author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17674726	chr2:231743193	2	231743193	ITM2C	Open sea	0.0054	0.00017	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17674726	chr2:231743193	2	231743193	ITM2C	Open sea	0.0035	None	4.7e-138	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg17674726	chr2:231743193	2	231743193	ITM2C	Open sea	-0.29256	0.00592	1.8e-111	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg17674726	chr2:231743193	2	231743193	ITM2C	Open sea	-	-	9.72e-52	-	28056824_age_4_vs_age_0
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 2531589 (gene symbol: ITM2C)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 2531589 (gene symbol: ITM2C)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg17674726	chr2:231743193	2	231743193	ITM2C	Open sea	None	None	4.4e-20	None	33752734_Yao-C_gene_expression_of_affymetrix_id__2531589__gene_symbol__itm2c__meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17674726	chr2:231743193	2	231743193	ITM2C	Open sea	-0.0732239	0.00823441	6.665830999999999e-19	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg17674726	chr2:231743193	2	231743193	ITM2C	Open sea	-0.0074	0.00095	0.0000000000000095	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17674726	chr2:231743193	2	231743193	ITM2C	Open sea	-0.0617703	0.0082408	0.00000000000006973276	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17674726	chr2:231743193	2	231743193	ITM2C	Open sea	-0.0593036	0.00824204	0.0000000000006536591	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Qi, Y	Han Chinese hospital outpatients	34539625	Sep 3, 2020	Chronic Spontaneous Urticaria	EFO_0005531	None	None	DNA methylation	Chronic Spontaneous Urticaria	Age, Sex, Smoking, Batch effects	Beta values	None	Illumina HumanMethylationEPIC	whole blood	None	190	1	Adults	Both	East Asian	cg17674726	chr2:231743193	2	231743193	ITM2C	Open sea	-0.061	None	0.000000036	beta is mean methylation cases - mean methylation controls	34539625_Qi,-Y_chronic_spontaneous_urticaria
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17674726	chr2:231743193	2	231743193	ITM2C	Open sea	-0.0406677	0.00824974	0.0000008331011	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17674726	chr2:231743193	2	231743193	ITM2C	Open sea	0.0392487	0.00825021	0.000001980688	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17674726	chr2:231743193	2	231743193	ITM2C	Open sea	-0.0373085	0.00825082	0.000006179962	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17674726	chr2:231743193	2	231743193	ITM2C	Open sea	-0.0351141	0.00825148	0.00002098834	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17674726	chr2:231743193	2	231743193	ITM2C	Open sea	-0.0342608	0.00825172	0.00003315017	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg17674726	chr2:231743193	2	231743193	ITM2C	Open sea	-0.0332625	0.008252	0.00005585898	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg17674726	chr2:231743193	2	231743193	ITM2C	Open sea	0.012	0.00301	0.00007	None	Robert-F-Hillary_Incident_COPD_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	RBM19 protein levels (SeqId = 11468-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RBM19 protein levels (SeqId = 11468-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Probable RNA-binding protein 19	774	1	Adults (18-65 years)	Both	European	cg17674726	chr2:231743193	2	231743193	ITM2C	Open sea	-0.339	0.087	0.000097	None	Gadd-DA_rbm19_protein_levels__seqid___11468-15__somascan_protein_measurement