels (SeqId = 4831-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SELL protein levels (SeqId = 4831-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: L-selectin	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.38	0.096	0.000087	None	Gadd-DA_sell_protein_levels__seqid___4831-4__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.032383	0.00825224	0.00008743555	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0337562	0.00862795	0.00009178727	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.0337281	0.00862625	0.00009273402	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CR1 protein levels (SeqId = 19556-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CR1 protein levels (SeqId = 19556-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement receptor type 1	774	1	Adults (18-65 years)	Both	European	cg16411857	chr16:57023191	16	57023191	NLRC5	Island	-0.37	0.095	0.000093	None	Gadd-DA_cr1_protein_levels__seqid___19556-12__somascan_protein_measurement