author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3755934 (gene symbol: ORMDL3)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3755934 (gene symbol: ORMDL3)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	None	None	5.6e-87	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3755934__gene_symbol__ormdl3__meta-analysis
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3755903 (gene symbol: GSDMB)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3755903 (gene symbol: GSDMB)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	None	None	2.7e-81	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3755903__gene_symbol__gsdmb__meta-analysis
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	0.25976	0.00861	5.7e-75	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Bonder MJ	-	25282492	2014-10-04	Fetal vs adult liver	UBERON_0002107, GO_0048513	-	Additional file 2	DNA methylation	Fetal vs adult liver	Sex and technical covariates	M values	-	Illumina HumanMethylation450	Liver	-	195	2	-	Missing	None	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	2.4917	0.10588	1.73e-39	-	25282492_fetal_vs_adult_liver
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	-	-	3.21e-32	-	23526956_clear_cell_renal_carcinoma
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a random effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	0.001	None	0.00000096	None	33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	OLFM1 protein levels (SeqId = 5703-26)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	OLFM1 protein levels (SeqId = 5703-26)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Noelin	774	1	Adults (18-65 years)	Both	European	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	0.758	0.159	0.000002	None	Gadd-DA_olfm1_protein_levels__seqid___5703-26__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	0.0403701	0.00855597	0.000002399575	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	-0.00062	0.00014	0.0000063	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	CISD2 protein levels (SeqId = 8094-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CISD2 protein levels (SeqId = 8094-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CDGSH iron-sulfur domain-containing protein 2	774	1	Adults (18-65 years)	Both	European	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	0.715	0.159	0.000007	None	Gadd-DA_cisd2_protein_levels__seqid___8094-20__somascan_protein_measurement
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	0.0042	0.00095	0.0000087	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	0.0381199	0.00876596	0.00001379218	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	0.0368736	0.00849266	0.00001422543	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Liu C	CHARGE+	27843151	2016-12-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	European ancestry	Table S5	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g der day	Illumina HumanMethylation450	Whole blood	-	9643	10	64.2	Both	European	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	-0.00011816	2.77e-05	0.0000204	-	27843151_alcohol_consumption_per_day_european_ancestry
Gadd DA	Generation Scotland	35945220	31/07/2022	GAGE2D protein levels (SeqId = 18273-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GAGE2D protein levels (SeqId = 18273-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: G antigen 2D	774	1	Adults (18-65 years)	Both	European	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	0.659	0.159	0.000033	None	Gadd-DA_gage2d_protein_levels__seqid___18273-14__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CEBPA protein levels (SeqId = 18874-66)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CEBPA protein levels (SeqId = 18874-66)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CCAAT/enhancer-binding protein alpha	774	1	Adults (18-65 years)	Both	European	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	0.65	0.159	0.000041	None	Gadd-DA_cebpa_protein_levels__seqid___18874-66__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	TXNDC11 protein levels (SeqId = 9573-108)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TXNDC11 protein levels (SeqId = 9573-108)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thioredoxin domain-containing protein 11	774	1	Adults (18-65 years)	Both	European	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	0.64	0.159	0.000063	None	Gadd-DA_txndc11_protein_levels__seqid___9573-108__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	-0.0325879	0.00825219	0.000078844	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	MTMR6 protein levels (SeqId = 12536-46)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MTMR6 protein levels (SeqId = 12536-46)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Myotubularin-related protein 6	774	1	Adults (18-65 years)	Both	European	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	0.62	0.159	0.00009	None	Gadd-DA_mtmr6_protein_levels__seqid___12536-46__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EXOSC1 protein levels (SeqId = 7930-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EXOSC1 protein levels (SeqId = 7930-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Exosome complex component CSL4	774	1	Adults (18-65 years)	Both	European	cg18711369	chr17:38081186	17	38081186	ORMDL3	North shelf	0.62	0.158	0.000091	None	Gadd-DA_exosc1_protein_levels__seqid___7930-3__somascan_protein_measurement