author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.036	0.0013	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.016	0.0013	0	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-9.4	0.304	9.1e-206	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.246283	0.0119612	6.924739e-93	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.221389	0.0108991	1.7434269999999998e-90	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.215405	0.011001	2.696291e-84	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.215762	0.0110524	8.307015e-84	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-6.2	0.339	6.600000000000001e-74	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.191349	0.0111118	8.289717000000001e-66	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.201848	0.0120946	5.87455e-62	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.178873	0.0109945	5.346141e-59	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.800665	0.0495389	2.486511e-58	None	39706196_Hannah-M.-Smith_bmi_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.844427	0.0522595	2.654722e-58	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.176467	0.0110125	2.651256e-57	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.779012	0.0496739	4.769723e-55	None	39706196_Hannah-M.-Smith_body_fat_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.821297	0.0526246	1.5450070000000002e-54	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.185251	0.0119559	1.009626e-53	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.767221	0.0497728	2.842018e-53	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.649222	0.0469987	3.4830830000000002e-43	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.152916	0.0111829	2.634351e-42	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.00181882	0.00012783	3.89e-42	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.151244	0.0111276	8.036426e-42	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.151793	0.0111761	9.174857e-42	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.144678	0.0111751	3.9785279999999996e-38	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.143707	0.0111556	9.094373999999999e-38	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.132663	0.0111839	2.622574e-32	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.00141692	0.00011974	1.92e-30	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.126779	0.0112007	1.405066e-29	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.126246	0.0111786	1.869445e-29	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.12785	0.0113661	3.110211e-29	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.124164	0.0112656	3.880604e-28	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.134665	0.0122898	7.8517040000000005e-28	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.121776	0.0112127	2.259499e-27	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.119619	0.0111953	1.503011e-26	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.132174	0.0124062	2.0898519999999998e-26	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.088	0.00828	2.1e-26	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.122955	0.0119925	1.39418e-24	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.113036	0.0111433	4.2405369999999996e-24	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.113082	0.0112293	8.937947e-24	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.11352	0.0113069	1.2133150000000001e-23	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.118531	0.0120764	1.1392230000000001e-22	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.11536	0.0117851	1.477292e-22	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.484247	0.0497366	2.411003e-22	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.104737	0.0109764	1.617793e-21	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_3
Ventham NT	-	27886173	2016-11-25	Inflammatory bowel disease	EFO_0003767	-	Table 1	DNA methylation	Inflammatory bowel disease	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	431	1	33	Both	None	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-	-	2.02e-20	-	27886173_inflammatory_bowel_disease
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.103386	0.0111966	2.966241e-20	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.48566	0.0526723	3.2932359999999997e-20	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.112606	0.012408	1.2761479999999999e-19	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_4
Ligthart S	CHARGE	27955697	2016-12-12	C-reactive protein	EFO_0004458	Discovery	Table S3	DNA methylation	C-reactive protein	Age, sex, smoking, body mass index, cell counts and technical covariates	Beta values	mg/l	Illumina HumanMethylation450	Whole blood	C-reactive protein levels were log-transformed	8863	9	65	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0043	0.000477	1.94e-19	-	27955697_creactive_protein_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.100591	0.0112062	3.1339389999999997e-19	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.107768	0.012269	1.7539900000000003e-18	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0992734	0.0113616	2.634648e-18	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.108122	0.0123872	2.855186e-18	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0984659	0.0113069	3.4051400000000002e-18	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.402386	0.0469914	1.186069e-17	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.105754	0.0123504	1.2103220000000001e-17	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_4
Nones K	-	24500968	2014-05-09	Pancreatic ductal adenocarcinoma	EFO_0002517	-	Table S4	DNA methylation	Pancreatic ductal adenocarcinoma	-	Beta values	-	Illumina HumanMethylation450	Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata	-	196	1	-	Missing	None	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-	-	2.47e-17	-	24500968_pancreatic_ductal_adenocarcinoma
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0940911	0.0111979	4.7663850000000004e-17	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	Discovery and replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	Weighted Z-test meta-analysis	10238	13	54.5	Both	European,South Asian	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-	-	6.2e-17	-	28002404_body_mass_index_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0935546	0.0112259	8.517999000000001e-17	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0928041	0.0112372	1.598401e-16	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.101319	0.0122774	1.682616e-16	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0918715	0.0112321	3.085358e-16	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0866635	0.010849	0.000000000000001471485	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0644237	0.00823942	0.000000000000005686904	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0890469	0.0114034	0.000000000000006162639	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Sun D	Bogalusa Heart Study, Georgia Stress and Heart Study	31510868	2019-09-12	body mass index	EFO_0004340	meta-analysis in Europeans	Online Table I	DNA methylation	body mass index	age, sex, smoking, cell composition (reference based), batch effects	Beta Values	kg/m2	Illumina HumanMethylation450	Whole blood	None	1247	2	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.001	None	0.0000000000000065	None	31510868_Sun-D_body_mass_index_meta-analysis_in_europeans
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0875683	0.011245	0.000000000000007302967	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0874236	0.011289	0.00000000000001024878	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0867322	0.0112042	0.0000000000000105041	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0634357	0.00823994	0.0000000000000146362	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0871569	0.0113536	0.00000000000001736447	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.085858	0.011231	0.00000000000002222773	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Mendelson MM	FHS	29740313	2018-04-24	Soluble tumor necrosis factor receptor 2	EFO_0008384, NCIT_C117749	None	Table S1	DNA methylation	Soluble tumor necrosis factor receptor 2	Age, sex, body mass index, smoking, batch effects	Beta Values	pg/ml	Illumina HumanMethylation450	Whole blood	None	2468	1	Adults	Both	Unclear	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0156	0.00204	0.000000000000034	None	29740313_Mendelson-MM_soluble_tumor_necrosis_factor_receptor_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.380464	0.0501867	0.00000000000003593547	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0834735	0.0112279	0.0000000000001108068	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_2
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.00834	0.00113	0.00000000000013	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0610914	0.00824115	0.0000000000001302439	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0608793	0.00824126	0.000000000000158104	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0828461	0.0112217	0.0000000000001634709	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0900486	0.012469	0.0000000000005383125	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_4
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry discovery	Table S3	Body mass index	DNA mehtylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	5387	4	54.5	Both	European,South Asian	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-21.7	2.8	0.00000000000059	-	28002404_body_mass_index_all_ancestry_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0791701	0.0112365	0.000000000001926521	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0873777	0.0124391	0.000000000002243944	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0780055	0.0112441	0.000000000004159006	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0846567	0.0122934	0.000000000005957873	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0850816	0.0124631	0.000000000009033015	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0846485	0.0124162	0.000000000009619098	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0776567	0.0113933	0.000000000009726613	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_3
Battram T	GEO	27886173	2020-09-15	Crohn's disease	EFO_0000384	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Crohn's disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	161	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0852	0.01148	0.00000000001	None	27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0752806	0.0112461	0.00000000002251281	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0698142	0.010467	0.0000000000265069	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Ligthart S	CHARGE	27955697	2016-12-12	C-reactive protein	EFO_0004458	Replication	Table S3	DNA methylation	C-reactive protein	Age, sex, smoking, body mass index, cell counts and technical covariates	Beta values	mg/l	Illumina HumanMethylation450	Whole blood	C-reactive protein levels were log-transformed	4111	4	59.7	Missing	African	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0078	0.001173	0.0000000000296	-	27955697_creactive_protein_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0817208	0.0123729	0.00000000004117565	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_4
Sun D	Georgia Stress and Heart Study	31510868	2019-09-12	body mass index	EFO_0004340	Replication in Africans	Online Table II	DNA methylation	body mass index	age, sex, smoking, cell composition (reference based), batch effects	Beta Values	kg/m2	Illumina HumanMethylation450	Unspecified	tissue type not specified for this cohort	228	1	Adults	Both	African	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0015	None	0.000000000047	None	31510868_Sun-D_body_mass_index_replication_in_africans
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	South Asian ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2680	1	51.0	Both	South Asian	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-46.47	6.22	0.000000000054	-	28002404_body_mass_index_south_asian_ancestry_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0746024	0.0114034	0.0000000000626623	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0741046	0.0114015	0.00000000008316971	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_3
Fernández-Sanlés A.	REGICOR, Framingham Offspring Cohort	29326313	2018-01-11	Cardiovascular risk	EFO_0003919, EFO_0004298	Age-independent cardiovascular risk was determined via the residuals approach, results meta-analysesd across discovery and replicaton cohorts	Table 2	DNA methylation	Cardiovascular risk	Sex, age, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole Blood	None	2746	2	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-4.7	0.73	0.00000000011	None	29326313_Fernández-Sanlés-A._cardiovascular_risk_age-independent_cardiovascular_risk_was_determined_via_the_residuals_approach__results_meta-analysesd_across_discovery_and_replicaton_cohorts
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0723741	0.0112478	0.0000000001276923	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0726309	0.0112921	0.000000000129811	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.071745	0.0112875	0.0000000002130132	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P22792	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P22792	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0711897	0.0112417	0.0000000002480265	P22792	41361833_Josephine_Robertson_P22792_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0699798	0.0112374	0.0000000004870964	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0678145	0.0109448	0.0000000005944292	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0698212	0.0113911	0.0000000009044508	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.050421	0.00824607	0.0000000009928492	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0503129	0.00824611	0.000000001077827	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Fernández-Sanlés A.	REGICOR, Framingham Offspring Cohort	29326313	2018-01-11	Cardiovascular risk	EFO_0003919, EFO_0004298	Age-independent cardiovascular risk was determined via the delta age approach, results meta-analysesd across discovery and replicaton cohorts	Table 2	DNA methylation	Cardiovascular risk	Sex, age, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole Blood	None	2746	2	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0097	0.0016	0.0000000012	None	29326313_Fernández-Sanlés-A._cardiovascular_risk_age-independent_cardiovascular_risk_was_determined_via_the_delta_age_approach__results_meta-analysesd_across_discovery_and_replicaton_cohorts
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	European ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2707	3	57.9	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-17.33	2.85	0.0000000012	-	28002404_body_mass_index_european_ancestry_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0682427	0.0112186	0.000000001208851	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0681919	0.0113208	0.000000001746835	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0670902	0.011244	0.000000002475713	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0665494	0.0112457	0.000000003335912	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0658599	0.0112175	0.000000004420595	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0712847	0.0123369	0.000000007705174	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0700758	0.012151	0.000000008227794	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0648311	0.0112963	0.000000009702875	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0704171	0.0123038	0.00000001065794	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0639285	0.011184	0.00000001111468	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0704534	0.0123493	0.00000001185401	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_4
Sun D	Georgia Stress and Heart Study	31510868	2019-09-12	body mass index	EFO_0004340	Replication in Europeans	Online Table I	DNA methylation	body mass index	age, sex, smoking, cell composition (reference based), batch effects	Beta Values	kg/m2	Illumina HumanMethylation450	Unspecified	tissue type not specified for this cohort	252	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0012	None	0.000000012	None	31510868_Sun-D_body_mass_index_replication_in_europeans
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.064956	0.0114125	0.00000001282345	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0646275	0.011361	0.00000001305854	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0642208	0.0112929	0.00000001318749	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_3
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.07	0.0123	0.000000014	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0700954	0.0123868	0.00000001552266	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P22792	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P22792	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0702463	0.0124621	0.00000001764507	P22792	41361833_Josephine_Robertson_P22792_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0700961	0.0124669	0.00000001915578	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0463579	0.00824769	0.00000001936392	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0623136	0.0111195	0.00000002132459	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P22792	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P22792	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0638333	0.0114052	0.00000002221541	P22792	41361833_Josephine_Robertson_P22792_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.069058	0.0124613	0.00000003045617	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0689222	0.0124421	0.0000000308698	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0617362	0.0111606	0.00000003227367	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0453278	0.00824809	0.00000003959782	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0674136	0.0123238	0.00000004569084	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.061424	0.0112334	0.00000004626495	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0449579	0.00824822	0.00000005100776	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0449099	0.00824824	0.00000005270078	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0619015	0.0113902	0.00000005578809	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.053	0.00975	0.000000061	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Chen Y	None	34670603	Oct 20, 2021	Body mass index	EFO_0004340	Multi-ethnic Asian meta-analysis	None	Body mass index	DNA methylation	Age, Sex, Smoking, Cell composition (reference free), control probe PCs	kg/m2	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	409	None	Adults (18-65 years)	Both	East Asian, South Asian, Admixed	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-40.4	7.5	0.000000067	None	34670603_Chen-Y_body_mass_index_multi-ethnic_asian_meta-analysis
Battram T	GEO	27886173	2020-09-15	Inflammatory bowel disease	EFO_0003767	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Inflammatory bowel disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	240	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0612	0.01099	0.000000073	None	27886173_Battram-T_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.06131	0.0113982	0.00000007608359	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0604961	0.0113621	0.000000102804	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Long P	Chinese	33499918	2021-01-27	Serum copper	EFO_0007578	Discovery	Table 2	DNA methylation	Serum copper	Age, sex, BMI, smoking, alcohol, cell composition (reference free), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	1243	1	Adults	Both	East Asian	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-5.3	1	0.00000011	z-score	33499918_Long-P_serum_copper_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	PACAP protein levels (SeqId = 16322-10)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PACAP protein levels (SeqId = 16322-10)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Marginal zone B- and B1-cell-specific protein	774	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-1.31	0.25	0.00000015	None	Gadd-DA_pacap_protein_levels__seqid___16322-10__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18059	1	Adults (18-65y)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.12	0.0234	0.00000017	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0634786	0.0121817	0.0000001904139	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0648623	0.0124517	0.0000001923439	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_4
Sun D	Bogalusa Heart Study	31510868	2019-09-12	body mass index	EFO_0004340	Discovery in Europeans	Online Table I	DNA methylation	body mass index	age, sex, smoking, cell composition (reference based), batch effects	Beta Values	kg/m2	Illumina HumanMethylation450	Whole blood	None	995	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0009	None	0.00000022	None	31510868_Sun-D_body_mass_index_discovery_in_europeans
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0577147	0.011227	0.0000002772293	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_2
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity, white blood cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.009	0.002	0.00000034	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts
Sikdar S	PACE	31536415	2019-09-19	Prenatal smoke exposure	EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318	Inverse varience-weighted fixed-effects meta-analysis	Table S1	DNA methylation	Prenatal smoke exposure	Maternal age, socioeconomic position, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Cord blood, whole blood	None	5648	9	Infants	Both	European, African, Unclear	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0087	0.0017	0.00000034	None	31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0632171	0.0123988	0.0000003463402	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_4
Ek WE	-	26681806	2016-02-15	Growth differentiation factor 15	OMIT_0026290	Meta-analysis	Table S2	Growth differentiation factor 15	DNA methylation	Age, sex, cell counts and technical covariates	-	Beta values	Illumina HumanMethylation450	Whole blood	Regression coefficients are for inverse normally transformed growth differentiation factor 15	1680	2	61.7	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-2.89	0.5698	0.000000393	-	26681806_growth_differentiation_factor_15_metaanalysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0417449	0.00824937	0.0000004234914	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0416132	0.00824942	0.0000004604386	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.009	0.002	0.000000479	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns
Marzi C	-	27824951	2016-11-08	C-reactive protein	EFO_0004458	KORA F4 discovery	Table SB	C-reactive protein	DNA methylation	Age, sex, smoking, body mass index, fasting status, cell counts and technical covariates	mg/l	Beta values	Illumina HumanMethylation450	Peripheral blood	-	1741	1	60.9	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.027	0.005	0.00000056	-	27824951_creactive_protein_kora_f4_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0570754	0.0114083	0.0000005710174	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0566861	0.0113794	0.00000063825	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0555826	0.0112534	0.0000007930736	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0559484	0.0113857	0.0000009024503	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0558202	0.0113602	0.0000009036496	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0404852	0.0082498	0.0000009327537	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0550539	0.0112435	0.0000009858778	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	CRTAM protein levels (SeqId = 7968-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CRTAM protein levels (SeqId = 7968-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cytotoxic and regulatory T-cell molecule	774	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-1.24	0.254	0.000001	None	Gadd-DA_crtam_protein_levels__seqid___7968-15__somascan_protein_measurement
Ek WE	-	26681806	2016-02-15	Growth differentiation factor 15	OMIT_0026290	NSPHS study	Table S2	Growth differentiation factor 15	DNA methylation	Age, sex, cell counts and technical covariates	-	Beta values	Illumina HumanMethylation450	Whole blood	Regression coefficients are for inverse normally transformed growth differentiation factor 15	717	1	50.4	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-3.98	0.8155	0.00000106	-	26681806_growth_differentiation_factor_15_nsphs_study
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0554116	0.011416	0.000001223405	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0543925	0.0112497	0.000001344918	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0543679	0.0112481	0.00000135503	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	South Asian ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	656	1	53.8	Both	South Asian	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-34.03	6.96	0.0000014	-	28002404_body_mass_index_south_asian_ancestry_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0543576	0.0114036	0.000001890664	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0535652	0.0112402	0.000001901765	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0584002	0.0123292	0.000002192106	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0588633	0.0124275	0.000002194348	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_4
Singmann P	-	26500701	2015-10-19	Sex	EFO_0001271	KORA F4	Additional file 2	DNA methylation	Sex	Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	1799	1	60	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-	-	0.00000224	-	26500701_sex_kora_f4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0588833	0.0124485	0.000002264522	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	IGFLR1 protein levels (SeqId = 7244-16)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IGFLR1 protein levels (SeqId = 7244-16)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: IGF-like family receptor 1	774	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-1.2	0.254	0.0000025	None	Gadd-DA_igflr1_protein_levels__seqid___7244-16__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0525869	0.0112073	0.000002727384	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_2
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.04056	0.0084	0.0000028	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0082	0.0017	0.0000028	-	27651444_smoking_current_vs_never_smoking
Sun D	Bogalusa Heart Study	31510868	2019-09-12	body mass index	EFO_0004340	Discovery in Africans	Online Table II	DNA methylation	body mass index	age, sex, smoking, cell composition (reference based), batch effects	Beta Values	kg/m2	Illumina HumanMethylation450	Whole blood	None	490	1	Adults	Both	African	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0011	None	0.0000029	None	31510868_Sun-D_body_mass_index_discovery_in_africans
Gadd DA	Generation Scotland	35945220	31/07/2022	C1RL protein levels (SeqId = 9348-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C1RL protein levels (SeqId = 9348-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement C1r subcomponent-like protein	774	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-1.18	0.253	0.0000031	None	Gadd-DA_c1rl_protein_levels__seqid___9348-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0523134	0.0112371	0.000003261378	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_2
Kashima K	None	33564054	2021-02-09	gestational age	EFO_0005112	None	Supplementary Table 6	DNA methylation	gestational age	sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia	Beta Values	weeks	Illumina HumanMethylation450	Cord blood	None	110	1	Infants	Both	East Asian	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0067	0.0014	0.0000036	None	33564054_Kashima-K_gestational_age
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Rheumatoid Arthritis (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Rheumatoid Arthritis (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18055	1	Adults (18-65y)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.083	0.018	0.0000038	None	Robert-F-Hillary_Prevalent_Rheumatoid_Arthritis_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.052561	0.0114171	0.000004185347	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_3
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	4851	9	54.5	Both	European,South Asian	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-5.8	1.3	0.0000047	-	28002404_body_mass_index_all_ancestry_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0516685	0.0114176	0.000006077137	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.056345	0.0124925	0.000006523683	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	C5 protein levels (SeqId = 4482-66)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C5 protein levels (SeqId = 4482-66)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement C5|Complement component C6	774	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-1.14	0.254	0.0000067	None	Gadd-DA_c5_protein_levels__seqid___4482-66__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01009	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01009	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0512176	0.011398	0.000007057484	P01009	41361833_Josephine_Robertson_P01009_OSCA_model_3
Chen Y	None	34670603	Oct 20, 2021	Waist Circumference	EFO_0004342	Multi-ethnic Asian meta-analysis	None	Waist Circumference	DNA methylation	Age, Sex, Smoking, Cell composition (reference free), control probe PCs	cm	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	409	None	Adults (18-65 years)	Both	East Asian, South Asian, Admixed	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-83	18.6	0.0000079	None	34670603_Chen-Y_waist_circumference_multi-ethnic_asian_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0501728	0.0112483	0.000008238501	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0505617	0.0113379	0.000008275438	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0546841	0.0124268	0.00001087665	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0548806	0.0124732	0.00001090758	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0361777	0.00825117	0.00001170316	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0544421	0.0124266	0.00001189085	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0545632	0.0124732	0.00001225823	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0544642	0.0124617	0.00001247987	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	B2M protein levels (SeqId = 3485-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	B2M protein levels (SeqId = 3485-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-2-microglobulin	774	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-1.11	0.254	0.000013	None	Gadd-DA_b2m_protein_levels__seqid___3485-28__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0539506	0.0123835	0.00001329572	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0490839	0.0113186	0.00001456847	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0492308	0.0114067	0.00001599471	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	TCN1 protein levels (SeqId = 19614-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TCN1 protein levels (SeqId = 19614-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Transcobalamin-1	774	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-1.08	0.25	0.000017	None	Gadd-DA_tcn1_protein_levels__seqid___19614-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FDCSP protein levels (SeqId = 17346-61)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FDCSP protein levels (SeqId = 17346-61)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Follicular dendritic cell secreted peptide	774	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-1.09	0.254	0.000019	None	Gadd-DA_fdcsp_protein_levels__seqid___17346-61__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CD8A protein levels (SeqId = 15462-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD8A protein levels (SeqId = 15462-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-cell surface glycoprotein CD8 alpha chain	774	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-1.09	0.254	0.000019	None	Gadd-DA_cd8a_protein_levels__seqid___15462-28__somascan_protein_measurement
Vehmeijer FOL	PACE	33239103	25/11/2020	Body mass index	EFO_0004340	adolescent BMI and methylation	Table S2D	DNA methylation	Body mass index	maternal age, maternal educational level, maternal smoking during pregnancy, maternal pre-pregnancy BMI, parity, gestational age at birth, cell composition (reference based)	Beta Values	kg/m2	Illumina HumanMethylation450	Whole blood	None	2842	23	Children	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0172	0.004	0.00002	None	33239103_Vehmeijer-FOL_body_mass_index_adolescent_bmi_and_methylation
Gadd DA	Generation Scotland	35945220	31/07/2022	RNASET2 protein levels (SeqId = 16913-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RNASET2 protein levels (SeqId = 16913-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ribonuclease T2	774	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-1.083	0.254	0.00002	None	Gadd-DA_rnaset2_protein_levels__seqid___16913-8__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0478069	0.0112256	0.00002068537	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0484179	0.0113974	0.00002168726	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.048456	0.0114101	0.00002182314	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0349107	0.00825154	0.00002342667	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0342795	0.00825172	0.00003282374	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0470849	0.0114164	0.00003738647	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0510118	0.012389	0.00003851066	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	C5 protein levels (SeqId = 2381-52)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C5 protein levels (SeqId = 2381-52)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement C5	774	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-1.04	0.253	0.000041	None	Gadd-DA_c5_protein_levels__seqid___2381-52__somascan_protein_measurement
Liu C	CHARGE+	27843151	2016-12-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	European ancestry	Table S5	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g der day	Illumina HumanMethylation450	Whole blood	-	9643	10	64.2	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.00011417	2.78e-05	0.0000411	-	27843151_alcohol_consumption_per_day_european_ancestry
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0512078	0.0124902	0.00004156744	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	FAIM3 protein levels (SeqId = 6574-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FAIM3 protein levels (SeqId = 6574-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fas apoptotic inhibitory molecule 3	774	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-1.038	0.254	0.000044	None	Gadd-DA_faim3_protein_levels__seqid___6574-11__somascan_protein_measurement
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Any maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	6685	13	0	Missing	European,East Asian,African,Admixed,Other	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.006	0.002	0.0000455	-	27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0335861	0.00825191	0.0000472395	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.046208	0.0114067	0.0000512702	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0482635	0.0119201	0.00005171748	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0455266	0.0112522	0.00005236434	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0332838	0.008252	0.00005524843	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0332809	0.008252	0.0000553305	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	LY9 protein levels (SeqId = 3324-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LY9 protein levels (SeqId = 3324-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: T-lymphocyte surface antigen Ly-9	774	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-1.02	0.252	0.000057	None	Gadd-DA_ly9_protein_levels__seqid___3324-51__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0449648	0.0112095	0.00006068289	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0449345	0.011249	0.00006513801	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.00086	0.00022	0.000069	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0327207	0.00825215	0.00007370887	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	SLAMF6 protein levels (SeqId = 5128-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SLAMF6 protein levels (SeqId = 5128-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: SLAM family member 6	774	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-1.01	0.254	0.000075	None	Gadd-DA_slamf6_protein_levels__seqid___5128-53__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PZP protein levels (SeqId = 6580-29)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PZP protein levels (SeqId = 6580-29)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Pregnancy zone protein	774	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.99	0.249	0.000075	None	Gadd-DA_pzp_protein_levels__seqid___6580-29__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0445104	0.0112387	0.00007515662	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_2
Battram T	GEO	23334450	2020-09-15	Rheumatoid arthritis	EFO_0000685	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE42861	None	DNA methylation	Rheumatoid arthritis	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	689	1	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0125	0.00313	0.000076	None	23334450_Battram-T_rheumatoid_arthritis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse42861
Anna Ulrich	None	38184627	Dec 5, 2023	Idiopathic/heritable pulmonary arterial hypertension	None	Discovery	None	DNA methylation	Idiopathic/heritable pulmonary arterial hypertension	Age, Sex, Smoking, Cell composition (reference based), Ancestry (other), first ten principal components computed from control probes	Beta values	None	Illumina HumanMethylationEPIC	whole blood	None	1655	4	Adults	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-21	5.2	0.000079	None	38184627_Anna-Ulrich_idiopathic_heritable_pulmonary_arterial_hypertension_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0444015	0.01125	0.00007957512	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Chronic Pain	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Chronic Pain	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	11591	1	Adults (18-65y)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.093	0.0236	0.000081	None	Robert-F-Hillary_Incident_Chronic_Pain_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	LAG3 protein levels (SeqId = 9950-229)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LAG3 protein levels (SeqId = 9950-229)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lymphocyte activation gene 3 protein	774	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-1	0.254	0.000081	None	Gadd-DA_lag3_protein_levels__seqid___9950-229__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	0.0442538	0.0112279	0.00008138133	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01009	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01009	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0490678	0.0124628	0.00008284101	P01009	41361833_Josephine_Robertson_P01009_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CLPSL1 protein levels (SeqId = 9526-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CLPSL1 protein levels (SeqId = 9526-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Colipase-like protein 1	774	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-1	0.254	0.000087	None	Gadd-DA_clpsl1_protein_levels__seqid___9526-3__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0447413	0.011399	0.00008711757	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0486658	0.0124484	0.00009294795	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0487396	0.0124896	0.00009565903	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Stroke	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Stroke	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18023	1	Adults (18-65y)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.031	0.00801	0.000097	None	Robert-F-Hillary_Incident_Stroke_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9BXR6	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q9BXR6	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18608055	chr19:1130866	19	1130866	SBNO2	Open sea	-0.0486562	0.0124824	0.00009743134	Q9BXR6	41361833_Josephine_Robertson_Q9BXR6_OSCA_model_4